Click here to switch to the map view.

The map label for this gene is clpP [H]

Identifier: 116327862

GI number: 116327862

Start: 1346523

End: 1347110

Strand: Direct

Name: clpP [H]

Synonym: LBL_1141

Alternate gene names: 116327862

Gene position: 1346523-1347110 (Clockwise)

Preceding gene: 116327861

Following gene: 116327863

Centisome position: 37.25

GC content: 42.01

Gene sequence:

>588_bases
ATGAGTGTAATTCCGTATGTGATCGAGCAGACGAGTCGAGGGGAGAGGTCTTACGATATATTTTCCCGGCTTTTAAAAGA
CAGAATTATTTTTCTCGGGAATGCAATCAATGACGATTACGCGAACGTCATTACGGCTCAGTTGTTATTTTTGGAAGCCG
AAAACCCCGAAAGAGACATCTATCTTTACCTCAATTCTCCGGGAGGTTACGTTTCCTCCGGTCTTGCAATTTATGACACA
ATGCAGTATATTAAACCGGATGTAAGAACTCTTTGTCTAGGACAGGCTTCTTCTATGGCGGCTTTGCTTTTGGCTGGAGG
AGCGGCTGGAAAACGTTCCGCGCTTCCGAATTCTAGAATCATGATGCATCAACCTATGGGAGGGGCAACGGGGCAAGCCA
GTGATATCGAAATTCAAGCGAGAGAAGTTCTCAAATTGAAAGAAATTCTTAATTCCATCTATCATAAACATACCGGAAAA
AGTGTGGAACAAATTCAGAAGGACACCGAAAGAAATTTTTACATGACGGCGGAAGAAGCAAAAAATTACGGAATCATAGA
TACGGTCATTCAGATTGATCGTAAATAA

Upstream 100 bases:

>100_bases
TGGATCATACCCTCTTTGATCTTGTAGAAAAGAAATACACTAACAAATTGAGTATTGGACAGGTAAAAGACTACCTGAAT
CAAAAGGAAGAACAGAAAGT

Downstream 100 bases:

>100_bases
GTTAAATTAGAGGAGTGATCCCTTGGCCAAGAAAACACCGGGAACCAACGGTAAACAAAAACTATTCTGCTCTTTTTGCG
GAAAGGAACAGGATGCGGTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSVIPYVIEQTSRGERSYDIFSRLLKDRIIFLGNAINDDYANVITAQLLFLEAENPERDIYLYLNSPGGYVSSGLAIYDT
MQYIKPDVRTLCLGQASSMAALLLAGGAAGKRSALPNSRIMMHQPMGGATGQASDIEIQAREVLKLKEILNSIYHKHTGK
SVEQIQKDTERNFYMTAEEAKNYGIIDTVIQIDRK

Sequences:

>Translated_195_residues
MSVIPYVIEQTSRGERSYDIFSRLLKDRIIFLGNAINDDYANVITAQLLFLEAENPERDIYLYLNSPGGYVSSGLAIYDT
MQYIKPDVRTLCLGQASSMAALLLAGGAAGKRSALPNSRIMMHQPMGGATGQASDIEIQAREVLKLKEILNSIYHKHTGK
SVEQIQKDTERNFYMTAEEAKNYGIIDTVIQIDRK
>Mature_194_residues
SVIPYVIEQTSRGERSYDIFSRLLKDRIIFLGNAINDDYANVITAQLLFLEAENPERDIYLYLNSPGGYVSSGLAIYDTM
QYIKPDVRTLCLGQASSMAALLLAGGAAGKRSALPNSRIMMHQPMGGATGQASDIEIQAREVLKLKEILNSIYHKHTGKS
VEQIQKDTERNFYMTAEEAKNYGIIDTVIQIDRK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=55.2631578947368, Blast_Score=228, Evalue=2e-60,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=62.1052631578947, Blast_Score=271, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=53.2258064516129, Blast_Score=212, Evalue=1e-55,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=58.1151832460733, Blast_Score=238, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21770; Mature: 21639

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIPYVIEQTSRGERSYDIFSRLLKDRIIFLGNAINDDYANVITAQLLFLEAENPERDI
CCCCCHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHEEEECCCCCCEE
YLYLNSPGGYVSSGLAIYDTMQYIKPDVRTLCLGQASSMAALLLAGGAAGKRSALPNSRI
EEEECCCCCCHHCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEE
MMHQPMGGATGQASDIEIQAREVLKLKEILNSIYHKHTGKSVEQIQKDTERNFYMTAEEA
EEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEHHHC
KNYGIIDTVIQIDRK
CCCCCEEHHEEECCC
>Mature Secondary Structure 
SVIPYVIEQTSRGERSYDIFSRLLKDRIIFLGNAINDDYANVITAQLLFLEAENPERDI
CCCCHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHEEEECCCCCCEE
YLYLNSPGGYVSSGLAIYDTMQYIKPDVRTLCLGQASSMAALLLAGGAAGKRSALPNSRI
EEEECCCCCCHHCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEE
MMHQPMGGATGQASDIEIQAREVLKLKEILNSIYHKHTGKSVEQIQKDTERNFYMTAEEA
EEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEHHHC
KNYGIIDTVIQIDRK
CCCCCEEHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA