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The map label for this gene is bioF [C]

Identifier: 116328113

GI number: 116328113

Start: 1643954

End: 1645084

Strand: Direct

Name: bioF [C]

Synonym: LBL_1411

Alternate gene names: 116328113

Gene position: 1643954-1645084 (Clockwise)

Preceding gene: 116328112

Following gene: 116328114

Centisome position: 45.48

GC content: 42.97

Gene sequence:

>1131_bases
TTGAACCTGAATCCGTCTACATTCTTTCAGAAAGCCTCTTTTGTTTTAGAATCTCTGAAAGAGAATTTTCTTTTTCGATC
CCTGGAAGTTCCTTCTGGGGTTGATTTGTCCTCCAACGATTACCTTGGTCTTACCCGCCATTCTAAACTCATCGAAAGCT
TGAAAGAAGGTTTAGCTCTTTACGGAGCCGGTTCAGGAGCTTCCAGACTGGTCAGCGGACATAGAGATTCCTTTGAAATC
GCGGAACAAACTTGCTCCGAATGGGTTGGAACGGAAACTTCCGTGTGGGTCGCCAATGGTTATGCGGCTAATCTAGGATT
GATTTCTTGTATCGCAAACGCAAAGTCTGAAATTTTCACGGATCGGCTCAATCATGCTTCGATTTTGGACGGGATTCGTC
TTTCGGGCGCAGAGAAAACATATTATAAACACCTAAACTTAAATCATCTCGAGGAACTTCTCCAAAAATCTAAAAGAAAG
GAAAGAATTATCATATCCGAAAGTGTATTCAGCATGGATGGAGATTTTGCGCCGATTTTGGATCTTCTCTATCTCAAAAA
TAAATACGATGCGGTTTTGATTTTGGATGATGCTCACGGGATCGGAATTTTTGGGCAAAGCGGAGAAGGTAGAGTGGCAC
AGGTTTTAGGCCCGGAAAGAATGGAAGAGGTGGACTTTATTACTTATACGGCCGGGAAGTCTCTGGGTTTGGAAGGCGCT
TGGATTGGAACTTCCCGGACTGGAAAAGAGTTTCTGATCAATAAGATGCGGACTTTTATTTATTCTACGGCGCCTATGCC
CGCGATCACACATGCGGTTCCGACTTCCATTTCAATCGTGCGGTCCATGAGAAAGGAAAGAGAGGATCTTTTAAAACGAG
CGGATCGCTTTCGTATTTCTCTTGAGGCGAAAAATTATCCGAAAACGACTTCCGAATCTCAGATTGTTCCTATTTTATTT
CCTTCCGAAAAAACCGTTTTGGATTCCGCAGAAATTTGTAAAAACAACGGACTTTATGTTAAGGCGATCCGTCCTCCAAC
CGTGAGCGTTCCCAGACTTCGAGTCAGCATTCATTCCGATACAACGGAATCAATATTAGAAAAATTGATTTCTCTTTTGC
CGGAGTTTTGA

Upstream 100 bases:

>100_bases
AACGACTTTGCGAAGGAAAAATTCAAAACTACTCATGATGAACTCATTTCCGAAAGAAATGAAGTGAAGGACATGCTCTA
GAATTCAAAAGAGAGGTTTT

Downstream 100 bases:

>100_bases
TGGCAGTATTTATCGGAGCCACTGGAACGGACATAGGTAAAACTCTTTTTAGTTCCCTCATCTTGGGGAAATACGGAAAG
TCCTTAGGACTCAAGTATTT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MNLNPSTFFQKASFVLESLKENFLFRSLEVPSGVDLSSNDYLGLTRHSKLIESLKEGLALYGAGSGASRLVSGHRDSFEI
AEQTCSEWVGTETSVWVANGYAANLGLISCIANAKSEIFTDRLNHASILDGIRLSGAEKTYYKHLNLNHLEELLQKSKRK
ERIIISESVFSMDGDFAPILDLLYLKNKYDAVLILDDAHGIGIFGQSGEGRVAQVLGPERMEEVDFITYTAGKSLGLEGA
WIGTSRTGKEFLINKMRTFIYSTAPMPAITHAVPTSISIVRSMRKEREDLLKRADRFRISLEAKNYPKTTSESQIVPILF
PSEKTVLDSAEICKNNGLYVKAIRPPTVSVPRLRVSIHSDTTESILEKLISLLPEF

Sequences:

>Translated_376_residues
MNLNPSTFFQKASFVLESLKENFLFRSLEVPSGVDLSSNDYLGLTRHSKLIESLKEGLALYGAGSGASRLVSGHRDSFEI
AEQTCSEWVGTETSVWVANGYAANLGLISCIANAKSEIFTDRLNHASILDGIRLSGAEKTYYKHLNLNHLEELLQKSKRK
ERIIISESVFSMDGDFAPILDLLYLKNKYDAVLILDDAHGIGIFGQSGEGRVAQVLGPERMEEVDFITYTAGKSLGLEGA
WIGTSRTGKEFLINKMRTFIYSTAPMPAITHAVPTSISIVRSMRKEREDLLKRADRFRISLEAKNYPKTTSESQIVPILF
PSEKTVLDSAEICKNNGLYVKAIRPPTVSVPRLRVSIHSDTTESILEKLISLLPEF
>Mature_376_residues
MNLNPSTFFQKASFVLESLKENFLFRSLEVPSGVDLSSNDYLGLTRHSKLIESLKEGLALYGAGSGASRLVSGHRDSFEI
AEQTCSEWVGTETSVWVANGYAANLGLISCIANAKSEIFTDRLNHASILDGIRLSGAEKTYYKHLNLNHLEELLQKSKRK
ERIIISESVFSMDGDFAPILDLLYLKNKYDAVLILDDAHGIGIFGQSGEGRVAQVLGPERMEEVDFITYTAGKSLGLEGA
WIGTSRTGKEFLINKMRTFIYSTAPMPAITHAVPTSISIVRSMRKEREDLLKRADRFRISLEAKNYPKTTSESQIVPILF
PSEKTVLDSAEICKNNGLYVKAIRPPTVSVPRLRVSIHSDTTESILEKLISLLPEF

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=356, Percent_Identity=28.3707865168539, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI7657118, Length=349, Percent_Identity=28.080229226361, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI83977440, Length=355, Percent_Identity=31.2676056338028, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI83977442, Length=355, Percent_Identity=31.2676056338028, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI83977444, Length=355, Percent_Identity=31.2676056338028, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI4502025, Length=331, Percent_Identity=29.607250755287, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI40316939, Length=331, Percent_Identity=29.607250755287, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4758668, Length=366, Percent_Identity=29.5081967213115, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI119220554, Length=391, Percent_Identity=25.3196930946292, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI5454084, Length=235, Percent_Identity=25.9574468085106, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1786993, Length=345, Percent_Identity=32.7536231884058, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1790046, Length=368, Percent_Identity=28.804347826087, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=349, Percent_Identity=32.0916905444126, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17560912, Length=308, Percent_Identity=28.8961038961039, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17560914, Length=308, Percent_Identity=28.8961038961039, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=26.5582655826558, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=262, Percent_Identity=22.9007633587786, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71982617, Length=262, Percent_Identity=22.9007633587786, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320438, Length=363, Percent_Identity=28.9256198347107, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320267, Length=395, Percent_Identity=26.0759493670886, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323954, Length=281, Percent_Identity=24.5551601423488, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24662918, Length=349, Percent_Identity=30.3724928366762, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI17137420, Length=319, Percent_Identity=28.2131661442006, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI17136286, Length=305, Percent_Identity=27.2131147540984, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653280, Length=272, Percent_Identity=26.8382352941176, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653276, Length=272, Percent_Identity=26.8382352941176, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24653278, Length=272, Percent_Identity=26.8382352941176, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 41756; Mature: 41756

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLNPSTFFQKASFVLESLKENFLFRSLEVPSGVDLSSNDYLGLTRHSKLIESLKEGLAL
CCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHCCEE
YGAGSGASRLVSGHRDSFEIAEQTCSEWVGTETSVWVANGYAANLGLISCIANAKSEIFT
EECCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
DRLNHASILDGIRLSGAEKTYYKHLNLNHLEELLQKSKRKERIIISESVFSMDGDFAPIL
HHCCHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCEEEEEHHHHCCCCCHHHHH
DLLYLKNKYDAVLILDDAHGIGIFGQSGEGRVAQVLGPERMEEVDFITYTAGKSLGLEGA
HHHHHCCCCCEEEEEECCCCCEEECCCCCCCEEECCCCHHHHHCCEEEEECCCCCCCCEE
WIGTSRTGKEFLINKMRTFIYSTAPMPAITHAVPTSISIVRSMRKEREDLLKRADRFRIS
EECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEE
LEAKNYPKTTSESQIVPILFPSEKTVLDSAEICKNNGLYVKAIRPPTVSVPRLRVSIHSD
EECCCCCCCCCCCEEEEEEECCCCCHHCCHHHHCCCCEEEEEECCCCCCCCEEEEEEECC
TTESILEKLISLLPEF
CHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLNPSTFFQKASFVLESLKENFLFRSLEVPSGVDLSSNDYLGLTRHSKLIESLKEGLAL
CCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHCCEE
YGAGSGASRLVSGHRDSFEIAEQTCSEWVGTETSVWVANGYAANLGLISCIANAKSEIFT
EECCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
DRLNHASILDGIRLSGAEKTYYKHLNLNHLEELLQKSKRKERIIISESVFSMDGDFAPIL
HHCCHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCEEEEEHHHHCCCCCHHHHH
DLLYLKNKYDAVLILDDAHGIGIFGQSGEGRVAQVLGPERMEEVDFITYTAGKSLGLEGA
HHHHHCCCCCEEEEEECCCCCEEECCCCCCCEEECCCCHHHHHCCEEEEECCCCCCCCEE
WIGTSRTGKEFLINKMRTFIYSTAPMPAITHAVPTSISIVRSMRKEREDLLKRADRFRIS
EECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEE
LEAKNYPKTTSESQIVPILFPSEKTVLDSAEICKNNGLYVKAIRPPTVSVPRLRVSIHSD
EECCCCCCCCCCCEEEEEEECCCCCHHCCHHHHCCCCEEEEEECCCCCCCCEEEEEEECC
TTESILEKLISLLPEF
CHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA