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The map label for this gene is zraS [C]

Identifier: 116327977

GI number: 116327977

Start: 1488649

End: 1489773

Strand: Reverse

Name: zraS [C]

Synonym: LBL_1266

Alternate gene names: 116327977

Gene position: 1489773-1488649 (Counterclockwise)

Preceding gene: 116327978

Following gene: 116327976

Centisome position: 41.22

GC content: 41.6

Gene sequence:

>1125_bases
TTGCAGGAAAATCTCTTAGAAAGAGCGGGTGAACTTCAATCCATCTTGGATGGGATTACCGAGCCGTTGGTACTCATTGA
TCCGGGATTTCGCATCCGGAGAGTAAATCGGTCCACACTGGAATTTTCGGGTCAATCTTCGTTCTCTTCCATTATAGGAA
AAAAATGCTACGAAGTACTCTACAACCGCAGTGATGTCTGTCCCTATTGTCCGATGAAAGAGATGCAACCGGAGGAAGAG
AACTTCAATCGATACTTCGAGTATTCGAAATCGGATGTAAACCGGGAAATTTTCCATTCCGTCAGAGGCCAAAAAGAAAC
TCTCTATCTGGACTTTTATCCGATCGAAAAAGATCATGTCATCGGTTCTGTTCTCGAAAAGGTAAGTAATATCACTCGAA
TCAGAGAAAAGGAAGAGGAAAATTTAAGAATCCGTAATCTGGCCTCTTTGGGAATTTTTATTTCCGGAGTCGCACACGAA
CTCAACAACCCACTTACCGGAATGAGTTTAACTCTTCAAAGTCTTTTGAACAATCTAACTTCGATCGATCCCGAGTTTTT
TCGGAAACGTTTGGATATGATGAAAGAAGATCTAACCCGCGCCGCGATGATTGTAACTGACATCATCAGTTTTGCCAAAC
CGGATCGTTTGATGACTACGACCGTAGATATATACGAAACGATTCAAAAAGCAAAGGAAAACGTAATCTGGGTGTACCCT
GTTCTTTCCAAAAATATCGCCTGGGAAATCCTTTGTGAGCCCGGAACCACATTTCAATTTAATCCGGTGAAGATGGAACG
TCTTTTTATCAATTTATTTAAGAATTCCTTGCAAGCCTTCGACTATGGAGAAGGAAAAATCCGTGTGGAAGTCCGTAAAA
CGAGAAATATGGTACATATCATCGTAGAAGACAACGCAGGAGGAATCCCCGACAATCTGATCGATAAAATATTCTCCCCT
TTCTTTACAAAAAATAAAACCGGAATCGGGACCGGACTCGGACTTTCTATTTGCCATTCCATCGTCAGAGAACACAGCGG
AGAATTATCGGTTAAATCTTTCGAAAAAAAAACCAGATTTCGAGTCTCCCTCCCTCTCACACAAAATCACGGATATTCTT
CCTGA

Upstream 100 bases:

>100_bases
TGAGACTTCAAGAAATGCAACGCCAGGAATCGGCAAAAAATAAAAAAAGTTACTGCAAACTTTTAAAGATTCTCTATAAT
ATTGAGTCTTCATGTCCTCG

Downstream 100 bases:

>100_bases
TGTATCGTATTCTTATCGTTGAAGACATTCATTCGATCCGAGAGGCAATTAAGGATTTACTTTCCGGAAAATATAAAATT
TTCGACGCGGAGAATTACGA

Product: sensor protein of a two component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MQENLLERAGELQSILDGITEPLVLIDPGFRIRRVNRSTLEFSGQSSFSSIIGKKCYEVLYNRSDVCPYCPMKEMQPEEE
NFNRYFEYSKSDVNREIFHSVRGQKETLYLDFYPIEKDHVIGSVLEKVSNITRIREKEEENLRIRNLASLGIFISGVAHE
LNNPLTGMSLTLQSLLNNLTSIDPEFFRKRLDMMKEDLTRAAMIVTDIISFAKPDRLMTTTVDIYETIQKAKENVIWVYP
VLSKNIAWEILCEPGTTFQFNPVKMERLFINLFKNSLQAFDYGEGKIRVEVRKTRNMVHIIVEDNAGGIPDNLIDKIFSP
FFTKNKTGIGTGLGLSICHSIVREHSGELSVKSFEKKTRFRVSLPLTQNHGYSS

Sequences:

>Translated_374_residues
MQENLLERAGELQSILDGITEPLVLIDPGFRIRRVNRSTLEFSGQSSFSSIIGKKCYEVLYNRSDVCPYCPMKEMQPEEE
NFNRYFEYSKSDVNREIFHSVRGQKETLYLDFYPIEKDHVIGSVLEKVSNITRIREKEEENLRIRNLASLGIFISGVAHE
LNNPLTGMSLTLQSLLNNLTSIDPEFFRKRLDMMKEDLTRAAMIVTDIISFAKPDRLMTTTVDIYETIQKAKENVIWVYP
VLSKNIAWEILCEPGTTFQFNPVKMERLFINLFKNSLQAFDYGEGKIRVEVRKTRNMVHIIVEDNAGGIPDNLIDKIFSP
FFTKNKTGIGTGLGLSICHSIVREHSGELSVKSFEKKTRFRVSLPLTQNHGYSS
>Mature_374_residues
MQENLLERAGELQSILDGITEPLVLIDPGFRIRRVNRSTLEFSGQSSFSSIIGKKCYEVLYNRSDVCPYCPMKEMQPEEE
NFNRYFEYSKSDVNREIFHSVRGQKETLYLDFYPIEKDHVIGSVLEKVSNITRIREKEEENLRIRNLASLGIFISGVAHE
LNNPLTGMSLTLQSLLNNLTSIDPEFFRKRLDMMKEDLTRAAMIVTDIISFAKPDRLMTTTVDIYETIQKAKENVIWVYP
VLSKNIAWEILCEPGTTFQFNPVKMERLFINLFKNSLQAFDYGEGKIRVEVRKTRNMVHIIVEDNAGGIPDNLIDKIFSP
FFTKNKTGIGTGLGLSICHSIVREHSGELSVKSFEKKTRFRVSLPLTQNHGYSS

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=29.535864978903, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790300, Length=257, Percent_Identity=27.6264591439689, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=26.530612244898, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=26.2172284644195, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=25.8620689655172, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786783, Length=222, Percent_Identity=26.1261261261261, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788393, Length=232, Percent_Identity=24.1379310344828, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42973; Mature: 42973

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQENLLERAGELQSILDGITEPLVLIDPGFRIRRVNRSTLEFSGQSSFSSIIGKKCYEVL
CCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHH
YNRSDVCPYCPMKEMQPEEENFNRYFEYSKSDVNREIFHSVRGQKETLYLDFYPIEKDHV
HCCCCCCCCCCCHHCCCCHHHHHHHHHHCHHHCCHHHHHHHCCCCEEEEEEEEECCHHHH
IGSVLEKVSNITRIREKEEENLRIRNLASLGIFISGVAHELNNPLTGMSLTLQSLLNNLT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
SIDPEFFRKRLDMMKEDLTRAAMIVTDIISFAKPDRLMTTTVDIYETIQKAKENVIWVYP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCEEEEEE
VLSKNIAWEILCEPGTTFQFNPVKMERLFINLFKNSLQAFDYGEGKIRVEVRKTRNMVHI
ECCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEE
IVEDNAGGIPDNLIDKIFSPFFTKNKTGIGTGLGLSICHSIVREHSGELSVKSFEKKTRF
EEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCEE
RVSLPLTQNHGYSS
EEEECEECCCCCCC
>Mature Secondary Structure
MQENLLERAGELQSILDGITEPLVLIDPGFRIRRVNRSTLEFSGQSSFSSIIGKKCYEVL
CCCHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHH
YNRSDVCPYCPMKEMQPEEENFNRYFEYSKSDVNREIFHSVRGQKETLYLDFYPIEKDHV
HCCCCCCCCCCCHHCCCCHHHHHHHHHHCHHHCCHHHHHHHCCCCEEEEEEEEECCHHHH
IGSVLEKVSNITRIREKEEENLRIRNLASLGIFISGVAHELNNPLTGMSLTLQSLLNNLT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
SIDPEFFRKRLDMMKEDLTRAAMIVTDIISFAKPDRLMTTTVDIYETIQKAKENVIWVYP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCEEEEEE
VLSKNIAWEILCEPGTTFQFNPVKMERLFINLFKNSLQAFDYGEGKIRVEVRKTRNMVHI
ECCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEE
IVEDNAGGIPDNLIDKIFSPFFTKNKTGIGTGLGLSICHSIVREHSGELSVKSFEKKTRF
EEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCEE
RVSLPLTQNHGYSS
EEEECEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]