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The map label for this gene is xseA

Identifier: 116328175

GI number: 116328175

Start: 1756669

End: 1757937

Strand: Reverse

Name: xseA

Synonym: LBL_1499

Alternate gene names: 116328175

Gene position: 1757937-1756669 (Counterclockwise)

Preceding gene: 116328176

Following gene: 116328174

Centisome position: 48.64

GC content: 43.97

Gene sequence:

>1269_bases
TTGGAAGATTCCAAACCGCTTACCGTTTCGGAAGTCACGAGAATCCTTAAGAACCTAATCACAGGATCCAAAGATTTAAA
GAATATTTGGGTTCGAGGAGAAATTTCCAATTATAGCAAAGCCAGTTCGGGACATATTTATTTCTCCCTTAAAGATTCAA
GTTCGCTAATGCGATGCACTTTTTTCAACTACTCGAACAAGAATTATTCCGGAAAGCCCCTCTCTGATGGAAAGGAAGTT
CAGGTCTATGGAACGGTTACGCTCTACGAAGCCGGAGGTTCTTATAATCTCAATGTGGCTAGAGTGGAGGAATTGGGTCA
AGGGGATATTCTACTTCAAATCGAAAAACTCAAACAGAAGCTCGCGGCCGAAGGGATCTTTGATCCGGAACGAAAAAGAA
GAATCCCGTCTTTTCCGAAAACTCTCGGAATTGCAACTTCTCCCTCCGGTGCGGCAATAGAAGATATTATCAAAATCGCC
CGCTCTCGTTTTCCGGGAATTAACATTCTCATTTCTCCTTGTTTCGTTCAAGGAGACGAAGCCCCGGATTCAATCGTTGC
CGCGATCGAAGAACTGAATCATCCTAGTTGGGGGGTCGACGTAATTATAGCAGGCAGAGGAGGAGGTAGTTTCGAAGACC
TGATGGCGTTTAACGACGAAAAGGTGGTTCGGGCTTACGCAAATTCCAGAATTCCCATCATCTCTGCAGTAGGTCATCAA
ACCGACGTTTTACTAAGCGACTTTGCAGCGGACTATTCTACCCCGACTCCCACCGCTGCGGCAGAATATGCAGTTCCTAA
AGAAGAAGATGTACTTCAATTCTTAACCCAGTTGGAAGGACGGCTGAAAACCTCCCTGCTTGCAAAAATTTCATCTAGTA
AAGACAGACTTAGACTTTTGTCCGGAAAATTTATCTTTAAGGAACCGATGCAACTTCTCAACCAGAGAAACCAAAGAGTG
GATGAGATCGGAGTTCGTTTACAAAAGGCCGTATTCAACAAAGTGGGTCTGGCCCGGGTTCGATTGGAACGGTACGAAGA
TCTCACATCCAGAATGCGGAATATTTTTTTTCATAAAAAACAAAAAGCGGAATTCTGGACCACGAAGGTGGAAGACCTTT
CTCCACCAGCCACGATGAAACGGGGATATTCGATTCTTAGGAACCAAAAAGGAAAAATCATACGATCTCCGGAAGAAACA
AAGCCGGAAGAAGAATTGCAAGTTTTACTTTCGGGTGGAACGATGCAAGTAATCAGAAAAGGAAAGTAA

Upstream 100 bases:

>100_bases
GCTGGGTCCGGTCGTAGTCACATTAGTTGTCATTCTTTGGGATTTTTGGAAACTGTATCGCAAGGAATTAATCTTAAGCA
AGGGACATCGGTAGTAAACA

Downstream 100 bases:

>100_bases
GAATGGCGGAAGCAAGATCAAAAATTTCATTTGAAGATGCTCTGGTTGAGCTGGAACAAATCGCGGAAAAATTGGAGCGC
CAAGACTTTAGTCTGGAAGA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MEDSKPLTVSEVTRILKNLITGSKDLKNIWVRGEISNYSKASSGHIYFSLKDSSSLMRCTFFNYSNKNYSGKPLSDGKEV
QVYGTVTLYEAGGSYNLNVARVEELGQGDILLQIEKLKQKLAAEGIFDPERKRRIPSFPKTLGIATSPSGAAIEDIIKIA
RSRFPGINILISPCFVQGDEAPDSIVAAIEELNHPSWGVDVIIAGRGGGSFEDLMAFNDEKVVRAYANSRIPIISAVGHQ
TDVLLSDFAADYSTPTPTAAAEYAVPKEEDVLQFLTQLEGRLKTSLLAKISSSKDRLRLLSGKFIFKEPMQLLNQRNQRV
DEIGVRLQKAVFNKVGLARVRLERYEDLTSRMRNIFFHKKQKAEFWTTKVEDLSPPATMKRGYSILRNQKGKIIRSPEET
KPEEELQVLLSGGTMQVIRKGK

Sequences:

>Translated_422_residues
MEDSKPLTVSEVTRILKNLITGSKDLKNIWVRGEISNYSKASSGHIYFSLKDSSSLMRCTFFNYSNKNYSGKPLSDGKEV
QVYGTVTLYEAGGSYNLNVARVEELGQGDILLQIEKLKQKLAAEGIFDPERKRRIPSFPKTLGIATSPSGAAIEDIIKIA
RSRFPGINILISPCFVQGDEAPDSIVAAIEELNHPSWGVDVIIAGRGGGSFEDLMAFNDEKVVRAYANSRIPIISAVGHQ
TDVLLSDFAADYSTPTPTAAAEYAVPKEEDVLQFLTQLEGRLKTSLLAKISSSKDRLRLLSGKFIFKEPMQLLNQRNQRV
DEIGVRLQKAVFNKVGLARVRLERYEDLTSRMRNIFFHKKQKAEFWTTKVEDLSPPATMKRGYSILRNQKGKIIRSPEET
KPEEELQVLLSGGTMQVIRKGK
>Mature_422_residues
MEDSKPLTVSEVTRILKNLITGSKDLKNIWVRGEISNYSKASSGHIYFSLKDSSSLMRCTFFNYSNKNYSGKPLSDGKEV
QVYGTVTLYEAGGSYNLNVARVEELGQGDILLQIEKLKQKLAAEGIFDPERKRRIPSFPKTLGIATSPSGAAIEDIIKIA
RSRFPGINILISPCFVQGDEAPDSIVAAIEELNHPSWGVDVIIAGRGGGSFEDLMAFNDEKVVRAYANSRIPIISAVGHQ
TDVLLSDFAADYSTPTPTAAAEYAVPKEEDVLQFLTQLEGRLKTSLLAKISSSKDRLRLLSGKFIFKEPMQLLNQRNQRV
DEIGVRLQKAVFNKVGLARVRLERYEDLTSRMRNIFFHKKQKAEFWTTKVEDLSPPATMKRGYSILRNQKGKIIRSPEET
KPEEELQVLLSGGTMQVIRKGK

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=431, Percent_Identity=33.6426914153132, Blast_Score=259, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_LEPBJ (Q04TB1)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_800617.1
- STRING:   Q04TB1
- GeneID:   4410784
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_1274
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   SSQIRCA
- PhylomeDB:   Q04TB1
- ProtClustDB:   PRK00286
- BioCyc:   LBOR355277:LBJ_1274-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 47096; Mature: 47096

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDSKPLTVSEVTRILKNLITGSKDLKNIWVRGEISNYSKASSGHIYFSLKDSSSLMRCT
CCCCCCCCHHHHHHHHHHHHCCCCCHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEE
FFNYSNKNYSGKPLSDGKEVQVYGTVTLYEAGGSYNLNVARVEELGQGDILLQIEKLKQK
EEECCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHCCCCCEEEEHHHHHHH
LAAEGIFDPERKRRIPSFPKTLGIATSPSGAAIEDIIKIARSRFPGINILISPCFVQGDE
HHHCCCCCCHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCC
APDSIVAAIEELNHPSWGVDVIIAGRGGGSFEDLMAFNDEKVVRAYANSRIPIISAVGHQ
CHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCHHHHHHHHCCCCCEEEECCCC
TDVLLSDFAADYSTPTPTAAAEYAVPKEEDVLQFLTQLEGRLKTSLLAKISSSKDRLRLL
HHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SGKFIFKEPMQLLNQRNQRVDEIGVRLQKAVFNKVGLARVRLERYEDLTSRMRNIFFHKK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QKAEFWTTKVEDLSPPATMKRGYSILRNQKGKIIRSPEETKPEEELQVLLSGGTMQVIRK
CCCHHHHCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHCCCCEEEHCC
GK
CC
>Mature Secondary Structure
MEDSKPLTVSEVTRILKNLITGSKDLKNIWVRGEISNYSKASSGHIYFSLKDSSSLMRCT
CCCCCCCCHHHHHHHHHHHHCCCCCHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEE
FFNYSNKNYSGKPLSDGKEVQVYGTVTLYEAGGSYNLNVARVEELGQGDILLQIEKLKQK
EEECCCCCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHCCCCCEEEEHHHHHHH
LAAEGIFDPERKRRIPSFPKTLGIATSPSGAAIEDIIKIARSRFPGINILISPCFVQGDE
HHHCCCCCCHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCC
APDSIVAAIEELNHPSWGVDVIIAGRGGGSFEDLMAFNDEKVVRAYANSRIPIISAVGHQ
CHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCHHHHHHHHCCCCCEEEECCCC
TDVLLSDFAADYSTPTPTAAAEYAVPKEEDVLQFLTQLEGRLKTSLLAKISSSKDRLRLL
HHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SGKFIFKEPMQLLNQRNQRVDEIGVRLQKAVFNKVGLARVRLERYEDLTSRMRNIFFHKK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QKAEFWTTKVEDLSPPATMKRGYSILRNQKGKIIRSPEETKPEEELQVLLSGGTMQVIRK
CCCHHHHCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHCCCCEEEHCC
GK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA