BacMap

Definition	Leptospira borgpetersenii serovar Hardjo-bovis L550 chromosome 1, complete sequence.
Accession	NC_008508
Length	3,614,446

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The map label for this gene is crt [H]

Identifier: 116327657

GI number: 116327657

Start: 1050690

End: 1051463

Strand: Direct

Name: crt [H]

Synonym: LBL_0903

Alternate gene names: 116327657

Gene position: 1050690-1051463 (Clockwise)

Preceding gene: 116327656

Following gene: 116327658

Centisome position: 29.07

GC content: 44.19

Gene sequence:

>774_bases
ATGAGTGAAAAATTAATCGAAGTAGTTAAAGAAGGACAGATCGCGATTCTTACGATTCAAAGGCCTTCCGCATTGAACGC
TCTCAATCGAGAGGCCTTGACCCAAATCGGTCAAGAAATGGATGTTCTTGAAAAGGATAAAAATATCCGAGTATTAATCG
TAACCGGAGAAGGAAAGGCATTTGTTGCCGGAGCCGATATCGCCGAAATGAAAGCCTTGAACGTTTCCGAGGGAGAAGAA
TTTTCCAAGTTGGGAAATACAGTATTCCAAAAATTGCATCAATCCAGAATCGTTTCGATCGCCGCGATCAACGGCTTTTC
TCTTGGTGGGGGAATGGAACTTGCACTTGCTTGTGATATACGAGTCGGATCGGAAAAGACGAAACTAGGATTGCCCGAGG
TCTCCTTAGGATTGATTCCCGGTTTCGGAGGAACACAAAGGCTTGCGAGATTGATCGGTTATGCGCGGGCGATCGAACTC
GTGGTTACCGGCGATATGATCACCGCCGAAGAAGGATATAGAATCGGGATTCTCAATAAACTGGTAAAAGAAGGAGAAAA
TATATTAGATTTTTCTAAAACGATTGCGGATTCCATTTTGAAAAAAGGACCTCGCGCAATCGAGAGAGTTAAAAGGACGA
TCCAACAAGGGCTGGACGTTACTTTAAAAGACGGGATTTCCATCGAAGAGAAAGAGTTCGGTGCATGTTTTGACGGAGGG
CAGTCCAAAGAAGGGATGACCGCGTTTTTGGAAAAAAGACCTCCTCGATTTTAA

Upstream 100 bases:

>100_bases
TTTAAGGCGAACGTCCAAAAGGCAGTCGAAAACTTTTTCGGAAACGTCGCCTTGGAGGACGATACCCTCTTTCTCATCGT
GGAAGTGGAGTAAAAAAGAA

Downstream 100 bases:

>100_bases
CGCAGCGAAAGTACTGGCGCTAACGGTTAAAATAGTAACCGGTAATTAGAAGCTATCTCAAAAATATCTTAGAATGATTG
GCACCCGCATTTCAAGCGAA

Product: enoyl-CoA hydratase/isomerase family protein

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MSEKLIEVVKEGQIAILTIQRPSALNALNREALTQIGQEMDVLEKDKNIRVLIVTGEGKAFVAGADIAEMKALNVSEGEE
FSKLGNTVFQKLHQSRIVSIAAINGFSLGGGMELALACDIRVGSEKTKLGLPEVSLGLIPGFGGTQRLARLIGYARAIEL
VVTGDMITAEEGYRIGILNKLVKEGENILDFSKTIADSILKKGPRAIERVKRTIQQGLDVTLKDGISIEEKEFGACFDGG
QSKEGMTAFLEKRPPRF

Sequences:

>Translated_257_residues
MSEKLIEVVKEGQIAILTIQRPSALNALNREALTQIGQEMDVLEKDKNIRVLIVTGEGKAFVAGADIAEMKALNVSEGEE
FSKLGNTVFQKLHQSRIVSIAAINGFSLGGGMELALACDIRVGSEKTKLGLPEVSLGLIPGFGGTQRLARLIGYARAIEL
VVTGDMITAEEGYRIGILNKLVKEGENILDFSKTIADSILKKGPRAIERVKRTIQQGLDVTLKDGISIEEKEFGACFDGG
QSKEGMTAFLEKRPPRF
>Mature_256_residues
SEKLIEVVKEGQIAILTIQRPSALNALNREALTQIGQEMDVLEKDKNIRVLIVTGEGKAFVAGADIAEMKALNVSEGEEF
SKLGNTVFQKLHQSRIVSIAAINGFSLGGGMELALACDIRVGSEKTKLGLPEVSLGLIPGFGGTQRLARLIGYARAIELV
VTGDMITAEEGYRIGILNKLVKEGENILDFSKTIADSILKKGPRAIERVKRTIQQGLDVTLKDGISIEEKEFGACFDGGQ
SKEGMTAFLEKRPPRF

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=248, Percent_Identity=36.2903225806452, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI4502327, Length=248, Percent_Identity=36.6935483870968, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI20127408, Length=177, Percent_Identity=35.0282485875706, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI68989263, Length=272, Percent_Identity=28.6764705882353, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI150378541, Length=248, Percent_Identity=30.6451612903226, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI157694516, Length=238, Percent_Identity=25.2100840336134, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI213417737, Length=238, Percent_Identity=25.2100840336134, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI70995211, Length=233, Percent_Identity=25.7510729613734, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI261878539, Length=179, Percent_Identity=31.2849162011173, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI31542718, Length=247, Percent_Identity=27.5303643724696, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI37594471, Length=187, Percent_Identity=34.2245989304813, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI37594469, Length=187, Percent_Identity=34.2245989304813, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI62530384, Length=183, Percent_Identity=30.0546448087432, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI157694520, Length=198, Percent_Identity=23.7373737373737, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI295842266, Length=181, Percent_Identity=27.0718232044199, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1787659, Length=260, Percent_Identity=35, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1790281, Length=188, Percent_Identity=34.0425531914894, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1788682, Length=189, Percent_Identity=39.1534391534392, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI221142681, Length=266, Percent_Identity=32.3308270676692, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1787660, Length=264, Percent_Identity=29.9242424242424, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87082183, Length=269, Percent_Identity=27.8810408921933, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788597, Length=255, Percent_Identity=25.8823529411765, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=249, Percent_Identity=38.9558232931727, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17554946, Length=253, Percent_Identity=37.9446640316205, Blast_Score=178, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17540714, Length=226, Percent_Identity=36.7256637168142, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17558304, Length=193, Percent_Identity=36.2694300518135, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI25144276, Length=181, Percent_Identity=38.6740331491713, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17508953, Length=181, Percent_Identity=38.6740331491713, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17508951, Length=181, Percent_Identity=38.6740331491713, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17534483, Length=269, Percent_Identity=25.6505576208178, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17560910, Length=257, Percent_Identity=27.6264591439689, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17536985, Length=238, Percent_Identity=27.3109243697479, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25141363, Length=221, Percent_Identity=26.6968325791855, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25144157, Length=218, Percent_Identity=29.3577981651376, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25144160, Length=218, Percent_Identity=29.3577981651376, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17535521, Length=254, Percent_Identity=22.4409448818898, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17540306, Length=254, Percent_Identity=22.4409448818898, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=188, Percent_Identity=28.1914893617021, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20129971, Length=252, Percent_Identity=38.0952380952381, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24653477, Length=252, Percent_Identity=38.0952380952381, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24653139, Length=248, Percent_Identity=35.4838709677419, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI19920382, Length=223, Percent_Identity=27.3542600896861, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI19922422, Length=245, Percent_Identity=26.1224489795918, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357171, Length=201, Percent_Identity=31.3432835820896, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921000, Length=174, Percent_Identity=37.9310344827586, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24583077, Length=174, Percent_Identity=37.9310344827586, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24583079, Length=174, Percent_Identity=37.9310344827586, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24650670, Length=188, Percent_Identity=32.4468085106383, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24654903, Length=183, Percent_Identity=25.1366120218579, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571729, Length=177, Percent_Identity=32.2033898305085, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571730, Length=177, Percent_Identity=32.2033898305085, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24583165, Length=246, Percent_Identity=25.2032520325203, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921018, Length=202, Percent_Identity=27.2277227722772, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 27816; Mature: 27685

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00879 ODR_DC_2_2 ; PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKLIEVVKEGQIAILTIQRPSALNALNREALTQIGQEMDVLEKDKNIRVLIVTGEGKA
CCHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCE
FVAGADIAEMKALNVSEGEEFSKLGNTVFQKLHQSRIVSIAAINGFSLGGGMELALACDI
EEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCEECCCCCEEEEEEEE
RVGSEKTKLGLPEVSLGLIPGFGGTQRLARLIGYARAIELVVTGDMITAEEGYRIGILNK
EECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHEEEEEECCEEECCCCCEEHHHHH
LVKEGENILDFSKTIADSILKKGPRAIERVKRTIQQGLDVTLKDGISIEEKEFGACFDGG
HHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHCCCCCCCC
QSKEGMTAFLEKRPPRF
CCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
SEKLIEVVKEGQIAILTIQRPSALNALNREALTQIGQEMDVLEKDKNIRVLIVTGEGKA
CHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCE
FVAGADIAEMKALNVSEGEEFSKLGNTVFQKLHQSRIVSIAAINGFSLGGGMELALACDI
EEECCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCEECCCCCEEEEEEEE
RVGSEKTKLGLPEVSLGLIPGFGGTQRLARLIGYARAIELVVTGDMITAEEGYRIGILNK
EECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHEEEEEECCEEECCCCCEEHHHHH
LVKEGENILDFSKTIADSILKKGPRAIERVKRTIQQGLDVTLKDGISIEEKEFGACFDGG
HHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHCCCCCCCC
QSKEGMTAFLEKRPPRF
CCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]