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The map label for this gene is iscS1 [H]

Identifier: 116328277

GI number: 116328277

Start: 1886417

End: 1887547

Strand: Reverse

Name: iscS1 [H]

Synonym: LBL_1610

Alternate gene names: 116328277

Gene position: 1887547-1886417 (Counterclockwise)

Preceding gene: 116328278

Following gene: 116328274

Centisome position: 52.22

GC content: 44.12

Gene sequence:

>1131_bases
ATGTCGAAGAAGATTCGTTATTTTGATTACAATGCGACTCATCCTCCGTTTTCCGACGTGCTTGTAGAAATTCAAAAAGA
TTATTTCGAAGACTTCTACAATCCTTCCGGAGCGACTCGGTTTTCCTTGGCTAGACAAGGCAAGATAGAAACGGCTCGAA
AAACCCTGGAGAGATACACGGGTAAACCCGCAAAAGAATTCGTTTTTTCTTCCACAGGAACCGAAGCGAATCACCTGCTT
GCATACGCAATTCGAGGAAAATTTTCGGGTTCCGCAATCGTTTCTTCTGTGGAGCATTCTTCCGTGTATTCTGCTCTTGA
GTTCGCGGGTTTTGATTTTAGAAAAATTCATTCCTTAAAAAACGGTGAGATCGATCTAAATCATCTCGAGGTTCTTTTAA
AAGAACAACCCGCCCCCGTTTTTATACTTCACGTCGCAAACGAATCGGGTGTGATTCAGCCCATCGAAAAAATTTCTGTG
CTTACTCGCAAGTTTTCGGTTCCGCTCTTTTCGGATCTGATGCAGTCCTTCTGTAAATTGGAAATTCCTTTTCCGCTCCT
CGATGGTTTTACTTTTTCCGGTCATAAAATCGGAGCGGGAATGGGAGCCTCCGGAACCTGGGTTCGTTCCGATCTCGTCT
CCGAAAAGGAATTTGCGATCTTTCACGGCGGTAATCAGGAAAACAACCACAGAGCCGGGACCGAAAACTCGCCTTCTATA
TTAGCACTTTCTGAAGTAATAAAGCATAGGCTTCCCGAGCAGAAATTCAAATCCGAAATTTCAATAACTTTCCGCACGCA
AATCGAAACCGTTTTGGAAAGTTGCGGTTGCGAGATCATCGGAAAAGAAGCGTCTCGAATTCCTACGACCTCCTTTTGTA
TTCTTCCAACCCAAGACGTAGATTTTTTTATGATGGGAATGGAGGAAGCGGGTTTCATTGTTTCCACCGGGTCTTCTTGT
AAGTCTAGATCCAGAGAACCTGCGCCTTCCCTTCTTTCCATGGGTTTTACCGAAGAGGAAGCGTTACGTGCCATTCGAAT
TTCCACGGGTTGGTTTACGACCCAGGAAGAGGTGGACGAACTTTGTATTCAAATCCAAAAAGTTTTGAAAGCTTTACTGG
ACGATTTGTAA

Upstream 100 bases:

>100_bases
GTCACAGGCAGTGGAAGAAATGATCTTGTGGAAGATCGTAAAAAACTTCTCAGGTACGTTCTCAGAAAAAAAGGAAGGTA
CGAAGAGGCGGACGAGCTTT

Downstream 100 bases:

>100_bases
ATCGAACTGTCTAAGAAAAAATTGCAAAACTCTTTTCATTTTCCGCTAAAAACAAGATTCAGGTAAACCATGATACGAAC
TTTCATCCATTCTGTTTTTA

Product: cysteine sulfinate desulfinase or cysteine desulfhydrase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MSKKIRYFDYNATHPPFSDVLVEIQKDYFEDFYNPSGATRFSLARQGKIETARKTLERYTGKPAKEFVFSSTGTEANHLL
AYAIRGKFSGSAIVSSVEHSSVYSALEFAGFDFRKIHSLKNGEIDLNHLEVLLKEQPAPVFILHVANESGVIQPIEKISV
LTRKFSVPLFSDLMQSFCKLEIPFPLLDGFTFSGHKIGAGMGASGTWVRSDLVSEKEFAIFHGGNQENNHRAGTENSPSI
LALSEVIKHRLPEQKFKSEISITFRTQIETVLESCGCEIIGKEASRIPTTSFCILPTQDVDFFMMGMEEAGFIVSTGSSC
KSRSREPAPSLLSMGFTEEEALRAIRISTGWFTTQEEVDELCIQIQKVLKALLDDL

Sequences:

>Translated_376_residues
MSKKIRYFDYNATHPPFSDVLVEIQKDYFEDFYNPSGATRFSLARQGKIETARKTLERYTGKPAKEFVFSSTGTEANHLL
AYAIRGKFSGSAIVSSVEHSSVYSALEFAGFDFRKIHSLKNGEIDLNHLEVLLKEQPAPVFILHVANESGVIQPIEKISV
LTRKFSVPLFSDLMQSFCKLEIPFPLLDGFTFSGHKIGAGMGASGTWVRSDLVSEKEFAIFHGGNQENNHRAGTENSPSI
LALSEVIKHRLPEQKFKSEISITFRTQIETVLESCGCEIIGKEASRIPTTSFCILPTQDVDFFMMGMEEAGFIVSTGSSC
KSRSREPAPSLLSMGFTEEEALRAIRISTGWFTTQEEVDELCIQIQKVLKALLDDL
>Mature_375_residues
SKKIRYFDYNATHPPFSDVLVEIQKDYFEDFYNPSGATRFSLARQGKIETARKTLERYTGKPAKEFVFSSTGTEANHLLA
YAIRGKFSGSAIVSSVEHSSVYSALEFAGFDFRKIHSLKNGEIDLNHLEVLLKEQPAPVFILHVANESGVIQPIEKISVL
TRKFSVPLFSDLMQSFCKLEIPFPLLDGFTFSGHKIGAGMGASGTWVRSDLVSEKEFAIFHGGNQENNHRAGTENSPSIL
ALSEVIKHRLPEQKFKSEISITFRTQIETVLESCGCEIIGKEASRIPTTSFCILPTQDVDFFMMGMEEAGFIVSTGSSCK
SRSREPAPSLLSMGFTEEEALRAIRISTGWFTTQEEVDELCIQIQKVLKALLDDL

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=384, Percent_Identity=29.1666666666667, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI156713448, Length=427, Percent_Identity=26.6978922716628, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI48994898, Length=391, Percent_Identity=31.2020460358056, Blast_Score=134, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI25143064, Length=383, Percent_Identity=29.5039164490862, Blast_Score=108, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6319831, Length=378, Percent_Identity=26.984126984127, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20129463, Length=377, Percent_Identity=29.973474801061, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41924; Mature: 41793

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKIRYFDYNATHPPFSDVLVEIQKDYFEDFYNPSGATRFSLARQGKIETARKTLERYT
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCCHHHHHHHHHHHC
GKPAKEFVFSSTGTEANHLLAYAIRGKFSGSAIVSSVEHSSVYSALEFAGFDFRKIHSLK
CCCHHHHHCCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
NGEIDLNHLEVLLKEQPAPVFILHVANESGVIQPIEKISVLTRKFSVPLFSDLMQSFCKL
CCCEEHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
EIPFPLLDGFTFSGHKIGAGMGASGTWVRSDLVSEKEFAIFHGGNQENNHRAGTENSPSI
CCCCHHHCCCCCCCCEECCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCC
LALSEVIKHRLPEQKFKSEISITFRTQIETVLESCGCEIIGKEASRIPTTSFCILPTQDV
HHHHHHHHHHCCHHHHHCCEEEEEHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCC
DFFMMGMEEAGFIVSTGSSCKSRSREPAPSLLSMGFTEEEALRAIRISTGWFTTQEEVDE
CEEEECCCCCCEEEECCCHHHHCCCCCCHHHHHCCCCHHHHHHEEEEECCCCCCHHHHHH
LCIQIQKVLKALLDDL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKKIRYFDYNATHPPFSDVLVEIQKDYFEDFYNPSGATRFSLARQGKIETARKTLERYT
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCCHHHHHHHHHHHC
GKPAKEFVFSSTGTEANHLLAYAIRGKFSGSAIVSSVEHSSVYSALEFAGFDFRKIHSLK
CCCHHHHHCCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
NGEIDLNHLEVLLKEQPAPVFILHVANESGVIQPIEKISVLTRKFSVPLFSDLMQSFCKL
CCCEEHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
EIPFPLLDGFTFSGHKIGAGMGASGTWVRSDLVSEKEFAIFHGGNQENNHRAGTENSPSI
CCCCHHHCCCCCCCCEECCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCC
LALSEVIKHRLPEQKFKSEISITFRTQIETVLESCGCEIIGKEASRIPTTSFCILPTQDV
HHHHHHHHHHCCHHHHHCCEEEEEHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCC
DFFMMGMEEAGFIVSTGSSCKSRSREPAPSLLSMGFTEEEALRAIRISTGWFTTQEEVDE
CEEEECCCCCCEEEECCCHHHHCCCCCCHHHHHCCCCHHHHHHEEEEECCCCCCHHHHHH
LCIQIQKVLKALLDDL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]