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The map label for this gene is gmhA-1

Identifier: 116328071

GI number: 116328071

Start: 1599776

End: 1600363

Strand: Direct

Name: gmhA-1

Synonym: LBL_1368

Alternate gene names: 116328071

Gene position: 1599776-1600363 (Clockwise)

Preceding gene: 116328070

Following gene: 116328072

Centisome position: 44.26

GC content: 42.86

Gene sequence:

>588_bases
ATGGATATAAAGGAAATCGCGCTCGGTCAGATTCGGGATTCCATTGCCACCAAACAGAAATGTATCGATTCGATTTTGGG
TGATATCACCAAAGCGGGGGAAATGGTTTCCAAGGTTTTACAAAGCGGCAACACGGTGTATCTTTGTGGAAACGGAGGTT
CTTCTTGCGATGCTTCTCATATTGCCGCGGAACTCGTGGTAAGATATAAATCCGGAAACGAAAGAAAAGCTTTACCTGCC
CTTTCTCTTTCCGGAGACTCTGCGGTATTGACGGCTTGTTCGAATGACTACGGCTACGAAGAAATTTTTGCCAGACAGAT
AGAAGCCTTCGGTAGAAAGGGAGATCTTCTCATCGGACTTTCCACGAGTGGAAATTCGAAGAATGTTTTGTTGGCTTTGG
AAAAAGCGAAAACCAGAGGAGTCAAAACCATATCCTTGTTGGGCGGAGACGGAGGTAGAATAAAAAATCTTTCCGACCTT
GACATAATTGTTCCGAGCAAAGTAACCGCTAGAATTCAAGAGTCTCACATTTTAATCGGACATATCCTTTGTAGTATCGT
GGAATATAATCTTTTCAAAATGGAATGA

Upstream 100 bases:

>100_bases
CCGTATACGGAAAATCTTTCCCTTCAGGATTTCGAAAAAGCGAAGGCGGAATTTTTTCAAGTGATCGAACAGATTCGAAA
AAAAAGAGGAGCAAACTAAG

Downstream 100 bases:

>100_bases
TCGCTTTTTCGTGGATTCTTCCCTAGTCGAAATCACGGGTCTCAAGGTTTCCGTACCCGGTCGTTCCATTCTCAAAGGAA
TCGACTTCACTCTTCGTTCC

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MDIKEIALGQIRDSIATKQKCIDSILGDITKAGEMVSKVLQSGNTVYLCGNGGSSCDASHIAAELVVRYKSGNERKALPA
LSLSGDSAVLTACSNDYGYEEIFARQIEAFGRKGDLLIGLSTSGNSKNVLLALEKAKTRGVKTISLLGGDGGRIKNLSDL
DIIVPSKVTARIQESHILIGHILCSIVEYNLFKME

Sequences:

>Translated_195_residues
MDIKEIALGQIRDSIATKQKCIDSILGDITKAGEMVSKVLQSGNTVYLCGNGGSSCDASHIAAELVVRYKSGNERKALPA
LSLSGDSAVLTACSNDYGYEEIFARQIEAFGRKGDLLIGLSTSGNSKNVLLALEKAKTRGVKTISLLGGDGGRIKNLSDL
DIIVPSKVTARIQESHILIGHILCSIVEYNLFKME
>Mature_195_residues
MDIKEIALGQIRDSIATKQKCIDSILGDITKAGEMVSKVLQSGNTVYLCGNGGSSCDASHIAAELVVRYKSGNERKALPA
LSLSGDSAVLTACSNDYGYEEIFARQIEAFGRKGDLLIGLSTSGNSKNVLLALEKAKTRGVKTISLLGGDGGRIKNLSDL
DIIVPSKVTARIQESHILIGHILCSIVEYNLFKME

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1789539, Length=186, Percent_Identity=37.6344086021505, Blast_Score=143, Evalue=7e-36,
Organism=Escherichia coli, GI1786416, Length=172, Percent_Identity=42.4418604651163, Blast_Score=141, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_LEPBJ (Q04RN4)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_801194.1
- ProteinModelPortal:   Q04RN4
- SMR:   Q04RN4
- STRING:   Q04RN4
- GeneID:   4411962
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_1916
- eggNOG:   COG0279
- HOGENOM:   HBG671955
- OMA:   IIAHARD
- PhylomeDB:   Q04RN4
- ProtClustDB:   PRK13937
- BioCyc:   LBOR355277:LBJ_1916-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR020620
- InterPro:   IPR001347

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20803; Mature: 20803

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS51464 SIS

Important sites: BINDING 64-64 BINDING 126-126 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKEIALGQIRDSIATKQKCIDSILGDITKAGEMVSKVLQSGNTVYLCGNGGSSCDASH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHH
IAAELVVRYKSGNERKALPALSLSGDSAVLTACSNDYGYEEIFARQIEAFGRKGDLLIGL
HHHHHHHEECCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEE
STSGNSKNVLLALEKAKTRGVKTISLLGGDGGRIKNLSDLDIIVPSKVTARIQESHILIG
ECCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCEEECCCHHHHHHHHCEEHHH
HILCSIVEYNLFKME
HHHHHHHHHHHEECC
>Mature Secondary Structure
MDIKEIALGQIRDSIATKQKCIDSILGDITKAGEMVSKVLQSGNTVYLCGNGGSSCDASH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHH
IAAELVVRYKSGNERKALPALSLSGDSAVLTACSNDYGYEEIFARQIEAFGRKGDLLIGL
HHHHHHHEECCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEE
STSGNSKNVLLALEKAKTRGVKTISLLGGDGGRIKNLSDLDIIVPSKVTARIQESHILIG
ECCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCEEECCCHHHHHHHHCEEHHH
HILCSIVEYNLFKME
HHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA