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The map label for this gene is thrA [H]

Identifier: 116327046

GI number: 116327046

Start: 262773

End: 264062

Strand: Reverse

Name: thrA [H]

Synonym: LBL_0219

Alternate gene names: 116327046

Gene position: 264062-262773 (Counterclockwise)

Preceding gene: 116327049

Following gene: 116327045

Centisome position: 7.31

GC content: 41.01

Gene sequence:

>1290_bases
ATGGAACGCATTCGTATTGGATTGATCGGAGCCGGAACCGTAGGATCAGGCGTTATCGAAATTCTTAAAAAAGAAAGTAC
CTCGTATCGTGAAAAATTCGGAATAGAGCTGGTTCTTTTCTCCGTTTGTACTCGAACCCCTGAAAAAATTAAAAAAGAAC
TCCAGAATTTTCCAAATTGTAAACTGGAATCCGATTATCAAAAGATTATTACCGATCCTGAAATCGATATGATTTTAGAA
CTTGTAGGTGGAACGGAGATCGCCTACTCAATTGTAAAAGAAGCTTTAAAGAATGGAAAAACGGTGATTACCGCAAACAA
AGCTTTACTTTCTCAAAAAGGGGATGAATTGTTTTCTCTCGCTCAAGAGCTGGGTCTAGAAATCGGAATGGAAGCATCCG
TAGCGGGAGCCATTCCAGTGATTCGCTCGATCAAAACCGCGCTTAGTTCCGATTCGTTTCTTTCTTTATATGGTATTCTT
AATGGAACGACGAATTTTATCCTTTCTAAGATGGAGTTAGAACATTTGGATTACTCGGAGGCTCTTCGGATCGCTCAAGA
CCTAGGTTTCGCAGAGAAAGATCCCACGTTCGACGTAGAAGGAATTGATACCGCTCACAAAATTAGTATTTTGGGAAGTT
TAGCATTCTCCGAAAAAATTCCTTTACAGAGCATACAAATCGAAGGTATAACAAAGATTAGCAAATTAGATATCCAATTT
GCGAGTGAACTCGGTTATAGAATTAAACTTCTCGGGCTGGTGCGAAAGTTGTCTCATCGAATCGAAGCCAGAGTTCAACC
TGTGATGATTCCGGTCAAACATCCGTTTGCAAATATTATGAACGAGATGAATGCGGTTTATTATCAAACCGTATACGCAG
GACCGGGAATGTTTGTGGGAAAAGGAGCCGGATCTTTGCCGACCGCTTCTTCAGTCGTTTCCGATGTGCTTTATTATGGG
GCGAGAAGAAACAAAGGCCTTTCTCGGGAAAAGAATCTTTTTCCACAAGCAACGATCTCGGAAGCGAACGGCTTCCTAGT
ACGTTATTATCTCAGGTTTACTACCGTGGATTTACCCGGAGTTCTTTCTGAAATTTCTAAGGTACTGGGAGACCATGGAA
TTTCGATTTCTTCGGTGAGACAAAATGAAGCTGAAAAAGAACCCGTTGAAGTTGTTGTGATTACACATCCTGCAACGGAA
GAGAATATAAAAAAATCATTGAAGATCATAGACGAGCTGCCTTTAATCCGGCATACTTCGGTCGCAATTCGACTAGAAGA
CAAACTCTGA

Upstream 100 bases:

>100_bases
ACGATGCGTTGTAAATTAAAATTTCAATCCATCCAAGAACACCGCTTTGCCGTCGAAAATTGAGGTGAATCTTCCCTGCA
AACTACGAAGATGGTAAACC

Downstream 100 bases:

>100_bases
GAATTCCTTGAATAGAACGGGAGGATTTTAAGTTATCTTTGTATTCAGAGAAAAATGAGAAAGGCTTATATTCTTCTTGA
TCAGAGTAAGAAAATCCTCT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MERIRIGLIGAGTVGSGVIEILKKESTSYREKFGIELVLFSVCTRTPEKIKKELQNFPNCKLESDYQKIITDPEIDMILE
LVGGTEIAYSIVKEALKNGKTVITANKALLSQKGDELFSLAQELGLEIGMEASVAGAIPVIRSIKTALSSDSFLSLYGIL
NGTTNFILSKMELEHLDYSEALRIAQDLGFAEKDPTFDVEGIDTAHKISILGSLAFSEKIPLQSIQIEGITKISKLDIQF
ASELGYRIKLLGLVRKLSHRIEARVQPVMIPVKHPFANIMNEMNAVYYQTVYAGPGMFVGKGAGSLPTASSVVSDVLYYG
ARRNKGLSREKNLFPQATISEANGFLVRYYLRFTTVDLPGVLSEISKVLGDHGISISSVRQNEAEKEPVEVVVITHPATE
ENIKKSLKIIDELPLIRHTSVAIRLEDKL

Sequences:

>Translated_429_residues
MERIRIGLIGAGTVGSGVIEILKKESTSYREKFGIELVLFSVCTRTPEKIKKELQNFPNCKLESDYQKIITDPEIDMILE
LVGGTEIAYSIVKEALKNGKTVITANKALLSQKGDELFSLAQELGLEIGMEASVAGAIPVIRSIKTALSSDSFLSLYGIL
NGTTNFILSKMELEHLDYSEALRIAQDLGFAEKDPTFDVEGIDTAHKISILGSLAFSEKIPLQSIQIEGITKISKLDIQF
ASELGYRIKLLGLVRKLSHRIEARVQPVMIPVKHPFANIMNEMNAVYYQTVYAGPGMFVGKGAGSLPTASSVVSDVLYYG
ARRNKGLSREKNLFPQATISEANGFLVRYYLRFTTVDLPGVLSEISKVLGDHGISISSVRQNEAEKEPVEVVVITHPATE
ENIKKSLKIIDELPLIRHTSVAIRLEDKL
>Mature_429_residues
MERIRIGLIGAGTVGSGVIEILKKESTSYREKFGIELVLFSVCTRTPEKIKKELQNFPNCKLESDYQKIITDPEIDMILE
LVGGTEIAYSIVKEALKNGKTVITANKALLSQKGDELFSLAQELGLEIGMEASVAGAIPVIRSIKTALSSDSFLSLYGIL
NGTTNFILSKMELEHLDYSEALRIAQDLGFAEKDPTFDVEGIDTAHKISILGSLAFSEKIPLQSIQIEGITKISKLDIQF
ASELGYRIKLLGLVRKLSHRIEARVQPVMIPVKHPFANIMNEMNAVYYQTVYAGPGMFVGKGAGSLPTASSVVSDVLYYG
ARRNKGLSREKNLFPQATISEANGFLVRYYLRFTTVDLPGVLSEISKVLGDHGISISSVRQNEAEKEPVEVVVITHPATE
ENIKKSLKIIDELPLIRHTSVAIRLEDKL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=246, Percent_Identity=27.6422764227642, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790376, Length=349, Percent_Identity=24.3553008595989, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=342, Percent_Identity=25.1461988304094, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47230; Mature: 47230

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERIRIGLIGAGTVGSGVIEILKKESTSYREKFGIELVLFSVCTRTPEKIKKELQNFPNC
CCCEEEEEEECCCHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCC
KLESDYQKIITDPEIDMILELVGGTEIAYSIVKEALKNGKTVITANKALLSQKGDELFSL
CCCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECHHHHHCCCHHHHHH
AQELGLEIGMEASVAGAIPVIRSIKTALSSDSFLSLYGILNGTTNFILSKMELEHLDYSE
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHHCCHHH
ALRIAQDLGFAEKDPTFDVEGIDTAHKISILGSLAFSEKIPLQSIQIEGITKISKLDIQF
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
ASELGYRIKLLGLVRKLSHRIEARVQPVMIPVKHPFANIMNEMNAVYYQTVYAGPGMFVG
HHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHEEEEECCCCEEEE
KGAGSLPTASSVVSDVLYYGARRNKGLSREKNLFPQATISEANGFLVRYYLRFTTVDLPG
CCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHCCCCEEEEEEEHHHCCCCHH
VLSEISKVLGDHGISISSVRQNEAEKEPVEVVVITHPATEENIKKSLKIIDELPLIRHTS
HHHHHHHHHCCCCCEEHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEECE
VAIRLEDKL
EEEEEECCC
>Mature Secondary Structure
MERIRIGLIGAGTVGSGVIEILKKESTSYREKFGIELVLFSVCTRTPEKIKKELQNFPNC
CCCEEEEEEECCCHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHCCCC
KLESDYQKIITDPEIDMILELVGGTEIAYSIVKEALKNGKTVITANKALLSQKGDELFSL
CCCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECHHHHHCCCHHHHHH
AQELGLEIGMEASVAGAIPVIRSIKTALSSDSFLSLYGILNGTTNFILSKMELEHLDYSE
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHHHHHCCHHH
ALRIAQDLGFAEKDPTFDVEGIDTAHKISILGSLAFSEKIPLQSIQIEGITKISKLDIQF
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
ASELGYRIKLLGLVRKLSHRIEARVQPVMIPVKHPFANIMNEMNAVYYQTVYAGPGMFVG
HHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHEEEEECCCCEEEE
KGAGSLPTASSVVSDVLYYGARRNKGLSREKNLFPQATISEANGFLVRYYLRFTTVDLPG
CCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHCCCCEEEEEEEHHHCCCCHH
VLSEISKVLGDHGISISSVRQNEAEKEPVEVVVITHPATEENIKKSLKIIDELPLIRHTS
HHHHHHHHHCCCCCEEHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEECE
VAIRLEDKL
EEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]