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The map label for this gene is yegE [H]

Identifier: 116327093

GI number: 116327093

Start: 318514

End: 320046

Strand: Direct

Name: yegE [H]

Synonym: LBL_0268

Alternate gene names: 116327093

Gene position: 318514-320046 (Clockwise)

Preceding gene: 116327092

Following gene: 116327094

Centisome position: 8.81

GC content: 36.14

Gene sequence:

>1533_bases
TTGAGAGAATTCGATTTTCAGTCGGCTGATTTTTATAAATTTCTAATCGAAAGAAGTCCTGAGTTGATTAGCTTTCACGA
TCCGGATGGAATCTTTCTCTATGTAAGTCCTTCGGTAACTTCTATTTTAGGTTATCAACCGGAAGAATTAATCGGCAAAA
ATCCCTATGATTATTTTAGTCCTCTCGATAAGAACAGAATTTTTGAAAGTTCTCATCAGCCGATTTTAAAAGGAAGAGAA
ATCGAACATGTCGAATATCAGTTTCTCAGAAAAGACGGAAAATACGTTTGGTTGCAGACAATTACTCAATCGATTCGAGA
TGATCACGAAACCGTAATCGCTCTTTTTAGTACTTCCAGGGAATATTTAGGGCTCAATGCAATTCTTGACGAGACGGAAA
AAAAACAGGTTCTCGATGAGATTCGTCTTTCGGAAGAAAAGTTTTCCAATGCGTTTTATTATTCGGGTATCGGTATGGCT
CTCGTTTCTTTAGAAGGAAAATGGCTAGAAGTAAATTCAAGCCTTTTAGATATAATCGGCTACTCGAGGGACGAGATTTT
AAAACTTACCTTTCAAGATATAACTCATCCGGATGATCTTACCGTCGATTTAAATCTTTTACAAGAGACGTTAGAAGGTA
AAAGAGATAGTTATAGAATGGAGAAAAGATATTTCCATAAAAACGGAAGTACGATATGGATCTTATTGATAGTGTCTATT
GTGAGGGATTCCCAAAAGAAACCTTTATTTTTCATCTCTCAGATTCAGGATATTACCGATCGCAAAAATATGCTTTCTGC
TTTAATCGAAAAGAACGAAACCCTGCAGGCATTGAGCAATCACTTAACGGAAAGAAATTCTCAGTTGGAAGAATTCAATC
AGATCGTTTCTCACAATCTACGCGCGCCAATCGGGAATATTTTTACGCTTACGACTATGTTGAGTGAGAAATATGGTACA
GACAAGGATGAGCTTCTACAATCTTTGGAAATGAGTGTAAAAGATTTGATGACCACATTGAGCGATATCGTGGAAGTGAT
CAAAATTCGCAGAAATCGGAATGTGGATAAACAACCTATTTTTTTTAAGGATGCTTTTATCAAGATTCAGAATCTTCTCT
CCACTGAGATCAAGAAGACGAGTGCGGAAATTCAAACGGATTTTACCGCGGCTCCGGAAATTCTTTATTCAAAGGTGTAT
CTGGAGAGTATATTATTGAATTTATTAAGCAATGCTTTAAAATATTCCGATCCTAATAGAAAGTTGGAGATTTCTCTCGT
CTCCTATATAAAAGACAAAAAAATCTTTTTGGTAGTTCGTGATAATGGTTTAGGAATCGATCTCCGAAAATACGGTCACC
AAATCTTTAAAATGAATAAAACGTTCCATAGGGAAAAAGAAGGGCAAGGTATCGGGTTATTTATGACAAAAAATCAAATA
GAATCCCTGGGGGGTGAAATAACAGTTGAAAGTTCTCCCGGTAAAGGTACATCTTTCCTCGTCAATTTCGATAAATACAA
TGATCTCGAATAG

Upstream 100 bases:

>100_bases
TTTGGACGCGAACAAAAACATAAAAATCTATGTTTCAGTTTCGTAATGGATTGTCTTTTCTAAAATAGGACCTATTTTAA
GGAAAACCAAAGGTGTCACT

Downstream 100 bases:

>100_bases
CGGTAATATGAACTTCTGGTTGGTTGATGATGATTCCATCTACATTATGATCGCAAGACGTTTTTTGGAAAAAGACGGTA
GGATCACGAAACTACGCGAT

Product: sensor histidine kinase of a two component response regulator

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MREFDFQSADFYKFLIERSPELISFHDPDGIFLYVSPSVTSILGYQPEELIGKNPYDYFSPLDKNRIFESSHQPILKGRE
IEHVEYQFLRKDGKYVWLQTITQSIRDDHETVIALFSTSREYLGLNAILDETEKKQVLDEIRLSEEKFSNAFYYSGIGMA
LVSLEGKWLEVNSSLLDIIGYSRDEILKLTFQDITHPDDLTVDLNLLQETLEGKRDSYRMEKRYFHKNGSTIWILLIVSI
VRDSQKKPLFFISQIQDITDRKNMLSALIEKNETLQALSNHLTERNSQLEEFNQIVSHNLRAPIGNIFTLTTMLSEKYGT
DKDELLQSLEMSVKDLMTTLSDIVEVIKIRRNRNVDKQPIFFKDAFIKIQNLLSTEIKKTSAEIQTDFTAAPEILYSKVY
LESILLNLLSNALKYSDPNRKLEISLVSYIKDKKIFLVVRDNGLGIDLRKYGHQIFKMNKTFHREKEGQGIGLFMTKNQI
ESLGGEITVESSPGKGTSFLVNFDKYNDLE

Sequences:

>Translated_510_residues
MREFDFQSADFYKFLIERSPELISFHDPDGIFLYVSPSVTSILGYQPEELIGKNPYDYFSPLDKNRIFESSHQPILKGRE
IEHVEYQFLRKDGKYVWLQTITQSIRDDHETVIALFSTSREYLGLNAILDETEKKQVLDEIRLSEEKFSNAFYYSGIGMA
LVSLEGKWLEVNSSLLDIIGYSRDEILKLTFQDITHPDDLTVDLNLLQETLEGKRDSYRMEKRYFHKNGSTIWILLIVSI
VRDSQKKPLFFISQIQDITDRKNMLSALIEKNETLQALSNHLTERNSQLEEFNQIVSHNLRAPIGNIFTLTTMLSEKYGT
DKDELLQSLEMSVKDLMTTLSDIVEVIKIRRNRNVDKQPIFFKDAFIKIQNLLSTEIKKTSAEIQTDFTAAPEILYSKVY
LESILLNLLSNALKYSDPNRKLEISLVSYIKDKKIFLVVRDNGLGIDLRKYGHQIFKMNKTFHREKEGQGIGLFMTKNQI
ESLGGEITVESSPGKGTSFLVNFDKYNDLE
>Mature_510_residues
MREFDFQSADFYKFLIERSPELISFHDPDGIFLYVSPSVTSILGYQPEELIGKNPYDYFSPLDKNRIFESSHQPILKGRE
IEHVEYQFLRKDGKYVWLQTITQSIRDDHETVIALFSTSREYLGLNAILDETEKKQVLDEIRLSEEKFSNAFYYSGIGMA
LVSLEGKWLEVNSSLLDIIGYSRDEILKLTFQDITHPDDLTVDLNLLQETLEGKRDSYRMEKRYFHKNGSTIWILLIVSI
VRDSQKKPLFFISQIQDITDRKNMLSALIEKNETLQALSNHLTERNSQLEEFNQIVSHNLRAPIGNIFTLTTMLSEKYGT
DKDELLQSLEMSVKDLMTTLSDIVEVIKIRRNRNVDKQPIFFKDAFIKIQNLLSTEIKKTSAEIQTDFTAAPEILYSKVY
LESILLNLLSNALKYSDPNRKLEISLVSYIKDKKIFLVVRDNGLGIDLRKYGHQIFKMNKTFHREKEGQGIGLFMTKNQI
ESLGGEITVESSPGKGTSFLVNFDKYNDLE

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2202

COG function: function code T; FOG: PAS/PAC domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=119, Percent_Identity=48.7394957983193, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788713, Length=264, Percent_Identity=27.6515151515151, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=255, Percent_Identity=28.2352941176471, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=25.8771929824561, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=25.1968503937008, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=25.5411255411255, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1790346, Length=246, Percent_Identity=23.1707317073171, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 59071; Mature: 59071

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREFDFQSADFYKFLIERSPELISFHDPDGIFLYVSPSVTSILGYQPEELIGKNPYDYFS
CCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCHHHHHCCCCHHHHCCCCCHHCC
PLDKNRIFESSHQPILKGREIEHVEYQFLRKDGKYVWLQTITQSIRDDHETVIALFSTSR
CCCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHCCCHHHEEEEECCCH
EYLGLNAILDETEKKQVLDEIRLSEEKFSNAFYYSGIGMALVSLEGKWLEVNSSLLDIIG
HHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCEEECCHHHHHHHC
YSRDEILKLTFQDITHPDDLTVDLNLLQETLEGKRDSYRMEKRYFHKNGSTIWILLIVSI
CCHHHHEEEEHHHCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
VRDSQKKPLFFISQIQDITDRKNMLSALIEKNETLQALSNHLTERNSQLEEFNQIVSHNL
HHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RAPIGNIFTLTTMLSEKYGTDKDELLQSLEMSVKDLMTTLSDIVEVIKIRRNRNVDKQPI
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
FFKDAFIKIQNLLSTEIKKTSAEIQTDFTAAPEILYSKVYLESILLNLLSNALKYSDPNR
EHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KLEISLVSYIKDKKIFLVVRDNGLGIDLRKYGHQIFKMNKTFHREKEGQGIGLFMTKNQI
EEEEEHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHH
ESLGGEITVESSPGKGTSFLVNFDKYNDLE
HHCCCEEEEECCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MREFDFQSADFYKFLIERSPELISFHDPDGIFLYVSPSVTSILGYQPEELIGKNPYDYFS
CCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCHHHHHCCCCHHHHCCCCCHHCC
PLDKNRIFESSHQPILKGREIEHVEYQFLRKDGKYVWLQTITQSIRDDHETVIALFSTSR
CCCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHCCCHHHEEEEECCCH
EYLGLNAILDETEKKQVLDEIRLSEEKFSNAFYYSGIGMALVSLEGKWLEVNSSLLDIIG
HHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCEEECCHHHHHHHC
YSRDEILKLTFQDITHPDDLTVDLNLLQETLEGKRDSYRMEKRYFHKNGSTIWILLIVSI
CCHHHHEEEEHHHCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
VRDSQKKPLFFISQIQDITDRKNMLSALIEKNETLQALSNHLTERNSQLEEFNQIVSHNL
HHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RAPIGNIFTLTTMLSEKYGTDKDELLQSLEMSVKDLMTTLSDIVEVIKIRRNRNVDKQPI
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
FFKDAFIKIQNLLSTEIKKTSAEIQTDFTAAPEILYSKVYLESILLNLLSNALKYSDPNR
EHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KLEISLVSYIKDKKIFLVVRDNGLGIDLRKYGHQIFKMNKTFHREKEGQGIGLFMTKNQI
EEEEEHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHH
ESLGGEITVESSPGKGTSFLVNFDKYNDLE
HHCCCEEEEECCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]