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The map label for this gene is argH [H]

Identifier: 116328057

GI number: 116328057

Start: 1584991

End: 1586403

Strand: Direct

Name: argH [H]

Synonym: LBL_1352

Alternate gene names: 116328057

Gene position: 1584991-1586403 (Clockwise)

Preceding gene: 116328056

Following gene: 116328058

Centisome position: 43.85

GC content: 42.53

Gene sequence:

>1413_bases
ATGACTGGAAAAGAAAAAAAACTCTGGGGCGGAAGATTTCAAGAAAAACCTTCTTCGATTCTGGAACGAATCGGAGAATC
CGTATCCTTCGATCATAAACTTTATAAAGAAGATATCCAAGGAAGTATCGCGCACGCGAGAATGTTGAAACAAATCGGAA
TCTTAAGCGGAGATGAATTGTCGAAGATCGAAACCTCTCTCTTGCAGATTAAAACCGAATTGGAGGAAGGCAAGTTGGAA
TTCAAATCGGAACTCGAAGACATTCATATGCATATCGAGTCCCGTTTGACCGAACTTATCGGAGAAACCGGAAAAAAATT
ACATACCGCAAGATCTAGGAACGATCAAGTGACTCAAGACGTACGACTGTATATCTTAGGTCGAGGAAAAGAAATTCTCA
AATCCATTGTAAGTCTTAGATTTTCTTTGTATGAAAAAGCGAAACGGAGTGTGGATGTAATCATACCTGGATACACACAT
CTGCAAGTCGCACAACCGATCCGCGCCTCTCAGTACTTGCTTTCTTGGTTTTGGGCGTTGGAAAGGGATCAGGAATTTTT
TCGTTTTGCTTTAAAAGCCTCGGATGAGTTGGCTCTCGGTGGCGGAGCGATGGCGGGAGTCAATTATGCGACCGACAGGG
AATTCTTAAAAAAAGAATTAGGACTTTCTAAAGTATCTCCGAATTCCATGGATGGAGTTTCGAGCCGTGATCATATTCTA
GAATTCTTATTTGCGTGTACTCAGCTAATGATCCATGCTTCTCGGATTTGCGAGGACATCATACTTTATTCTTCCCAGGA
ATTTGGAATTTTAAAACTGTCGGATTCTCTAACTACGGGTTCGTCCATCATGCCGCAGAAAAAAAATCCGGATATCGCGG
AACTCATCCGAGGAAAGGCGGGGAGGGTGATCGGAAATCTAAATCATCTCCTCGTGATGTTGAAAGGTTTGCCTTCTACT
TACAACCGGGATCTTCAGGAGGATAAGTTGGCTCTTTTCGATTCGGTTGAAACAGTGGAAATCAGTTTGGAAGGGATCCG
GGAAATGATCGAAGATTGGGTCTGGGTTCCCGAAAGAGCGGAATCTTCCTTAAAAAACGGATTTGCTACGGCGACGGATT
TAGCGGATTTTCTCGTTTATGAAAAGAAAGTTCCGTTTCGAACCGCTCACGAACTCGTGGGAACGCTTGTAAGAGTTTGT
GTGGAGCAAAAAAGGACCTTGTTTGATTTGCCCGAACCGGATCGAATTGCGGTTTCGGAACATTTTGTGGGAAAAGAATA
CGAAAATGCGGTTTCTCTTTCTCTTTCCGCGGACAAAAAAATCTCTTACGGAGGAACTTCCAAAAAAAGACAGGAAGAAC
AATTAAAAATTGCGCTGGAATCTTTGAAGCAAACTGAAACGTTGTTTTTATGA

Upstream 100 bases:

>100_bases
AAGTTACCCAAGAAGAACTGCAAGTTTTGAAGAATTGGGTTCAGGATTTAGAAGAAGAGTATCGGAAAGAATAATTAAAA
ATAATTTGGCAAAGATCGTA

Downstream 100 bases:

>100_bases
GAATTATTTCTGGAATTTTAACGTTTGTTTGTTTTTTAGCCTGTAATCGAAATCCGTTTGCACAGACCAGATACCAACCG
GAAGTTTATACACCGTCTGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MTGKEKKLWGGRFQEKPSSILERIGESVSFDHKLYKEDIQGSIAHARMLKQIGILSGDELSKIETSLLQIKTELEEGKLE
FKSELEDIHMHIESRLTELIGETGKKLHTARSRNDQVTQDVRLYILGRGKEILKSIVSLRFSLYEKAKRSVDVIIPGYTH
LQVAQPIRASQYLLSWFWALERDQEFFRFALKASDELALGGGAMAGVNYATDREFLKKELGLSKVSPNSMDGVSSRDHIL
EFLFACTQLMIHASRICEDIILYSSQEFGILKLSDSLTTGSSIMPQKKNPDIAELIRGKAGRVIGNLNHLLVMLKGLPST
YNRDLQEDKLALFDSVETVEISLEGIREMIEDWVWVPERAESSLKNGFATATDLADFLVYEKKVPFRTAHELVGTLVRVC
VEQKRTLFDLPEPDRIAVSEHFVGKEYENAVSLSLSADKKISYGGTSKKRQEEQLKIALESLKQTETLFL

Sequences:

>Translated_470_residues
MTGKEKKLWGGRFQEKPSSILERIGESVSFDHKLYKEDIQGSIAHARMLKQIGILSGDELSKIETSLLQIKTELEEGKLE
FKSELEDIHMHIESRLTELIGETGKKLHTARSRNDQVTQDVRLYILGRGKEILKSIVSLRFSLYEKAKRSVDVIIPGYTH
LQVAQPIRASQYLLSWFWALERDQEFFRFALKASDELALGGGAMAGVNYATDREFLKKELGLSKVSPNSMDGVSSRDHIL
EFLFACTQLMIHASRICEDIILYSSQEFGILKLSDSLTTGSSIMPQKKNPDIAELIRGKAGRVIGNLNHLLVMLKGLPST
YNRDLQEDKLALFDSVETVEISLEGIREMIEDWVWVPERAESSLKNGFATATDLADFLVYEKKVPFRTAHELVGTLVRVC
VEQKRTLFDLPEPDRIAVSEHFVGKEYENAVSLSLSADKKISYGGTSKKRQEEQLKIALESLKQTETLFL
>Mature_469_residues
TGKEKKLWGGRFQEKPSSILERIGESVSFDHKLYKEDIQGSIAHARMLKQIGILSGDELSKIETSLLQIKTELEEGKLEF
KSELEDIHMHIESRLTELIGETGKKLHTARSRNDQVTQDVRLYILGRGKEILKSIVSLRFSLYEKAKRSVDVIIPGYTHL
QVAQPIRASQYLLSWFWALERDQEFFRFALKASDELALGGGAMAGVNYATDREFLKKELGLSKVSPNSMDGVSSRDHILE
FLFACTQLMIHASRICEDIILYSSQEFGILKLSDSLTTGSSIMPQKKNPDIAELIRGKAGRVIGNLNHLLVMLKGLPSTY
NRDLQEDKLALFDSVETVEISLEGIREMIEDWVWVPERAESSLKNGFATATDLADFLVYEKKVPFRTAHELVGTLVRVCV
EQKRTLFDLPEPDRIAVSEHFVGKEYENAVSLSLSADKKISYGGTSKKRQEEQLKIALESLKQTETLFL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=456, Percent_Identity=41.4473684210526, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI68303542, Length=456, Percent_Identity=41.4473684210526, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI68303549, Length=456, Percent_Identity=39.4736842105263, Blast_Score=302, Evalue=5e-82,
Organism=Homo sapiens, GI68303547, Length=456, Percent_Identity=38.3771929824561, Blast_Score=281, Evalue=8e-76,
Organism=Escherichia coli, GI1790398, Length=453, Percent_Identity=40.1766004415011, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI1787896, Length=342, Percent_Identity=25.4385964912281, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17553882, Length=236, Percent_Identity=30.0847457627119, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321806, Length=462, Percent_Identity=40.2597402597403, Blast_Score=311, Evalue=2e-85,
Organism=Drosophila melanogaster, GI221473854, Length=451, Percent_Identity=37.0288248337029, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI78706858, Length=451, Percent_Identity=37.0288248337029, Blast_Score=295, Evalue=4e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 53146; Mature: 53015

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKEKKLWGGRFQEKPSSILERIGESVSFDHKLYKEDIQGSIAHARMLKQIGILSGDEL
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
SKIETSLLQIKTELEEGKLEFKSELEDIHMHIESRLTELIGETGKKLHTARSRNDQVTQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHC
VRLYILGRGKEILKSIVSLRFSLYEKAKRSVDVIIPGYTHLQVAQPIRASQYLLSWFWAL
EEEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHCHHHHHHHHHHHHHHH
ERDQEFFRFALKASDELALGGGAMAGVNYATDREFLKKELGLSKVSPNSMDGVSSRDHIL
HCCHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
EFLFACTQLMIHASRICEDIILYSSQEFGILKLSDSLTTGSSIMPQKKNPDIAELIRGKA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCC
GRVIGNLNHLLVMLKGLPSTYNRDLQEDKLALFDSVETVEISLEGIREMIEDWVWVPERA
CHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHCCCHHEEHHHHHHHHHHHHHCCCCHHH
ESSLKNGFATATDLADFLVYEKKVPFRTAHELVGTLVRVCVEQKRTLFDLPEPDRIAVSE
HHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHH
HFVGKEYENAVSLSLSADKKISYGGTSKKRQEEQLKIALESLKQTETLFL
HHCCCHHHCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGKEKKLWGGRFQEKPSSILERIGESVSFDHKLYKEDIQGSIAHARMLKQIGILSGDEL
CCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
SKIETSLLQIKTELEEGKLEFKSELEDIHMHIESRLTELIGETGKKLHTARSRNDQVTQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHC
VRLYILGRGKEILKSIVSLRFSLYEKAKRSVDVIIPGYTHLQVAQPIRASQYLLSWFWAL
EEEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHCHHHHHHHHHHHHHHH
ERDQEFFRFALKASDELALGGGAMAGVNYATDREFLKKELGLSKVSPNSMDGVSSRDHIL
HCCHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
EFLFACTQLMIHASRICEDIILYSSQEFGILKLSDSLTTGSSIMPQKKNPDIAELIRGKA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCC
GRVIGNLNHLLVMLKGLPSTYNRDLQEDKLALFDSVETVEISLEGIREMIEDWVWVPERA
CHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHCCCHHEEHHHHHHHHHHHHHCCCCHHH
ESSLKNGFATATDLADFLVYEKKVPFRTAHELVGTLVRVCVEQKRTLFDLPEPDRIAVSE
HHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHH
HFVGKEYENAVSLSLSADKKISYGGTSKKRQEEQLKIALESLKQTETLFL
HHCCCHHHCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA