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The map label for this gene is allB [H]

Identifier: 116248795

GI number: 116248795

Start: 119028

End: 120362

Strand: Reverse

Name: allB [H]

Synonym: pRL120121

Alternate gene names: 116248795

Gene position: 120362-119028 (Counterclockwise)

Preceding gene: 116248796

Following gene: 116248794

Centisome position: 13.83

GC content: 62.32

Gene sequence:

>1335_bases
ATGTTCGACACGCTGATCACCGGCGGCATGGTCGTCAACGCAAGCGGTCAACTTCCTGCGGATATCGGCATTCTCGACGG
CGTCGTCGTGGCCCTCCTTGCGCCTGGCGAGCCCGCCATGGCACGCGGCTTCATCAATGCGAGCGGCAAAATGGTGCTGC
CCGGCCTGGTCGATGCGCATGTTCATCTGCGCGAACCGGGAATGACGCAGAAGGAGGATTTCGAAAGCGGCACACACGCA
GCGGCGCTCGGCGGCGTGACGACCATCCTCGACATGCCGACGGACGATCCCTGGACGGCGACTGCGCAGCAATTGTCGGA
TAAGATGGCAAGCGCGGCGGGGGGTATTCATGTCGATGTCGGCTTTCAGGCCGTGGTTTCGAAGAGTTATGACAGCCTGG
AGGACCTGCTTGCTTTGTCCCCGGTCTCTCTTGAACTGTTCACGGCCGACGTACCCGTCGACTATCGGTTCGATAGTCTG
GATGCTGTCACGGAGATGCTGCGCCGGCTGGCGGGTACGGGCGCGGTGATTGGCGTTTCCCCCGGCGACCAGTCGATCCT
CGAGGGAACCGGCTTGCGGGAGCGCAGTGTTGGCATTCCGGCATTCCTGGCCAGCAGACCGCCGCTCGCCGAAGCCGGCG
GTATCGCACGCGCGGTACTGGCGGCGGCTGAGACCGGCGCGCGCGTGCATGTGCGTCAAATCAATTCGAGGCTCGGCGTC
GAGACCTGGCGCCGTCTTCGGAGCATGGCTGATGTCACCGTCGAAACGACACCGCAGAACCTGTTCTTCACATCCGACGA
CTACGAGTCGGAAGGTGCCCGGCTGAAGGGATCGCCTCCGTTTCGCGGCCGCGACGATGTCGCGGCCTTGCGCCGAGCGG
TCTCTGAGGGCCTGATCACAATCATGGCGACGGATCATGCGCCGCACAGCCCGGCCGAAAAGTCGGCAGTCTATGGATCT
TTCGCAGATATTCCCGGCGGGATGCCGGGTCTTCAGACATTGCTCTCGGTGATGCTGGACCTTGTGGCGGAGAAGGTAAT
AGGGCTTACGGATCTCGTGCGGATCTGCGCCTACAATCCCGCCCATCGCTTCGGACTTGGACGTTCGAAAGGGTCGATTG
CCGTCGGCAGCGATGCCGACATTCTAATTGTCGATATGGACCGATCGGCTGTTATCACCAATACCGAGCAGGCCTCCCGT
GCCGCCTATTCACCATTTCACGGCAAGCGCACGGCCGGCCGGTTGACCGACGTCTTCCTGCGCGGCGCACGCATCGTCAA
AGACGGAACGCTTATTAATCCCCGTCGCGGCCAAGTCGTCCGCAGGACTGCATAA

Upstream 100 bases:

>100_bases
CCCTCGACAAGGTCAAGGCCGGGCAGGCGGCCCTTATCGAGGTCGTCACGCACGAAGAGTCGCGGCTCGCGGGTCTATGG
TAGGGGAGGCGAAGGCGACT

Downstream 100 bases:

>100_bases
AGGAACGCCGATGCCTTTGCTCGACAGGAAAATTGCCATTGTCACCGGCGCGAGCTCTGGCCTCGGCCGCGCGATCGCAC
TTCGCTACGCCGAAGAGGGT

Product: putative dihydroorotase

Products: NA

Alternate protein names: Allantoin-utilizing enzyme [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MFDTLITGGMVVNASGQLPADIGILDGVVVALLAPGEPAMARGFINASGKMVLPGLVDAHVHLREPGMTQKEDFESGTHA
AALGGVTTILDMPTDDPWTATAQQLSDKMASAAGGIHVDVGFQAVVSKSYDSLEDLLALSPVSLELFTADVPVDYRFDSL
DAVTEMLRRLAGTGAVIGVSPGDQSILEGTGLRERSVGIPAFLASRPPLAEAGGIARAVLAAAETGARVHVRQINSRLGV
ETWRRLRSMADVTVETTPQNLFFTSDDYESEGARLKGSPPFRGRDDVAALRRAVSEGLITIMATDHAPHSPAEKSAVYGS
FADIPGGMPGLQTLLSVMLDLVAEKVIGLTDLVRICAYNPAHRFGLGRSKGSIAVGSDADILIVDMDRSAVITNTEQASR
AAYSPFHGKRTAGRLTDVFLRGARIVKDGTLINPRRGQVVRRTA

Sequences:

>Translated_444_residues
MFDTLITGGMVVNASGQLPADIGILDGVVVALLAPGEPAMARGFINASGKMVLPGLVDAHVHLREPGMTQKEDFESGTHA
AALGGVTTILDMPTDDPWTATAQQLSDKMASAAGGIHVDVGFQAVVSKSYDSLEDLLALSPVSLELFTADVPVDYRFDSL
DAVTEMLRRLAGTGAVIGVSPGDQSILEGTGLRERSVGIPAFLASRPPLAEAGGIARAVLAAAETGARVHVRQINSRLGV
ETWRRLRSMADVTVETTPQNLFFTSDDYESEGARLKGSPPFRGRDDVAALRRAVSEGLITIMATDHAPHSPAEKSAVYGS
FADIPGGMPGLQTLLSVMLDLVAEKVIGLTDLVRICAYNPAHRFGLGRSKGSIAVGSDADILIVDMDRSAVITNTEQASR
AAYSPFHGKRTAGRLTDVFLRGARIVKDGTLINPRRGQVVRRTA
>Mature_444_residues
MFDTLITGGMVVNASGQLPADIGILDGVVVALLAPGEPAMARGFINASGKMVLPGLVDAHVHLREPGMTQKEDFESGTHA
AALGGVTTILDMPTDDPWTATAQQLSDKMASAAGGIHVDVGFQAVVSKSYDSLEDLLALSPVSLELFTADVPVDYRFDSL
DAVTEMLRRLAGTGAVIGVSPGDQSILEGTGLRERSVGIPAFLASRPPLAEAGGIARAVLAAAETGARVHVRQINSRLGV
ETWRRLRSMADVTVETTPQNLFFTSDDYESEGARLKGSPPFRGRDDVAALRRAVSEGLITIMATDHAPHSPAEKSAVYGS
FADIPGGMPGLQTLLSVMLDLVAEKVIGLTDLVRICAYNPAHRFGLGRSKGSIAVGSDADILIVDMDRSAVITNTEQASR
AAYSPFHGKRTAGRLTDVFLRGARIVKDGTLINPRRGQVVRRTA

Specific function: Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Allantoinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=428, Percent_Identity=28.7383177570093, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4503051, Length=461, Percent_Identity=27.5488069414317, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI62422571, Length=461, Percent_Identity=27.5488069414317, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4503379, Length=447, Percent_Identity=27.0693512304251, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI4503377, Length=452, Percent_Identity=27.6548672566372, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI190194363, Length=460, Percent_Identity=27.6086956521739, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4503375, Length=449, Percent_Identity=24.7216035634744, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI19923821, Length=452, Percent_Identity=24.3362831858407, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1786722, Length=455, Percent_Identity=31.4285714285714, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI87082175, Length=457, Percent_Identity=31.5098468271335, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI193204318, Length=395, Percent_Identity=29.3670886075949, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71989490, Length=447, Percent_Identity=26.1744966442953, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI86575075, Length=419, Percent_Identity=24.1050119331742, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322218, Length=415, Percent_Identity=30.3614457831325, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24642586, Length=395, Percent_Identity=28.3544303797468, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18859883, Length=402, Percent_Identity=28.3582089552239, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17137462, Length=455, Percent_Identity=27.6923076923077, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI221377917, Length=465, Percent_Identity=28.3870967741935, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24644287, Length=260, Percent_Identity=29.2307692307692, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017593
- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.5 [H]

Molecular weight: Translated: 46845; Mature: 46845

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDTLITGGMVVNASGQLPADIGILDGVVVALLAPGEPAMARGFINASGKMVLPGLVDAH
CCCCEEECCEEEECCCCCCCCHHHHHHHHHEEECCCCHHHHHHEECCCCCEEECCCCCCE
VHLREPGMTQKEDFESGTHAAALGGVTTILDMPTDDPWTATAQQLSDKMASAAGGIHVDV
EEECCCCCCCHHHHCCCCCHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEC
GFQAVVSKSYDSLEDLLALSPVSLELFTADVPVDYRFDSLDAVTEMLRRLAGTGAVIGVS
CHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
PGDQSILEGTGLRERSVGIPAFLASRPPLAEAGGIARAVLAAAETGARVHVRQINSRLGV
CCCHHHHHCCCCCCCCCCCCHHHCCCCCCHHHCHHHHHHHHHHHCCCEEEEEHHHHHCCH
ETWRRLRSMADVTVETTPQNLFFTSDDYESEGARLKGSPPFRGRDDVAALRRAVSEGLIT
HHHHHHHHHHCCEEEECCCEEEEECCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCEEE
IMATDHAPHSPAEKSAVYGSFADIPGGMPGLQTLLSVMLDLVAEKVIGLTDLVRICAYNP
EEEECCCCCCCCHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AHRFGLGRSKGSIAVGSDADILIVDMDRSAVITNTEQASRAAYSPFHGKRTAGRLTDVFL
HHHHCCCCCCCCEEECCCCCEEEEECCCCEEEECCHHHHHHHCCCCCCCCCHHHHHHHHH
RGARIVKDGTLINPRRGQVVRRTA
HCCEEEECCCEECCCCCCEEECCC
>Mature Secondary Structure
MFDTLITGGMVVNASGQLPADIGILDGVVVALLAPGEPAMARGFINASGKMVLPGLVDAH
CCCCEEECCEEEECCCCCCCCHHHHHHHHHEEECCCCHHHHHHEECCCCCEEECCCCCCE
VHLREPGMTQKEDFESGTHAAALGGVTTILDMPTDDPWTATAQQLSDKMASAAGGIHVDV
EEECCCCCCCHHHHCCCCCHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEC
GFQAVVSKSYDSLEDLLALSPVSLELFTADVPVDYRFDSLDAVTEMLRRLAGTGAVIGVS
CHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
PGDQSILEGTGLRERSVGIPAFLASRPPLAEAGGIARAVLAAAETGARVHVRQINSRLGV
CCCHHHHHCCCCCCCCCCCCHHHCCCCCCHHHCHHHHHHHHHHHCCCEEEEEHHHHHCCH
ETWRRLRSMADVTVETTPQNLFFTSDDYESEGARLKGSPPFRGRDDVAALRRAVSEGLIT
HHHHHHHHHHCCEEEECCCEEEEECCCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCEEE
IMATDHAPHSPAEKSAVYGSFADIPGGMPGLQTLLSVMLDLVAEKVIGLTDLVRICAYNP
EEEECCCCCCCCHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AHRFGLGRSKGSIAVGSDADILIVDMDRSAVITNTEQASRAAYSPFHGKRTAGRLTDVFL
HHHHCCCCCCCCEEECCCCCEEEEECCCCEEEECCHHHHHHHCCCCCCCCCHHHHHHHHH
RGARIVKDGTLINPRRGQVVRRTA
HCCEEEECCCEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA