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The map label for this gene is xylB [H]

Identifier: 116249170

GI number: 116249170

Start: 548573

End: 549679

Strand: Direct

Name: xylB [H]

Synonym: pRL120506

Alternate gene names: 116249170

Gene position: 548573-549679 (Clockwise)

Preceding gene: 116249169

Following gene: 116249171

Centisome position: 63.05

GC content: 64.86

Gene sequence:

>1107_bases
ATGAAAATCCATGCCGCGGTGGCGCGTGCGCCCCATACGCCGTTTTCGCTGGAAAGGCTCGATCTGGAGGAGCCACGTGA
GGGTGAAATCCTGGTTCGCGTCGTGGCGACAGGGGTTTGCCACACCGATATCGTCATGCGTGACCAGCACCTGCCGGTGC
CGCAGCCGGTCGTGCTCGGTCATGAAGGCGCCGGCATCGTCGAGCGTGTCGGGCCGGGCGTTGCCAAGGTCAAGCCCGGC
GATCACGTGGTCATGACCTTCAATTCCTGCGGTCATTGCCCGAGCTGCAACGATCACCAGGAGACCTATTGCCACGAATT
CTTCCCGCGCAACTTCTTCGGTGCGCGTGCCGATGGTTCGAGCGGGCTCTCATGCGAGGGAGTGCGGGTTCACGGCAATA
TTTTCGGGCAATCCTCCTTCGCCAGCCACGCGCTGTGCCATGAGCGCAATATCGTGAAAGTGCCTGAGGATGCCGATCTG
GCGTTGCTCGGGCCGCTCGCCTGCGGCATCCAGACCGGCGCCGGCGCGGTCATGAACGCGCTGAAGGTCGAGCCGGGAAA
GGTGCTCGCGGTTTTCGGCATGGGCTCCGTCGGCCTTGCCGCGGTGATGGCGGCGCGGATCGTCGGCGCTTCACGGATCA
TCGCCGTCGATGTCAACGAGACGCGGCTGGCACTTGCGGCGGAACTCGGCGCGACCGACATCGTCAACGGCAAGGCGAGC
GACGCGGTTGCCGCAATCATGGCGCTGACCGGCGCCGGCGTCGATTATTCGATCGATGCCTCCGGCGTGCCGGCCGTCAT
CGACCAATGCGTGCGGGTGCTGGCGCCGCGCGGCACCTGCGGAATCGTCGGGGCCTCGCCCCATGGCGCGACGCTGACGC
TCGACCTCACCCATATCCTGTCCGGCGGACGCCGGGTCCGCGGCATCGTCGAGGGCGATTCCAATCCCGACGTTTTGATC
CCGTTGTTGATCGACCTCCATCGGCAGGGCCGCTTCCCCTTCGACAGGCTCATCACCTTCTATGATTTCGCCGACATCAA
CCAGGCGGTGGAGGATTCGGAAAAGGGCATCGTGCTGAAACCGGTCGTGCGTCAGCCGGCCGTCTGA

Upstream 100 bases:

>100_bases
AAACCTATCAGCCGGGGCTCGGCGCCTACCAGCGCGACCGCTGAGCACGGGTCCGGTTCGCCGGGCCGTTCACGAGCCGA
TCATCGGGAGGAGTAAAGCA

Downstream 100 bases:

>100_bases
CACCGTTCAAGGGAGGAAACAATGAACACCATCACCGCAATCGCCACCGATACCAGCCCCGATGTCATGAAGGCGCTGCT
TGACCGGCAAAGGGCGTCTT

Product: putative aryl-alcohol dehydrogenase

Products: NA

Alternate protein names: Benzyl alcohol dehydrogenase; BADH [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKIHAAVARAPHTPFSLERLDLEEPREGEILVRVVATGVCHTDIVMRDQHLPVPQPVVLGHEGAGIVERVGPGVAKVKPG
DHVVMTFNSCGHCPSCNDHQETYCHEFFPRNFFGARADGSSGLSCEGVRVHGNIFGQSSFASHALCHERNIVKVPEDADL
ALLGPLACGIQTGAGAVMNALKVEPGKVLAVFGMGSVGLAAVMAARIVGASRIIAVDVNETRLALAAELGATDIVNGKAS
DAVAAIMALTGAGVDYSIDASGVPAVIDQCVRVLAPRGTCGIVGASPHGATLTLDLTHILSGGRRVRGIVEGDSNPDVLI
PLLIDLHRQGRFPFDRLITFYDFADINQAVEDSEKGIVLKPVVRQPAV

Sequences:

>Translated_368_residues
MKIHAAVARAPHTPFSLERLDLEEPREGEILVRVVATGVCHTDIVMRDQHLPVPQPVVLGHEGAGIVERVGPGVAKVKPG
DHVVMTFNSCGHCPSCNDHQETYCHEFFPRNFFGARADGSSGLSCEGVRVHGNIFGQSSFASHALCHERNIVKVPEDADL
ALLGPLACGIQTGAGAVMNALKVEPGKVLAVFGMGSVGLAAVMAARIVGASRIIAVDVNETRLALAAELGATDIVNGKAS
DAVAAIMALTGAGVDYSIDASGVPAVIDQCVRVLAPRGTCGIVGASPHGATLTLDLTHILSGGRRVRGIVEGDSNPDVLI
PLLIDLHRQGRFPFDRLITFYDFADINQAVEDSEKGIVLKPVVRQPAV
>Mature_368_residues
MKIHAAVARAPHTPFSLERLDLEEPREGEILVRVVATGVCHTDIVMRDQHLPVPQPVVLGHEGAGIVERVGPGVAKVKPG
DHVVMTFNSCGHCPSCNDHQETYCHEFFPRNFFGARADGSSGLSCEGVRVHGNIFGQSSFASHALCHERNIVKVPEDADL
ALLGPLACGIQTGAGAVMNALKVEPGKVLAVFGMGSVGLAAVMAARIVGASRIIAVDVNETRLALAAELGATDIVNGKAS
DAVAAIMALTGAGVDYSIDASGVPAVIDQCVRVLAPRGTCGIVGASPHGATLTLDLTHILSGGRRVRGIVEGDSNPDVLI
PLLIDLHRQGRFPFDRLITFYDFADINQAVEDSEKGIVLKPVVRQPAV

Specific function: Oxidizes primary alcohols with an aromatic or cyclohex- 1-ene ring. It is highly specific for benzyl alcohol [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=374, Percent_Identity=34.4919786096257, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4501939, Length=367, Percent_Identity=35.149863760218, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=35.3260869565217, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI4501929, Length=356, Percent_Identity=34.2696629213483, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=33.695652173913, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=32.7077747989276, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI71565154, Length=373, Percent_Identity=33.5120643431635, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=31.6216216216216, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=31.6216216216216, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI156627571, Length=373, Percent_Identity=24.6648793565684, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786552, Length=371, Percent_Identity=33.1536388140162, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1788073, Length=378, Percent_Identity=29.1005291005291, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI87081918, Length=249, Percent_Identity=32.5301204819277, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788407, Length=267, Percent_Identity=26.2172284644195, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790045, Length=289, Percent_Identity=28.0276816608997, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082125, Length=276, Percent_Identity=27.1739130434783, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1786518, Length=304, Percent_Identity=27.9605263157895, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788075, Length=294, Percent_Identity=27.891156462585, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790718, Length=344, Percent_Identity=27.3255813953488, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787863, Length=346, Percent_Identity=24.8554913294798, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=377, Percent_Identity=33.6870026525199, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI71997431, Length=379, Percent_Identity=33.509234828496, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17565904, Length=340, Percent_Identity=33.5294117647059, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17562876, Length=367, Percent_Identity=26.7029972752044, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=270, Percent_Identity=27.7777777777778, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=304, Percent_Identity=24.3421052631579, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=304, Percent_Identity=24.6710526315789, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562582, Length=317, Percent_Identity=25.8675078864353, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=378, Percent_Identity=30.952380952381, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324486, Length=291, Percent_Identity=29.2096219931272, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=278, Percent_Identity=26.978417266187, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=287, Percent_Identity=28.9198606271777, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=288, Percent_Identity=29.8611111111111, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=284, Percent_Identity=28.8732394366197, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=273, Percent_Identity=25.2747252747253, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=279, Percent_Identity=28.3154121863799, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=31.7073170731707, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI17137530, Length=358, Percent_Identity=25.6983240223464, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17737897, Length=357, Percent_Identity=24.6498599439776, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.90 [H]

Molecular weight: Translated: 38647; Mature: 38647

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHAAVARAPHTPFSLERLDLEEPREGEILVRVVATGVCHTDIVMRDQHLPVPQPVVLG
CEECHHHHCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEC
HEGAGIVERVGPGVAKVKPGDHVVMTFNSCGHCPSCNDHQETYCHEFFPRNFFGARADGS
CCCCCHHHHCCCCCEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCC
SGLSCEGVRVHGNIFGQSSFASHALCHERNIVKVPEDADLALLGPLACGIQTGAGAVMNA
CCCEECEEEEEEEEECCCCHHHHHHHHCCCCEECCCCCCEEEECHHHHCCCCCCHHHHHH
LKVEPGKVLAVFGMGSVGLAAVMAARIVGASRIIAVDVNETRLALAAELGATDIVNGKAS
HCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHCCCCEECCCCCH
DAVAAIMALTGAGVDYSIDASGVPAVIDQCVRVLAPRGTCGIVGASPHGATLTLDLTHIL
HHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEHHHHH
SGGRRVRGIVEGDSNPDVLIPLLIDLHRQGRFPFDRLITFYDFADINQAVEDSEKGIVLK
CCCCEEEEEEECCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
PVVRQPAV
CHHCCCCC
>Mature Secondary Structure
MKIHAAVARAPHTPFSLERLDLEEPREGEILVRVVATGVCHTDIVMRDQHLPVPQPVVLG
CEECHHHHCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCEEEC
HEGAGIVERVGPGVAKVKPGDHVVMTFNSCGHCPSCNDHQETYCHEFFPRNFFGARADGS
CCCCCHHHHCCCCCEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCC
SGLSCEGVRVHGNIFGQSSFASHALCHERNIVKVPEDADLALLGPLACGIQTGAGAVMNA
CCCEECEEEEEEEEECCCCHHHHHHHHCCCCEECCCCCCEEEECHHHHCCCCCCHHHHHH
LKVEPGKVLAVFGMGSVGLAAVMAARIVGASRIIAVDVNETRLALAAELGATDIVNGKAS
HCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHCCCCEECCCCCH
DAVAAIMALTGAGVDYSIDASGVPAVIDQCVRVLAPRGTCGIVGASPHGATLTLDLTHIL
HHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEHHHHH
SGGRRVRGIVEGDSNPDVLIPLLIDLHRQGRFPFDRLITFYDFADINQAVEDSEKGIVLK
CCCCEEEEEEECCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
PVVRQPAV
CHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8496150; 1989592 [H]