Click here to switch to the map view.

The map label for this gene is clpA-3 [H]

Identifier: 116327125

GI number: 116327125

Start: 356579

End: 359122

Strand: Direct

Name: clpA-3 [H]

Synonym: LBL_0301

Alternate gene names: 116327125

Gene position: 356579-359122 (Clockwise)

Preceding gene: 116327124

Following gene: 116327126

Centisome position: 9.87

GC content: 43.83

Gene sequence:

>2544_bases
ATGCTGGAATTTACGAAACGAGCCAAAAGAGTTATCAATGAGATTGCTCAGGATGAGGCGAAGCGTCTTGGTAGCGACTA
TATCGGGCCGGAGCACATCCTGCTTGGTCTTCTGAAAGAAGAAGATTCGGTTGCTATCAAAATCCTGAACAACCTCAACA
TTAACCTCAACGAATTACGAAAAGAGGTGGAGAGAAGAACACGGGAAGCTTCAGGAGCCTTGCTCATGGATGTGGCCGGA
GGTCAGGATCGTTATCAAAAAATCATCGAACTTTCTAAAGAAGAGGCTAAACGTCTCAAGCACAATTACGTGGGAACGGA
GCACATCCTTCTTGCATTGTTAAGAGATAACAACAATATAGCAGGTGGCGCGCTTTATTCTTTTAGCGTAAATTATAATG
TTATAAAGAGCGAAATTTTGCGTTTACTCGGAGCTCCTCCTACTAGTTCCGTTGGTGTAAGCTCTGCCGCCCAATCTGGG
CCACAAGGGACCACGTCTCGTCAGGAGAAAACAAAAACTCCGATCTTAGACGAATTTGCGCGCGACCTGACCCAGCTTGC
AAGAGATAAGAAGCTGGATCCGGTCGTAGGAAGAGCTACTGAAATTCAGAGAGTGATCCAGATTCTTTCCAGGAAAACCA
AAAACAATCCTGTTCTCGTGGGAGAATCCGGAGTCGGTAAAACCGCAATCGTGGAAGGGTTGGCACTTGCGATCGTAGAA
AAAAGCGTTCCTGATCTATTGTTCGAAAAAAGAGTTCTTTCTTTGGATCTTGCGTCCTTAATTGCAGGAACCAAATACAG
AGGGGAATTTGAAGAACGTCTGAAAAAAATTATGAAGGAGATTACTTCTTCCACGAATATTATCATTTTGATCGACGAAC
TTCACACTCTGATCGGAGCAGGCGCCGCGGAAGGAGCTGTTGATGCGGCGAATATTCTCAAACCTGCTCTTGCAAGAGGA
GAACTTCAATGTATTGGTGCGACTACAAGTGCGGAATACCGGAAATACATTGAAAAAGATTCCGCGTTGGAAAGAAGATT
TCAAGTCGTGAAAGTTGCGGAACCTTCCGTGAGTGACACGATTCAAATTCTCCAAGGCCTTAAGAAAGCTTATGAAACTC
ATCATAAAGTGCGATACTCCGATAAAGCGTTGGAACAATCCGTAAAACTTTCTCACAGATATATCAACGATCGATATCTA
CCCGACAAAGCGATCGATATCATTGACGAAGCGGGAGCAAAGGCCCGTTTAGCGAACTGTGCGCGTCCTCAAACGATCAA
AGATTTGGAAGAGGAAATTAAATCACTTGCCTCTAAAAAAGAGGAATTGGTTCGTGCCCAAGAATACGAGAAGGCCGCAG
GTGTTCGTGATGAAGTAAATCGGAAAAAACAGGCGATGGAAGAAAAAATTCGCGCTTGGCAAGAGAAGATGGAAGATTTT
GCGGTCAATATCGATGAAGACGATATTCTTTCCGTAGTATCTTTGTGGACTGGAATTCCTTTGGAGAAAATGGAAGAATC
CGAATCGGATAAACTTCTTCGTTTGGAAGACGAGTTGAAAAAACGAATCGTCGGTCAGGAAGAAGCGATCGAAAAAATCG
CAAAAGCGGTTCGCCGTGCTAGAACCGGATTCAAAAGCGAAAGACGTCCTACCGGGTCTTTTATTTTCTTAGGACCTACT
GGAGTCGGCAAAACCGAGCTTGCAAAAGCGCTTGCAAATTTCCTTTTCGGAAATGATGATGCTATGCTTCGTGTGGACAT
GTCCGAATATATGGAGCCACACGCGGTAAGTCGTCTGATCGGAGCTCCACCGGGTTACGTGGGATATGACGACGGAGGTC
AATTGACTGAGTTCGTCAGAAAGAGACCTTATTCCATTATTCTTTTGGACGAAATTGAAAAAGCGCACCACGACATTTTC
AATATTCTCCTCCAAATTATGGAAGAAGGAAACTTGACTGATACGAAAGGACGGAAAGTAAACTTCCGAGACACAATCAT
CATCATGACTTCCAACATTGGTGCCAAAGAAATCCAAGCCGGAGGAAGACTCGGATTCGAAGATCGCAAAGACGAAGCTT
TGAAATACAAATCGGATCAGACACGCGATCAATTGAAAAAGTATTTCAATCCCGAGTTCTTAAATCGTGTGGATGAAGTT
ATCTATTTCGGTTCCCTCACCAAGGAAAATATCATGTCCATCATCGATATTATGGTGACCGATACGAACAAAAGACTTCG
TGAAAAAATGATTCAAGTTTCCGCTACTCAAGCGGCAAAGGATCATATCATGGACATCGGTTATGATGAGAAGTTTGGCG
CAAGGCCTCTTCGAAGAGTTTTCCAAAGAGAATTGGAAGATCATATGGCGGTACAAACGCTTAAAGGAGCTTATAAGGAG
CCTACAAAAATTGAAATCGATTTCAAAGAAGGTAAGCTTGAGTTTATAGAGACTCCATGGACGGATTATAAACCGGCCGA
GGCCGGAGGAGACGACAATTCTTCCGGTAATCCCGAAAGGTCGGAAGAGATTGCCTTAGTCTAA

Upstream 100 bases:

>100_bases
GTTCCGATACCTAATTTAAATCGATGATCCATTCCCTTGGGTGGGAATTTCAAAGCGAATTTAGTCTAATCATTACAAAT
AAAATACGAAGGCGCTTGAT

Downstream 100 bases:

>100_bases
GGATGCCTATACTCATCCCCGTATTGATTTTGGTTTCCTATCTTCTGATTCGGAAGATCTGGTTTCACTTGAGGAAAATC
AGGACCATTGCGGGGATTGA

Product: ATP-dependent Clp protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 847; Mature: 847

Protein sequence:

>847_residues
MLEFTKRAKRVINEIAQDEAKRLGSDYIGPEHILLGLLKEEDSVAIKILNNLNINLNELRKEVERRTREASGALLMDVAG
GQDRYQKIIELSKEEAKRLKHNYVGTEHILLALLRDNNNIAGGALYSFSVNYNVIKSEILRLLGAPPTSSVGVSSAAQSG
PQGTTSRQEKTKTPILDEFARDLTQLARDKKLDPVVGRATEIQRVIQILSRKTKNNPVLVGESGVGKTAIVEGLALAIVE
KSVPDLLFEKRVLSLDLASLIAGTKYRGEFEERLKKIMKEITSSTNIIILIDELHTLIGAGAAEGAVDAANILKPALARG
ELQCIGATTSAEYRKYIEKDSALERRFQVVKVAEPSVSDTIQILQGLKKAYETHHKVRYSDKALEQSVKLSHRYINDRYL
PDKAIDIIDEAGAKARLANCARPQTIKDLEEEIKSLASKKEELVRAQEYEKAAGVRDEVNRKKQAMEEKIRAWQEKMEDF
AVNIDEDDILSVVSLWTGIPLEKMEESESDKLLRLEDELKKRIVGQEEAIEKIAKAVRRARTGFKSERRPTGSFIFLGPT
GVGKTELAKALANFLFGNDDAMLRVDMSEYMEPHAVSRLIGAPPGYVGYDDGGQLTEFVRKRPYSIILLDEIEKAHHDIF
NILLQIMEEGNLTDTKGRKVNFRDTIIIMTSNIGAKEIQAGGRLGFEDRKDEALKYKSDQTRDQLKKYFNPEFLNRVDEV
IYFGSLTKENIMSIIDIMVTDTNKRLREKMIQVSATQAAKDHIMDIGYDEKFGARPLRRVFQRELEDHMAVQTLKGAYKE
PTKIEIDFKEGKLEFIETPWTDYKPAEAGGDDNSSGNPERSEEIALV

Sequences:

>Translated_847_residues
MLEFTKRAKRVINEIAQDEAKRLGSDYIGPEHILLGLLKEEDSVAIKILNNLNINLNELRKEVERRTREASGALLMDVAG
GQDRYQKIIELSKEEAKRLKHNYVGTEHILLALLRDNNNIAGGALYSFSVNYNVIKSEILRLLGAPPTSSVGVSSAAQSG
PQGTTSRQEKTKTPILDEFARDLTQLARDKKLDPVVGRATEIQRVIQILSRKTKNNPVLVGESGVGKTAIVEGLALAIVE
KSVPDLLFEKRVLSLDLASLIAGTKYRGEFEERLKKIMKEITSSTNIIILIDELHTLIGAGAAEGAVDAANILKPALARG
ELQCIGATTSAEYRKYIEKDSALERRFQVVKVAEPSVSDTIQILQGLKKAYETHHKVRYSDKALEQSVKLSHRYINDRYL
PDKAIDIIDEAGAKARLANCARPQTIKDLEEEIKSLASKKEELVRAQEYEKAAGVRDEVNRKKQAMEEKIRAWQEKMEDF
AVNIDEDDILSVVSLWTGIPLEKMEESESDKLLRLEDELKKRIVGQEEAIEKIAKAVRRARTGFKSERRPTGSFIFLGPT
GVGKTELAKALANFLFGNDDAMLRVDMSEYMEPHAVSRLIGAPPGYVGYDDGGQLTEFVRKRPYSIILLDEIEKAHHDIF
NILLQIMEEGNLTDTKGRKVNFRDTIIIMTSNIGAKEIQAGGRLGFEDRKDEALKYKSDQTRDQLKKYFNPEFLNRVDEV
IYFGSLTKENIMSIIDIMVTDTNKRLREKMIQVSATQAAKDHIMDIGYDEKFGARPLRRVFQRELEDHMAVQTLKGAYKE
PTKIEIDFKEGKLEFIETPWTDYKPAEAGGDDNSSGNPERSEEIALV
>Mature_847_residues
MLEFTKRAKRVINEIAQDEAKRLGSDYIGPEHILLGLLKEEDSVAIKILNNLNINLNELRKEVERRTREASGALLMDVAG
GQDRYQKIIELSKEEAKRLKHNYVGTEHILLALLRDNNNIAGGALYSFSVNYNVIKSEILRLLGAPPTSSVGVSSAAQSG
PQGTTSRQEKTKTPILDEFARDLTQLARDKKLDPVVGRATEIQRVIQILSRKTKNNPVLVGESGVGKTAIVEGLALAIVE
KSVPDLLFEKRVLSLDLASLIAGTKYRGEFEERLKKIMKEITSSTNIIILIDELHTLIGAGAAEGAVDAANILKPALARG
ELQCIGATTSAEYRKYIEKDSALERRFQVVKVAEPSVSDTIQILQGLKKAYETHHKVRYSDKALEQSVKLSHRYINDRYL
PDKAIDIIDEAGAKARLANCARPQTIKDLEEEIKSLASKKEELVRAQEYEKAAGVRDEVNRKKQAMEEKIRAWQEKMEDF
AVNIDEDDILSVVSLWTGIPLEKMEESESDKLLRLEDELKKRIVGQEEAIEKIAKAVRRARTGFKSERRPTGSFIFLGPT
GVGKTELAKALANFLFGNDDAMLRVDMSEYMEPHAVSRLIGAPPGYVGYDDGGQLTEFVRKRPYSIILLDEIEKAHHDIF
NILLQIMEEGNLTDTKGRKVNFRDTIIIMTSNIGAKEIQAGGRLGFEDRKDEALKYKSDQTRDQLKKYFNPEFLNRVDEV
IYFGSLTKENIMSIIDIMVTDTNKRLREKMIQVSATQAAKDHIMDIGYDEKFGARPLRRVFQRELEDHMAVQTLKGAYKE
PTKIEIDFKEGKLEFIETPWTDYKPAEAGGDDNSSGNPERSEEIALV

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=328, Percent_Identity=32.0121951219512, Blast_Score=192, Evalue=1e-48,
Organism=Escherichia coli, GI1788943, Length=869, Percent_Identity=42.692750287687, Blast_Score=653, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=806, Percent_Identity=38.9578163771712, Blast_Score=541, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6320464, Length=731, Percent_Identity=45.827633378933, Blast_Score=601, Evalue=1e-172,
Organism=Saccharomyces cerevisiae, GI6323002, Length=901, Percent_Identity=35.9600443951165, Blast_Score=518, Evalue=1e-147,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 95203; Mature: 95203

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEFTKRAKRVINEIAQDEAKRLGSDYIGPEHILLGLLKEEDSVAIKILNNLNINLNELR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEHHCCCCCHHHHH
KEVERRTREASGALLMDVAGGQDRYQKIIELSKEEAKRLKHNYVGTEHILLALLRDNNNI
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
AGGALYSFSVNYNVIKSEILRLLGAPPTSSVGVSSAAQSGPQGTTSRQEKTKTPILDEFA
CCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHCCCCHHHHHH
RDLTQLARDKKLDPVVGRATEIQRVIQILSRKTKNNPVLVGESGVGKTAIVEGLALAIVE
HHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHH
KSVPDLLFEKRVLSLDLASLIAGTKYRGEFEERLKKIMKEITSSTNIIILIDELHTLIGA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCC
GAAEGAVDAANILKPALARGELQCIGATTSAEYRKYIEKDSALERRFQVVKVAEPSVSDT
CCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHH
IQILQGLKKAYETHHKVRYSDKALEQSVKLSHRYINDRYLPDKAIDIIDEAGAKARLANC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHC
ARPQTIKDLEEEIKSLASKKEELVRAQEYEKAAGVRDEVNRKKQAMEEKIRAWQEKMEDF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVNIDEDDILSVVSLWTGIPLEKMEESESDKLLRLEDELKKRIVGQEEAIEKIAKAVRRA
CCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHH
RTGFKSERRPTGSFIFLGPTGVGKTELAKALANFLFGNDDAMLRVDMSEYMEPHAVSRLI
HCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHCCHHHHHHHH
GAPPGYVGYDDGGQLTEFVRKRPYSIILLDEIEKAHHDIFNILLQIMEEGNLTDTKGRKV
CCCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
NFRDTIIIMTSNIGAKEIQAGGRLGFEDRKDEALKYKSDQTRDQLKKYFNPEFLNRVDEV
ECCCEEEEEECCCCHHHHCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHCCHHHHHHHHHH
IYFGSLTKENIMSIIDIMVTDTNKRLREKMIQVSATQAAKDHIMDIGYDEKFGARPLRRV
HHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
FQRELEDHMAVQTLKGAYKEPTKIEIDFKEGKLEFIETPWTDYKPAEAGGDDNSSGNPER
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
SEEIALV
CCCCCCC
>Mature Secondary Structure
MLEFTKRAKRVINEIAQDEAKRLGSDYIGPEHILLGLLKEEDSVAIKILNNLNINLNELR
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEHHCCCCCHHHHH
KEVERRTREASGALLMDVAGGQDRYQKIIELSKEEAKRLKHNYVGTEHILLALLRDNNNI
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
AGGALYSFSVNYNVIKSEILRLLGAPPTSSVGVSSAAQSGPQGTTSRQEKTKTPILDEFA
CCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHCCCCHHHHHH
RDLTQLARDKKLDPVVGRATEIQRVIQILSRKTKNNPVLVGESGVGKTAIVEGLALAIVE
HHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHH
KSVPDLLFEKRVLSLDLASLIAGTKYRGEFEERLKKIMKEITSSTNIIILIDELHTLIGA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCC
GAAEGAVDAANILKPALARGELQCIGATTSAEYRKYIEKDSALERRFQVVKVAEPSVSDT
CCCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHH
IQILQGLKKAYETHHKVRYSDKALEQSVKLSHRYINDRYLPDKAIDIIDEAGAKARLANC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHC
ARPQTIKDLEEEIKSLASKKEELVRAQEYEKAAGVRDEVNRKKQAMEEKIRAWQEKMEDF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVNIDEDDILSVVSLWTGIPLEKMEESESDKLLRLEDELKKRIVGQEEAIEKIAKAVRRA
CCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHH
RTGFKSERRPTGSFIFLGPTGVGKTELAKALANFLFGNDDAMLRVDMSEYMEPHAVSRLI
HCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHCCHHHHHHHH
GAPPGYVGYDDGGQLTEFVRKRPYSIILLDEIEKAHHDIFNILLQIMEEGNLTDTKGRKV
CCCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
NFRDTIIIMTSNIGAKEIQAGGRLGFEDRKDEALKYKSDQTRDQLKKYFNPEFLNRVDEV
ECCCEEEEEECCCCHHHHCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHCCHHHHHHHHHH
IYFGSLTKENIMSIIDIMVTDTNKRLREKMIQVSATQAAKDHIMDIGYDEKFGARPLRRV
HHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
FQRELEDHMAVQTLKGAYKEPTKIEIDFKEGKLEFIETPWTDYKPAEAGGDDNSSGNPER
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
SEEIALV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]