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The map label for this gene is glcA [H]

Identifier: 115352857

GI number: 115352857

Start: 3095300

End: 3097000

Strand: Direct

Name: glcA [H]

Synonym: Bamb_2806

Alternate gene names: 115352857

Gene position: 3095300-3097000 (Clockwise)

Preceding gene: 115352856

Following gene: 115352863

Centisome position: 87.03

GC content: 69.37

Gene sequence:

>1701_bases
ATGCAGGTTTGGCATCAGATCTACACGCCGCTCGGCAGCCTCGGGCTGTCGGCGTTCGTCGCCGCAATTCCGATCATCTT
CTTTTTCATCGCGCTAGCCGCCTTGCGGATGAAGGGGCACGTGGCCGCCGCGATCACGCTGCTGCTGTCGCTCGGCGTCG
CGATTCTCGCGTACGGGATGCCCGTGCCGCAGGCGCTCGCGGCGGCCGGCTTCGGCTTCGCGTACGGCCTGTGGCCGATC
GCGTGGATCATCGTCGCGGCCGTGTTCCTGTACAAGATCGTCGTGAAGACCGGCCAGTTCGACATCATCCGCGCATCGGT
GCTGTCGATCACCGACGACCAGCGGCTGCAGATGCTGCTGATCGGCTTCTCGTTCGGCGCGTTCCTCGAAGGCGCCGCCG
GCTTCGGCGCGCCCGTCGCGATCACGGCCGCGCTGCTCGTCGGCCTCGGCTTCAAGCCGCTGCACGCGGCGGGACTGTGC
CTGATCGCGAACACCGCGCCGGTCGCGTTCGGCGCGATGGGCATCCCGATCATCGTCGCCGGGCAGGTGACGGGCATCGA
CCCGCTCCACATCGGCGCGATGGCCGGCCGGCAGCTGCCGCTGCTGTCGCTGGCGGTGCCGTTCTGGCTCGTGTTCATGA
TGGACGGGCTGCGCGGCGTGCGGCAGACCTGGCCGGCCGCGCTCGTCGCGGGCGGCAGCTTCGCGATCACGCAGTACTTC
ACGTCGAATCACATCGGGCCCGAGCTGCCGGACATCACGTCGTCGCTCGTCAGCCTCGTGTCGCTGGCCGTGTTCCTGAA
GGTGTGGCAGCCGAGCAGCGCGAAGCAGACGGCAGGCGGCGTCGTCGCGTCCGGCGGCGGCGCGGCGCTCGCGGGGTTCG
GCGCGGGCGGCAACGGTTCGGGCGCAAGCCGCCAGGCGTCGCCGTACTCGCTCGCGCAGACCGTGCGCGCGTGGTCGCCG
TTCCTGATCCTGACGGCCGTCGTCACCGTGTGGAGCATCGCGCCGTTCAAGGCGCTGTTCGCCGCGCACGGCGCGCTCGC
GTCGACCGTCCTGAAGTTCCATGTGGCCGGGCTCGACCAGCTCGTCGTGAAGACCGCGCCGATCGCCGCGACGCCGAAGG
CACTCGACGCAGTGCTGAAGCTCGACCTCGTGTCGGCGGTGGGCAGCGCGATCCTCGTGACCGCGCTGATCTCGATGGCG
CTGCTGCGGATGAAGCCGCGCGACGCGCTCGTCACGTTCGGCGAGACGCTGAAGGAACTCACGCGCCCGATCCTGTCGAT
CGGCCTCGTGCTCGCGTTCGCGTTCGTCGCGAATTACTCGGGGATGTCGTCGACGCTCGCGTTGATGCTGGCCGGCACCG
GCGCCGCGTTCCCGTTCTTCTCGCCGTTCCTCGGCTGGCTCGGCGTGTTCCTGACCGGCTCGGACACGTCGTCCAACGCG
CTGTTCTGCTCGCTGCAGCAGGCGACCGCGCACCAGCTCGGCGTGCCAGAGACGCTCGCGGTCGCCGCGAACACGACGGG
CGGCGTGACCGCGAAGATGATCTCGCCGCAGTCGATCGCGGTGGCATGCGCGGCGACCGGCCTCGTCGGCAAGGAGTCCG
ATCTGTTCCGCTTCACGGTGCGCCACAGCCTACTGTTCGCGGTGATCGTCGGCCTGATCACGCTGGTGCAGGCCTACGTG
TTGCCGGGAATGGTGCCGTAA

Upstream 100 bases:

>100_bases
GCCGCGCAGCCTGTCCGACCTGCTGCGCGCGCGCGGCCAGCCCGAATAGAACACCCCGCTTTCAAACCCGTACCCCGATA
AATCCATGGAGGAGACAACC

Downstream 100 bases:

>100_bases
GCACGCGGCGCGGCCGCTTTCCGGGCCTCCAAAAACAAAACCCCACGCCCGAAAAAGCGTGGGGTTTGGTTCATCCCGGG
CGCCGGACGAAGCCGGCGCC

Product: L-lactate transport

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MQVWHQIYTPLGSLGLSAFVAAIPIIFFFIALAALRMKGHVAAAITLLLSLGVAILAYGMPVPQALAAAGFGFAYGLWPI
AWIIVAAVFLYKIVVKTGQFDIIRASVLSITDDQRLQMLLIGFSFGAFLEGAAGFGAPVAITAALLVGLGFKPLHAAGLC
LIANTAPVAFGAMGIPIIVAGQVTGIDPLHIGAMAGRQLPLLSLAVPFWLVFMMDGLRGVRQTWPAALVAGGSFAITQYF
TSNHIGPELPDITSSLVSLVSLAVFLKVWQPSSAKQTAGGVVASGGGAALAGFGAGGNGSGASRQASPYSLAQTVRAWSP
FLILTAVVTVWSIAPFKALFAAHGALASTVLKFHVAGLDQLVVKTAPIAATPKALDAVLKLDLVSAVGSAILVTALISMA
LLRMKPRDALVTFGETLKELTRPILSIGLVLAFAFVANYSGMSSTLALMLAGTGAAFPFFSPFLGWLGVFLTGSDTSSNA
LFCSLQQATAHQLGVPETLAVAANTTGGVTAKMISPQSIAVACAATGLVGKESDLFRFTVRHSLLFAVIVGLITLVQAYV
LPGMVP

Sequences:

>Translated_566_residues
MQVWHQIYTPLGSLGLSAFVAAIPIIFFFIALAALRMKGHVAAAITLLLSLGVAILAYGMPVPQALAAAGFGFAYGLWPI
AWIIVAAVFLYKIVVKTGQFDIIRASVLSITDDQRLQMLLIGFSFGAFLEGAAGFGAPVAITAALLVGLGFKPLHAAGLC
LIANTAPVAFGAMGIPIIVAGQVTGIDPLHIGAMAGRQLPLLSLAVPFWLVFMMDGLRGVRQTWPAALVAGGSFAITQYF
TSNHIGPELPDITSSLVSLVSLAVFLKVWQPSSAKQTAGGVVASGGGAALAGFGAGGNGSGASRQASPYSLAQTVRAWSP
FLILTAVVTVWSIAPFKALFAAHGALASTVLKFHVAGLDQLVVKTAPIAATPKALDAVLKLDLVSAVGSAILVTALISMA
LLRMKPRDALVTFGETLKELTRPILSIGLVLAFAFVANYSGMSSTLALMLAGTGAAFPFFSPFLGWLGVFLTGSDTSSNA
LFCSLQQATAHQLGVPETLAVAANTTGGVTAKMISPQSIAVACAATGLVGKESDLFRFTVRHSLLFAVIVGLITLVQAYV
LPGMVP
>Mature_566_residues
MQVWHQIYTPLGSLGLSAFVAAIPIIFFFIALAALRMKGHVAAAITLLLSLGVAILAYGMPVPQALAAAGFGFAYGLWPI
AWIIVAAVFLYKIVVKTGQFDIIRASVLSITDDQRLQMLLIGFSFGAFLEGAAGFGAPVAITAALLVGLGFKPLHAAGLC
LIANTAPVAFGAMGIPIIVAGQVTGIDPLHIGAMAGRQLPLLSLAVPFWLVFMMDGLRGVRQTWPAALVAGGSFAITQYF
TSNHIGPELPDITSSLVSLVSLAVFLKVWQPSSAKQTAGGVVASGGGAALAGFGAGGNGSGASRQASPYSLAQTVRAWSP
FLILTAVVTVWSIAPFKALFAAHGALASTVLKFHVAGLDQLVVKTAPIAATPKALDAVLKLDLVSAVGSAILVTALISMA
LLRMKPRDALVTFGETLKELTRPILSIGLVLAFAFVANYSGMSSTLALMLAGTGAAFPFFSPFLGWLGVFLTGSDTSSNA
LFCSLQQATAHQLGVPETLAVAANTTGGVTAKMISPQSIAVACAATGLVGKESDLFRFTVRHSLLFAVIVGLITLVQAYV
LPGMVP

Specific function: Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=565, Percent_Identity=69.3805309734513, Blast_Score=752, Evalue=0.0,
Organism=Escherichia coli, GI1790031, Length=566, Percent_Identity=65.017667844523, Blast_Score=692, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 58347; Mature: 58347

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 11283302; 11785976 [H]