Click here to switch to the map view.

The map label for this gene is lpxD-1 [H]

Identifier: 116326901

GI number: 116326901

Start: 69010

End: 70050

Strand: Reverse

Name: lpxD-1 [H]

Synonym: LBL_0059

Alternate gene names: 116326901

Gene position: 70050-69010 (Counterclockwise)

Preceding gene: 116326908

Following gene: 116326900

Centisome position: 1.94

GC content: 40.15

Gene sequence:

>1041_bases
ATGTCCCAGATCAAATTATCAGAATTAACGAAAAAAATAAGCGGGTCTAAAATTATAAACACCCAGATACCGGACACGAT
CATTCTAGAGAAAATCGTCTCCATCTTTCCCGGAGCAAAAAATTCCGTAAGTTTTCTTTCCAATAAAAAAATGTTAAACG
AAGCCAAAAAAACTCTTTCCAGCGTGATACTAACTACCGAAGAACTTGCAAAGGAATTGTCTATTCCTTGCCTTGTGGTT
TCTAATCCGGAACTAAGTCTTGCAGAAGTTCTTAACGTTCTTTATCCCTCTTACGTTCCTTCCGGAAAAATTTCTTCCAC
TGCTTCTATTCATCCGACTGCTAAACTAGGTTTTGGAGTTACGGTAGGAGAATTTGTGGTGATCGGAGAAAACTCTGTGA
TTGGAGCGAACACCTATCTTGAGGACGGAGTTAAGGTTTCCAGAAATGTAATCATTGGAGAAGATTCTCACATCGGTCTT
AATTCTTCCATTCAACATGGAGTCCTTATTGGAAAGAGATTTATCTGTTCCGGAAATTGTTCGATCGGTGGAGATGGATT
CAAATTTGTTACCGCAAATGGTAAACACCATAAAATTCCTCAAGTGGGCGGAGTAAAAATTGGAGACGACGTTGAAATAG
GATCTTTGTGTACAATCGATCGAGGTGATTTGGAGGACACGATTATTGGAGACGGATGCAAATTCGATAATATGGTTCAC
GTTGCTCACAATTGTGTATTGGGAAAAAACATCATCATCGCTGGACAAAGTGGCGTTGCTGGTAGTACGATTGTTGAAGA
CGACGTGATTATTGGAGGAGCTTGTGCGGTCGCGGATCATCTTCATGTTCCGGCGGGAACGATCCTTGCGGGTGGAACTT
CTTTGAGAAATTCCCCGAAGAAAAAAGAAATTTTCGTAGGTTGGGATTACGGTTTAACTTTTCCCGAATTTCAAAAAGTT
CGTGTAAATATTCACAATCTCGTGAATTTCCAGAAATGGGCCCAAAAGAATCAAAGAGTTGGAAAAACACGCTGGAATTA
A

Upstream 100 bases:

>100_bases
TTATAAATCGATAATTTTCTATGTACAACCTTTCTTCTTTTTTGCGTGACGATCGGAATTGTCCATTTCTCCGTGTAATA
ACGAAATAAAACGAGGAAAC

Downstream 100 bases:

>100_bases
AGTAGAAGAAAAGGAATGAGCTTGACAGGACTTGAAATTGGAAAGCATTCTTTTTCTACATCTTATTTGGAGGATTTCCC
TTGTATTCCCGAGCAAACGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N- acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSQIKLSELTKKISGSKIINTQIPDTIILEKIVSIFPGAKNSVSFLSNKKMLNEAKKTLSSVILTTEELAKELSIPCLVV
SNPELSLAEVLNVLYPSYVPSGKISSTASIHPTAKLGFGVTVGEFVVIGENSVIGANTYLEDGVKVSRNVIIGEDSHIGL
NSSIQHGVLIGKRFICSGNCSIGGDGFKFVTANGKHHKIPQVGGVKIGDDVEIGSLCTIDRGDLEDTIIGDGCKFDNMVH
VAHNCVLGKNIIIAGQSGVAGSTIVEDDVIIGGACAVADHLHVPAGTILAGGTSLRNSPKKKEIFVGWDYGLTFPEFQKV
RVNIHNLVNFQKWAQKNQRVGKTRWN

Sequences:

>Translated_346_residues
MSQIKLSELTKKISGSKIINTQIPDTIILEKIVSIFPGAKNSVSFLSNKKMLNEAKKTLSSVILTTEELAKELSIPCLVV
SNPELSLAEVLNVLYPSYVPSGKISSTASIHPTAKLGFGVTVGEFVVIGENSVIGANTYLEDGVKVSRNVIIGEDSHIGL
NSSIQHGVLIGKRFICSGNCSIGGDGFKFVTANGKHHKIPQVGGVKIGDDVEIGSLCTIDRGDLEDTIIGDGCKFDNMVH
VAHNCVLGKNIIIAGQSGVAGSTIVEDDVIIGGACAVADHLHVPAGTILAGGTSLRNSPKKKEIFVGWDYGLTFPEFQKV
RVNIHNLVNFQKWAQKNQRVGKTRWN
>Mature_345_residues
SQIKLSELTKKISGSKIINTQIPDTIILEKIVSIFPGAKNSVSFLSNKKMLNEAKKTLSSVILTTEELAKELSIPCLVVS
NPELSLAEVLNVLYPSYVPSGKISSTASIHPTAKLGFGVTVGEFVVIGENSVIGANTYLEDGVKVSRNVIIGEDSHIGLN
SSIQHGVLIGKRFICSGNCSIGGDGFKFVTANGKHHKIPQVGGVKIGDDVEIGSLCTIDRGDLEDTIIGDGCKFDNMVHV
AHNCVLGKNIIIAGQSGVAGSTIVEDDVIIGGACAVADHLHVPAGTILAGGTSLRNSPKKKEIFVGWDYGLTFPEFQKVR
VNIHNLVNFQKWAQKNQRVGKTRWN

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=283, Percent_Identity=32.8621908127208, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36955; Mature: 36824

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQIKLSELTKKISGSKIINTQIPDTIILEKIVSIFPGAKNSVSFLSNKKMLNEAKKTLS
CCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
SVILTTEELAKELSIPCLVVSNPELSLAEVLNVLYPSYVPSGKISSTASIHPTAKLGFGV
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCE
TVGEFVVIGENSVIGANTYLEDGVKVSRNVIIGEDSHIGLNSSIQHGVLIGKRFICSGNC
EECCEEEECCCCEEECCCHHHCCCEEECEEEECCCCCCCCCCCCCCCEEECEEEEEECCC
SIGGDGFKFVTANGKHHKIPQVGGVKIGDDVEIGSLCTIDRGDLEDTIIGDGCKFDNMVH
CCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCEEECCCCCCCCEEE
VAHNCVLGKNIIIAGQSGVAGSTIVEDDVIIGGACAVADHLHVPAGTILAGGTSLRNSPK
EHHHEEECCEEEEECCCCCCCCEEECCCEEECCHHHHHHCCCCCCCEEEECCCHHCCCCC
KKEIFVGWDYGLTFPEFQKVRVNIHNLVNFQKWAQKNQRVGKTRWN
CCEEEEEECCCCCCCCHHEEEEEHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SQIKLSELTKKISGSKIINTQIPDTIILEKIVSIFPGAKNSVSFLSNKKMLNEAKKTLS
CCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
SVILTTEELAKELSIPCLVVSNPELSLAEVLNVLYPSYVPSGKISSTASIHPTAKLGFGV
HHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCE
TVGEFVVIGENSVIGANTYLEDGVKVSRNVIIGEDSHIGLNSSIQHGVLIGKRFICSGNC
EECCEEEECCCCEEECCCHHHCCCEEECEEEECCCCCCCCCCCCCCCEEECEEEEEECCC
SIGGDGFKFVTANGKHHKIPQVGGVKIGDDVEIGSLCTIDRGDLEDTIIGDGCKFDNMVH
CCCCCCEEEEEECCCCCCCCCCCCEEECCCCCCCCEEEECCCCCCCEEECCCCCCCCEEE
VAHNCVLGKNIIIAGQSGVAGSTIVEDDVIIGGACAVADHLHVPAGTILAGGTSLRNSPK
EHHHEEECCEEEEECCCCCCCCEEECCCEEECCHHHHHHCCCCCCCEEEECCCHHCCCCC
KKEIFVGWDYGLTFPEFQKVRVNIHNLVNFQKWAQKNQRVGKTRWN
CCEEEEEECCCCCCCCHHEEEEEHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA