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The map label for this gene is aroE

Identifier: 116327550

GI number: 116327550

Start: 886801

End: 887673

Strand: Reverse

Name: aroE

Synonym: LBL_0779

Alternate gene names: 116327550

Gene position: 887673-886801 (Counterclockwise)

Preceding gene: 116327555

Following gene: 116327549

Centisome position: 24.56

GC content: 41.47

Gene sequence:

>873_bases
TTGAACAGCAAAACAAATCAAACCGCCAAAACTTTCGGCATAGTCGGGTTTCCACTCTCACATTCTCTTTCCCCTCTTAT
CCATAATTCAATTTATAAAGATAGAGGAATTGACGCCTCTTATCTCGTTTTTGAAACCCCTGAATTGAATTCGAAAACGA
TTCAGGAATTCCGAAACTCGGGAATACTCGGTCTTTCGGTGACGATCCCTCACAAAGAAAAAGCCTTTCTTCTGGCCGAC
AAAGCGGACAGCACGTCCACAATCATGAAAGCATCCAACACTTTATTGATCGGTCCCGATTCGATTCATGCGTACAATAC
GGACGGAGAAGGAGCCTATCGTTCCATTTTAGAATTATCTCCAGAGTCCTTAAACGTTGGTAATACGGTTATTCTTGGAA
GCGGAGGAAGTGCGAGAGGAATCGCATACAATTTAGCCGCCTCAGGCAAAATTCAAAATTTATTCCTTTGTTCGAGAAAT
GAAATGACTGCAAAAGAAATCTGTTTTTTGATTTCCAAGAATTCGAACGTCAAAATGGAACATATCACTCAGGATTCTCT
TTTTTCTCGAAAGGAAGAAATTTCCCTAGTGATCCACACAACTCCACTTGGAATGAAAGGCCAAGCCCCGGGTCCGTTTC
TTTCGGAAAAATTTTTTAATCCGAACATGACTCTCTTTGATATCGTTTATAATCCTTTGGAAACCCCTTTGGTTAAGGCC
GCCAAAAAGGCCGGAGCGAAAATCATTCCCGGATCGGAGATGCTTTTACATCAGGCGATGAAACAGTTCGAACTTTTCAC
GGGTATTTCGCCTAATGCAAGCGATATCCTCAAAACCAGAGAACGTTTGTCTCAAACATTAACAAATCAATGA

Upstream 100 bases:

>100_bases
TCAAAAGTCTTGAGTCCATTTCATTTATTTAACAAGAAACGAATCAAGCAAACGAAATCCTAAGATCTGTTTGTAATGCC
AAACAACGAGAAAACCAAAT

Downstream 100 bases:

>100_bases
GTGAAGATTCCGACTTTTTCAAATTTATCAACCAACTTCCCAACTTAGAGAAAACCAGAAACTTTAACGTTTTTACCGGA
TATTCTCTCGAACCGTTCGC

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MNSKTNQTAKTFGIVGFPLSHSLSPLIHNSIYKDRGIDASYLVFETPELNSKTIQEFRNSGILGLSVTIPHKEKAFLLAD
KADSTSTIMKASNTLLIGPDSIHAYNTDGEGAYRSILELSPESLNVGNTVILGSGGSARGIAYNLAASGKIQNLFLCSRN
EMTAKEICFLISKNSNVKMEHITQDSLFSRKEEISLVIHTTPLGMKGQAPGPFLSEKFFNPNMTLFDIVYNPLETPLVKA
AKKAGAKIIPGSEMLLHQAMKQFELFTGISPNASDILKTRERLSQTLTNQ

Sequences:

>Translated_290_residues
MNSKTNQTAKTFGIVGFPLSHSLSPLIHNSIYKDRGIDASYLVFETPELNSKTIQEFRNSGILGLSVTIPHKEKAFLLAD
KADSTSTIMKASNTLLIGPDSIHAYNTDGEGAYRSILELSPESLNVGNTVILGSGGSARGIAYNLAASGKIQNLFLCSRN
EMTAKEICFLISKNSNVKMEHITQDSLFSRKEEISLVIHTTPLGMKGQAPGPFLSEKFFNPNMTLFDIVYNPLETPLVKA
AKKAGAKIIPGSEMLLHQAMKQFELFTGISPNASDILKTRERLSQTLTNQ
>Mature_290_residues
MNSKTNQTAKTFGIVGFPLSHSLSPLIHNSIYKDRGIDASYLVFETPELNSKTIQEFRNSGILGLSVTIPHKEKAFLLAD
KADSTSTIMKASNTLLIGPDSIHAYNTDGEGAYRSILELSPESLNVGNTVILGSGGSARGIAYNLAASGKIQNLFLCSRN
EMTAKEICFLISKNSNVKMEHITQDSLFSRKEEISLVIHTTPLGMKGQAPGPFLSEKFFNPNMTLFDIVYNPLETPLVKA
AKKAGAKIIPGSEMLLHQAMKQFELFTGISPNASDILKTRERLSQTLTNQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=268, Percent_Identity=28.7313432835821, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1789675, Length=284, Percent_Identity=28.5211267605634, Blast_Score=92, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320332, Length=279, Percent_Identity=27.9569892473118, Blast_Score=83, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_LEPBJ (Q04QM3)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_801555.1
- ProteinModelPortal:   Q04QM3
- SMR:   Q04QM3
- STRING:   Q04QM3
- GeneID:   4410592
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_2329
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   TPIGMSG
- PhylomeDB:   Q04QM3
- ProtClustDB:   CLSK573591
- BioCyc:   LBOR355277:LBJ_2329-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31654; Mature: 31654

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: ACT_SITE 72-72

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKTNQTAKTFGIVGFPLSHSLSPLIHNSIYKDRGIDASYLVFETPELNSKTIQEFRNS
CCCCCCCCHHHEEEEECCHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCC
GILGLSVTIPHKEKAFLLADKADSTSTIMKASNTLLIGPDSIHAYNTDGEGAYRSILELS
CEEEEEEECCCCCCEEEEEECCCCCHHHEECCCEEEECCCCEEEECCCCCHHHHHHHHCC
PESLNVGNTVILGSGGSARGIAYNLAASGKIQNLFLCSRNEMTAKEICFLISKNSNVKME
CCCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEEECCCCCCHHHEEEEEECCCCEEEE
HITQDSLFSRKEEISLVIHTTPLGMKGQAPGPFLSEKFFNPNMTLFDIVYNPLETPLVKA
EECHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHCCCCCEEEEEHHCCCCHHHHHH
AKKAGAKIIPGSEMLLHQAMKQFELFTGISPNASDILKTRERLSQTLTNQ
HHHCCCEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSKTNQTAKTFGIVGFPLSHSLSPLIHNSIYKDRGIDASYLVFETPELNSKTIQEFRNS
CCCCCCCCHHHEEEEECCHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCC
GILGLSVTIPHKEKAFLLADKADSTSTIMKASNTLLIGPDSIHAYNTDGEGAYRSILELS
CEEEEEEECCCCCCEEEEEECCCCCHHHEECCCEEEECCCCEEEECCCCCHHHHHHHHCC
PESLNVGNTVILGSGGSARGIAYNLAASGKIQNLFLCSRNEMTAKEICFLISKNSNVKME
CCCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEEECCCCCCHHHEEEEEECCCCEEEE
HITQDSLFSRKEEISLVIHTTPLGMKGQAPGPFLSEKFFNPNMTLFDIVYNPLETPLVKA
EECHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHHHCCCCCEEEEEHHCCCCHHHHHH
AKKAGAKIIPGSEMLLHQAMKQFELFTGISPNASDILKTRERLSQTLTNQ
HHHCCCEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA