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The map label for this gene is dxr

Identifier: 116327679

GI number: 116327679

Start: 1067012

End: 1068181

Strand: Direct

Name: dxr

Synonym: LBL_0925

Alternate gene names: 116327679

Gene position: 1067012-1068181 (Clockwise)

Preceding gene: 116327678

Following gene: 116327680

Centisome position: 29.52

GC content: 47.61

Gene sequence:

>1170_bases
ATGACAACTTCCGTCAGTCTTTTAGGTGCGTCCGGTTCCGTAGGGGAATCCACTCTTAGGGTGCTCCGTGCTTATCCCCA
AGAATTCCGTCTTCATTCTTTCAGCGTTCATTCGAATCTGGAAAAGGCCAGAGAAATTCAAAAGGAATTTTCTCCGGAAT
TTCTCTGCGTGAGCGACAGCACCGCGGACCGCACCGTTCTCGGAAATAAAATCGGCAAAACACAAGTCCTTTATGGAGAA
TCTGCTCTTTGCGAGCTTGTTCGAGAACCCGAAGTTCAAATCGTAATCACCGCTATCGTAGGTTCCGTGGGTTTACGTCC
GACGATCGCCGCGATCACTTCCGGTAAAAGATTAGGAATCGCGAATAAAGAAACATTAGTCACATTTGGCCCGCTCGTCA
ATTCTTTGATTGCAAAACATAAAACCAAAGTGGTTCCGGTCGATTCGGAGCATAACGCTCTCTTTCAACTTTTGGAATCT
TTGAACCGCGACTCTGTGGAGAAGATCGTTCTAACGGCGTCGGGCGGTTCGTTCCGGGATTTATCCGTAGAACAACTTGC
GTATGTTACGAAAGAACAAGCGCTTCATCATCCTACTTGGAACATGGGACCTAAGATCACCGTGGATTCCAATGGTATGA
TTAACAAAGGACTCGAAGTCATCGAAGCTCATTTTTTGTTCGGAGTTCCTTACGAGCGCATCGGAGTCGTGATTCATCCT
CAGAGTATCGCGCACGGTATCGTGGAATTAAAAGACGGCGCTTCGTTCGTTTATGCTTCTTACCCGGATATGATTTTTCC
GATTGCACATTCTCTCTTTCATCCGGAACCGGTTCCTAAGTCGCTTCGGTCCTATTCCGCTAAGGATTGGGGAAAACTGG
AATTTTGGGAGCCGGATTTAAAACGATATCCGGGACTTGGATTAGCGTTTGAGGCGGGTAAGGCGGGGGGGACGGCTCCC
TGCATTTTTAACGCGGCCAACGAGGCGGCCGTGGAATTGTTCTTAAAGGATGAGATCCGTTTTACGGAGATTCCGGATTA
TATCTGGTACACGTTAGATGAAATGCCGATCGATTTTCCGACTTCTTTGGAAGAATACGAGGAAGTCGATCGGATCGCCC
GTAAAACCGTCCTAAATCTGAAAGCAAGGAAGGTGGTGTCCGCATGTTAA

Upstream 100 bases:

>100_bases
TGGAATACTCGATCTCGCAGACGCTCTTTTGATCACAATCCCCGTTTTATATTATTATCTTCAGATCAAGGGGAATCTCG
GATTCCAAGTCTAATCAGAT

Downstream 100 bases:

>100_bases
TCATGATATTAGGCGCAGTGTTTATGCTGGCTATTTCTATTTTTATTCACGAGTTGGGTCATCTTCTTTGTGGAATGCTC
GTAGGAGTTAAGGCTAGAAT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTTSVSLLGASGSVGESTLRVLRAYPQEFRLHSFSVHSNLEKAREIQKEFSPEFLCVSDSTADRTVLGNKIGKTQVLYGE
SALCELVREPEVQIVITAIVGSVGLRPTIAAITSGKRLGIANKETLVTFGPLVNSLIAKHKTKVVPVDSEHNALFQLLES
LNRDSVEKIVLTASGGSFRDLSVEQLAYVTKEQALHHPTWNMGPKITVDSNGMINKGLEVIEAHFLFGVPYERIGVVIHP
QSIAHGIVELKDGASFVYASYPDMIFPIAHSLFHPEPVPKSLRSYSAKDWGKLEFWEPDLKRYPGLGLAFEAGKAGGTAP
CIFNAANEAAVELFLKDEIRFTEIPDYIWYTLDEMPIDFPTSLEEYEEVDRIARKTVLNLKARKVVSAC

Sequences:

>Translated_389_residues
MTTSVSLLGASGSVGESTLRVLRAYPQEFRLHSFSVHSNLEKAREIQKEFSPEFLCVSDSTADRTVLGNKIGKTQVLYGE
SALCELVREPEVQIVITAIVGSVGLRPTIAAITSGKRLGIANKETLVTFGPLVNSLIAKHKTKVVPVDSEHNALFQLLES
LNRDSVEKIVLTASGGSFRDLSVEQLAYVTKEQALHHPTWNMGPKITVDSNGMINKGLEVIEAHFLFGVPYERIGVVIHP
QSIAHGIVELKDGASFVYASYPDMIFPIAHSLFHPEPVPKSLRSYSAKDWGKLEFWEPDLKRYPGLGLAFEAGKAGGTAP
CIFNAANEAAVELFLKDEIRFTEIPDYIWYTLDEMPIDFPTSLEEYEEVDRIARKTVLNLKARKVVSAC
>Mature_388_residues
TTSVSLLGASGSVGESTLRVLRAYPQEFRLHSFSVHSNLEKAREIQKEFSPEFLCVSDSTADRTVLGNKIGKTQVLYGES
ALCELVREPEVQIVITAIVGSVGLRPTIAAITSGKRLGIANKETLVTFGPLVNSLIAKHKTKVVPVDSEHNALFQLLESL
NRDSVEKIVLTASGGSFRDLSVEQLAYVTKEQALHHPTWNMGPKITVDSNGMINKGLEVIEAHFLFGVPYERIGVVIHPQ
SIAHGIVELKDGASFVYASYPDMIFPIAHSLFHPEPVPKSLRSYSAKDWGKLEFWEPDLKRYPGLGLAFEAGKAGGTAPC
IFNAANEAAVELFLKDEIRFTEIPDYIWYTLDEMPIDFPTSLEEYEEVDRIARKTVLNLKARKVVSAC

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=393, Percent_Identity=39.6946564885496, Blast_Score=269, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_LEPBJ (Q04U66)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_800312.1
- ProteinModelPortal:   Q04U66
- SMR:   Q04U66
- STRING:   Q04U66
- GeneID:   4409806
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_0910
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q04U66
- ProtClustDB:   PRK05447
- BioCyc:   LBOR355277:LBJ_0910-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42931; Mature: 42799

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSVSLLGASGSVGESTLRVLRAYPQEFRLHSFSVHSNLEKAREIQKEFSPEFLCVSDS
CCCEEEEECCCCCCCHHHHHHHHHCHHHHCEEEEHHHHHHHHHHHHHHHCCCCEEEEECC
TADRTVLGNKIGKTQVLYGESALCELVREPEVQIVITAIVGSVGLRPTIAAITSGKRLGI
CCCHHHHCCCCCCEEEEECCHHHHHHHCCCCCEEEEEEHHCCCCCCCHHHHHCCCCEECC
ANKETLVTFGPLVNSLIAKHKTKVVPVDSEHNALFQLLESLNRDSVEKIVLTASGGSFRD
CCCCCEEEHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
LSVEQLAYVTKEQALHHPTWNMGPKITVDSNGMINKGLEVIEAHFLFGVPYERIGVVIHP
CCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHEEEEECC
QSIAHGIVELKDGASFVYASYPDMIFPIAHSLFHPEPVPKSLRSYSAKDWGKLEFWEPDL
HHHHCCCEEECCCCCEEEECCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEECCCCHH
KRYPGLGLAFEAGKAGGTAPCIFNAANEAAVELFLKDEIRFTEIPDYIWYTLDEMPIDFP
HHCCCCCEEEECCCCCCCCCEEEECCCCCEEEEEEECCCEEEECCCHHEEECCCCCCCCC
TSLEEYEEVDRIARKTVLNLKARKVVSAC
CCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTSVSLLGASGSVGESTLRVLRAYPQEFRLHSFSVHSNLEKAREIQKEFSPEFLCVSDS
CCEEEEECCCCCCCHHHHHHHHHCHHHHCEEEEHHHHHHHHHHHHHHHCCCCEEEEECC
TADRTVLGNKIGKTQVLYGESALCELVREPEVQIVITAIVGSVGLRPTIAAITSGKRLGI
CCCHHHHCCCCCCEEEEECCHHHHHHHCCCCCEEEEEEHHCCCCCCCHHHHHCCCCEECC
ANKETLVTFGPLVNSLIAKHKTKVVPVDSEHNALFQLLESLNRDSVEKIVLTASGGSFRD
CCCCCEEEHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCC
LSVEQLAYVTKEQALHHPTWNMGPKITVDSNGMINKGLEVIEAHFLFGVPYERIGVVIHP
CCHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCHHHEEEEECC
QSIAHGIVELKDGASFVYASYPDMIFPIAHSLFHPEPVPKSLRSYSAKDWGKLEFWEPDL
HHHHCCCEEECCCCCEEEECCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEECCCCHH
KRYPGLGLAFEAGKAGGTAPCIFNAANEAAVELFLKDEIRFTEIPDYIWYTLDEMPIDFP
HHCCCCCEEEECCCCCCCCCEEEECCCCCEEEEEEECCCEEEECCCHHEEECCCCCCCCC
TSLEEYEEVDRIARKTVLNLKARKVVSAC
CCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA