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The map label for this gene is guaA [H]

Identifier: 116328066

GI number: 116328066

Start: 1592880

End: 1594691

Strand: Direct

Name: guaA [H]

Synonym: LBL_1361

Alternate gene names: 116328066

Gene position: 1592880-1594691 (Clockwise)

Preceding gene: 116328063

Following gene: 116328069

Centisome position: 44.07

GC content: 43.21

Gene sequence:

>1812_bases
ATGGAAGTCCGGAAGAAAATTGCCGTGGTTGATTTTGGTGGGCAATATGCTCACTTGATAGCATCCAGAATTCGAAGATT
AGGCGCTTATACGGAAATTCTTTCTAACGAAGAACCTCTTTCCAATTATCAAAAATATACGGGTATTATTCTTTCCGGCG
GGCCGGAAAGTGTTTACGAACCCGATTCTCCAACGATTACAACTCGGATTTTCGAACTAGGAATTCCGGTCCTCGGAATT
TGTTATGGCCATCAGTTGATTATGAAGCTTCTCGGCGGAGTTGTAAAACGTTCCGGAACGGGAGAATACGGTCCTACTTC
TTTACAAATTCATGATTCCGGCGAAAACTTTCTTTTGAAGAATTTTATAGGAGGGGAACGGGTTTGGATGAATCACGCCG
ACGAAGTCGTAAAACTTCCGGAGGGTTTTACAAGGACCGCTTCTTCGAAAGATTGTGGTTATGCGGTTGTGGAGAATACT
TCCAAGAAAATTTTCGGAATTCAATTTCATGCGGAAGTAAGTCATAGCGAAAATGGTTCTCTTCTTCTTGATAATTTTAT
TCAAATTTGCGGAGCTTCTAGAACCTGGGGAATCGATCGGTTCTTAAAAAAAAAGATCGAAGAGATTCAAAAAACCGTAA
AGCCGGAACAAAAGATTTTTATGCTCGTTTCGGGTGGAGTGGATTCCACCGTTTCTTATCTTCTTCTGTGCAAAGCTCTC
GGTGCGGAAAGAGTTTTCGGATTTTTAGTCGACACCGGTTTTATGAGAAAAGGAGAAGTTCTTTATCTTCAAGAAAGACT
GGCTCTTCAGGATATCCGTCTAACGGTAAGAGACGAATCGAATCTTTTTTATGAAAGTTTAAAAGGGAAATCCGATCCCG
AAGAAAAAAGAAAAATCGTAGGAAACTTATTTCTAGAAGTTAGGGACCGCGCCATAAAAGATTTAGATCTGGAACACGGG
GATTGGCTCCTCGGTCAAGGTACTATCTATCCGGACACGATTGAATCCGGTGGGACGAAACATTCTCATACTATTAAAAC
GCATCATAATCGAGTCGAAGCGATTCAAAAATTGATCGAAGAGGGAAAGATCATTGAACCGATCCGAGATCTTTATAAAG
ACGAGGTCAGAGATCTGGGAGTTCTTCTTGGGTTGGAAGCGGAATGGGTAGGCCGCCATCCGTTTCCAGGACCCGGACTT
GTGGTGCGCATGTTAGCGGTTGAAAAAAAAGGAACGAGCGAGGACCAAAAGGAAATCGATTCTTATCTTGCGACTCAAGG
GGGATTATCCGGCAAAATCCTTCCCGTCGCCAGCGTAGGCGTTAAAGGAGATCGAAGATCCTATGCAAACTGTGTAGTGT
TAAGCGACATCGGAACGAATTGGAAAACTTTGGATCGGGTCGCTACACATCTTTCCAATCAGTTTTCCTTTATTAATCGT
GTAGTTCTCTTACCTTTCGAGACCGACGTCAAAAAATTGAATTTTCAATTTACTGGAATGCAGTTGGATAAGAATTATTC
CGATTTGCTTCGGGAAGCGGATTATGCGGTCGAGTCCGTGATTCGCAAAGCCGGTCTTTACGATAAGATTTGGCAGATGC
CCGTCGTTCTTTTGCCCATCGGGGAAAAGAAGAATGAAAAGAGTATCGTTCTTCGTCCGGTTGAATCTCAGGAGGCGATG
ACGGCTAACTTTTTCCCGATGGAACGCTTTTTGTTGCAGGAAATCAAAGACGTGGTTTCCAAGATCAGCGGGATTCGTTA
CGTATTTTTCGATCTTACGAACAAGCCGCCGGGTACGATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
GGATGATTCGTTTTCATGATGACCAGATTTTTCGATCTTTTCTCCTCGAAAATTCTTTTTCCCAAATTGAATTCGTATCA
AAGTCCCAAAGAGGGGTGGA

Downstream 100 bases:

>100_bases
TCAAATTCGAATATTCCAATTTGATTGTATGGTGATTTTACGTATAGATTTTGGTTACCATAATCGATAATTCAGACTTT
TTCTAAAAAGTCAGATTGAG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MEVRKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSNYQKYTGIILSGGPESVYEPDSPTITTRIFELGIPVLGI
CYGHQLIMKLLGGVVKRSGTGEYGPTSLQIHDSGENFLLKNFIGGERVWMNHADEVVKLPEGFTRTASSKDCGYAVVENT
SKKIFGIQFHAEVSHSENGSLLLDNFIQICGASRTWGIDRFLKKKIEEIQKTVKPEQKIFMLVSGGVDSTVSYLLLCKAL
GAERVFGFLVDTGFMRKGEVLYLQERLALQDIRLTVRDESNLFYESLKGKSDPEEKRKIVGNLFLEVRDRAIKDLDLEHG
DWLLGQGTIYPDTIESGGTKHSHTIKTHHNRVEAIQKLIEEGKIIEPIRDLYKDEVRDLGVLLGLEAEWVGRHPFPGPGL
VVRMLAVEKKGTSEDQKEIDSYLATQGGLSGKILPVASVGVKGDRRSYANCVVLSDIGTNWKTLDRVATHLSNQFSFINR
VVLLPFETDVKKLNFQFTGMQLDKNYSDLLREADYAVESVIRKAGLYDKIWQMPVVLLPIGEKKNEKSIVLRPVESQEAM
TANFFPMERFLLQEIKDVVSKISGIRYVFFDLTNKPPGTIEWE

Sequences:

>Translated_603_residues
MEVRKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSNYQKYTGIILSGGPESVYEPDSPTITTRIFELGIPVLGI
CYGHQLIMKLLGGVVKRSGTGEYGPTSLQIHDSGENFLLKNFIGGERVWMNHADEVVKLPEGFTRTASSKDCGYAVVENT
SKKIFGIQFHAEVSHSENGSLLLDNFIQICGASRTWGIDRFLKKKIEEIQKTVKPEQKIFMLVSGGVDSTVSYLLLCKAL
GAERVFGFLVDTGFMRKGEVLYLQERLALQDIRLTVRDESNLFYESLKGKSDPEEKRKIVGNLFLEVRDRAIKDLDLEHG
DWLLGQGTIYPDTIESGGTKHSHTIKTHHNRVEAIQKLIEEGKIIEPIRDLYKDEVRDLGVLLGLEAEWVGRHPFPGPGL
VVRMLAVEKKGTSEDQKEIDSYLATQGGLSGKILPVASVGVKGDRRSYANCVVLSDIGTNWKTLDRVATHLSNQFSFINR
VVLLPFETDVKKLNFQFTGMQLDKNYSDLLREADYAVESVIRKAGLYDKIWQMPVVLLPIGEKKNEKSIVLRPVESQEAM
TANFFPMERFLLQEIKDVVSKISGIRYVFFDLTNKPPGTIEWE
>Mature_603_residues
MEVRKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSNYQKYTGIILSGGPESVYEPDSPTITTRIFELGIPVLGI
CYGHQLIMKLLGGVVKRSGTGEYGPTSLQIHDSGENFLLKNFIGGERVWMNHADEVVKLPEGFTRTASSKDCGYAVVENT
SKKIFGIQFHAEVSHSENGSLLLDNFIQICGASRTWGIDRFLKKKIEEIQKTVKPEQKIFMLVSGGVDSTVSYLLLCKAL
GAERVFGFLVDTGFMRKGEVLYLQERLALQDIRLTVRDESNLFYESLKGKSDPEEKRKIVGNLFLEVRDRAIKDLDLEHG
DWLLGQGTIYPDTIESGGTKHSHTIKTHHNRVEAIQKLIEEGKIIEPIRDLYKDEVRDLGVLLGLEAEWVGRHPFPGPGL
VVRMLAVEKKGTSEDQKEIDSYLATQGGLSGKILPVASVGVKGDRRSYANCVVLSDIGTNWKTLDRVATHLSNQFSFINR
VVLLPFETDVKKLNFQFTGMQLDKNYSDLLREADYAVESVIRKAGLYDKIWQMPVVLLPIGEKKNEKSIVLRPVESQEAM
TANFFPMERFLLQEIKDVVSKISGIRYVFFDLTNKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=675, Percent_Identity=35.4074074074074, Blast_Score=364, Evalue=1e-100,
Organism=Escherichia coli, GI1788854, Length=515, Percent_Identity=36.6990291262136, Blast_Score=297, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI71992717, Length=694, Percent_Identity=34.4380403458213, Blast_Score=343, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI71992710, Length=694, Percent_Identity=34.4380403458213, Blast_Score=343, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI133901714, Length=694, Percent_Identity=34.4380403458213, Blast_Score=342, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6323873, Length=502, Percent_Identity=40.4382470119522, Blast_Score=329, Evalue=1e-90,
Organism=Drosophila melanogaster, GI281365319, Length=676, Percent_Identity=35.0591715976331, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 67796; Mature: 67796

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVRKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSNYQKYTGIILSGGPESVYE
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCEEEEECCCCCCCC
PDSPTITTRIFELGIPVLGICYGHQLIMKLLGGVVKRSGTGEYGPTSLQIHDSGENFLLK
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEH
NFIGGERVWMNHADEVVKLPEGFTRTASSKDCGYAVVENTSKKIFGIQFHAEVSHSENGS
HCCCCCEEECCCCHHHHCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEEEECCCCCCC
LLLDNFIQICGASRTWGIDRFLKKKIEEIQKTVKPEQKIFMLVSGGVDSTVSYLLLCKAL
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHH
GAERVFGFLVDTGFMRKGEVLYLQERLALQDIRLTVRDESNLFYESLKGKSDPEEKRKIV
CHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHEEEEEECCCHHHHHHHCCCCCHHHHHHHH
GNLFLEVRDRAIKDLDLEHGDWLLGQGTIYPDTIESGGTKHSHTIKTHHNRVEAIQKLIE
HHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGKIIEPIRDLYKDEVRDLGVLLGLEAEWVGRHPFPGPGLVVRMLAVEKKGTSEDQKEID
CCCCHHHHHHHHHHHHHHHHHHEECCHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHH
SYLATQGGLSGKILPVASVGVKGDRRSYANCVVLSDIGTNWKTLDRVATHLSNQFSFINR
HHHHHCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCE
VVLLPFETDVKKLNFQFTGMQLDKNYSDLLREADYAVESVIRKAGLYDKIWQMPVVLLPI
EEEEECCCCHHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEC
GEKKNEKSIVLRPVESQEAMTANFFPMERFLLQEIKDVVSKISGIRYVFFDLTNKPPGTI
CCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
EWE
CCC
>Mature Secondary Structure
MEVRKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSNYQKYTGIILSGGPESVYE
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCEEEEECCCCCCCC
PDSPTITTRIFELGIPVLGICYGHQLIMKLLGGVVKRSGTGEYGPTSLQIHDSGENFLLK
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEH
NFIGGERVWMNHADEVVKLPEGFTRTASSKDCGYAVVENTSKKIFGIQFHAEVSHSENGS
HCCCCCEEECCCCHHHHCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEEEECCCCCCC
LLLDNFIQICGASRTWGIDRFLKKKIEEIQKTVKPEQKIFMLVSGGVDSTVSYLLLCKAL
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHH
GAERVFGFLVDTGFMRKGEVLYLQERLALQDIRLTVRDESNLFYESLKGKSDPEEKRKIV
CHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHEEEEEECCCHHHHHHHCCCCCHHHHHHHH
GNLFLEVRDRAIKDLDLEHGDWLLGQGTIYPDTIESGGTKHSHTIKTHHNRVEAIQKLIE
HHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGKIIEPIRDLYKDEVRDLGVLLGLEAEWVGRHPFPGPGLVVRMLAVEKKGTSEDQKEID
CCCCHHHHHHHHHHHHHHHHHHEECCHHHCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHH
SYLATQGGLSGKILPVASVGVKGDRRSYANCVVLSDIGTNWKTLDRVATHLSNQFSFINR
HHHHHCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCE
VVLLPFETDVKKLNFQFTGMQLDKNYSDLLREADYAVESVIRKAGLYDKIWQMPVVLLPI
EEEEECCCCHHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEC
GEKKNEKSIVLRPVESQEAMTANFFPMERFLLQEIKDVVSKISGIRYVFFDLTNKPPGTI
CCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
EWE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA