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The map label for this gene is appC [H]

Identifier: 116249444

GI number: 116249444

Start: 853558

End: 854679

Strand: Direct

Name: appC [H]

Synonym: pRL120782

Alternate gene names: 116249444

Gene position: 853558-854679 (Clockwise)

Preceding gene: 116249443

Following gene: 116249445

Centisome position: 98.11

GC content: 62.48

Gene sequence:

>1122_bases
GTGGCCGACATCCCCATTACAAATATTCAGCCGGATCGCGCCGCCGTCGCGTCGCAGTGGCAGCTCATCTGGTGGGCTTT
CCGCCGGCACCGGCTGGCCATGGTGGCGCTGGTCGTCACCGTACTGATGTATATCGTCGCCGTCATTCCCGGCTTCTTCG
CCATCAACGATCCGTACCTGCAAAATGCGCGGGCGACCTTTCACCCGCCGCAGAAATTGCATCTGATCGATACTGAGAAC
GGCTTCTCCTTCGGCCCGCATTATTATCCGATGAAGCTGACCCGCGATCCGGAAACGCTGGCCGCCATCTACAAGGAAGA
CACGACGAAACGTGTCGATGTCCAGTTCTTTGGGCGCGGTTATGAATATTCCGTGTTCGGCCTGTTCAGGACCAACATCC
ATCTGATCGCCTCGCCCGACAAGACGACGCCGCTGCTTCTGTTCGGCGCCGACAGGCTTGGGCGCGACGTCTTCAGCCGA
ACGGTGCAGGGCTCGCAGATTTCGTTGTCGATCGGCCTCGTCGGCGTCTTCTTCTCGCTGATCCTCGGCATCGTGCTCGG
CGGCATCTCGGGGTACTACGGCGGCCGCATCGATTTCTTCCTGCAGCGGGTGATCGATTTCGTGCTGTCGCTGCCGACGA
TCCCGATCTGGCTGGCAATGGCGGCGGCCCTGCCGCAGGACTGGCCTGCGACGCTGCAATATATGATGATCACGATCATC
CTGTCGCTGACCGGCTGGGCGCAGCTCGCCCGCGTCGTTCGCGGCCGCTTCCTGTCCTTGCGCACCGAGGAATTCGTCGC
CGCCGCGAGGCTCGACGGCGTTCGCGAAAGGCGCATCATCTTTCGCCACATGCTGCCGAGCTTTGCCAGCCATATCATCG
CGTCGATCACGCTTGCGGTGCCGGCGATGATCCTTGCCGAAACCTCTCTCTCCTTCCTGGGGCTCGGGCTACAGCCGCCG
ACCATCTCCTGGGGCGTGCTTCTGCGCGAGGCCCAGAACATTCGCTCGATCGCCACCGCGCCATGGCTCTTCATGCCGGG
CTGTGCCGTCGTGGTCGCCGTGATGGCGCTCAACCTTCTCGGCGACGGCCTGCGCGATGCGGCCGACCCCTACAACAAAT
GA

Upstream 100 bases:

>100_bases
CGTTCTGCTGATCTGCGCGCTGACGCTGATAGGCTCTCTGATCAGCGATATCCTGCTTGCGCTGGTCGATCCCCGCATCC
GGTTGGAATAGGAGCCTCAC

Downstream 100 bases:

>100_bases
GGCCGGCATGACCGATATTCTTCCCATTGCCGGCAGGCCGCTGCTTCAAGTGAAAAATCTGACGGTCGAGTTCCCGCTGC
GCACCGGCGTCTTTCGCGCC

Product: putative transmembrane permease component of ABC transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MADIPITNIQPDRAAVASQWQLIWWAFRRHRLAMVALVVTVLMYIVAVIPGFFAINDPYLQNARATFHPPQKLHLIDTEN
GFSFGPHYYPMKLTRDPETLAAIYKEDTTKRVDVQFFGRGYEYSVFGLFRTNIHLIASPDKTTPLLLFGADRLGRDVFSR
TVQGSQISLSIGLVGVFFSLILGIVLGGISGYYGGRIDFFLQRVIDFVLSLPTIPIWLAMAAALPQDWPATLQYMMITII
LSLTGWAQLARVVRGRFLSLRTEEFVAAARLDGVRERRIIFRHMLPSFASHIIASITLAVPAMILAETSLSFLGLGLQPP
TISWGVLLREAQNIRSIATAPWLFMPGCAVVVAVMALNLLGDGLRDAADPYNK

Sequences:

>Translated_373_residues
MADIPITNIQPDRAAVASQWQLIWWAFRRHRLAMVALVVTVLMYIVAVIPGFFAINDPYLQNARATFHPPQKLHLIDTEN
GFSFGPHYYPMKLTRDPETLAAIYKEDTTKRVDVQFFGRGYEYSVFGLFRTNIHLIASPDKTTPLLLFGADRLGRDVFSR
TVQGSQISLSIGLVGVFFSLILGIVLGGISGYYGGRIDFFLQRVIDFVLSLPTIPIWLAMAAALPQDWPATLQYMMITII
LSLTGWAQLARVVRGRFLSLRTEEFVAAARLDGVRERRIIFRHMLPSFASHIIASITLAVPAMILAETSLSFLGLGLQPP
TISWGVLLREAQNIRSIATAPWLFMPGCAVVVAVMALNLLGDGLRDAADPYNK
>Mature_372_residues
ADIPITNIQPDRAAVASQWQLIWWAFRRHRLAMVALVVTVLMYIVAVIPGFFAINDPYLQNARATFHPPQKLHLIDTENG
FSFGPHYYPMKLTRDPETLAAIYKEDTTKRVDVQFFGRGYEYSVFGLFRTNIHLIASPDKTTPLLLFGADRLGRDVFSRT
VQGSQISLSIGLVGVFFSLILGIVLGGISGYYGGRIDFFLQRVIDFVLSLPTIPIWLAMAAALPQDWPATLQYMMITIIL
SLTGWAQLARVVRGRFLSLRTEEFVAAARLDGVRERRIIFRHMLPSFASHIIASITLAVPAMILAETSLSFLGLGLQPPT
ISWGVLLREAQNIRSIATAPWLFMPGCAVVVAVMALNLLGDGLRDAADPYNK

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787054, Length=226, Percent_Identity=39.8230088495575, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787498, Length=227, Percent_Identity=36.5638766519824, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789889, Length=235, Percent_Identity=37.4468085106383, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1787760, Length=225, Percent_Identity=35.5555555555556, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788505, Length=354, Percent_Identity=27.683615819209, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1789964, Length=230, Percent_Identity=36.0869565217391, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787549, Length=225, Percent_Identity=34.2222222222222, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 41538; Mature: 41407

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIPITNIQPDRAAVASQWQLIWWAFRRHRLAMVALVVTVLMYIVAVIPGFFAINDPYL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHH
QNARATFHPPQKLHLIDTENGFSFGPHYYPMKLTRDPETLAAIYKEDTTKRVDVQFFGRG
HCCCCCCCCCCEEEEEECCCCCCCCCEECCEEECCCHHHHHHHHHCCCCCEEEEEEECCC
YEYSVFGLFRTNIHLIASPDKTTPLLLFGADRLGRDVFSRTVQGSQISLSIGLVGVFFSL
CEEEEEEEEECCEEEEECCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHH
ILGIVLGGISGYYGGRIDFFLQRVIDFVLSLPTIPIWLAMAAALPQDWPATLQYMMITII
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
LSLTGWAQLARVVRGRFLSLRTEEFVAAARLDGVRERRIIFRHMLPSFASHIIASITLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PAMILAETSLSFLGLGLQPPTISWGVLLREAQNIRSIATAPWLFMPGCAVVVAVMALNLL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHH
GDGLRDAADPYNK
CCHHHHCCCCCCC
>Mature Secondary Structure 
ADIPITNIQPDRAAVASQWQLIWWAFRRHRLAMVALVVTVLMYIVAVIPGFFAINDPYL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHH
QNARATFHPPQKLHLIDTENGFSFGPHYYPMKLTRDPETLAAIYKEDTTKRVDVQFFGRG
HCCCCCCCCCCEEEEEECCCCCCCCCEECCEEECCCHHHHHHHHHCCCCCEEEEEEECCC
YEYSVFGLFRTNIHLIASPDKTTPLLLFGADRLGRDVFSRTVQGSQISLSIGLVGVFFSL
CEEEEEEEEECCEEEEECCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHH
ILGIVLGGISGYYGGRIDFFLQRVIDFVLSLPTIPIWLAMAAALPQDWPATLQYMMITII
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
LSLTGWAQLARVVRGRFLSLRTEEFVAAARLDGVRERRIIFRHMLPSFASHIIASITLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PAMILAETSLSFLGLGLQPPTISWGVLLREAQNIRSIATAPWLFMPGCAVVVAVMALNLL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHH
GDGLRDAADPYNK
CCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]