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The map label for this gene is mutS [H]

Identifier: 116326983

GI number: 116326983

Start: 179712

End: 181538

Strand: Direct

Name: mutS [H]

Synonym: LBL_0152

Alternate gene names: 116326983

Gene position: 179712-181538 (Clockwise)

Preceding gene: 116326982

Following gene: 116326991

Centisome position: 4.97

GC content: 36.67

Gene sequence:

>1827_bases
ATGAAACCTCCTATTCTGATCGATCGGCTTTCGCGCAGAGCAGGAAAATTAAAAAGATTCTACGATCGAGTTTCCATTCT
TCTTTTTAAACTTTCTCTGTTCCGCCTTATTTCCTTTTGTGCATTCGTTCTTTGGATTTCCGTTTTTTATTATTTCCATT
CTTCGGTTTTTTATTATTTTCCTTCCTTAGTTTTTCTTCTCATTTTTTTCTTTTTTATTGGAAGGTATAAAAAGATTCTT
TCGACTCGAGAAAAAATTCGACTTTGGATTTTTGTTTTAGAAAGAGAATCTGCAAGAATTGGAATTAAAGGTTTCGGGAA
AAAATTCGGAACTAAAGTTGTTTTGGAAAAAATTTCTCCTTTGGCAAGAGACTTGGATCTATTCCGGGAAACTGGCTTGT
TTCCTTGGTTGGATACTACGTTTACTTCAACTGCGGAACGTCGGTTAATTTCTCTTTTGGACCCGGAAGATTCTTCGACC
GATTTTAAAAGAGAAAATATTCTACTTCGCCAGTCAATTGTTCGATCGATTTCCGAAAAAGAATTAGCAATTCCTAAAAT
ACTTAGACTTTCCTCTTATCTGAGGGAAAATCGAGATCTTTCTCTCAATCAAGAAAAGATGGAAATGAAATTGATCCACA
ACGACGGTGCTTCGGAACTTTGGAAACGATATCCATGGTTAAAAAGAATTTACAGGCCGGTTGCAATTCTAGTTCTTGCG
TTTATTCCTGCAAATGTGTTTTTGGGAGCCCCTTTTCCGGCTTCCGTTCTGTTTTTAAATTTGATTTTATTTGGATTGTA
TCGCTCCCGTTCTTTGGAAATTTTTCGACAATATTATTCCCTTTCTGGAAGTATAGAAGGACTTCAGAAAATTCTAATAT
ATCTAAAAGGTTTGAATGTTCGGGATAAAAACGGTAAATCTCTTTTGCAGGGCACTTCCAAGGAGGAGTTAAAATCTGCT
TACGAGGGTTTGGATCGTATATTGAAGCGTGTCGCTTTGACCGAAGCCCCTTTATTGCATCTAATTTTAAATAGTCTTTT
TCTTTACGATCTTTGGATTTTGGGGAAAATTTCCAAATGGAAGGAAAAACATTCCGCGCTTTTGGAAAAATCCATCGATG
ATTTAACCGTATTCGATTCTCTATTTCCTTTTGCGAATTTGAAGTGGATGTTTTCCGATTATTGTTTCCCTGAGATTCTT
TCTGAAAATTTTAAGGAGGGAATTTCGGGAGAAGATCTTTTCCACCCCCTTCTTTCTTTCAGAGTTTCTAATCCGTTAGA
TCAAGTTCTGGAAGGAAATATTGTTCTCATCACGGGTTCGAATATGTCCGGTAAAACGACATATTTACGTACAATCGCCG
TTTCTTCCATTCTCGCGTTGGCAGGTGGACCGGCGCCTGCGTCTCGATTTTCTTTACCGGTTTTGAAAATTCATACGAGC
ATGAGAAACGAAGATAACTTAGAGGAAGGAATTTCTTTTTTTTATGCGGAAGTAAGAAGACTTTCGGAGATCGTAAAAAA
AATTCAGAATTCGGATTTACCTCATCTTGTTTTGCTTGATGAAATTTTAAAAGGAACGAACACAAGGGAACGTTCTCTTG
CTTGTAAAGGAATTTTAAAAGAACTTAAAAAGAATCGTGTAATGGGTTTGGTTACGAGTCATGACTTGGAACTGGCTAAA
GTCGAGGATGTTATTTTGAAACATTTCCAAGAAGAAATTGTAAACGGTTCCATGTGCTTTGATTATAAAATTCGAGAAGG
TTTGGTCCAAACAAGCAATGCGCTGCGGATTTTGGTTCAAGAAGGATTGGATTTGGATTTTACTTAG

Upstream 100 bases:

>100_bases
GCTGGGTAATGCCCGACCTAGGATCACTGGTTCGTTTGTTGGATTTTGAAATTTATAAGCGAGAAAACGAACACTACGAA
AATATAAGCTCCTTAGTCGG

Downstream 100 bases:

>100_bases
AACTTATATTAAGAATTTATTTTCGTTTGTTTGATTCGAAAAGCTGCAGTAATTTATCTGGTATCGCTAACAAGTGTTTA
AGATTTTTTCAAAAGGATAA

Product: DNA mismatch repair protein ATPase component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MKPPILIDRLSRRAGKLKRFYDRVSILLFKLSLFRLISFCAFVLWISVFYYFHSSVFYYFPSLVFLLIFFFFIGRYKKIL
STREKIRLWIFVLERESARIGIKGFGKKFGTKVVLEKISPLARDLDLFRETGLFPWLDTTFTSTAERRLISLLDPEDSST
DFKRENILLRQSIVRSISEKELAIPKILRLSSYLRENRDLSLNQEKMEMKLIHNDGASELWKRYPWLKRIYRPVAILVLA
FIPANVFLGAPFPASVLFLNLILFGLYRSRSLEIFRQYYSLSGSIEGLQKILIYLKGLNVRDKNGKSLLQGTSKEELKSA
YEGLDRILKRVALTEAPLLHLILNSLFLYDLWILGKISKWKEKHSALLEKSIDDLTVFDSLFPFANLKWMFSDYCFPEIL
SENFKEGISGEDLFHPLLSFRVSNPLDQVLEGNIVLITGSNMSGKTTYLRTIAVSSILALAGGPAPASRFSLPVLKIHTS
MRNEDNLEEGISFFYAEVRRLSEIVKKIQNSDLPHLVLLDEILKGTNTRERSLACKGILKELKKNRVMGLVTSHDLELAK
VEDVILKHFQEEIVNGSMCFDYKIREGLVQTSNALRILVQEGLDLDFT

Sequences:

>Translated_608_residues
MKPPILIDRLSRRAGKLKRFYDRVSILLFKLSLFRLISFCAFVLWISVFYYFHSSVFYYFPSLVFLLIFFFFIGRYKKIL
STREKIRLWIFVLERESARIGIKGFGKKFGTKVVLEKISPLARDLDLFRETGLFPWLDTTFTSTAERRLISLLDPEDSST
DFKRENILLRQSIVRSISEKELAIPKILRLSSYLRENRDLSLNQEKMEMKLIHNDGASELWKRYPWLKRIYRPVAILVLA
FIPANVFLGAPFPASVLFLNLILFGLYRSRSLEIFRQYYSLSGSIEGLQKILIYLKGLNVRDKNGKSLLQGTSKEELKSA
YEGLDRILKRVALTEAPLLHLILNSLFLYDLWILGKISKWKEKHSALLEKSIDDLTVFDSLFPFANLKWMFSDYCFPEIL
SENFKEGISGEDLFHPLLSFRVSNPLDQVLEGNIVLITGSNMSGKTTYLRTIAVSSILALAGGPAPASRFSLPVLKIHTS
MRNEDNLEEGISFFYAEVRRLSEIVKKIQNSDLPHLVLLDEILKGTNTRERSLACKGILKELKKNRVMGLVTSHDLELAK
VEDVILKHFQEEIVNGSMCFDYKIREGLVQTSNALRILVQEGLDLDFT
>Mature_608_residues
MKPPILIDRLSRRAGKLKRFYDRVSILLFKLSLFRLISFCAFVLWISVFYYFHSSVFYYFPSLVFLLIFFFFIGRYKKIL
STREKIRLWIFVLERESARIGIKGFGKKFGTKVVLEKISPLARDLDLFRETGLFPWLDTTFTSTAERRLISLLDPEDSST
DFKRENILLRQSIVRSISEKELAIPKILRLSSYLRENRDLSLNQEKMEMKLIHNDGASELWKRYPWLKRIYRPVAILVLA
FIPANVFLGAPFPASVLFLNLILFGLYRSRSLEIFRQYYSLSGSIEGLQKILIYLKGLNVRDKNGKSLLQGTSKEELKSA
YEGLDRILKRVALTEAPLLHLILNSLFLYDLWILGKISKWKEKHSALLEKSIDDLTVFDSLFPFANLKWMFSDYCFPEIL
SENFKEGISGEDLFHPLLSFRVSNPLDQVLEGNIVLITGSNMSGKTTYLRTIAVSSILALAGGPAPASRFSLPVLKIHTS
MRNEDNLEEGISFFYAEVRRLSEIVKKIQNSDLPHLVLLDEILKGTNTRERSLACKGILKELKKNRVMGLVTSHDLELAK
VEDVILKHFQEEIVNGSMCFDYKIREGLVQTSNALRILVQEGLDLDFT

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=301, Percent_Identity=27.906976744186, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI284813531, Length=184, Percent_Identity=28.804347826087, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1789089, Length=251, Percent_Identity=27.4900398406374, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17508445, Length=200, Percent_Identity=29.5, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321912, Length=253, Percent_Identity=26.8774703557312, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=187, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24584320, Length=238, Percent_Identity=26.890756302521, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24664545, Length=189, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 70126; Mature: 70126

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPPILIDRLSRRAGKLKRFYDRVSILLFKLSLFRLISFCAFVLWISVFYYFHSSVFYYF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PSLVFLLIFFFFIGRYKKILSTREKIRLWIFVLERESARIGIKGFGKKFGTKVVLEKISP
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEECHHHHHHHHHHHHHHHHHHH
LARDLDLFRETGLFPWLDTTFTSTAERRLISLLDPEDSSTDFKRENILLRQSIVRSISEK
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ELAIPKILRLSSYLRENRDLSLNQEKMEMKLIHNDGASELWKRYPWLKRIYRPVAILVLA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHH
FIPANVFLGAPFPASVLFLNLILFGLYRSRSLEIFRQYYSLSGSIEGLQKILIYLKGLNV
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
RDKNGKSLLQGTSKEELKSAYEGLDRILKRVALTEAPLLHLILNSLFLYDLWILGKISKW
CCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKHSALLEKSIDDLTVFDSLFPFANLKWMFSDYCFPEILSENFKEGISGEDLFHPLLSF
HHHHHHHHHHCCHHHHHHHHHCCHHCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHH
RVSNPLDQVLEGNIVLITGSNMSGKTTYLRTIAVSSILALAGGPAPASRFSLPVLKIHTS
HHCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHH
MRNEDNLEEGISFFYAEVRRLSEIVKKIQNSDLPHLVLLDEILKGTNTRERSLACKGILK
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
ELKKNRVMGLVTSHDLELAKVEDVILKHFQEEIVNGSMCFDYKIREGLVQTSNALRILVQ
HHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHH
EGLDLDFT
CCCCCCCC
>Mature Secondary Structure
MKPPILIDRLSRRAGKLKRFYDRVSILLFKLSLFRLISFCAFVLWISVFYYFHSSVFYYF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PSLVFLLIFFFFIGRYKKILSTREKIRLWIFVLERESARIGIKGFGKKFGTKVVLEKISP
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEECHHHHHHHHHHHHHHHHHHH
LARDLDLFRETGLFPWLDTTFTSTAERRLISLLDPEDSSTDFKRENILLRQSIVRSISEK
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ELAIPKILRLSSYLRENRDLSLNQEKMEMKLIHNDGASELWKRYPWLKRIYRPVAILVLA
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHH
FIPANVFLGAPFPASVLFLNLILFGLYRSRSLEIFRQYYSLSGSIEGLQKILIYLKGLNV
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
RDKNGKSLLQGTSKEELKSAYEGLDRILKRVALTEAPLLHLILNSLFLYDLWILGKISKW
CCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKHSALLEKSIDDLTVFDSLFPFANLKWMFSDYCFPEILSENFKEGISGEDLFHPLLSF
HHHHHHHHHHCCHHHHHHHHHCCHHCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHH
RVSNPLDQVLEGNIVLITGSNMSGKTTYLRTIAVSSILALAGGPAPASRFSLPVLKIHTS
HHCCCHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHH
MRNEDNLEEGISFFYAEVRRLSEIVKKIQNSDLPHLVLLDEILKGTNTRERSLACKGILK
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
ELKKNRVMGLVTSHDLELAKVEDVILKHFQEEIVNGSMCFDYKIREGLVQTSNALRILVQ
HHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHH
EGLDLDFT
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA