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The map label for this gene is pyrC [H]

Identifier: 116327048

GI number: 116327048

Start: 264930

End: 266204

Strand: Direct

Name: pyrC [H]

Synonym: LBL_0221

Alternate gene names: 116327048

Gene position: 264930-266204 (Clockwise)

Preceding gene: 116327047

Following gene: 116327052

Centisome position: 7.33

GC content: 41.73

Gene sequence:

>1275_bases
ATGATTAATAAAATATCCGGTAGAATTATCACTCACGAGAAAGATTTTTTGGGAACCGTGGAATGGGATTCTAAAACAGG
GCTCATTCTTGGGATTCGGGAGTACACAGAAGCAAAAACATTTTGGAATACGCGACCAAAAGAGGATGAAATCCGATTTG
ATCCTTCCGAGACGGTGATATTTCCGGGTTTTGGGGACATTCATATTCACGCAAGGGAAGATGAAAGTGGTAAACACATC
TACAAGGAGGATTTTATTTCCGCGAGTGCGGCGGCAGTTAATGGCGGAGTTATTCACGTTGCAGATATGCCGAACAATCC
GATCCCTCCCGTAGACGAACCAACATATTCAAAAAAGCGCAAGTTAGCCGATCGATCCAATATACACATAACATTATATG
CGGGAATCGGACCGAACACGAAACCTTTAAAACAATCCGTTCCTTATAAAGTTTTTATGGGTCCGAGTATAGGGGAGCTT
TTCTTCCATGATAATCAAACTCTGGAAGATACGATCCGCGCCTATGCGGGGGAGAATGTAAGTTTTCATTGTGAAGATCC
CGAAATTCTTGAGAAATATCAGAATGAAAAATTTCACGAGGACAGAAGGCCTCCCGAAGCGGAAACGACGGCAACCGACT
TTGCTTTATATCTGATCGAAAAATACGATCTCAGAGGAAAACTTTGCCATTATTCTACCGGAAAAGGTTTGAGCAAAATC
AAACTCGCAAAACAAAAAGGACTCAAAATTACCTGTGAAGTAACGCCCACTCATTTATTTTTCGATAGGTCTATGTTGAC
TTCCCAGAATCGTCATTGGTTTCAGATGAATCCTCCTTTGCGGGACAGGGAAGATCGGAAAAGAATGCTTGAGGGAGTCA
AACAAGGCTGGATCGATTATCTCGCGACGGATCACGCTCCTCACAGTATCGAAGAAAAACACAAGGGCACGAGCGGAATC
TCTCAGCTGGATACGTATTCACTTTTTGTAACATGGTTGATCTTGAAGGCGGGAGTGGAATTAAAAACGATTGCAAGGAT
TTGCGCAAAAAATCCGGGGGACTTTGTGAACGAATATCTTCCCGGAAGATTCGGCAAAGGCTTCGGTGAAATAGAACCTG
GTTATTCGGCGAATTTCACCATTTTAAATTTAAAAAAACCTAAGAAATTTCTAAAAGAAGAAATCAAAAGTAAATCCGGT
TGGTCCCCTTTTGAAAACTATGAGTTTCCGGGTTCGATCGAAGCGGTATTTTTTTGTGGCGTTAAAATGAAATAA

Upstream 100 bases:

>100_bases
AAGTGAAGTTAGGGTAATTCCGTTTTGTTTTAAGAAATAAGATGAAATTTTATTTCTTTGCGGACGGACTTTCTTCGGGT
TTTATGCCGGGAGATCCTGT

Downstream 100 bases:

>100_bases
TCGGAAGATTTCTGAATTTTTACGATTATACGTTTCACTTGAACCTGTCGGACAATTAAGCGTAACTATAGTCGAATTAA
GAGTCTGTTCCAAAACCTTA

Product: cyclic amidohydrolase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MINKISGRIITHEKDFLGTVEWDSKTGLILGIREYTEAKTFWNTRPKEDEIRFDPSETVIFPGFGDIHIHAREDESGKHI
YKEDFISASAAAVNGGVIHVADMPNNPIPPVDEPTYSKKRKLADRSNIHITLYAGIGPNTKPLKQSVPYKVFMGPSIGEL
FFHDNQTLEDTIRAYAGENVSFHCEDPEILEKYQNEKFHEDRRPPEAETTATDFALYLIEKYDLRGKLCHYSTGKGLSKI
KLAKQKGLKITCEVTPTHLFFDRSMLTSQNRHWFQMNPPLRDREDRKRMLEGVKQGWIDYLATDHAPHSIEEKHKGTSGI
SQLDTYSLFVTWLILKAGVELKTIARICAKNPGDFVNEYLPGRFGKGFGEIEPGYSANFTILNLKKPKKFLKEEIKSKSG
WSPFENYEFPGSIEAVFFCGVKMK

Sequences:

>Translated_424_residues
MINKISGRIITHEKDFLGTVEWDSKTGLILGIREYTEAKTFWNTRPKEDEIRFDPSETVIFPGFGDIHIHAREDESGKHI
YKEDFISASAAAVNGGVIHVADMPNNPIPPVDEPTYSKKRKLADRSNIHITLYAGIGPNTKPLKQSVPYKVFMGPSIGEL
FFHDNQTLEDTIRAYAGENVSFHCEDPEILEKYQNEKFHEDRRPPEAETTATDFALYLIEKYDLRGKLCHYSTGKGLSKI
KLAKQKGLKITCEVTPTHLFFDRSMLTSQNRHWFQMNPPLRDREDRKRMLEGVKQGWIDYLATDHAPHSIEEKHKGTSGI
SQLDTYSLFVTWLILKAGVELKTIARICAKNPGDFVNEYLPGRFGKGFGEIEPGYSANFTILNLKKPKKFLKEEIKSKSG
WSPFENYEFPGSIEAVFFCGVKMK
>Mature_424_residues
MINKISGRIITHEKDFLGTVEWDSKTGLILGIREYTEAKTFWNTRPKEDEIRFDPSETVIFPGFGDIHIHAREDESGKHI
YKEDFISASAAAVNGGVIHVADMPNNPIPPVDEPTYSKKRKLADRSNIHITLYAGIGPNTKPLKQSVPYKVFMGPSIGEL
FFHDNQTLEDTIRAYAGENVSFHCEDPEILEKYQNEKFHEDRRPPEAETTATDFALYLIEKYDLRGKLCHYSTGKGLSKI
KLAKQKGLKITCEVTPTHLFFDRSMLTSQNRHWFQMNPPLRDREDRKRMLEGVKQGWIDYLATDHAPHSIEEKHKGTSGI
SQLDTYSLFVTWLILKAGVELKTIARICAKNPGDFVNEYLPGRFGKGFGEIEPGYSANFTILNLKKPKKFLKEEIKSKSG
WSPFENYEFPGSIEAVFFCGVKMK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786722, Length=398, Percent_Identity=24.8743718592965, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082175, Length=404, Percent_Identity=22.7722772277228, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193204318, Length=369, Percent_Identity=25.2032520325203, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=445, Percent_Identity=23.1460674157303, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24642586, Length=373, Percent_Identity=26.5415549597855, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48360; Mature: 48360

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINKISGRIITHEKDFLGTVEWDSKTGLILGIREYTEAKTFWNTRPKEDEIRFDPSETVI
CCCCCCCEEEEECHHHEEEEEECCCCCEEEEEHHHHHHHHHCCCCCCCCCEEECCCCEEE
FPGFGDIHIHAREDESGKHIYKEDFISASAAAVNGGVIHVADMPNNPIPPVDEPTYSKKR
ECCCCEEEEEECCCCCCCEEHHHHHHCHHHHEECCCEEEEECCCCCCCCCCCCCCCHHHH
KLADRSNIHITLYAGIGPNTKPLKQSVPYKVFMGPSIGELFFHDNQTLEDTIRAYAGENV
HHHCCCCEEEEEEECCCCCCCHHHHCCCEEEEECCCCCEEEECCCCCHHHHHHHHCCCCC
SFHCEDPEILEKYQNEKFHEDRRPPEAETTATDFALYLIEKYDLRGKLCHYSTGKGLSKI
EEECCCHHHHHHHHCCHHHHHCCCCCCCCHHHHHHEEEEHHHCCCCCEEECCCCCCHHHH
KLAKQKGLKITCEVTPTHLFFDRSMLTSQNRHWFQMNPPLRDREDRKRMLEGVKQGWIDY
HHHHHCCCEEEEEECCCEEEECHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
LATDHAPHSIEEKHKGTSGISQLDTYSLFVTWLILKAGVELKTIARICAKNPGDFVNEYL
HHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHC
PGRFGKGFGEIEPGYSANFTILNLKKPKKFLKEEIKSKSGWSPFENYEFPGSIEAVFFCG
CCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEC
VKMK
EECC
>Mature Secondary Structure
MINKISGRIITHEKDFLGTVEWDSKTGLILGIREYTEAKTFWNTRPKEDEIRFDPSETVI
CCCCCCCEEEEECHHHEEEEEECCCCCEEEEEHHHHHHHHHCCCCCCCCCEEECCCCEEE
FPGFGDIHIHAREDESGKHIYKEDFISASAAAVNGGVIHVADMPNNPIPPVDEPTYSKKR
ECCCCEEEEEECCCCCCCEEHHHHHHCHHHHEECCCEEEEECCCCCCCCCCCCCCCHHHH
KLADRSNIHITLYAGIGPNTKPLKQSVPYKVFMGPSIGELFFHDNQTLEDTIRAYAGENV
HHHCCCCEEEEEEECCCCCCCHHHHCCCEEEEECCCCCEEEECCCCCHHHHHHHHCCCCC
SFHCEDPEILEKYQNEKFHEDRRPPEAETTATDFALYLIEKYDLRGKLCHYSTGKGLSKI
EEECCCHHHHHHHHCCHHHHHCCCCCCCCHHHHHHEEEEHHHCCCCCEEECCCCCCHHHH
KLAKQKGLKITCEVTPTHLFFDRSMLTSQNRHWFQMNPPLRDREDRKRMLEGVKQGWIDY
HHHHHCCCEEEEEECCCEEEECHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
LATDHAPHSIEEKHKGTSGISQLDTYSLFVTWLILKAGVELKTIARICAKNPGDFVNEYL
HHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHC
PGRFGKGFGEIEPGYSANFTILNLKKPKKFLKEEIKSKSGWSPFENYEFPGSIEAVFFCG
CCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEC
VKMK
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]