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The map label for this gene is hisM [H]

Identifier: 115352502

GI number: 115352502

Start: 2698531

End: 2699244

Strand: Direct

Name: hisM [H]

Synonym: Bamb_2451

Alternate gene names: 115352502

Gene position: 2698531-2699244 (Clockwise)

Preceding gene: 115352501

Following gene: 115352503

Centisome position: 75.88

GC content: 64.29

Gene sequence:

>714_bases
ATGATCGAACTCATCCAAGAATACTGGCGCAACTACCTCTATACCGACGGCTTCCGGATCACCGGCGTCGCGATCACGCT
GTGGCTGCTCGTCGTGTCGATCGGCCTGGGCTTCTGCCTGTCGGTGCCGCTCGCGGTGGCCCGCGTGTCGAAGAGGAAGT
GGCTGTCGGGCGCCGTGTGGCTCTACACGTACGTGTTCCGCGGCACGCCGCTCTACGTGCAGCTGCTGCTCTGCTACACC
GGCCTCTACAGCCTGCAGTTCATACGCGGCACGCCGCTGCTCGATTCGTTCTTCCGCGACGGGATGCGCTGCACGCTGCT
CGCGTTCACGCTGAACACCTGCGCGTACACCACCGAGATCTTCGCGGGCGCGATCAAGGCGACCTCGTACGGCGAGATCG
AAGCCGCGCGCGCATACGGGATGTCCACCTTCACGATGTATCGCCGCGTGATCCTGCCGTCCGCGCTGCGCCGCGCGCTG
CCGCTCTACAGCAACGAAGTGATCCTGATGCTGCACGCGACCACCGTCGCGTTCACCGCGACCGTGCCGGACATCCTGAA
GATCGCCCGCGACGTGAACTCGGCGACCTACATGTCGTTCCATGCATTCGGCATCGCCGCGCTGCTCTATCTCGTGATCT
CGTTCATGCTCGTGTGGCTGTTCCGCCAGGCCGAGCGTCGCTGGCTCGCGTATCTGCGCCCGCAAGGCAAGTAA

Upstream 100 bases:

>100_bases
TGATCGCGGGTGCCGTCTACCTCGCCATCACGACGATCTCGAACTTCGTGCTGATGTGGCTCGAAAAGCGCTACTCGACC
GGTGTCCGCAAGGCTGACCT

Downstream 100 bases:

>100_bases
GTTTTCGCAGGACTATATGAATTCCCAGACTCAGAAGCTTTTCGTCGACGATCTGCACAAGCGGTACGGCGACAACGAGG
TGCTCAAGGGCGTGTCGCTG

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIELIQEYWRNYLYTDGFRITGVAITLWLLVVSIGLGFCLSVPLAVARVSKRKWLSGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQFIRGTPLLDSFFRDGMRCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLVISFMLVWLFRQAERRWLAYLRPQGK

Sequences:

>Translated_237_residues
MIELIQEYWRNYLYTDGFRITGVAITLWLLVVSIGLGFCLSVPLAVARVSKRKWLSGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQFIRGTPLLDSFFRDGMRCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLVISFMLVWLFRQAERRWLAYLRPQGK
>Mature_237_residues
MIELIQEYWRNYLYTDGFRITGVAITLWLLVVSIGLGFCLSVPLAVARVSKRKWLSGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQFIRGTPLLDSFFRDGMRCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLVISFMLVWLFRQAERRWLAYLRPQGK

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=236, Percent_Identity=64.8305084745763, Blast_Score=330, Evalue=5e-92,
Organism=Escherichia coli, GI1787086, Length=217, Percent_Identity=33.6405529953917, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788226, Length=226, Percent_Identity=32.7433628318584, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787030, Length=210, Percent_Identity=29.0476190476191, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1788646, Length=215, Percent_Identity=28.3720930232558, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786873, Length=226, Percent_Identity=26.9911504424779, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787087, Length=221, Percent_Identity=23.9819004524887, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI48994930, Length=184, Percent_Identity=27.7173913043478, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 27023; Mature: 27023

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELIQEYWRNYLYTDGFRITGVAITLWLLVVSIGLGFCLSVPLAVARVSKRKWLSGAVW
CHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQFIRGTPLLDSFFRDGMRCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLVISFMLVWLFRQAERRWLAYLRPQGK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIELIQEYWRNYLYTDGFRITGVAITLWLLVVSIGLGFCLSVPLAVARVSKRKWLSGAVW
CHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQFIRGTPLLDSFFRDGMRCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
FAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLVISFMLVWLFRQAERRWLAYLRPQGK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]