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The map label for this gene is hdaH [H]

Identifier: 115351970

GI number: 115351970

Start: 2114673

End: 2115782

Strand: Direct

Name: hdaH [H]

Synonym: Bamb_1919

Alternate gene names: 115351970

Gene position: 2114673-2115782 (Clockwise)

Preceding gene: 115351969

Following gene: 115351971

Centisome position: 59.46

GC content: 69.1

Gene sequence:

>1110_bases
ATGAATCGCACTGCCTTCTTCACCGACGAACGCACCTTCTGGCACACCGGCGGCACGCACGCGCTGTTCTTCCCGGTCGG
CGGCTGGGTCCAGCCGCCATCGAGCGCCGGCTACGCGGAGTCTCCCGATTCGAAGCGCCGCTTCCTGTCGCTCGTGCAGG
CGTCGGGCCTTGCCGCTCACCTCGACATGCGCGGCGCCGCGCCGGCCACCGCCGACGATCTGCTGCGCATCCATCCGGCC
AGCTATCTCGACGCGTTCCGCGCGCTCAGCGATGCGCACGGCGGCGACCTCGGCGATCTCGCGCCGTTCGGCAAGGGCAG
CTACGAGATCGCCACGCTGTCCGCGGGCCTCGCGATCGCGGCGATCGACACCGTCGTCGCCGAGCATGCGGCCAGCGCAT
TCTCGCTGTCGCGGCCGCCCGGCCATCACTGCCTGCGCGATCGCCCGATGGGCTTCTGCCTGCTCGCGAACATTCCGATC
GCGATCGAGGCCGCGCGCGCGAAGCACGGCATCGACCGCGTCGCGGTGATCGACTGGGACGTGCATCACGGCAACGGCAC
GCAGTCGATCTACTACGACGATCCCAACACGCTGACGATCTCGCTGCATCAGGACCGCTGCTTTCCGCCCGGCTACAGCG
GCGGCAGCGACCGCGGCGAAGGCGCGGGCGTCGGAGCGAACCTGAACGTGCCGTTGCTGGCAGGCAGCGGAGATGACGCG
TATCGGTATGCGTTCGAGCGGATCGTGCTGCCGGCGCTCGAACGGTTCCGGCCGGAACTGATCGTCGTCGCGAGCGGCCT
CGATGCGAGCGCGGTCGATCCGCTCGCGCGCATGCTGCTGCATACCGACAGCTACCGGTTCATGACGCGGGCGGTGAAGG
ACGCGGCACAGCGCCACTGCGGCGGGCGGCTCGTGATCGTCCATGAAGGCGGGTATTCGGAGGCGTATGTGCCGTTCTGC
GGGCTCGCGATCGTCGAGGAACTGGCCGGCATCCGTACCGAGGTCGCCGATCCGATGCTCGAGCTCGCGATCGCGCAGCA
GCCCGGCGAGCGGTTCGTCGCGTTCCAGCGCGAGCTGCTCGACGAACTGGCGGCGTCGTTCGGCTTGTAA

Upstream 100 bases:

>100_bases
GGCGCGATCGCGTCGTTCGCCGCGCTGCGCCATCTCGATCGCCGCGCGCGCACGCCCATGACTTCCGTTTCTTCCCAACC
GTGACAGGTCGAGCACATCC

Downstream 100 bases:

>100_bases
CGGGCCTTCACACAAGATACGGGGCCGGCATGCGCCGGCCCTTGCGCGATCGGTGCGGATGGGGTTTCCTGTGCTTTTAC
ACCTGCCAGGCCCCTCGTCA

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: HDAC-like amidohydrolase; HDAH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAHLDMRGAAPATADDLLRIHPA
SYLDAFRALSDAHGGDLGDLAPFGKGSYEIATLSAGLAIAAIDTVVAEHAASAFSLSRPPGHHCLRDRPMGFCLLANIPI
AIEAARAKHGIDRVAVIDWDVHHGNGTQSIYYDDPNTLTISLHQDRCFPPGYSGGSDRGEGAGVGANLNVPLLAGSGDDA
YRYAFERIVLPALERFRPELIVVASGLDASAVDPLARMLLHTDSYRFMTRAVKDAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGIRTEVADPMLELAIAQQPGERFVAFQRELLDELAASFGL

Sequences:

>Translated_369_residues
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAHLDMRGAAPATADDLLRIHPA
SYLDAFRALSDAHGGDLGDLAPFGKGSYEIATLSAGLAIAAIDTVVAEHAASAFSLSRPPGHHCLRDRPMGFCLLANIPI
AIEAARAKHGIDRVAVIDWDVHHGNGTQSIYYDDPNTLTISLHQDRCFPPGYSGGSDRGEGAGVGANLNVPLLAGSGDDA
YRYAFERIVLPALERFRPELIVVASGLDASAVDPLARMLLHTDSYRFMTRAVKDAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGIRTEVADPMLELAIAQQPGERFVAFQRELLDELAASFGL
>Mature_369_residues
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAHLDMRGAAPATADDLLRIHPA
SYLDAFRALSDAHGGDLGDLAPFGKGSYEIATLSAGLAIAAIDTVVAEHAASAFSLSRPPGHHCLRDRPMGFCLLANIPI
AIEAARAKHGIDRVAVIDWDVHHGNGTQSIYYDDPNTLTISLHQDRCFPPGYSGGSDRGEGAGVGANLNVPLLAGSGDDA
YRYAFERIVLPALERFRPELIVVASGLDASAVDPLARMLLHTDSYRFMTRAVKDAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGIRTEVADPMLELAIAQQPGERFVAFQRELLDELAASFGL

Specific function: Exhibits significant levels of protein deacetylase activity comparable to those of eukaryotic HDACs in assays both with fluorogenic peptidic substrates and acetate-radiolabeled histones. Accepts proteins with epsilon-acetylated lysine residues and tritiat

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=288, Percent_Identity=32.6388888888889, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI153085395, Length=259, Percent_Identity=32.046332046332, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI20070354, Length=284, Percent_Identity=32.0422535211268, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI169234807, Length=251, Percent_Identity=33.4661354581673, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI148539870, Length=251, Percent_Identity=33.4661354581673, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI30795202, Length=259, Percent_Identity=30.8880308880309, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI30795204, Length=259, Percent_Identity=30.8880308880309, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI17158039, Length=259, Percent_Identity=30.8880308880309, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI62750347, Length=245, Percent_Identity=32.6530612244898, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI62750349, Length=245, Percent_Identity=32.6530612244898, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI226529806, Length=285, Percent_Identity=29.4736842105263, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI13128860, Length=249, Percent_Identity=25.7028112449799, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI293336691, Length=249, Percent_Identity=25.7028112449799, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI8923769, Length=252, Percent_Identity=28.1746031746032, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI13128862, Length=251, Percent_Identity=26.2948207171315, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI262073092, Length=228, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI262073088, Length=139, Percent_Identity=31.6546762589928, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI209862883, Length=235, Percent_Identity=26.3829787234043, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=309, Percent_Identity=31.0679611650485, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17540332, Length=309, Percent_Identity=31.0679611650485, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI193206283, Length=309, Percent_Identity=31.0679611650485, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI193209491, Length=230, Percent_Identity=33.0434782608696, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17508561, Length=313, Percent_Identity=28.7539936102236, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17561978, Length=297, Percent_Identity=28.2828282828283, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17534739, Length=299, Percent_Identity=26.4214046822742, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI25154020, Length=287, Percent_Identity=26.4808362369338, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17537347, Length=256, Percent_Identity=29.6875, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI25154022, Length=287, Percent_Identity=25.7839721254355, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324307, Length=285, Percent_Identity=32.6315789473684, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321244, Length=274, Percent_Identity=29.5620437956204, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323999, Length=288, Percent_Identity=27.7777777777778, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6325141, Length=263, Percent_Identity=30.4182509505703, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325325, Length=199, Percent_Identity=24.6231155778894, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24642146, Length=334, Percent_Identity=33.2335329341317, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI281360899, Length=334, Percent_Identity=33.2335329341317, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24642142, Length=334, Percent_Identity=33.2335329341317, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24642144, Length=334, Percent_Identity=33.2335329341317, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI281360799, Length=224, Percent_Identity=35.7142857142857, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24641720, Length=224, Percent_Identity=35.7142857142857, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI281360801, Length=224, Percent_Identity=35.7142857142857, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24657891, Length=249, Percent_Identity=29.718875502008, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24644244, Length=301, Percent_Identity=26.9102990033223, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 39565; Mature: 39565

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAH
CCCCEEEECCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LDMRGAAPATADDLLRIHPASYLDAFRALSDAHGGDLGDLAPFGKGSYEIATLSAGLAIA
EECCCCCCCCHHHHHEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCHHH
AIDTVVAEHAASAFSLSRPPGHHCLRDRPMGFCLLANIPIAIEAARAKHGIDRVAVIDWD
HHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCEEEEEHHHHCCCCEEEEEEEE
VHHGNGTQSIYYDDPNTLTISLHQDRCFPPGYSGGSDRGEGAGVGANLNVPLLAGSGDDA
EECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHH
YRYAFERIVLPALERFRPELIVVASGLDASAVDPLARMLLHTDSYRFMTRAVKDAAQRHC
HHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
GGRLVIVHEGGYSEAYVPFCGLAIVEELAGIRTEVADPMLELAIAQQPGERFVAFQRELL
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DELAASFGL
HHHHHHHCC
>Mature Secondary Structure
MNRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSSAGYAESPDSKRRFLSLVQASGLAAH
CCCCEEEECCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LDMRGAAPATADDLLRIHPASYLDAFRALSDAHGGDLGDLAPFGKGSYEIATLSAGLAIA
EECCCCCCCCHHHHHEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCHHH
AIDTVVAEHAASAFSLSRPPGHHCLRDRPMGFCLLANIPIAIEAARAKHGIDRVAVIDWD
HHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCEEEEEHHHHCCCCEEEEEEEE
VHHGNGTQSIYYDDPNTLTISLHQDRCFPPGYSGGSDRGEGAGVGANLNVPLLAGSGDDA
EECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHH
YRYAFERIVLPALERFRPELIVVASGLDASAVDPLARMLLHTDSYRFMTRAVKDAAQRHC
HHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
GGRLVIVHEGGYSEAYVPFCGLAIVEELAGIRTEVADPMLELAIAQQPGERFVAFQRELL
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DELAASFGL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA