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The map label for this gene is uvrC

Identifier: 116328133

GI number: 116328133

Start: 1664115

End: 1665944

Strand: Direct

Name: uvrC

Synonym: LBL_1431

Alternate gene names: 116328133

Gene position: 1664115-1665944 (Clockwise)

Preceding gene: 116328132

Following gene: 116328134

Centisome position: 46.04

GC content: 42.19

Gene sequence:

>1830_bases
ATGCCTGAAATTTTAAATCATATTCTGATTCTGGAAAAAATCAAAAACTTAGGCATTTCTCCGGGCTGTTATCTTTGGAA
ATCCAGAAAGGGAGAGGTTTTATACATAGGTAAGGCTAAAAATTTGGACAAAAGAGTCCGTAATTATCTCAAAGAAAATC
ATCCCGATATAAAAACACGAGCGCTTCAAAAGGAAATCTTCGATTTGGATTGGATTGCAACCGGAACCGAAAAAGAGGCT
TTGATTCTAGAAGCGACTCTCATCAAAAAACACAATCCTCGTTTTAATGTCCGTTTCAAAGACGATAAGAAATATCCGTA
TATTTGCGTTTCTCTTTCGGAGTCCTTTCCGATGGTTTATATCACAAGAAAACTAAAAGACAATGGAGATCGTTATTTCG
GTCCTTATTCGGACGTAAAATCCACAAGGGAAACATTAGACATCATTTTAAGAATCTTTCCGGTTCGTAAAACGAGACAA
GTGCTCCCGTTACCGAAACCCAGAAGACCCTGTTTAAACTTTGATATGGGGCGTTGTCTCGGCCCTTGCCAAGGAAATAT
TCCCGTAGAAGATTATAAAATTGTAATCGATCAAGTGATTCAATTCTTGGAAGGTAAAAAAGAATCTCTTGTGGGGGATC
TCAGTATCAAAATGAGTGCGTCGTCGAATCGGATGGATTTTGAAAAAGCCGCTCGTTATCGGGATATGCTCCAGCGAATT
CAAAACTTCCGAGAGAAACAAACTGTGGTCAGCGCGGAAGGCGGGGACGAGGACGTGATCGGATTTGCCAGGAAGAAGGA
CGAAGGTCAGGTTATTCTTCTTGAAGTTCGGGGCGGAAGGTTGGAAACCAAAAAATCTTTTCCGATTCAAGGAGTTTTGG
ATGCGGAAGATTCGGAAATTCTAGGAGCTTTTTTCAGGGATTATTATTTAAATGCGGCTTTGGTTCCGCCTTTGATTTTT
GTTCCGGCGGACATTCAAGAGGAAACTGCCGCGGTTATGGATGTGCTTCAGGAGAAAACGGGTTTCAGACCCAAACTCAA
ATCCCCTCGCGGTGGAGATAAACGTTCCCTTTTAAAAATTGCGGAGAAAAATGCGGAACTTGGATTGACCGAAAGACTAC
TTGCAACTCACTACAGAGATCAAACAGCTTCTTTGAAAGAAATTCAAGAGATGTTTTCTTTAGAACATCCTCCTCATATC
ATCGAATGCTACGATATCAGTCACTTCCAAGGTTCTGAGCCGGTTGCGAGTGGTGTGATGTTTGTGGAAGGAAAACCTTT
CAAACAAGGATACAGAAAGTATAATATAAGGGGTTATAAGGGAATCAACGATCCCGGAATGATCCACGAAGTGATTTCTA
GGCGTCTACAAAGAATCGCCAACGAGGAAAGTGTTTTTCCGGATCTCATCGTGATCGACGGAGGACCGACCCAGCTGGCC
AAGGCCTGCGAAGCCGCAATGGAAGCGGGAGCGGAAAGAATTCCTATGATCGGTCTTGCAAAGAAGAGAGAAGAGATCTA
TTTTCCGGGAGACAACGAACCTTTTATCTTTGATATGAATTCATCTGGAATGAAACTACTTCGTCATCTTCGGGACGAGG
CGCATCGATTCGGAGTTTCACATCATAGATCGCGTAGGAACAAGGAGACGATGCGCTCTCTCATTCAAAATGTTCCGGAT
ATCGGTTTGAAAAGAAGTAAACTACTCCTCAGACACTTTTCGGGAGAAAAAAAAATCGAAGACGCAACCAAAGAGGAGCT
TCTTGCCGTTCCTGGAATTGGGGAAAATCTCGCCGAAAAAATCCTAAAACGAATTAGAAAAAAAGAATAA

Upstream 100 bases:

>100_bases
TTGTCTAACTAAGGGAGATGGTCGTTTAAACTCGAAATCACCTGTCGATTTTCGATAAAGTAAAAACCGAGTTCTATCAC
AATCATCAAAAAGGTTCATT

Downstream 100 bases:

>100_bases
AAAATCTCTAAAATTCAAAACGAGTCGAATGTTTTCGAAACCGTACCGGATGGAGGAAAACATGAAACTCAAATTCGTGT
TTACAGCGATTTTTCTTCTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MPEILNHILILEKIKNLGISPGCYLWKSRKGEVLYIGKAKNLDKRVRNYLKENHPDIKTRALQKEIFDLDWIATGTEKEA
LILEATLIKKHNPRFNVRFKDDKKYPYICVSLSESFPMVYITRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQ
VLPLPKPRRPCLNFDMGRCLGPCQGNIPVEDYKIVIDQVIQFLEGKKESLVGDLSIKMSASSNRMDFEKAARYRDMLQRI
QNFREKQTVVSAEGGDEDVIGFARKKDEGQVILLEVRGGRLETKKSFPIQGVLDAEDSEILGAFFRDYYLNAALVPPLIF
VPADIQEETAAVMDVLQEKTGFRPKLKSPRGGDKRSLLKIAEKNAELGLTERLLATHYRDQTASLKEIQEMFSLEHPPHI
IECYDISHFQGSEPVASGVMFVEGKPFKQGYRKYNIRGYKGINDPGMIHEVISRRLQRIANEESVFPDLIVIDGGPTQLA
KACEAAMEAGAERIPMIGLAKKREEIYFPGDNEPFIFDMNSSGMKLLRHLRDEAHRFGVSHHRSRRNKETMRSLIQNVPD
IGLKRSKLLLRHFSGEKKIEDATKEELLAVPGIGENLAEKILKRIRKKE

Sequences:

>Translated_609_residues
MPEILNHILILEKIKNLGISPGCYLWKSRKGEVLYIGKAKNLDKRVRNYLKENHPDIKTRALQKEIFDLDWIATGTEKEA
LILEATLIKKHNPRFNVRFKDDKKYPYICVSLSESFPMVYITRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQ
VLPLPKPRRPCLNFDMGRCLGPCQGNIPVEDYKIVIDQVIQFLEGKKESLVGDLSIKMSASSNRMDFEKAARYRDMLQRI
QNFREKQTVVSAEGGDEDVIGFARKKDEGQVILLEVRGGRLETKKSFPIQGVLDAEDSEILGAFFRDYYLNAALVPPLIF
VPADIQEETAAVMDVLQEKTGFRPKLKSPRGGDKRSLLKIAEKNAELGLTERLLATHYRDQTASLKEIQEMFSLEHPPHI
IECYDISHFQGSEPVASGVMFVEGKPFKQGYRKYNIRGYKGINDPGMIHEVISRRLQRIANEESVFPDLIVIDGGPTQLA
KACEAAMEAGAERIPMIGLAKKREEIYFPGDNEPFIFDMNSSGMKLLRHLRDEAHRFGVSHHRSRRNKETMRSLIQNVPD
IGLKRSKLLLRHFSGEKKIEDATKEELLAVPGIGENLAEKILKRIRKKE
>Mature_608_residues
PEILNHILILEKIKNLGISPGCYLWKSRKGEVLYIGKAKNLDKRVRNYLKENHPDIKTRALQKEIFDLDWIATGTEKEAL
ILEATLIKKHNPRFNVRFKDDKKYPYICVSLSESFPMVYITRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQV
LPLPKPRRPCLNFDMGRCLGPCQGNIPVEDYKIVIDQVIQFLEGKKESLVGDLSIKMSASSNRMDFEKAARYRDMLQRIQ
NFREKQTVVSAEGGDEDVIGFARKKDEGQVILLEVRGGRLETKKSFPIQGVLDAEDSEILGAFFRDYYLNAALVPPLIFV
PADIQEETAAVMDVLQEKTGFRPKLKSPRGGDKRSLLKIAEKNAELGLTERLLATHYRDQTASLKEIQEMFSLEHPPHII
ECYDISHFQGSEPVASGVMFVEGKPFKQGYRKYNIRGYKGINDPGMIHEVISRRLQRIANEESVFPDLIVIDGGPTQLAK
ACEAAMEAGAERIPMIGLAKKREEIYFPGDNEPFIFDMNSSGMKLLRHLRDEAHRFGVSHHRSRRNKETMRSLIQNVPDI
GLKRSKLLLRHFSGEKKIEDATKEELLAVPGIGENLAEKILKRIRKKE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=33.4975369458128, Blast_Score=329, Evalue=3e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_LEPBJ (Q04RU6)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_801132.1
- ProteinModelPortal:   Q04RU6
- STRING:   Q04RU6
- GeneID:   4409998
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_1853
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q04RU6
- ProtClustDB:   PRK00558
- BioCyc:   LBOR355277:LBJ_1853-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF00633 HHH; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 69681; Mature: 69550

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEILNHILILEKIKNLGISPGCYLWKSRKGEVLYIGKAKNLDKRVRNYLKENHPDIKTR
CHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHH
ALQKEIFDLDWIATGTEKEALILEATLIKKHNPRFNVRFKDDKKYPYICVSLSESFPMVY
HHHHHHHCCCEEECCCCCCEEEEEEHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCEEE
ITRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQVLPLPKPRRPCLNFDMGRCL
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHCC
GPCQGNIPVEDYKIVIDQVIQFLEGKKESLVGDLSIKMSASSNRMDFEKAARYRDMLQRI
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHEEEEEEEEECCCCCCCHHHHHHHHHHHHHH
QNFREKQTVVSAEGGDEDVIGFARKKDEGQVILLEVRGGRLETKKSFPIQGVLDAEDSEI
HHHHHHHHEEECCCCCCHHEHHHCCCCCCCEEEEEECCCEECCCCCCCCCEEECCCCHHH
LGAFFRDYYLNAALVPPLIFVPADIQEETAAVMDVLQEKTGFRPKLKSPRGGDKRSLLKI
HHHHHHHHHCCHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
AEKNAELGLTERLLATHYRDQTASLKEIQEMFSLEHPPHIIECYDISHFQGSEPVASGVM
HHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHCCEE
FVEGKPFKQGYRKYNIRGYKGINDPGMIHEVISRRLQRIANEESVFPDLIVIDGGPTQLA
EECCCCHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHH
KACEAAMEAGAERIPMIGLAKKREEIYFPGDNEPFIFDMNSSGMKLLRHLRDEAHRFGVS
HHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCHH
HHRSRRNKETMRSLIQNVPDIGLKRSKLLLRHFSGEKKIEDATKEELLAVPGIGENLAEK
HHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEECCCCCHHHHHH
ILKRIRKKE
HHHHHHCCC
>Mature Secondary Structure 
PEILNHILILEKIKNLGISPGCYLWKSRKGEVLYIGKAKNLDKRVRNYLKENHPDIKTR
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHH
ALQKEIFDLDWIATGTEKEALILEATLIKKHNPRFNVRFKDDKKYPYICVSLSESFPMVY
HHHHHHHCCCEEECCCCCCEEEEEEHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCEEE
ITRKLKDNGDRYFGPYSDVKSTRETLDIILRIFPVRKTRQVLPLPKPRRPCLNFDMGRCL
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHCC
GPCQGNIPVEDYKIVIDQVIQFLEGKKESLVGDLSIKMSASSNRMDFEKAARYRDMLQRI
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHEEEEEEEEECCCCCCCHHHHHHHHHHHHHH
QNFREKQTVVSAEGGDEDVIGFARKKDEGQVILLEVRGGRLETKKSFPIQGVLDAEDSEI
HHHHHHHHEEECCCCCCHHEHHHCCCCCCCEEEEEECCCEECCCCCCCCCEEECCCCHHH
LGAFFRDYYLNAALVPPLIFVPADIQEETAAVMDVLQEKTGFRPKLKSPRGGDKRSLLKI
HHHHHHHHHCCHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
AEKNAELGLTERLLATHYRDQTASLKEIQEMFSLEHPPHIIECYDISHFQGSEPVASGVM
HHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHCCEE
FVEGKPFKQGYRKYNIRGYKGINDPGMIHEVISRRLQRIANEESVFPDLIVIDGGPTQLA
EECCCCHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHH
KACEAAMEAGAERIPMIGLAKKREEIYFPGDNEPFIFDMNSSGMKLLRHLRDEAHRFGVS
HHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCHH
HHRSRRNKETMRSLIQNVPDIGLKRSKLLLRHFSGEKKIEDATKEELLAVPGIGENLAEK
HHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEECCCCCHHHHHH
ILKRIRKKE
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA