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The map label for this gene is fbp

Identifier: 116328267

GI number: 116328267

Start: 1871088

End: 1872116

Strand: Reverse

Name: fbp

Synonym: LBL_1595

Alternate gene names: 116328267

Gene position: 1872116-1871088 (Counterclockwise)

Preceding gene: 116328274

Following gene: 116328262

Centisome position: 51.8

GC content: 43.15

Gene sequence:

>1029_bases
ATGTCTGTTCACCCTACACAAACATTGAGTCTTTCCCAATACTTGATCGAGGAACAACTCAAATTACCCCAAGCAACCGG
AGATTTTACGGCTTTGATGAGCCATTTGGTCTATGCAGCCAAGATTGTTTCCAGAGAGGTTCGAAAAGCGGGACTTTTAG
AAAATGTTCTTGGTTCTAACGAAACTGTAAACGTTCAGGGAGAAACCCAAATGAAATTGGACGAATATGCGGATAAGGTT
TTCAATCATACCTTGACTCGTTCTGGCCATCTTTGTATCTTAGGAAGTGAAGAACATGAAGAAACCGTTTCTGTTCCGAG
CGGGTATAAAATTGGAAAATATACGATCGCAATCGATCCACTCGACGGTTCTTCCAATATAGACGCAAATGTTTCCATCG
GAACTATTTTCTCCGTTCATTTGAGAAAAAGCCCGGCCGACACTCCAGGAACATTGAGTGACCTTCTCCAAAAAGGTTCC
GGCCAAAGAGCCGCCGGTTACGTTTTGTACGGATCCTCCACGATGCTTGTGCTCTGTACGGGCAAAGGAGTTTCCGGATT
TACGCTGGACCCCTCTTGTGGAGAATTTATCCTTTCGCATCCCGATATGCAAATGCCAGAGACTGGAGGCATTTACTCCA
TCAACGAAGGAAATTATAACTATTGGTCCGATGAAGTAAAAAACTATATCCGAGACATCAAATCGATCGAAGGTGGGAAA
AAACCTCAGTCCGGTCGTTACATCGGTTCTTTAGTCGCTGACTTCCACAGAAATCTTTTGAAAGGTGGAATTTTCCTTTA
TCCAAATGACACCAAGTCCACAAAATATCCAAACGGTAAATTAAGGCTCCTTTATGAAGCGGCTCCTATGGCGTTTATCG
CAGAACAAGCTGGTGGAATGGCCGTTACTGTTTATGGAGAAAGAATCCTGGATCTCACTCCAAAGGAACTCCATGAGCGT
ACAACCTTGGTTGTTGGAAGTAAAAAAGAAGTGGAACACTTTTTAAAGTTTGCTCCGAAAAAACCTTAG

Upstream 100 bases:

>100_bases
TTCTTTTTTTCAAGTAAGAATGGACTTCTTAAAAAAGCTTTTCGCTTGAATTCGAAGGTGCTTGAAAAACCCTGTTGGAA
TCATTTTCCAAGAGGAATCT

Downstream 100 bases:

>100_bases
AATCGTCCTAAATCTTATCGAGCGACCGCAAAAGCGAGGCACTTTAGTTTTTTCGAGCGCCAATATGAGTGGTTAGAACT
TAAAATACCAATTTGGAAAC

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSVHPTQTLSLSQYLIEEQLKLPQATGDFTALMSHLVYAAKIVSREVRKAGLLENVLGSNETVNVQGETQMKLDEYADKV
FNHTLTRSGHLCILGSEEHEETVSVPSGYKIGKYTIAIDPLDGSSNIDANVSIGTIFSVHLRKSPADTPGTLSDLLQKGS
GQRAAGYVLYGSSTMLVLCTGKGVSGFTLDPSCGEFILSHPDMQMPETGGIYSINEGNYNYWSDEVKNYIRDIKSIEGGK
KPQSGRYIGSLVADFHRNLLKGGIFLYPNDTKSTKYPNGKLRLLYEAAPMAFIAEQAGGMAVTVYGERILDLTPKELHER
TTLVVGSKKEVEHFLKFAPKKP

Sequences:

>Translated_342_residues
MSVHPTQTLSLSQYLIEEQLKLPQATGDFTALMSHLVYAAKIVSREVRKAGLLENVLGSNETVNVQGETQMKLDEYADKV
FNHTLTRSGHLCILGSEEHEETVSVPSGYKIGKYTIAIDPLDGSSNIDANVSIGTIFSVHLRKSPADTPGTLSDLLQKGS
GQRAAGYVLYGSSTMLVLCTGKGVSGFTLDPSCGEFILSHPDMQMPETGGIYSINEGNYNYWSDEVKNYIRDIKSIEGGK
KPQSGRYIGSLVADFHRNLLKGGIFLYPNDTKSTKYPNGKLRLLYEAAPMAFIAEQAGGMAVTVYGERILDLTPKELHER
TTLVVGSKKEVEHFLKFAPKKP
>Mature_341_residues
SVHPTQTLSLSQYLIEEQLKLPQATGDFTALMSHLVYAAKIVSREVRKAGLLENVLGSNETVNVQGETQMKLDEYADKVF
NHTLTRSGHLCILGSEEHEETVSVPSGYKIGKYTIAIDPLDGSSNIDANVSIGTIFSVHLRKSPADTPGTLSDLLQKGSG
QRAAGYVLYGSSTMLVLCTGKGVSGFTLDPSCGEFILSHPDMQMPETGGIYSINEGNYNYWSDEVKNYIRDIKSIEGGKK
PQSGRYIGSLVADFHRNLLKGGIFLYPNDTKSTKYPNGKLRLLYEAAPMAFIAEQAGGMAVTVYGERILDLTPKELHERT
TLVVGSKKEVEHFLKFAPKKP

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI22907028, Length=335, Percent_Identity=43.2835820895522, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI189083692, Length=335, Percent_Identity=44.7761194029851, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI16579888, Length=335, Percent_Identity=44.7761194029851, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1790679, Length=334, Percent_Identity=50, Blast_Score=310, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17508131, Length=335, Percent_Identity=48.955223880597, Blast_Score=310, Evalue=8e-85,
Organism=Saccharomyces cerevisiae, GI6323409, Length=332, Percent_Identity=47.5903614457831, Blast_Score=305, Evalue=6e-84,
Organism=Drosophila melanogaster, GI45550998, Length=333, Percent_Identity=48.048048048048, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI19921562, Length=333, Percent_Identity=48.048048048048, Blast_Score=274, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_LEPBJ (Q04T19)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_800709.1
- ProteinModelPortal:   Q04T19
- SMR:   Q04T19
- STRING:   Q04T19
- GeneID:   4410171
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_1370
- eggNOG:   COG0158
- HOGENOM:   HBG731261
- OMA:   HWEAPVQ
- PhylomeDB:   Q04T19
- ProtClustDB:   PRK09293
- BioCyc:   LBOR355277:LBJ_1370-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- InterPro:   IPR020548
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 37443; Mature: 37312

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00124 FBPASE

Important sites: BINDING 215-215 BINDING 247-247 BINDING 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVHPTQTLSLSQYLIEEQLKLPQATGDFTALMSHLVYAAKIVSREVRKAGLLENVLGSN
CCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ETVNVQGETQMKLDEYADKVFNHTLTRSGHLCILGSEEHEETVSVPSGYKIGKYTIAIDP
CEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEECCCCCCEEEEEEEEEEC
LDGSSNIDANVSIGTIFSVHLRKSPADTPGTLSDLLQKGSGQRAAGYVLYGSSTMLVLCT
CCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEECCCEEEEEEE
GKGVSGFTLDPSCGEFILSHPDMQMPETGGIYSINEGNYNYWSDEVKNYIRDIKSIEGGK
CCCCCCEEECCCCCHHEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
KPQSGRYIGSLVADFHRNLLKGGIFLYPNDTKSTKYPNGKLRLLYEAAPMAFIAEQAGGM
CCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCHHHHHHCCCCE
AVTVYGERILDLTPKELHERTTLVVGSKKEVEHFLKFAPKKP
EEEEECCEEECCCHHHHHCCEEEEECCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVHPTQTLSLSQYLIEEQLKLPQATGDFTALMSHLVYAAKIVSREVRKAGLLENVLGSN
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ETVNVQGETQMKLDEYADKVFNHTLTRSGHLCILGSEEHEETVSVPSGYKIGKYTIAIDP
CEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEECCCCCCEEEEEEEEEEC
LDGSSNIDANVSIGTIFSVHLRKSPADTPGTLSDLLQKGSGQRAAGYVLYGSSTMLVLCT
CCCCCCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEECCCEEEEEEE
GKGVSGFTLDPSCGEFILSHPDMQMPETGGIYSINEGNYNYWSDEVKNYIRDIKSIEGGK
CCCCCCEEECCCCCHHEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
KPQSGRYIGSLVADFHRNLLKGGIFLYPNDTKSTKYPNGKLRLLYEAAPMAFIAEQAGGM
CCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCHHHHHHCCCCE
AVTVYGERILDLTPKELHERTTLVVGSKKEVEHFLKFAPKKP
EEEEECCEEECCCHHHHHCCEEEEECCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA