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The map label for this gene is comC [H]

Identifier: 116249266

GI number: 116249266

Start: 652001

End: 653035

Strand: Direct

Name: comC [H]

Synonym: pRL120601

Alternate gene names: 116249266

Gene position: 652001-653035 (Clockwise)

Preceding gene: 116249263

Following gene: 116249267

Centisome position: 74.94

GC content: 68.99

Gene sequence:

>1035_bases
ATGCGCGTATCCGAAACGGCAGCGCTTGCGCTTGCCACCCGCCTGCTGGAAGAGCATGGCGCACCGCGTGACCATGCGGC
CCTGCAGGCTCGCGTCCTGGTAACGGCGGAGATGAAGGGGCACCCCTCGCATGGCCTGTACCGGCTTCCGCGGCTGGTCG
AACGGATCGAGCGCGGGGTCATTGACCCGCAGACGAAGGGCACCCAGCGCTGGCGCGCGGATGCGGTGCTGGAGGTGGAG
GGTTCGTCGGGATTTGGCCCCGTCGTCGCCATGGCCGCGATCGAGCGGCTAGCGCCTCACATTCCGGATCTTGGCATCGG
CCTTGTCGCCGTGCGCAATGCCAACCATCTCGGCATGCTTGCGCAGTATGTGGAGGCCATCGCCGCAATGGGTTTCGTCG
GCATCGCGCTCTCGTCGAGCGAGGCGCTGGTCCATCCCTTCGGCGGTACCCGGGCCATGCTCGGCACCAATCCCATCGCC
ATCGCCGTGCCCACGGCCGAGGAACCGCTCGTGCTCGACCTGGCCACCAGCCTCGTGCCGATGGGCAGGATCCATCATCA
CGCGGCGACCGGCAGACCCATTCCCGAGGGATGGGCGCGCGATGCGGCCGGCAACCCGACGACCGATCCGGGGCGTGCGA
AGGCCGGCGCGATTGCGCCCTTCGGCGACGCGAAGGGCTACGGGCTCGGCATAGCCATGGAGCTGCTGGTGGCAGCTCTT
GCCGGCTCGGCGCTCGCGCCGGATGTGCGCGGCACGCTCGACAGCCAGTCGCCATGCAACAAGGGCGACGTCTTCATCTT
GATCGAGCCCAGTCTGGCGCCGGGACTGCCGGCGCGACTGTCGACCTATCTCGATGCCGTGCGCGGTTCACCACCCGCCG
GCGCTGGCGAACCGGTTCTCGTCCCGGGCGATCGTGCCCGCCGGCGGCGGGCGGCGGCGAGCCGCAACGGGTTCGAGATC
GACCAGCGCCTCTGGGAAGACCTCAACGCGCTTTCGCGCCCTCGCATTCTGGCCTTCGAGGGACAAGGATCATGA

Upstream 100 bases:

>100_bases
TCATCTGCTGCCTTGCCTCTTGACAGGTTCAATCGCTAGCACGATGCTGCGGCCAAGACAATCCTATATCCTATACGATT
TAATATAGGGAGGAAAAATC

Downstream 100 bases:

>100_bases
GCCTCTTTGCCGCCCTGAGGCTGCCGCAGGAAATCCTGTTTGGCGTCGGCCAGCGCCATGCGCTCGCGAGCGTCGCCAGC
AGAACCGGCCGGCGCGCACT

Product: putative L-lactate dehydrogenase family protein

Products: NA

Alternate protein names: (R)-2-hydroxyacid dehydrogenase; (R)-sulfolactate dehydrogenase [H]

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MRVSETAALALATRLLEEHGAPRDHAALQARVLVTAEMKGHPSHGLYRLPRLVERIERGVIDPQTKGTQRWRADAVLEVE
GSSGFGPVVAMAAIERLAPHIPDLGIGLVAVRNANHLGMLAQYVEAIAAMGFVGIALSSSEALVHPFGGTRAMLGTNPIA
IAVPTAEEPLVLDLATSLVPMGRIHHHAATGRPIPEGWARDAAGNPTTDPGRAKAGAIAPFGDAKGYGLGIAMELLVAAL
AGSALAPDVRGTLDSQSPCNKGDVFILIEPSLAPGLPARLSTYLDAVRGSPPAGAGEPVLVPGDRARRRRAAASRNGFEI
DQRLWEDLNALSRPRILAFEGQGS

Sequences:

>Translated_344_residues
MRVSETAALALATRLLEEHGAPRDHAALQARVLVTAEMKGHPSHGLYRLPRLVERIERGVIDPQTKGTQRWRADAVLEVE
GSSGFGPVVAMAAIERLAPHIPDLGIGLVAVRNANHLGMLAQYVEAIAAMGFVGIALSSSEALVHPFGGTRAMLGTNPIA
IAVPTAEEPLVLDLATSLVPMGRIHHHAATGRPIPEGWARDAAGNPTTDPGRAKAGAIAPFGDAKGYGLGIAMELLVAAL
AGSALAPDVRGTLDSQSPCNKGDVFILIEPSLAPGLPARLSTYLDAVRGSPPAGAGEPVLVPGDRARRRRAAASRNGFEI
DQRLWEDLNALSRPRILAFEGQGS
>Mature_344_residues
MRVSETAALALATRLLEEHGAPRDHAALQARVLVTAEMKGHPSHGLYRLPRLVERIERGVIDPQTKGTQRWRADAVLEVE
GSSGFGPVVAMAAIERLAPHIPDLGIGLVAVRNANHLGMLAQYVEAIAAMGFVGIALSSSEALVHPFGGTRAMLGTNPIA
IAVPTAEEPLVLDLATSLVPMGRIHHHAATGRPIPEGWARDAAGNPTTDPGRAKAGAIAPFGDAKGYGLGIAMELLVAAL
AGSALAPDVRGTLDSQSPCNKGDVFILIEPSLAPGLPARLSTYLDAVRGSPPAGAGEPVLVPGDRARRRRAAASRNGFEI
DQRLWEDLNALSRPRILAFEGQGS

Specific function: Catalyzes the reduction of sulfopyruvate to (R)- sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynth

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1790000, Length=335, Percent_Identity=28.6567164179104, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786727, Length=335, Percent_Identity=29.5522388059701, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1787020, Length=333, Percent_Identity=29.7297297297297, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17536633, Length=316, Percent_Identity=29.746835443038, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17507179, Length=322, Percent_Identity=30.1242236024845, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45553211, Length=300, Percent_Identity=31.6666666666667, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24667912, Length=300, Percent_Identity=31.6666666666667, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24667908, Length=300, Percent_Identity=31.6666666666667, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24667904, Length=300, Percent_Identity=31.6666666666667, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24658010, Length=310, Percent_Identity=27.741935483871, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24648360, Length=315, Percent_Identity=25.3968253968254, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.272 [H]

Molecular weight: Translated: 36001; Mature: 36001

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVSETAALALATRLLEEHGAPRDHAALQARVLVTAEMKGHPSHGLYRLPRLVERIERGV
CCCCHHHHHHHHHHHHHHCCCCCHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCC
IDPQTKGTQRWRADAVLEVEGSSGFGPVVAMAAIERLAPHIPDLGIGLVAVRNANHLGML
CCCCCCCCHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHH
AQYVEAIAAMGFVGIALSSSEALVHPFGGTRAMLGTNPIAIAVPTAEEPLVLDLATSLVP
HHHHHHHHHHHHHHEEECCCCCEEECCCCCEEEECCCCEEEEECCCCCCEEHHHHHHHHH
MGRIHHHAATGRPIPEGWARDAAGNPTTDPGRAKAGAIAPFGDAKGYGLGIAMELLVAAL
HHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AGSALAPDVRGTLDSQSPCNKGDVFILIEPSLAPGLPARLSTYLDAVRGSPPAGAGEPVL
HCCCCCCCHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEE
VPGDRARRRRAAASRNGFEIDQRLWEDLNALSRPRILAFEGQGS
ECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCC
>Mature Secondary Structure
MRVSETAALALATRLLEEHGAPRDHAALQARVLVTAEMKGHPSHGLYRLPRLVERIERGV
CCCCHHHHHHHHHHHHHHCCCCCHHHHHEEEEEEEEECCCCCCCCHHHHHHHHHHHHHCC
IDPQTKGTQRWRADAVLEVEGSSGFGPVVAMAAIERLAPHIPDLGIGLVAVRNANHLGML
CCCCCCCCHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHH
AQYVEAIAAMGFVGIALSSSEALVHPFGGTRAMLGTNPIAIAVPTAEEPLVLDLATSLVP
HHHHHHHHHHHHHHEEECCCCCEEECCCCCEEEECCCCEEEEECCCCCCEEHHHHHHHHH
MGRIHHHAATGRPIPEGWARDAAGNPTTDPGRAKAGAIAPFGDAKGYGLGIAMELLVAAL
HHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AGSALAPDVRGTLDSQSPCNKGDVFILIEPSLAPGLPARLSTYLDAVRGSPPAGAGEPVL
HCCCCCCCHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEE
VPGDRARRRRAAASRNGFEIDQRLWEDLNALSRPRILAFEGQGS
ECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10850983 [H]