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The map label for this gene is ghrA [H]

Identifier: 115353057

GI number: 115353057

Start: 3325824

End: 3326765

Strand: Direct

Name: ghrA [H]

Synonym: Bamb_3006

Alternate gene names: 115353057

Gene position: 3325824-3326765 (Clockwise)

Preceding gene: 115353056

Following gene: 115353058

Centisome position: 93.51

GC content: 72.19

Gene sequence:

>942_bases
ATGAAGATCCTGTTCTACTCGCCGCACCAGGAAGCCGACGCATGGCGCGACGCGATCGCGCAGGCGCTGCCCGACGCCGA
GCTGCGCGCATGGCAGCCGGGCGACACGGCCGCCGCCGACTACGCGCTCGTGTGGCGCGCGCCGCGCGAGCTGTTCGCGC
CGCGCGACGGCCTGCGCGCGATCTTCAATCTCGGCGCGGGCGTCGACGCGCTGCTCGCACTCGAGCACGCGCATCCCGGC
ACGCTGCCGCGCGACGTGCCGCTGGTGCGCCTCGAGGATTCGGGCATGGCGCAGCAGATGATCGAATACGTGACGCACGC
GGTGCTGCGCTACCTGCGCCGCTTCGACGAATACGAAGCGCTGCAGCGCGAGCGCCGCTGGCAGGTGCTCGAACCGCATC
CGCGCGCGCGCTTCACCGTCGCGGTGCTCGGCCTCGGCGTGCTCGGTGCGCAGGTCGCGCAGGCGCTCGCCGCGCTCGGC
CTGCCGGTGCGCGGCTACAGCCGCAGCCCGAAGCGGCTCGACGGTATCGACACCTTCGCGGGCGACGACGCATTCGACGC
GTGCATCGACGGCGCGAAGGTGCTCGTGAACCTGCTGCCGAGCACACGCGATACCGACGGGATCCTGTCGGCGCGCACCT
TCGCCCGGCTCGCGCCGGGTGCGTACCTGGTGAACGTCGCACGCGGCGCGCATCTCGTCGAAGCCGACCTGCTCGACGCC
CTCGCAAGTGGCCAGCTCGCCGCGGCGACGCTCGACGTGTTCCAGCACGAGCCGCTACCGGCCGATCATCCGTTCTGGCA
CGCGCCGCGCATCACGATCACGCCGCACTGTTCGGCCGAGACGCTGCGCGACGAAGCGGTCGAGCAGATCGCGGGCAAGA
TCCGCGCGCTCGAGCGCGGCGAGCGGGTCGGCGGCATCGTCGACTACGCGCGCGGCTACTGA

Upstream 100 bases:

>100_bases
GTCGGCGAGCAAGCGACGATGTTCTTCCTCGATCCGTGCGGCAACGCGCTCGAATTCAAGGCGTTCGCCGACATCGGCCA
GCTGTTCGCGAAGTAAGCGC

Downstream 100 bases:

>100_bases
ATTCCGCCCTACACAAACTGGAGACAACCATGACGTTCCCCACCGCCGTCAAGATCGTCGAAGTCGGCCCGCGCGACGGG
CTGCAGAATGAAAAGACCTT

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MKILFYSPHQEADAWRDAIAQALPDAELRAWQPGDTAAADYALVWRAPRELFAPRDGLRAIFNLGAGVDALLALEHAHPG
TLPRDVPLVRLEDSGMAQQMIEYVTHAVLRYLRRFDEYEALQRERRWQVLEPHPRARFTVAVLGLGVLGAQVAQALAALG
LPVRGYSRSPKRLDGIDTFAGDDAFDACIDGAKVLVNLLPSTRDTDGILSARTFARLAPGAYLVNVARGAHLVEADLLDA
LASGQLAAATLDVFQHEPLPADHPFWHAPRITITPHCSAETLRDEAVEQIAGKIRALERGERVGGIVDYARGY

Sequences:

>Translated_313_residues
MKILFYSPHQEADAWRDAIAQALPDAELRAWQPGDTAAADYALVWRAPRELFAPRDGLRAIFNLGAGVDALLALEHAHPG
TLPRDVPLVRLEDSGMAQQMIEYVTHAVLRYLRRFDEYEALQRERRWQVLEPHPRARFTVAVLGLGVLGAQVAQALAALG
LPVRGYSRSPKRLDGIDTFAGDDAFDACIDGAKVLVNLLPSTRDTDGILSARTFARLAPGAYLVNVARGAHLVEADLLDA
LASGQLAAATLDVFQHEPLPADHPFWHAPRITITPHCSAETLRDEAVEQIAGKIRALERGERVGGIVDYARGY
>Mature_313_residues
MKILFYSPHQEADAWRDAIAQALPDAELRAWQPGDTAAADYALVWRAPRELFAPRDGLRAIFNLGAGVDALLALEHAHPG
TLPRDVPLVRLEDSGMAQQMIEYVTHAVLRYLRRFDEYEALQRERRWQVLEPHPRARFTVAVLGLGVLGAQVAQALAALG
LPVRGYSRSPKRLDGIDTFAGDDAFDACIDGAKVLVNLLPSTRDTDGILSARTFARLAPGAYLVNVARGAHLVEADLLDA
LASGQLAAATLDVFQHEPLPADHPFWHAPRITITPHCSAETLRDEAVEQIAGKIRALERGERVGGIVDYARGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=267, Percent_Identity=28.0898876404494, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI6912396, Length=256, Percent_Identity=27.34375, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI87081824, Length=313, Percent_Identity=49.8402555910543, Blast_Score=307, Evalue=6e-85,
Organism=Escherichia coli, GI87082289, Length=153, Percent_Identity=28.7581699346405, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=172, Percent_Identity=29.0697674418605, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=199, Percent_Identity=26.6331658291457, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320925, Length=199, Percent_Identity=26.6331658291457, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24585516, Length=145, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921140, Length=149, Percent_Identity=33.5570469798658, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574286, Length=147, Percent_Identity=31.2925170068027, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34285; Mature: 34285

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILFYSPHQEADAWRDAIAQALPDAELRAWQPGDTAAADYALVWRAPRELFAPRDGLRA
CEEEEECCCCHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHEECCCHHHHCCCHHHHH
IFNLGAGVDALLALEHAHPGTLPRDVPLVRLEDSGMAQQMIEYVTHAVLRYLRRFDEYEA
HHHCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQRERRWQVLEPHPRARFTVAVLGLGVLGAQVAQALAALGLPVRGYSRSPKRLDGIDTFA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCHHCC
GDDAFDACIDGAKVLVNLLPSTRDTDGILSARTFARLAPGAYLVNVARGAHLVEADLLDA
CCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHEEEHHCCCHHHHHHHHHH
LASGQLAAATLDVFQHEPLPADHPFWHAPRITITPHCSAETLRDEAVEQIAGKIRALERG
HHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
ERVGGIVDYARGY
HHHCCHHHHHCCC
>Mature Secondary Structure
MKILFYSPHQEADAWRDAIAQALPDAELRAWQPGDTAAADYALVWRAPRELFAPRDGLRA
CEEEEECCCCHHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHEECCCHHHHCCCHHHHH
IFNLGAGVDALLALEHAHPGTLPRDVPLVRLEDSGMAQQMIEYVTHAVLRYLRRFDEYEA
HHHCCCCHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQRERRWQVLEPHPRARFTVAVLGLGVLGAQVAQALAALGLPVRGYSRSPKRLDGIDTFA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCCHHCC
GDDAFDACIDGAKVLVNLLPSTRDTDGILSARTFARLAPGAYLVNVARGAHLVEADLLDA
CCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHEEEHHCCCHHHHHHHHHH
LASGQLAAATLDVFQHEPLPADHPFWHAPRITITPHCSAETLRDEAVEQIAGKIRALERG
HHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
ERVGGIVDYARGY
HHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA