Click here to switch to the map view.

The map label for this gene is msrA [H]

Identifier: 116327186

GI number: 116327186

Start: 426908

End: 427438

Strand: Reverse

Name: msrA [H]

Synonym: LBL_0365

Alternate gene names: 116327186

Gene position: 427438-426908 (Counterclockwise)

Preceding gene: 116327187

Following gene: 116327185

Centisome position: 11.83

GC content: 40.87

Gene sequence:

>531_bases
ATGGAACAAGCAACATTAGGTGGCGGTTGTTTTTGGTGTCTCGAAGCTGTGTATCAAATGGTGGAAGGAATAGAATCTGT
CGTGTCCGGATACGCCGCCGGACAGACGAAAAATCCGGATTACCGCTCCGTATGTTCGGGAACAACGGGACACGCAGAAA
CGGTTCAAATCACTTTCGATTCGAAGGTTATCAGTTATTTTGAAATTCTCGAAATTTTCTGGATCTCTCACGATCCTACA
ACATTAAACCGACAAGGAAACGACGTAGGAATACAATATCGATCCATCATTCCCTACCATTCTCCCGAACAGAAAAAACA
AGCGGAACAATCCATACAAAAAGCCGGAGAACATTTTTCGGATCCGATCGTAACCCAGGTGGAAATACTAAAAGAATTTT
ATCCTGCGGAAGATTACCATCAAAATTATTTCAGAACCAATCCCAAACAGGCTTATTGTCATTATGTAATCAAACCGAAA
ATCGATAAATATCTCAAAACGGGTTTCAAAGTTAAAAAAGAAGGTTCCTAG

Upstream 100 bases:

>100_bases
AAAATCTAAACTTTGATTTCAAATTTCGGTTGCACAGAAGTAAAATAACGAAGGAAAATCTCGCGAAGATTCTCACATCA
AACGGAATTTGTGGTTAAGT

Downstream 100 bases:

>100_bases
ATCGTCTAAGAATTCTACTTGCCCCTCTCCGAATCGGAGGATAGTTTGATTTTCTAATGAACGCTACTATACGAAGGATT
TTTCTAATTCTCCTCCTGGG

Product: protein-methionine-S-oxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MEQATLGGGCFWCLEAVYQMVEGIESVVSGYAAGQTKNPDYRSVCSGTTGHAETVQITFDSKVISYFEILEIFWISHDPT
TLNRQGNDVGIQYRSIIPYHSPEQKKQAEQSIQKAGEHFSDPIVTQVEILKEFYPAEDYHQNYFRTNPKQAYCHYVIKPK
IDKYLKTGFKVKKEGS

Sequences:

>Translated_176_residues
MEQATLGGGCFWCLEAVYQMVEGIESVVSGYAAGQTKNPDYRSVCSGTTGHAETVQITFDSKVISYFEILEIFWISHDPT
TLNRQGNDVGIQYRSIIPYHSPEQKKQAEQSIQKAGEHFSDPIVTQVEILKEFYPAEDYHQNYFRTNPKQAYCHYVIKPK
IDKYLKTGFKVKKEGS
>Mature_176_residues
MEQATLGGGCFWCLEAVYQMVEGIESVVSGYAAGQTKNPDYRSVCSGTTGHAETVQITFDSKVISYFEILEIFWISHDPT
TLNRQGNDVGIQYRSIIPYHSPEQKKQAEQSIQKAGEHFSDPIVTQVEILKEFYPAEDYHQNYFRTNPKQAYCHYVIKPK
IDKYLKTGFKVKKEGS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=42.1383647798742, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=43.5897435897436, Blast_Score=127, Evalue=6e-30,
Organism=Homo sapiens, GI208609993, Length=112, Percent_Identity=42.8571428571429, Blast_Score=87, Evalue=6e-18,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=45.7516339869281, Blast_Score=135, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17533973, Length=144, Percent_Identity=37.5, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=37.6543209876543, Blast_Score=105, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24664627, Length=174, Percent_Identity=33.9080459770115, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24664631, Length=174, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45553131, Length=169, Percent_Identity=33.1360946745562, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20061; Mature: 20061

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQATLGGGCFWCLEAVYQMVEGIESVVSGYAAGQTKNPDYRSVCSGTTGHAETVQITFD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEEEEC
SKVISYFEILEIFWISHDPTTLNRQGNDVGIQYRSIIPYHSPEQKKQAEQSIQKAGEHFS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCC
DPIVTQVEILKEFYPAEDYHQNYFRTNPKQAYCHYVIKPKIDKYLKTGFKVKKEGS
CCHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHEEEEECCHHHHHHHCCCCEECCCC
>Mature Secondary Structure
MEQATLGGGCFWCLEAVYQMVEGIESVVSGYAAGQTKNPDYRSVCSGTTGHAETVQITFD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCEEEEEEEC
SKVISYFEILEIFWISHDPTTLNRQGNDVGIQYRSIIPYHSPEQKKQAEQSIQKAGEHFS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCC
DPIVTQVEILKEFYPAEDYHQNYFRTNPKQAYCHYVIKPKIDKYLKTGFKVKKEGS
CCHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHEEEEECCHHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA