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The map label for this gene is acdA [H]

Identifier: 116327480

GI number: 116327480

Start: 795284

End: 796960

Strand: Reverse

Name: acdA [H]

Synonym: LBL_0703

Alternate gene names: 116327480

Gene position: 796960-795284 (Counterclockwise)

Preceding gene: 116327481

Following gene: 116327479

Centisome position: 22.05

GC content: 46.87

Gene sequence:

>1677_bases
ATGAGCGCAACCAATACCGTCGTTGATCAAACGACCGTGAAAAAAGCACTTTCCGTTTCCGCAGGAGTGATCGAAGAAGT
TACGAAAGCACTTGCAGCACGTTGCAATGTTAACGGAAAAGTCTCCATTGACAAAATGGACGAAAACCAACTCGTTCAAT
ACCAAATCGCCTGGCTTACTTCCGAACAAAAAATCGCGGAGAAATTCATTGAATATGCTTGGGATACGTCCCGAGGAACA
GGGGATCTCGAACAGGAAATGGCGGTCGTTTTTGCGGCTGAAACTGTGAACCACGTTCGTTCCGAAATTAGTTCCCGTCC
TTCCGAGTACGGAATCAAAGCTTCCAGTCTGGTTTCCAAAATATTCAACGACGAAATCAATCAATTCTTAGAAAACGCGA
TGGCGATCCAAAATTACAACCAGATCGCGGACAAGATCGTTGCCAAAGGTCATTTCGGAGCCTACGGTCTGGACGACGAT
CACGAAATGTTTCGTGAAACGTTTAAGAAGTTTGCGGAAGACGTGGTCATGCCGCACGCGGAACACGTTCATAGACACGA
CGATATCATTCCCGAAGACATCATCGGCGGATTGAAAGACATGGGTTGTTTCGGTCTTTGTATTCCGGAATCATACGGCG
GAATCCAACCGAACGATAAACCGGATAATTTATCCATGCTCGTCGTCACCGAAGAACTTTCCAGAGGGGGATTGGGAATT
GCGGGCTCTCTCATCACTAGACCGGAAATTATGTCCAAGGCTCTTCTGAAAGGAGGAACTCAAGAACAGAAAGACAAGTG
GCTTCCTCTTCTTGCATCCGGGGAAAGAATGGCCGGAATCATGGTGACCGAACCGAACTACGGTTCGGACGTAGCGGGAG
TTTCCGTAACGGCAAAACAAACAAATGGAGGTTGGGTCATCAATGGTGTTAAAACTTGGTGTACGTTTGCGGGTTATGCA
AACCTCCTTTTGGTCCTTTGTAGAACCGAATCCGATCCTTCCCTGAAACACAAAGGACTTTCCATTCTACTTGCGGAAAA
ACCGAGTTTTACCGGTCACGAATTCGCCTACACTCAACCCGAAGGTGGAAAGATAGAAGGAAAAGCGATTGGTACTATCG
GATACAGAGGAATGCATTCTTTCGAAGTTTCCTTCGACAACTACTTCGTTCCCGCAGAAAACCTGTTAGGCGGAGAAGCG
GGAAGAGGAAAAGGATTTTACTTCCAGATGGAAGGATTTGCCGGTGGAAGGATTCAGACCGCGGCCCGTGCTCACGGTGT
GATGCAAGCCGCTCTGGAAGCGGCTCTACGTTATGCGCAAGATAGATCCGTATTTCAAAAACCGATCTACGAATACAACT
TAACGAAATACAAAATAGCGAAAATGGCGGTGATTTTACAGGCTTCTCGTCAATTTGCAAATCATGTAGCTAGTTTATTG
GATAATCACCAAGGCCAGATGGAGGCAACGTTGATCAAGTTTTACGCTTCCAAAGTCGCCGAATGGGTGACAAGAGAAGC
GATGCAAATTCATGGTGGAATGGGTTATGCGGAAGAATACGCCGTTTCCCGTTACTTTGTGGACGCCCGAGTGTTCTCCA
TCTTCGAAGGCGCCGAAGAAGTAATGGCCCTAAGAGTAATTGCAAAATCCCTAATGGACCAATACGTAGGCGCATAA

Upstream 100 bases:

>100_bases
TTGCCATCCGGAAACGTCGTTCAAAAAGCAAATGACAGTGGTAGAAGTCGTGATTTTGTAGGTTTCAGATTCGAATTTTT
TACTTCAGGATTAAAAACCC

Downstream 100 bases:

>100_bases
AAGCGGCGAACCGAAAAATTTAAAGAAATTAGACAGCAAGCGGCTAACACCTTGAAAAGTGCATTCCAAAATCGTAATGC
AGAAGTTGGTTCTTTGAAAA

Product: Acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MSATNTVVDQTTVKKALSVSAGVIEEVTKALAARCNVNGKVSIDKMDENQLVQYQIAWLTSEQKIAEKFIEYAWDTSRGT
GDLEQEMAVVFAAETVNHVRSEISSRPSEYGIKASSLVSKIFNDEINQFLENAMAIQNYNQIADKIVAKGHFGAYGLDDD
HEMFRETFKKFAEDVVMPHAEHVHRHDDIIPEDIIGGLKDMGCFGLCIPESYGGIQPNDKPDNLSMLVVTEELSRGGLGI
AGSLITRPEIMSKALLKGGTQEQKDKWLPLLASGERMAGIMVTEPNYGSDVAGVSVTAKQTNGGWVINGVKTWCTFAGYA
NLLLVLCRTESDPSLKHKGLSILLAEKPSFTGHEFAYTQPEGGKIEGKAIGTIGYRGMHSFEVSFDNYFVPAENLLGGEA
GRGKGFYFQMEGFAGGRIQTAARAHGVMQAALEAALRYAQDRSVFQKPIYEYNLTKYKIAKMAVILQASRQFANHVASLL
DNHQGQMEATLIKFYASKVAEWVTREAMQIHGGMGYAEEYAVSRYFVDARVFSIFEGAEEVMALRVIAKSLMDQYVGA

Sequences:

>Translated_558_residues
MSATNTVVDQTTVKKALSVSAGVIEEVTKALAARCNVNGKVSIDKMDENQLVQYQIAWLTSEQKIAEKFIEYAWDTSRGT
GDLEQEMAVVFAAETVNHVRSEISSRPSEYGIKASSLVSKIFNDEINQFLENAMAIQNYNQIADKIVAKGHFGAYGLDDD
HEMFRETFKKFAEDVVMPHAEHVHRHDDIIPEDIIGGLKDMGCFGLCIPESYGGIQPNDKPDNLSMLVVTEELSRGGLGI
AGSLITRPEIMSKALLKGGTQEQKDKWLPLLASGERMAGIMVTEPNYGSDVAGVSVTAKQTNGGWVINGVKTWCTFAGYA
NLLLVLCRTESDPSLKHKGLSILLAEKPSFTGHEFAYTQPEGGKIEGKAIGTIGYRGMHSFEVSFDNYFVPAENLLGGEA
GRGKGFYFQMEGFAGGRIQTAARAHGVMQAALEAALRYAQDRSVFQKPIYEYNLTKYKIAKMAVILQASRQFANHVASLL
DNHQGQMEATLIKFYASKVAEWVTREAMQIHGGMGYAEEYAVSRYFVDARVFSIFEGAEEVMALRVIAKSLMDQYVGA
>Mature_557_residues
SATNTVVDQTTVKKALSVSAGVIEEVTKALAARCNVNGKVSIDKMDENQLVQYQIAWLTSEQKIAEKFIEYAWDTSRGTG
DLEQEMAVVFAAETVNHVRSEISSRPSEYGIKASSLVSKIFNDEINQFLENAMAIQNYNQIADKIVAKGHFGAYGLDDDH
EMFRETFKKFAEDVVMPHAEHVHRHDDIIPEDIIGGLKDMGCFGLCIPESYGGIQPNDKPDNLSMLVVTEELSRGGLGIA
GSLITRPEIMSKALLKGGTQEQKDKWLPLLASGERMAGIMVTEPNYGSDVAGVSVTAKQTNGGWVINGVKTWCTFAGYAN
LLLVLCRTESDPSLKHKGLSILLAEKPSFTGHEFAYTQPEGGKIEGKAIGTIGYRGMHSFEVSFDNYFVPAENLLGGEAG
RGKGFYFQMEGFAGGRIQTAARAHGVMQAALEAALRYAQDRSVFQKPIYEYNLTKYKIAKMAVILQASRQFANHVASLLD
NHQGQMEATLIKFYASKVAEWVTREAMQIHGGMGYAEEYAVSRYFVDARVFSIFEGAEEVMALRVIAKSLMDQYVGA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=400, Percent_Identity=31.5, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI21361497, Length=365, Percent_Identity=33.1506849315069, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI4557235, Length=396, Percent_Identity=32.0707070707071, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI76496475, Length=397, Percent_Identity=32.7455919395466, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI226958412, Length=400, Percent_Identity=28.5, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI4501859, Length=398, Percent_Identity=28.643216080402, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI4557231, Length=403, Percent_Identity=28.5359801488834, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI187960098, Length=403, Percent_Identity=28.5359801488834, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI226958414, Length=357, Percent_Identity=29.4117647058824, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI4501857, Length=399, Percent_Identity=27.3182957393484, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI7656849, Length=403, Percent_Identity=28.0397022332506, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI4503943, Length=396, Percent_Identity=25.7575757575758, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI38505218, Length=306, Percent_Identity=28.4313725490196, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI7669494, Length=388, Percent_Identity=25.5154639175258, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI48976061, Length=294, Percent_Identity=27.5510204081633, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI211971008, Length=294, Percent_Identity=27.5510204081633, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1786223, Length=404, Percent_Identity=27.970297029703, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI87081958, Length=366, Percent_Identity=31.4207650273224, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI87082384, Length=289, Percent_Identity=27.3356401384083, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=408, Percent_Identity=31.3725490196078, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17534899, Length=415, Percent_Identity=30.8433734939759, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17569725, Length=403, Percent_Identity=29.2803970223325, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71985184, Length=362, Percent_Identity=32.0441988950276, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17570075, Length=399, Percent_Identity=29.3233082706767, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17506239, Length=400, Percent_Identity=26.25, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17508101, Length=402, Percent_Identity=27.1144278606965, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17505929, Length=428, Percent_Identity=26.1682242990654, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17533517, Length=406, Percent_Identity=28.0788177339901, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17551932, Length=397, Percent_Identity=25.1889168765743, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI71985192, Length=321, Percent_Identity=29.595015576324, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17534353, Length=393, Percent_Identity=25.4452926208651, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32563615, Length=250, Percent_Identity=26.8, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71990804, Length=314, Percent_Identity=25.4777070063694, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562446, Length=303, Percent_Identity=25.4125412541254, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982178, Length=301, Percent_Identity=23.2558139534884, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356377, Length=400, Percent_Identity=32.5, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24660351, Length=410, Percent_Identity=30.7317073170732, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24646207, Length=414, Percent_Identity=30.4347826086957, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI21355753, Length=405, Percent_Identity=30.6172839506173, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI281363737, Length=401, Percent_Identity=30.4239401496259, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24666513, Length=402, Percent_Identity=28.1094527363184, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI19920834, Length=394, Percent_Identity=25.6345177664975, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 61370; Mature: 61238

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATNTVVDQTTVKKALSVSAGVIEEVTKALAARCNVNGKVSIDKMDENQLVQYQIAWLT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEEEC
SEQKIAEKFIEYAWDTSRGTGDLEQEMAVVFAAETVNHVRSEISSRPSEYGIKASSLVSK
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHH
IFNDEINQFLENAMAIQNYNQIADKIVAKGHFGAYGLDDDHEMFRETFKKFAEDVVMPHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCH
EHVHRHDDIIPEDIIGGLKDMGCFGLCIPESYGGIQPNDKPDNLSMLVVTEELSRGGLGI
HHHHHCCCCCCHHHHCCHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEHHCCCCCCE
AGSLITRPEIMSKALLKGGTQEQKDKWLPLLASGERMAGIMVTEPNYGSDVAGVSVTAKQ
EHHHHCCHHHHHHHHHCCCCHHHHHCCCCEEECCCCEEEEEEECCCCCCCCCCEEEEEEE
TNGGWVINGVKTWCTFAGYANLLLVLCRTESDPSLKHKGLSILLAEKPSFTGHEFAYTQP
CCCCEEEECHHHHHHHHHHHHHHEEEEECCCCCCCHHCCCEEEEECCCCCCCCCEEEECC
EGGKIEGKAIGTIGYRGMHSFEVSFDNYFVPAENLLGGEAGRGKGFYFQMEGFAGGRIQT
CCCEECCEEEEEECCCCCEEEEEECCCEECCHHHHCCCCCCCCCCEEEEECCCCCCCCHH
AARAHGVMQAALEAALRYAQDRSVFQKPIYEYNLTKYKIAKMAVILQASRQFANHVASLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DNHQGQMEATLIKFYASKVAEWVTREAMQIHGGMGYAEEYAVSRYFVDARVFSIFEGAEE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VMALRVIAKSLMDQYVGA
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SATNTVVDQTTVKKALSVSAGVIEEVTKALAARCNVNGKVSIDKMDENQLVQYQIAWLT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEEEC
SEQKIAEKFIEYAWDTSRGTGDLEQEMAVVFAAETVNHVRSEISSRPSEYGIKASSLVSK
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHH
IFNDEINQFLENAMAIQNYNQIADKIVAKGHFGAYGLDDDHEMFRETFKKFAEDVVMPHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCH
EHVHRHDDIIPEDIIGGLKDMGCFGLCIPESYGGIQPNDKPDNLSMLVVTEELSRGGLGI
HHHHHCCCCCCHHHHCCHHHCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEHHCCCCCCE
AGSLITRPEIMSKALLKGGTQEQKDKWLPLLASGERMAGIMVTEPNYGSDVAGVSVTAKQ
EHHHHCCHHHHHHHHHCCCCHHHHHCCCCEEECCCCEEEEEEECCCCCCCCCCEEEEEEE
TNGGWVINGVKTWCTFAGYANLLLVLCRTESDPSLKHKGLSILLAEKPSFTGHEFAYTQP
CCCCEEEECHHHHHHHHHHHHHHEEEEECCCCCCCHHCCCEEEEECCCCCCCCCEEEECC
EGGKIEGKAIGTIGYRGMHSFEVSFDNYFVPAENLLGGEAGRGKGFYFQMEGFAGGRIQT
CCCEECCEEEEEECCCCCEEEEEECCCEECCHHHHCCCCCCCCCCEEEEECCCCCCCCHH
AARAHGVMQAALEAALRYAQDRSVFQKPIYEYNLTKYKIAKMAVILQASRQFANHVASLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DNHQGQMEATLIKFYASKVAEWVTREAMQIHGGMGYAEEYAVSRYFVDARVFSIFEGAEE
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VMALRVIAKSLMDQYVGA
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]