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The map label for this gene is glxR [H]

Identifier: 115351868

GI number: 115351868

Start: 2005441

End: 2006334

Strand: Direct

Name: glxR [H]

Synonym: Bamb_1817

Alternate gene names: 115351868

Gene position: 2005441-2006334 (Clockwise)

Preceding gene: 115351867

Following gene: 115351869

Centisome position: 56.39

GC content: 66.67

Gene sequence:

>894_bases
ATGGCAACCATCGGATTCATCGGCCTCGGCATCATGGGCGCGCACATGGCGCGCAACCTGCTCAAGGGCGATCATCAGCT
CGTCGTGAACGGTGCGTTCCCGGTGCCGGACGACCTGCGCGCGAGCGCGAAGGTCGTCGCGAACTCGACCGAAGTCGCGC
AGAACGCGGACATCATCATCTCGATGGTGCCGGATACGCCCGACGTGCGTAACGTGCTGTTCGCCGACGACGGCGTCGCG
AAGGGCCTGACGGCCGGCAAGCTCGTGATCGACATGAGTTCGATCTCGCCGCTCGACACGCAGCAATTCGCGAAGCAGAT
CAATACGCTCGGCTGCGACTACCTCGACGCGCCGGTGTCCGGCGGCGAAGTCGGCGCCCGCGAAGCGACGCTCACGATCA
TGGTCGGCGGCCCGGAGCAGGCCTTCGAGCGCGCGAAGCCGCTGTTCGAGAAAATGGGCAAGAACATCACGCTCGTCGGC
GACAACGGCGCGGGCCAGACCTGCAAGGTCGCGAACCAGATCATCGTCGCGCTGAACATCGAGGCGGTCGGCGAAGCGCT
GCTGTTCGCCGCGCGCTCGGGGGCCGATCCGGAGCGCGTGCGCCAGGCGCTGATGGGCGGCTTCGCCGCGTCGCGGATCC
TCGAAGTGCATGGCGCGCGCATGACGAAGCGCACGTTCGATCCGGGCTTTCGCATCGAGCTGCATCAGAAGGACCTGAAC
CTCGCGCTCGACGGCGCACGCAAGCTTGGCCTCGCGCTGCCGCACACGGCGAGCGCGCAGCAACTGTTCAGCGTGTGCGC
GTCGCACGGCGGCAAGGCATGGGATCACTCGGCACTCGTGCGTGCGCTCGAGATCATGTCGAACTTCGAAATCGGCCAGA
CGCCGGCCGCGTAA

Upstream 100 bases:

>100_bases
TCGGCTGGCTGCAAAGCGTCGCCGGCTGCGCACCGGGCTCGGCGCGACGCGCCGCCTGAGATCCGCCCTTCCCACCTACG
CCCCTATAGGAGACTTTCAC

Downstream 100 bases:

>100_bases
CGCGGATGTAGCGGATGCAGCGGCGCGCGTTTCGCTACAACGGCGAACGCGCGCGGGCGCAGCGCGAGTGCAGCGCGGGC
GCTGCGCGACGCATACTCGC

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPVPDDLRASAKVVANSTEVAQNADIIISMVPDTPDVRNVLFADDGVA
KGLTAGKLVIDMSSISPLDTQQFAKQINTLGCDYLDAPVSGGEVGAREATLTIMVGGPEQAFERAKPLFEKMGKNITLVG
DNGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA

Sequences:

>Translated_297_residues
MATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPVPDDLRASAKVVANSTEVAQNADIIISMVPDTPDVRNVLFADDGVA
KGLTAGKLVIDMSSISPLDTQQFAKQINTLGCDYLDAPVSGGEVGAREATLTIMVGGPEQAFERAKPLFEKMGKNITLVG
DNGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA
>Mature_296_residues
ATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPVPDDLRASAKVVANSTEVAQNADIIISMVPDTPDVRNVLFADDGVAK
GLTAGKLVIDMSSISPLDTQQFAKQINTLGCDYLDAPVSGGEVGAREATLTIMVGGPEQAFERAKPLFEKMGKNITLVGD
NGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLNL
ALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=305, Percent_Identity=31.4754098360656, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=26.9503546099291, Blast_Score=104, Evalue=9e-23,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=65.3979238754325, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI145693186, Length=290, Percent_Identity=41.0344827586207, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1790315, Length=290, Percent_Identity=34.8275862068965, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789092, Length=289, Percent_Identity=29.0657439446367, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17557316, Length=288, Percent_Identity=32.6388888888889, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24655230, Length=273, Percent_Identity=37.3626373626374, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI19922568, Length=273, Percent_Identity=37.3626373626374, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI28574115, Length=286, Percent_Identity=28.3216783216783, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31278; Mature: 31147

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPVPDDLRASAKVVANSTEVAQNADIII
CCEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCHHHEECCHHHHCCCCEEE
SMVPDTPDVRNVLFADDGVAKGLTAGKLVIDMSSISPLDTQQFAKQINTLGCDYLDAPVS
EECCCCCCCCEEEEECCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGAREATLTIMVGGPEQAFERAKPLFEKMGKNITLVGDNGAGQTCKVANQIIVALNI
CCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCEEEEEEEH
EAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCC
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA
EEECCHHHCCEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ATIGFIGLGIMGAHMARNLLKGDHQLVVNGAFPVPDDLRASAKVVANSTEVAQNADIII
CEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCHHHEECCHHHHCCCCEEE
SMVPDTPDVRNVLFADDGVAKGLTAGKLVIDMSSISPLDTQQFAKQINTLGCDYLDAPVS
EECCCCCCCCEEEEECCCHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGAREATLTIMVGGPEQAFERAKPLFEKMGKNITLVGDNGAGQTCKVANQIIVALNI
CCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCEEEEEEEH
EAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCC
LALDGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIGQTPAA
EEECCHHHCCEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]