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The map label for this gene is accC2 [H]

Identifier: 116328575

GI number: 116328575

Start: 2254311

End: 2255762

Strand: Reverse

Name: accC2 [H]

Synonym: LBL_1932

Alternate gene names: 116328575

Gene position: 2255762-2254311 (Counterclockwise)

Preceding gene: 116328576

Following gene: 116328574

Centisome position: 62.41

GC content: 46.83

Gene sequence:

>1452_bases
TTGATCTCTAAACTACTGATTGCGAATCGAGGAGAAATCGCGGTTCGTGTGATCCGAACCTGTAAACGACTGGGAATCAA
AACGGTCGCCGTTTATTCGGATGCGGATAGGGATTCTCCTCATGTAAAACTTGCAAATGAATCCGTTTATGTGGGGGAAC
CGAGTCCCGCTTCTTCTTATTTAAATATTTCTAATATCCTTGAGGCGATCCGTAAAACGAAAGCGGAGGCCGTACATCCC
GGATACGGGTTTTTATCCGAAAAAAGCGAATTTGCAAAAGCATTACAAAAAGAGAATGTATTGTTTTTAGGTCCGACTCC
GGAATCGATGGAACTTATGGGAGATAAGATCAATTCCCGAATCAAGATGGAGGCTTCGGGAGTTCCGGTTGTTCCGGGTT
ACAACGGACAGGATCAAAATCCTAACGTTCTTCAAAGGGAAGCCGAAAAAATCGGATATCCTTTGATGATTAAGGCAACC
GCGGGAGGAGGGGGCAAGGGAATGAAACGGGTCTATAAACCGGAAGAATTTCTCACCTCGCTCGAATCGGCACAAAGGGA
AGCGCAAAAAGCTTTCGGAGATGGCACCGTATTTCTGGAAAAATACATAGAGATGCCTAGGCATGTCGAAGTGCAGGTTT
TCGGAGACAAACATGGAAACGTTATGCATCTTTTTGAACGGGAATGTTCGATTCAGAGAAGGCACCAAAAGGTGATCGAA
GAATCTCCCGCTCCCAATCTTCCTGCCGAGCTCCGGGACGAAATTTGTCAGGTAGCGGTCAAAGCGGCGCGGTCTATCGA
TTATGTGGGAGCCGGAACCGTGGAGTTTATTTTGGGGAAGGACGGAAAGTTCTATTTTTTGGAGATGAATACGAGACTGC
AGGTGGAACATCCGGTCACGGAATATACCACCGGACAGGACTTAGTGGAATGGCAGATCCGAGTCGCGGAAGGAAAAAAA
CTTTCGGATCTCACCGGCGGAAAAGAAATCACTCGGAACGGACACGCAATCGAAGCCCGCATCTATGCTGAAGATCCCGA
AAATAGTTTTTTACCTTCCACGGGAATATTAGAATATCTTGAATTTCCGGATCGCGAATTCCTTCGAGTGGAAACAGGAT
CAGAGATCACGGTCTACTACGATCCTATGATCGCCAAGATGATTTCCTGGGGAAAAACCAGGGAAGAATGTGCGGCCCGT
CTCAAGGAATCCATCGATTCCACGGTGATTTTTGGGCCGGTAACGAATACGTTTTTTCTTTCCGGAATTCTCTCCCATGA
AGAATTTAAAAAGGGACGTATTCACACGCACTTTTTGGAAGAACAGACGATTCTTTTCGTTCCCGAAAGGGAAATACAAG
CCGATGCGTTTTCCTTTGCGGCCTCGGCTCTTTCGGAAAAGAAAAGGTCCCAGGGAATTTGGGAAGCGGTCGGTCCGGGA
GGTTTTTGGTGA

Upstream 100 bases:

>100_bases
AGGAATTTAAGGATTTCATCTATGAAACGATGGATCGCGAAAAGAAGTCACTTGACGCTATGCTTTCTTCCGAAGTCCGA
AAGGAATCGGTACTGGTATC

Downstream 100 bases:

>100_bases
TCGAAGAAAATTTTCTTTTTAAACATAAAGAAGAAGAAATACCGGTTCGGGTTCGTTCAAATTCACCGGGAGATATGTCC
GTATCGATTCTGTTAGACGG

Product: Acetyl/propionyl-CoA carboxylase, alpha subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 2; ACC 2 [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MISKLLIANRGEIAVRVIRTCKRLGIKTVAVYSDADRDSPHVKLANESVYVGEPSPASSYLNISNILEAIRKTKAEAVHP
GYGFLSEKSEFAKALQKENVLFLGPTPESMELMGDKINSRIKMEASGVPVVPGYNGQDQNPNVLQREAEKIGYPLMIKAT
AGGGGKGMKRVYKPEEFLTSLESAQREAQKAFGDGTVFLEKYIEMPRHVEVQVFGDKHGNVMHLFERECSIQRRHQKVIE
ESPAPNLPAELRDEICQVAVKAARSIDYVGAGTVEFILGKDGKFYFLEMNTRLQVEHPVTEYTTGQDLVEWQIRVAEGKK
LSDLTGGKEITRNGHAIEARIYAEDPENSFLPSTGILEYLEFPDREFLRVETGSEITVYYDPMIAKMISWGKTREECAAR
LKESIDSTVIFGPVTNTFFLSGILSHEEFKKGRIHTHFLEEQTILFVPEREIQADAFSFAASALSEKKRSQGIWEAVGPG
GFW

Sequences:

>Translated_483_residues
MISKLLIANRGEIAVRVIRTCKRLGIKTVAVYSDADRDSPHVKLANESVYVGEPSPASSYLNISNILEAIRKTKAEAVHP
GYGFLSEKSEFAKALQKENVLFLGPTPESMELMGDKINSRIKMEASGVPVVPGYNGQDQNPNVLQREAEKIGYPLMIKAT
AGGGGKGMKRVYKPEEFLTSLESAQREAQKAFGDGTVFLEKYIEMPRHVEVQVFGDKHGNVMHLFERECSIQRRHQKVIE
ESPAPNLPAELRDEICQVAVKAARSIDYVGAGTVEFILGKDGKFYFLEMNTRLQVEHPVTEYTTGQDLVEWQIRVAEGKK
LSDLTGGKEITRNGHAIEARIYAEDPENSFLPSTGILEYLEFPDREFLRVETGSEITVYYDPMIAKMISWGKTREECAAR
LKESIDSTVIFGPVTNTFFLSGILSHEEFKKGRIHTHFLEEQTILFVPEREIQADAFSFAASALSEKKRSQGIWEAVGPG
GFW
>Mature_483_residues
MISKLLIANRGEIAVRVIRTCKRLGIKTVAVYSDADRDSPHVKLANESVYVGEPSPASSYLNISNILEAIRKTKAEAVHP
GYGFLSEKSEFAKALQKENVLFLGPTPESMELMGDKINSRIKMEASGVPVVPGYNGQDQNPNVLQREAEKIGYPLMIKAT
AGGGGKGMKRVYKPEEFLTSLESAQREAQKAFGDGTVFLEKYIEMPRHVEVQVFGDKHGNVMHLFERECSIQRRHQKVIE
ESPAPNLPAELRDEICQVAVKAARSIDYVGAGTVEFILGKDGKFYFLEMNTRLQVEHPVTEYTTGQDLVEWQIRVAEGKK
LSDLTGGKEITRNGHAIEARIYAEDPENSFLPSTGILEYLEFPDREFLRVETGSEITVYYDPMIAKMISWGKTREECAAR
LKESIDSTVIFGPVTNTFFLSGILSHEEFKKGRIHTHFLEEQTILFVPEREIQADAFSFAASALSEKKRSQGIWEAVGPG
GFW

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=475, Percent_Identity=49.6842105263158, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=51.2359550561798, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=51.2359550561798, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=51.2359550561798, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI106049528, Length=452, Percent_Identity=43.5840707964602, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=452, Percent_Identity=43.5840707964602, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=452, Percent_Identity=43.5840707964602, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI38679960, Length=502, Percent_Identity=31.0756972111554, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI38679977, Length=502, Percent_Identity=31.0756972111554, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI38679967, Length=502, Percent_Identity=31.0756972111554, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI38679974, Length=502, Percent_Identity=31.0756972111554, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI38679971, Length=502, Percent_Identity=31.0756972111554, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI134142062, Length=504, Percent_Identity=31.7460317460317, Blast_Score=248, Evalue=1e-65,
Organism=Escherichia coli, GI1789654, Length=449, Percent_Identity=47.2160356347439, Blast_Score=390, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71987519, Length=478, Percent_Identity=48.1171548117155, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17567343, Length=477, Percent_Identity=45.9119496855346, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=451, Percent_Identity=43.2372505543237, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=31.6973415132924, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71997168, Length=544, Percent_Identity=28.6764705882353, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71997163, Length=544, Percent_Identity=28.6764705882353, Blast_Score=223, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=43.6936936936937, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319695, Length=453, Percent_Identity=40.1766004415011, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6321376, Length=453, Percent_Identity=40.3973509933775, Blast_Score=313, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6324343, Length=511, Percent_Identity=30.7240704500978, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6323863, Length=465, Percent_Identity=30.752688172043, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6322331, Length=312, Percent_Identity=22.7564102564103, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651757, Length=469, Percent_Identity=53.3049040511727, Blast_Score=500, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24651759, Length=430, Percent_Identity=52.093023255814, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24652212, Length=456, Percent_Identity=45.8333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652210, Length=456, Percent_Identity=45.8333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652214, Length=456, Percent_Identity=45.8333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19921944, Length=456, Percent_Identity=45.8333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652216, Length=456, Percent_Identity=45.8333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281363050, Length=456, Percent_Identity=45.8333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652224, Length=456, Percent_Identity=45.8333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652222, Length=456, Percent_Identity=45.8333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652220, Length=456, Percent_Identity=45.8333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652218, Length=456, Percent_Identity=45.8333333333333, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI161076407, Length=498, Percent_Identity=31.9277108433735, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24586460, Length=498, Percent_Identity=31.9277108433735, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI161076409, Length=498, Percent_Identity=31.9277108433735, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24586458, Length=498, Percent_Identity=31.9277108433735, Blast_Score=241, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 54018; Mature: 54018

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKLLIANRGEIAVRVIRTCKRLGIKTVAVYSDADRDSPHVKLANESVYVGEPSPASSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCEEEECCCCCCCHH
LNISNILEAIRKTKAEAVHPGYGFLSEKSEFAKALQKENVLFLGPTPESMELMGDKINSR
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCE
IKMEASGVPVVPGYNGQDQNPNVLQREAEKIGYPLMIKATAGGGGKGMKRVYKPEEFLTS
EEEECCCCEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCHHHHHHH
LESAQREAQKAFGDGTVFLEKYIEMPRHVEVQVFGDKHGNVMHLFERECSIQRRHQKVIE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHH
ESPAPNLPAELRDEICQVAVKAARSIDYVGAGTVEFILGKDGKFYFLEMNTRLQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEECCEEEEECCCC
EYTTGQDLVEWQIRVAEGKKLSDLTGGKEITRNGHAIEARIYAEDPENSFLPSTGILEYL
CCCCCCCCEEEEEEECCCCCCHHCCCCHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHH
EFPDREFLRVETGSEITVYYDPMIAKMISWGKTREECAARLKESIDSTVIFGPVTNTFFL
HCCCCCEEEEECCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHH
SGILSHEEFKKGRIHTHFLEEQTILFVPEREIQADAFSFAASALSEKKRSQGIWEAVGPG
HHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
GFW
CCC
>Mature Secondary Structure
MISKLLIANRGEIAVRVIRTCKRLGIKTVAVYSDADRDSPHVKLANESVYVGEPSPASSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCEEEECCCCCCCHH
LNISNILEAIRKTKAEAVHPGYGFLSEKSEFAKALQKENVLFLGPTPESMELMGDKINSR
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCE
IKMEASGVPVVPGYNGQDQNPNVLQREAEKIGYPLMIKATAGGGGKGMKRVYKPEEFLTS
EEEECCCCEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCHHHHHHH
LESAQREAQKAFGDGTVFLEKYIEMPRHVEVQVFGDKHGNVMHLFERECSIQRRHQKVIE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHH
ESPAPNLPAELRDEICQVAVKAARSIDYVGAGTVEFILGKDGKFYFLEMNTRLQVEHPVT
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEECCEEEEECCCC
EYTTGQDLVEWQIRVAEGKKLSDLTGGKEITRNGHAIEARIYAEDPENSFLPSTGILEYL
CCCCCCCCEEEEEEECCCCCCHHCCCCHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHH
EFPDREFLRVETGSEITVYYDPMIAKMISWGKTREECAARLKESIDSTVIFGPVTNTFFL
HCCCCCEEEEECCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCHHHHH
SGILSHEEFKKGRIHTHFLEEQTILFVPEREIQADAFSFAASALSEKKRSQGIWEAVGPG
HHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
GFW
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]