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The map label for this gene is prs [H]

Identifier: 115352913

GI number: 115352913

Start: 3156491

End: 3157453

Strand: Direct

Name: prs [H]

Synonym: Bamb_2862

Alternate gene names: 115352913

Gene position: 3156491-3157453 (Clockwise)

Preceding gene: 115352912

Following gene: 115352914

Centisome position: 88.75

GC content: 62.82

Gene sequence:

>963_bases
ATGAGCAGCCACAGCCTTGATGGCCTGATGGTCTTTACTGGCAACGCGAATCCCGCGCTCGCACAGGAAGTCGTCAATAT
CCTTGGAATCCCCCTCGGCAAAGCAATGGTCAGCCGTTTCTCCGACGGCGAGATTCAAGTCGAGATCCAGGAAAACGTGC
GCGGCAAGGACGTCTTCGTCCTGCAATCCACGTGCGCGCCGACGAACGACAACCTGATGGAACTGATGATCATGGTCGAC
GCGCTCAAGCGTGCGTCCGCCGGCCGGATCACCGCTGCCATCCCCTACTTCGGCTATGCCCGCCAGGACCGTCGCCCGCG
CTCGGCGCGCGTCGCGATCTCGGCGAAGGTCATCGCGAACATGCTGGAAATCGCCGGCGTCGAGCGGATCATCACGATGG
ATCTGCACGCCGACCAGATTCAAGGCTTCTTCGACATCCCGGTCGACAACATCTACGCAACGCCGATCCTGCTGGGTGAC
CTGCGCAAGCAGAACTACTCGGATCTGCTCGTCGTGTCGCCGGACGTCGGCGGCGTGGTCCGCGCCCGGGCACTCGCGAA
GCAGCTCAACTGCGATCTCGCGATCATCGACAAGCGTCGTCCGAAGGCGAACGTCGCCGAAGTGATGAACATCATCGGTG
AAGTCGAAGGCCGCACCTGCGTGATCATGGACGACATGGTCGATACGGCCGGCACGCTCTGCAAGGCCGCGCAAGTTCTG
AAGAATCGCGGTGCGAAGCAGGTGTTCGCGTACGCGACGCACCCGGTTCTGTCGGGCGGCGCCGCCGAGCGTATCGCCGC
ATCGGAACTCGACGAGCTGGTCGTCACCGATACGATCCCGCTGTCGGCCGAATCGCTGGCCTGCTCGAAGATCCGCTCGC
TGACGAGCGCGAGCCTGCTGGCCGAAACGTTCTCGCGAATCCGTCGCGGCGACTCGGTGATGTCGCTGTTCGCGGAATCC
TGA

Upstream 100 bases:

>100_bases
AAGGCACCGGATTTTGATTCCGGCATGCGAGGGTTCGAGTCCTTCCTCCCCTGCCAAAAATTTTCCCGCATTTCCCGCCC
AAGCCTGAAGCAGGTGCACG

Downstream 100 bases:

>100_bases
TCGCGTAACGACAAAAAAAGCATGCGCGGAAAGCGAAGCGGCAACGCTTCGCTTTTTGCACAATCGGACGGGATAGACGA
AACCCCGCCCGTTTCATCAG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSSHSLDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFVLQSTCAPTNDNLMELMIMVD
ALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKVIANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGD
LRKQNYSDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
KNRGAKQVFAYATHPVLSGGAAERIAASELDELVVTDTIPLSAESLACSKIRSLTSASLLAETFSRIRRGDSVMSLFAES

Sequences:

>Translated_320_residues
MSSHSLDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFVLQSTCAPTNDNLMELMIMVD
ALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKVIANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGD
LRKQNYSDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
KNRGAKQVFAYATHPVLSGGAAERIAASELDELVVTDTIPLSAESLACSKIRSLTSASLLAETFSRIRRGDSVMSLFAES
>Mature_319_residues
SSHSLDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFVLQSTCAPTNDNLMELMIMVDA
LKRASAGRITAAIPYFGYARQDRRPRSARVAISAKVIANMLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDL
RKQNYSDLLVVSPDVGGVVRARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVLK
NRGAKQVFAYATHPVLSGGAAERIAASELDELVVTDTIPLSAESLACSKIRSLTSASLLAETFSRIRRGDSVMSLFAES

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=316, Percent_Identity=47.1518987341772, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI4506129, Length=316, Percent_Identity=46.5189873417722, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI28557709, Length=316, Percent_Identity=47.1518987341772, Blast_Score=298, Evalue=5e-81,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=45.9119496855346, Blast_Score=297, Evalue=8e-81,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=36.1271676300578, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=37.1014492753623, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=35.5704697986577, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=35.5704697986577, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=35.5704697986577, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=35.5704697986577, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=63.2258064516129, Blast_Score=412, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17554702, Length=316, Percent_Identity=45.8860759493671, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=46.6237942122186, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI25149168, Length=316, Percent_Identity=45.8860759493671, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71989924, Length=316, Percent_Identity=45.8860759493671, Blast_Score=295, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=33.0383480825959, Blast_Score=202, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320946, Length=319, Percent_Identity=43.2601880877743, Blast_Score=266, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6319403, Length=320, Percent_Identity=42.1875, Blast_Score=261, Evalue=9e-71,
Organism=Saccharomyces cerevisiae, GI6321776, Length=313, Percent_Identity=44.0894568690096, Blast_Score=261, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=43.3673469387755, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=108, Percent_Identity=39.8148148148148, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21355239, Length=318, Percent_Identity=46.8553459119497, Blast_Score=288, Evalue=2e-78,
Organism=Drosophila melanogaster, GI45551540, Length=340, Percent_Identity=43.8235294117647, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24651458, Length=362, Percent_Identity=33.1491712707182, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24651456, Length=362, Percent_Identity=33.1491712707182, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI281362873, Length=362, Percent_Identity=33.1491712707182, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24651454, Length=362, Percent_Identity=33.1491712707182, Blast_Score=204, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24651462, Length=210, Percent_Identity=37.6190476190476, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24651464, Length=210, Percent_Identity=37.6190476190476, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45552010, Length=210, Percent_Identity=37.6190476190476, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34508; Mature: 34377

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHSLDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFV
CCCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEE
LQSTCAPTNDNLMELMIMVDALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKVIAN
EECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHEEEEHHHHHHH
MLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDLRKQNYSDLLVVSPDVGGVV
HHHHCCCCEEEEEECCHHHHCCEEECCCCCEEECHHHHHHHHCCCCCCEEEECCCCCHHH
RARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
KNRGAKQVFAYATHPVLSGGAAERIAASELDELVVTDTIPLSAESLACSKIRSLTSASLL
HCCCHHHEEEEECCCHHCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHH
AETFSRIRRGDSVMSLFAES
HHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure 
SSHSLDGLMVFTGNANPALAQEVVNILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVFV
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEE
LQSTCAPTNDNLMELMIMVDALKRASAGRITAAIPYFGYARQDRRPRSARVAISAKVIAN
EECCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHEEEEHHHHHHH
MLEIAGVERIITMDLHADQIQGFFDIPVDNIYATPILLGDLRKQNYSDLLVVSPDVGGVV
HHHHCCCCEEEEEECCHHHHCCEEECCCCCEEECHHHHHHHHCCCCCCEEEECCCCCHHH
RARALAKQLNCDLAIIDKRRPKANVAEVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVL
HHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
KNRGAKQVFAYATHPVLSGGAAERIAASELDELVVTDTIPLSAESLACSKIRSLTSASLL
HCCCHHHEEEEECCCHHCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHH
AETFSRIRRGDSVMSLFAES
HHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]