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The map label for this gene is hmuU [H]

Identifier: 116249374

GI number: 116249374

Start: 775755

End: 776795

Strand: Reverse

Name: hmuU [H]

Synonym: pRL120712

Alternate gene names: 116249374

Gene position: 776795-775755 (Counterclockwise)

Preceding gene: 116249375

Following gene: 116249373

Centisome position: 89.28

GC content: 67.05

Gene sequence:

>1041_bases
GTGACTGAAGCGGGCCGTATCTTCCGGCAGCTGGGAGCCGTCCTCGCACTGCTCCTCGCCTCTTTCTGCCTCATCGCTAT
CGCCATTGGCGTCAGCGTCGGGATCGGCGACCTGCCGATCCCGCTTGCAACCACGTTTTCGGCCGTCACCAACCGGCTCG
GATGGACCGCGATCGAGCTGAACCGCATCCATGAGACCGTCATCTGGGATTATCGCCTGAGCCGCGCGCTCGTCGCCGCC
TTCTGCGGCGCGGGTCTGGCGCTGTCGGGCGCGATCATGCAGTCGCTGCTGCGCAACCCGCTTGCCGAACCCTATGTGCT
CGGCATCTCCGCCGGCGCCTCCACCGGCGCCGTCGCGATTGTCATCCTAGGGATCGGCTCGGGCGCGGTGTCGCTCTCGG
CCGGCGCATTCGCCGGCGCTTTCGCAGCCTTCTTCTTCGTGGCGCTGCTCTCGAACGGCACGCGCGGCGGCGCGGATCGC
ACCATCCTTGCCGGCGTCGCCGCATCGCAGCTCTTCAACGCCTCGACCTCCTATATCGTCACCACCTCGGCCAATGCGCA
GCAGGCCCGCGACGTCATGTTCTGGCTGCTCGGCAGTTTCGGCGGCGTGCGCTGGCCGGAATTCGCGCTGGTCTCGGTCG
TCGTCGGCATCGGCCTCGTCGGCTGCCTGTTTTATGCCCGCGTGCTCGACGCTTTCGCCTTTGGCGACGAGGCGGCATCC
TCGCTCGGAGTCAATGTCGGCCGTGCGCGGATGGTGCTCTTCGCGCTAACGGCGATGATGACGGCCACAATCGTCAGCAT
GGTGGGCTCGATCGGCTTCGTCGGCCTCGTCGTGCCGCATGTCGCCCGCTTCGTCGTCGGGCCGCTCCACATTCGTCTCC
TGCCGGCCTGCGCCATCGCGGGGGCGATCTTCATGGTGTTCGCCGACATCGCCGCACGCGCCCTCATTCCCGGCCAGATC
CTGCCGATCGGCGTCGTCACCGCCTTGGTGGGCGTCCCCTTCTTCTCGATCATCCTCTACCGGTTCCAGCGCGCATCATG
A

Upstream 100 bases:

>100_bases
CGATCGTGATCATGGACGGCCAGGCCATGAACCCGACCGTCCGCACGGTCTACGGCGCTGAGCAGGTGGCTGGCCAATTG
AAGGCTCTCGGTCTGTTGAA

Downstream 100 bases:

>100_bases
GCATCAAGGCCGACAACCTCATCTGGAAAATTGGCAGGAAGACCATTCTCGATGGCGTTTCCATGGAGGCGCAGCCTGGC
CGGATGCTCGGCCTGCTCGG

Product: putative permease component of ABC transporter

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTEAGRIFRQLGAVLALLLASFCLIAIAIGVSVGIGDLPIPLATTFSAVTNRLGWTAIELNRIHETVIWDYRLSRALVAA
FCGAGLALSGAIMQSLLRNPLAEPYVLGISAGASTGAVAIVILGIGSGAVSLSAGAFAGAFAAFFFVALLSNGTRGGADR
TILAGVAASQLFNASTSYIVTTSANAQQARDVMFWLLGSFGGVRWPEFALVSVVVGIGLVGCLFYARVLDAFAFGDEAAS
SLGVNVGRARMVLFALTAMMTATIVSMVGSIGFVGLVVPHVARFVVGPLHIRLLPACAIAGAIFMVFADIAARALIPGQI
LPIGVVTALVGVPFFSIILYRFQRAS

Sequences:

>Translated_346_residues
MTEAGRIFRQLGAVLALLLASFCLIAIAIGVSVGIGDLPIPLATTFSAVTNRLGWTAIELNRIHETVIWDYRLSRALVAA
FCGAGLALSGAIMQSLLRNPLAEPYVLGISAGASTGAVAIVILGIGSGAVSLSAGAFAGAFAAFFFVALLSNGTRGGADR
TILAGVAASQLFNASTSYIVTTSANAQQARDVMFWLLGSFGGVRWPEFALVSVVVGIGLVGCLFYARVLDAFAFGDEAAS
SLGVNVGRARMVLFALTAMMTATIVSMVGSIGFVGLVVPHVARFVVGPLHIRLLPACAIAGAIFMVFADIAARALIPGQI
LPIGVVTALVGVPFFSIILYRFQRAS
>Mature_345_residues
TEAGRIFRQLGAVLALLLASFCLIAIAIGVSVGIGDLPIPLATTFSAVTNRLGWTAIELNRIHETVIWDYRLSRALVAAF
CGAGLALSGAIMQSLLRNPLAEPYVLGISAGASTGAVAIVILGIGSGAVSLSAGAFAGAFAAFFFVALLSNGTRGGADRT
ILAGVAASQLFNASTSYIVTTSANAQQARDVMFWLLGSFGGVRWPEFALVSVVVGIGLVGCLFYARVLDAFAFGDEAASS
LGVNVGRARMVLFALTAMMTATIVSMVGSIGFVGLVVPHVARFVVGPLHIRLLPACAIAGAIFMVFADIAARALIPGQIL
PIGVVTALVGVPFFSIILYRFQRAS

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=313, Percent_Identity=34.8242811501597, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788004, Length=281, Percent_Identity=39.1459074733096, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790741, Length=281, Percent_Identity=35.5871886120996, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786805, Length=284, Percent_Identity=35.9154929577465, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1786804, Length=288, Percent_Identity=31.25, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786347, Length=295, Percent_Identity=31.5254237288136, Blast_Score=91, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35700; Mature: 35568

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAGRIFRQLGAVLALLLASFCLIAIAIGVSVGIGDLPIPLATTFSAVTNRLGWTAIEL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHH
NRIHETVIWDYRLSRALVAAFCGAGLALSGAIMQSLLRNPLAEPYVLGISAGASTGAVAI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEE
VILGIGSGAVSLSAGAFAGAFAAFFFVALLSNGTRGGADRTILAGVAASQLFNASTSYIV
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
TTSANAQQARDVMFWLLGSFGGVRWPEFALVSVVVGIGLVGCLFYARVLDAFAFGDEAAS
EECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SLGVNVGRARMVLFALTAMMTATIVSMVGSIGFVGLVVPHVARFVVGPLHIRLLPACAIA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAIFMVFADIAARALIPGQILPIGVVTALVGVPFFSIILYRFQRAS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEAGRIFRQLGAVLALLLASFCLIAIAIGVSVGIGDLPIPLATTFSAVTNRLGWTAIEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHH
NRIHETVIWDYRLSRALVAAFCGAGLALSGAIMQSLLRNPLAEPYVLGISAGASTGAVAI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEE
VILGIGSGAVSLSAGAFAGAFAAFFFVALLSNGTRGGADRTILAGVAASQLFNASTSYIV
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
TTSANAQQARDVMFWLLGSFGGVRWPEFALVSVVVGIGLVGCLFYARVLDAFAFGDEAAS
EECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SLGVNVGRARMVLFALTAMMTATIVSMVGSIGFVGLVVPHVARFVVGPLHIRLLPACAIA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAIFMVFADIAARALIPGQILPIGVVTALVGVPFFSIILYRFQRAS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]