| Definition | Leptospira borgpetersenii serovar Hardjo-bovis L550 chromosome 1, complete sequence. |
|---|---|
| Accession | NC_008508 |
| Length | 3,614,446 |
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The map label for this gene is pbpC [H]
Identifier: 116328249
GI number: 116328249
Start: 1845349
End: 1847430
Strand: Direct
Name: pbpC [H]
Synonym: LBL_1576
Alternate gene names: 116328249
Gene position: 1845349-1847430 (Clockwise)
Preceding gene: 116328248
Following gene: 116328250
Centisome position: 51.05
GC content: 42.8
Gene sequence:
>2082_bases ATGTATGATAAGAATATATTGGTATTTTTGTTCATTAGTATATTATTTTGTTCGAATGTAATTTTTTCCGAAGGGGTCCC TTCTTACAGGGAAATTCGGGATTCGTATCATCCTTCTGACGGGACGATTTTGGATCTTCACGGAAGATTTTTACAAACGA TTCGGTTTAATGTTCGGGAAAGAAAACTAGCTTGGACGGAAGAGGGAGAAATTCCGGAAACCTTATTACTTGCCTTATTT GTGCAGGAAGACAAACGGTTCTTTGAACATTCCGGAGTGGATCTACTTGCGATTTTAGGTGCAATGAAGGATAGAATCTT AGGGAATTCAAAGAGAGGTGCGAGTACACTTTCCATGCAACTCGCAGGAATTTTTCTCGGAACCAAACCGGGGCGTAGGA ACATTTTCGATAAATGGGAACAGATGAGGTTCGCTCAAAAAATAGAACAGACCTGGAGCAAGAACGAAATTCTCATCGGC TATCTCAATCTGATTCAGTTTCGTGGGGAGCACAAGGGGCTCAGAGCGGCGAGCCGAGGGCTTTTTCAAAAGGAGCCTTC CGCATTGAGTGATGCGGAGTCGGTTCTTCTTGTTGCGATGCTTCCGTTTCCGGGAGCAAGTCCTTTCGTTTTAGTCAAAC GAAGTTGTGCTCTTGCGAAAAAAATTCAAAGAGAGGAACTTTGCTATTTGTTTAAAAATGTGGTTGATCGGATGACCACA AAGATGGGTGCTTTGCCTGCTGTTGGAGGAATCGCGTTTCATGCGGCTCAAAAAATTTTTAGAGAGAATCCGGAATTTCT TTCCAGAGACGGGAAAGTAAAAACGACTTTGGACTTCGATCTTCAATGGAAGGTTACCGAACTTGCAAAAAATGTTATGG ACGGGTTGAAAAAACAAAACGTGGCTGAAACCGGAATTCTCGTTTTAGACAACTTATCCGGTGCGATTTTGGTTTACGTC GGAAATCTTCCGGATAGCTCTTCTTTTTATGTAGACTCGATTCCTTCTAAAAGACAGGCAGGTTCCACGTTGAAGCCGTT TTTATACGGACTTGCATTTGAGAAGGAAGTGTTAAAGCCGAATTCCATTTTGGAAGATACTCCTGCCGAATGGAATGCGG TTTCCGGAATTTACAGACCTTCGAATTACAGTGACATGTATCATGGAAACGTGCAGGCAAAATATGCGCTTGCTTCTTCC TTGAACATTCCCGCGATCCACGTTTTAGATCTTGTAAGTGTTTCTAGTTTTGTTCAGAGATTGAAGGACCTTGGTTTGAG CGGATTGAAACGAGCGGATTTTTATGGATCTTCACTGGCCCTTGGAAGTGCGGACGTTACACTTTTTGAATTGACTAACG CTTATAGAACTCTTGCGAACGGAGGGATGGGGTCTAAGCCTACTTTTTTTCCTTACGAAGCAAAACAAACACTTGAGGAA AATTTCCGAGAAGGAAATCGTTGGAATAGAATTTATACGAAACAAGCCGCTGAAACGTTAGGAGAAATTTTATCCAATCG GGAATACCGTTTTCTTTCCTTCGGTCTCAACAATCATCTTAGTACTCGATTTTTTACGGCGGTAAAAACGGGAACCTCCC AGGACATGAGAGACAATTGGTGTGTGGGATATTCGAAAAATTATACGGTCGGTGTTTGGGTCGGTAACTTGGACGGAAGC CCTATGTGGGACGTGAGTGGAGTTACGGGAGCGGCTCCGATTTGGAATGCGGTGATCGGCCTACTTCAGGAAAGAGAAAA CCAACCGGGTAACACGCTCTTCGAAACCTTTCGTGATTCGCACGTAAGTCGGCTTGTGGAATCATTTTCCATTCCTAAGA TTTTGATTCCTGGAAACGAAACAATTTACGCATTGGATCCCGATATCCCTGAAGGAAGGCAGAAACTCTATTTTTCTGCG TCCGCGTTTATGTCCGGATTTCGATGGGTTTTGGATGGAAAAAGAATTCAGGAAGCCAAACAAAAGGATATATTTTGGAA GCCCGAGCGCGGATTTCATATTCTTTCCTTACAAGATAAAGATGGAAAGATCATTGACAGTGTAGTTTTCGAAGTCAGAT AG
Upstream 100 bases:
>100_bases TTCGTCTTACCTCCGACTAGGACCGAAGCGATGTATTTTCCGGATCAGTTTGCGGAAATTCCGAACTCGGATCAAATCGT GACGAAGGAATAAATGCCTC
Downstream 100 bases:
>100_bases AGAAAAGGTTTTTCTCTTGCAGGGAACCACCTTCGCGTTAGAATCAATTTCAGACTCCATGAAACTATCCACTGAAACGT ATCTTTTATCTCCTGCATTG
Product: membrane carboxypeptidase/penicillin-binding protein
Products: NA
Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]
Number of amino acids: Translated: 693; Mature: 693
Protein sequence:
>693_residues MYDKNILVFLFISILFCSNVIFSEGVPSYREIRDSYHPSDGTILDLHGRFLQTIRFNVRERKLAWTEEGEIPETLLLALF VQEDKRFFEHSGVDLLAILGAMKDRILGNSKRGASTLSMQLAGIFLGTKPGRRNIFDKWEQMRFAQKIEQTWSKNEILIG YLNLIQFRGEHKGLRAASRGLFQKEPSALSDAESVLLVAMLPFPGASPFVLVKRSCALAKKIQREELCYLFKNVVDRMTT KMGALPAVGGIAFHAAQKIFRENPEFLSRDGKVKTTLDFDLQWKVTELAKNVMDGLKKQNVAETGILVLDNLSGAILVYV GNLPDSSSFYVDSIPSKRQAGSTLKPFLYGLAFEKEVLKPNSILEDTPAEWNAVSGIYRPSNYSDMYHGNVQAKYALASS LNIPAIHVLDLVSVSSFVQRLKDLGLSGLKRADFYGSSLALGSADVTLFELTNAYRTLANGGMGSKPTFFPYEAKQTLEE NFREGNRWNRIYTKQAAETLGEILSNREYRFLSFGLNNHLSTRFFTAVKTGTSQDMRDNWCVGYSKNYTVGVWVGNLDGS PMWDVSGVTGAAPIWNAVIGLLQERENQPGNTLFETFRDSHVSRLVESFSIPKILIPGNETIYALDPDIPEGRQKLYFSA SAFMSGFRWVLDGKRIQEAKQKDIFWKPERGFHILSLQDKDGKIIDSVVFEVR
Sequences:
>Translated_693_residues MYDKNILVFLFISILFCSNVIFSEGVPSYREIRDSYHPSDGTILDLHGRFLQTIRFNVRERKLAWTEEGEIPETLLLALF VQEDKRFFEHSGVDLLAILGAMKDRILGNSKRGASTLSMQLAGIFLGTKPGRRNIFDKWEQMRFAQKIEQTWSKNEILIG YLNLIQFRGEHKGLRAASRGLFQKEPSALSDAESVLLVAMLPFPGASPFVLVKRSCALAKKIQREELCYLFKNVVDRMTT KMGALPAVGGIAFHAAQKIFRENPEFLSRDGKVKTTLDFDLQWKVTELAKNVMDGLKKQNVAETGILVLDNLSGAILVYV GNLPDSSSFYVDSIPSKRQAGSTLKPFLYGLAFEKEVLKPNSILEDTPAEWNAVSGIYRPSNYSDMYHGNVQAKYALASS LNIPAIHVLDLVSVSSFVQRLKDLGLSGLKRADFYGSSLALGSADVTLFELTNAYRTLANGGMGSKPTFFPYEAKQTLEE NFREGNRWNRIYTKQAAETLGEILSNREYRFLSFGLNNHLSTRFFTAVKTGTSQDMRDNWCVGYSKNYTVGVWVGNLDGS PMWDVSGVTGAAPIWNAVIGLLQERENQPGNTLFETFRDSHVSRLVESFSIPKILIPGNETIYALDPDIPEGRQKLYFSA SAFMSGFRWVLDGKRIQEAKQKDIFWKPERGFHILSLQDKDGKIIDSVVFEVR >Mature_693_residues MYDKNILVFLFISILFCSNVIFSEGVPSYREIRDSYHPSDGTILDLHGRFLQTIRFNVRERKLAWTEEGEIPETLLLALF VQEDKRFFEHSGVDLLAILGAMKDRILGNSKRGASTLSMQLAGIFLGTKPGRRNIFDKWEQMRFAQKIEQTWSKNEILIG YLNLIQFRGEHKGLRAASRGLFQKEPSALSDAESVLLVAMLPFPGASPFVLVKRSCALAKKIQREELCYLFKNVVDRMTT KMGALPAVGGIAFHAAQKIFRENPEFLSRDGKVKTTLDFDLQWKVTELAKNVMDGLKKQNVAETGILVLDNLSGAILVYV GNLPDSSSFYVDSIPSKRQAGSTLKPFLYGLAFEKEVLKPNSILEDTPAEWNAVSGIYRPSNYSDMYHGNVQAKYALASS LNIPAIHVLDLVSVSSFVQRLKDLGLSGLKRADFYGSSLALGSADVTLFELTNAYRTLANGGMGSKPTFFPYEAKQTLEE NFREGNRWNRIYTKQAAETLGEILSNREYRFLSFGLNNHLSTRFFTAVKTGTSQDMRDNWCVGYSKNYTVGVWVGNLDGS PMWDVSGVTGAAPIWNAVIGLLQERENQPGNTLFETFRDSHVSRLVESFSIPKILIPGNETIYALDPDIPEGRQKLYFSA SAFMSGFRWVLDGKRIQEAKQKDIFWKPERGFHILSLQDKDGKIIDSVVFEVR
Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]
COG id: COG4953
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1788867, Length=608, Percent_Identity=29.9342105263158, Blast_Score=189, Evalue=5e-49, Organism=Escherichia coli, GI1786343, Length=568, Percent_Identity=25.1760563380282, Blast_Score=102, Evalue=1e-22, Organism=Escherichia coli, GI87082258, Length=369, Percent_Identity=24.1192411924119, Blast_Score=76, Evalue=8e-15, Organism=Escherichia coli, GI1789601, Length=142, Percent_Identity=35.9154929577465, Blast_Score=69, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011815 - InterPro: IPR009647 - InterPro: IPR001460 [H]
Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-
Molecular weight: Translated: 77961; Mature: 77961
Theoretical pI: Translated: 9.01; Mature: 9.01
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.5 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MYDKNILVFLFISILFCSNVIFSEGVPSYREIRDSYHPSDGTILDLHGRFLQTIRFNVRE CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHH RKLAWTEEGEIPETLLLALFVQEDKRFFEHSGVDLLAILGAMKDRILGNSKRGASTLSMQ HEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHE LAGIFLGTKPGRRNIFDKWEQMRFAQKIEQTWSKNEILIGYLNLIQFRGEHKGLRAASRG EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCCHHHHHCC LFQKEPSALSDAESVLLVAMLPFPGASPFVLVKRSCALAKKIQREELCYLFKNVVDRMTT CCCCCCCHHCCHHHEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KMGALPAVGGIAFHAAQKIFRENPEFLSRDGKVKTTLDFDLQWKVTELAKNVMDGLKKQN HHCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCEEEEHHHHHHHHHHHHHHCC VAETGILVLDNLSGAILVYVGNLPDSSSFYVDSIPSKRQAGSTLKPFLYGLAFEKEVLKP CHHCCEEEEECCCCEEEEEECCCCCCCCEEEECCCCHHHCCCCHHHHHHHHHHHHHHCCC NSILEDTPAEWNAVSGIYRPSNYSDMYHGNVQAKYALASSLNIPAIHVLDLVSVSSFVQR CCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHH LKDLGLSGLKRADFYGSSLALGSADVTLFELTNAYRTLANGGMGSKPTFFPYEAKQTLEE HHHCCCCCCCHHCCCCCCEEECCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH NFREGNRWNRIYTKQAAETLGEILSNREYRFLSFGLNNHLSTRFFTAVKTGTSQDMRDNW HHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHEEEEECCCCCCCCCCC CVGYSKNYTVGVWVGNLDGSPMWDVSGVTGAAPIWNAVIGLLQERENQPGNTLFETFRDS EECCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH HVSRLVESFSIPKILIPGNETIYALDPDIPEGRQKLYFSASAFMSGFRWVLDGKRIQEAK HHHHHHHHCCCCEEEECCCCEEEEECCCCCCCHHHEEEEHHHHHCCHHHHHCCHHHHHHH QKDIFWKPERGFHILSLQDKDGKIIDSVVFEVR HCCCEECCCCCEEEEEEECCCCCEEHHHHHCCC >Mature Secondary Structure MYDKNILVFLFISILFCSNVIFSEGVPSYREIRDSYHPSDGTILDLHGRFLQTIRFNVRE CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHH RKLAWTEEGEIPETLLLALFVQEDKRFFEHSGVDLLAILGAMKDRILGNSKRGASTLSMQ HEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHE LAGIFLGTKPGRRNIFDKWEQMRFAQKIEQTWSKNEILIGYLNLIQFRGEHKGLRAASRG EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCCCCHHHHHCC LFQKEPSALSDAESVLLVAMLPFPGASPFVLVKRSCALAKKIQREELCYLFKNVVDRMTT CCCCCCCHHCCHHHEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH KMGALPAVGGIAFHAAQKIFRENPEFLSRDGKVKTTLDFDLQWKVTELAKNVMDGLKKQN HHCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCEEEEHHHHHHHHHHHHHHCC VAETGILVLDNLSGAILVYVGNLPDSSSFYVDSIPSKRQAGSTLKPFLYGLAFEKEVLKP CHHCCEEEEECCCCEEEEEECCCCCCCCEEEECCCCHHHCCCCHHHHHHHHHHHHHHCCC NSILEDTPAEWNAVSGIYRPSNYSDMYHGNVQAKYALASSLNIPAIHVLDLVSVSSFVQR CCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHHHH LKDLGLSGLKRADFYGSSLALGSADVTLFELTNAYRTLANGGMGSKPTFFPYEAKQTLEE HHHCCCCCCCHHCCCCCCEEECCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH NFREGNRWNRIYTKQAAETLGEILSNREYRFLSFGLNNHLSTRFFTAVKTGTSQDMRDNW HHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHEEEEECCCCCCCCCCC CVGYSKNYTVGVWVGNLDGSPMWDVSGVTGAAPIWNAVIGLLQERENQPGNTLFETFRDS EECCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH HVSRLVESFSIPKILIPGNETIYALDPDIPEGRQKLYFSASAFMSGFRWVLDGKRIQEAK HHHHHHHHCCCCEEEECCCCEEEEECCCCCCCHHHEEEEHHHHHCCHHHHHCCHHHHHHH QKDIFWKPERGFHILSLQDKDGKIIDSVVFEVR HCCCEECCCCCEEEEEEECCCCCEEHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10542235; 9205837; 9278503; 9841666 [H]