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The map label for this gene is pth [H]

Identifier: 115352915

GI number: 115352915

Start: 3158353

End: 3158952

Strand: Direct

Name: pth [H]

Synonym: Bamb_2864

Alternate gene names: 115352915

Gene position: 3158353-3158952 (Clockwise)

Preceding gene: 115352914

Following gene: 115352916

Centisome position: 88.8

GC content: 68.0

Gene sequence:

>600_bases
ATGATCAAACTGATCGTCGGCCTCGGCAATCCCGGGGCGGAATACACCGCGACGCGCCACAACGCCGGCTTCTGGCTGGT
CGACCAGCTCGCCCGCGAAGCCGGCGCGACGCTGCGCGACGAGCGCCGCTTCCACGGCTTCTACGCGAAAGCGCGCCTGC
ACGGCGAGGAAGTCCACCTGCTCGAGCCGCAAACCTACATGAACCGCTCCGGCCAGTCGGTCGTCGCGCTCGCGAGTTTC
TTCAAGATCCTGCCCGACCAGATCCTCGTCGCACACGACGAGCTCGATCTGCCGCCCGGCACCGTGAAGCTGAAGCTCGG
CGGCGGCAGCGGCGGCCATAACGGCCTGAAGGACATCTCCGCGCACCTGTCGTCGCAGCAGTACTGGCGGCTGCGCATCG
GCATCGGCCATCCGCGCGACCTGATTCCGGAAGGCGCGCGTGCCGGCGCGAAGCCCGACGTCGCGAACTTCGTGCTGAAG
CCGCCGCGCCGCGAGGAGCAGGACGTGATCGACGCATCGATCGAGCGCGCGCTCGCCGTGATGCCGATGGTCGTCAAGGG
TGAGCTCGACCGCGCGACGATGCAGCTGCATCGCAACTGA

Upstream 100 bases:

>100_bases
TTCGATCCGTTTCACGAAACGGTCGACGCAACCCGCCGCGGCTCGCCCGGCGGGTTTTTCTTTTTCTGCGCCCAGGCGGC
GCTGCCGCCTACGAAACGTC

Downstream 100 bases:

>100_bases
AGCCGCCCCGGCATGGTGCAACGTGCCGTGCGGCGGCGCCGGGCGGCCTCCCGGTCCTGTGCAATTGCGCACCCCGTCGC
GCACATGCGGTAATCTGGTC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLHGEEVHLLEPQTYMNRSGQSVVALASF
FKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPEGARAGAKPDVANFVLK
PPRREEQDVIDASIERALAVMPMVVKGELDRATMQLHRN

Sequences:

>Translated_199_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLHGEEVHLLEPQTYMNRSGQSVVALASF
FKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPEGARAGAKPDVANFVLK
PPRREEQDVIDASIERALAVMPMVVKGELDRATMQLHRN
>Mature_199_residues
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLHGEEVHLLEPQTYMNRSGQSVVALASF
FKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDISAHLSSQQYWRLRIGIGHPRDLIPEGARAGAKPDVANFVLK
PPRREEQDVIDASIERALAVMPMVVKGELDRATMQLHRN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=137, Percent_Identity=39.4160583941606, Blast_Score=94, Evalue=7e-20,
Organism=Escherichia coli, GI1787455, Length=197, Percent_Identity=55.3299492385787, Blast_Score=181, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21952; Mature: 21952

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLHGEEVHL
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHEEEEEEECCCEEEE
LEPQTYMNRSGQSVVALASFFKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDIS
ECCHHHHCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDLIPEGARAGAKPDVANFVLKPPRREEQDVIDASIERALAV
HHCCCCCEEEEEEECCCCHHHCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHH
MPMVVKGELDRATMQLHRN
HHHHCCCCCCHHHHHHCCC
>Mature Secondary Structure
MIKLIVGLGNPGAEYTATRHNAGFWLVDQLAREAGATLRDERRFHGFYAKARLHGEEVHL
CEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHEEEEEEECCCEEEE
LEPQTYMNRSGQSVVALASFFKILPDQILVAHDELDLPPGTVKLKLGGGSGGHNGLKDIS
ECCHHHHCCCCCHHHHHHHHHHHCCHHEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHH
AHLSSQQYWRLRIGIGHPRDLIPEGARAGAKPDVANFVLKPPRREEQDVIDASIERALAV
HHCCCCCEEEEEEECCCCHHHCCCCCCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHH
MPMVVKGELDRATMQLHRN
HHHHCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA