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The map label for this gene is clpP-2 [H]

Identifier: 116328441

GI number: 116328441

Start: 2076787

End: 2077380

Strand: Reverse

Name: clpP-2 [H]

Synonym: LBL_1783

Alternate gene names: 116328441

Gene position: 2077380-2076787 (Counterclockwise)

Preceding gene: 116328442

Following gene: 116328440

Centisome position: 57.47

GC content: 44.78

Gene sequence:

>594_bases
ATGCCAGAAATAGAAAAAATCACGGAAGTATTCGAAGAACTCACAGGAAGTAAAATTTCCAAAAAATTCCTCGACCACAG
AAAGATTTTTCTTTGGGGTCCGGTAACCGACGAATCATCCAAAGACTTGGTCGGAAAACTTCTCTACCTGGAAATGAAAG
ACCCGGGTAAACCCATTACGTTTTATATCAATAGCCCCGGCGGTGTCGTCACTTCTGGAATGACCGTATTCGATACGATC
AAAATGATTTCTTCTCCCGTTCACACAGTTTGTATGGGAATGGCGGCTTCTATGGGTTCGGTTCTGCTTGCGGCGGGAAC
AAAGGGAGAACGTTCCATTTGGCCGAATGGAAAAGTGATGATTCACCAACCGAGTATTGGAGGACAGATCGTAGCCCCTG
CTACCGATTTAAAAATCCACGCCGAAGAAATTCTCAAGACAAAAGCGAAGTTGAATCAGATTCTTGCGGACGCTTGCGGA
CAGCCGGTTTCCAAAATCGAAGAGGATACCGACCGCGACTACTACATGGACGCGGAAGAAGCGATCCAATACGGAATCGT
AAACAAACTCGCTACAAAAATCGATTTTAATTAA

Upstream 100 bases:

>100_bases
TTTCTACGCAATCTTCTCTAGTTTTACTTGTATTGGAGTTTTCATAAAAATGAGGAAGAAGAAACTGGACTTTACCAGCT
AATAAAGGAAAGGTTCAGGA

Downstream 100 bases:

>100_bases
TCGGAATTTTTTCCCTTGTCTAAGACGTTATCCTTAGAGGAATTCTTAAAAGAATTTTTAACTTCTCCGTATCAGAAAGG
AAGAAATCCGAAAGAGGATC

Product: protease subunit of an ATP-dependent Clp protease

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MPEIEKITEVFEELTGSKISKKFLDHRKIFLWGPVTDESSKDLVGKLLYLEMKDPGKPITFYINSPGGVVTSGMTVFDTI
KMISSPVHTVCMGMAASMGSVLLAAGTKGERSIWPNGKVMIHQPSIGGQIVAPATDLKIHAEEILKTKAKLNQILADACG
QPVSKIEEDTDRDYYMDAEEAIQYGIVNKLATKIDFN

Sequences:

>Translated_197_residues
MPEIEKITEVFEELTGSKISKKFLDHRKIFLWGPVTDESSKDLVGKLLYLEMKDPGKPITFYINSPGGVVTSGMTVFDTI
KMISSPVHTVCMGMAASMGSVLLAAGTKGERSIWPNGKVMIHQPSIGGQIVAPATDLKIHAEEILKTKAKLNQILADACG
QPVSKIEEDTDRDYYMDAEEAIQYGIVNKLATKIDFN
>Mature_196_residues
PEIEKITEVFEELTGSKISKKFLDHRKIFLWGPVTDESSKDLVGKLLYLEMKDPGKPITFYINSPGGVVTSGMTVFDTIK
MISSPVHTVCMGMAASMGSVLLAAGTKGERSIWPNGKVMIHQPSIGGQIVAPATDLKIHAEEILKTKAKLNQILADACGQ
PVSKIEEDTDRDYYMDAEEAIQYGIVNKLATKIDFN

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=172, Percent_Identity=45.3488372093023, Blast_Score=154, Evalue=4e-38,
Organism=Escherichia coli, GI1786641, Length=174, Percent_Identity=48.8505747126437, Blast_Score=181, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17538017, Length=174, Percent_Identity=45.4022988505747, Blast_Score=160, Evalue=5e-40,
Organism=Drosophila melanogaster, GI20129427, Length=172, Percent_Identity=44.1860465116279, Blast_Score=151, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21606; Mature: 21475

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEIEKITEVFEELTGSKISKKFLDHRKIFLWGPVTDESSKDLVGKLLYLEMKDPGKPIT
CCCHHHHHHHHHHHHCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHEEEEEECCCCCCEE
FYINSPGGVVTSGMTVFDTIKMISSPVHTVCMGMAASMGSVLLAAGTKGERSIWPNGKVM
EEEECCCCEEECCHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEE
IHQPSIGGQIVAPATDLKIHAEEILKTKAKLNQILADACGQPVSKIEEDTDRDYYMDAEE
EECCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEECHHH
AIQYGIVNKLATKIDFN
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PEIEKITEVFEELTGSKISKKFLDHRKIFLWGPVTDESSKDLVGKLLYLEMKDPGKPIT
CCHHHHHHHHHHHHCCHHHHHHHCCCEEEEECCCCCCCCHHHHHHEEEEEECCCCCCEE
FYINSPGGVVTSGMTVFDTIKMISSPVHTVCMGMAASMGSVLLAAGTKGERSIWPNGKVM
EEEECCCCEEECCHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEE
IHQPSIGGQIVAPATDLKIHAEEILKTKAKLNQILADACGQPVSKIEEDTDRDYYMDAEE
EECCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEECHHH
AIQYGIVNKLATKIDFN
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA