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The map label for this gene is oprM [H]

Identifier: 115351575

GI number: 115351575

Start: 1672876

End: 1674333

Strand: Direct

Name: oprM [H]

Synonym: Bamb_1522

Alternate gene names: 115351575

Gene position: 1672876-1674333 (Clockwise)

Preceding gene: 115351574

Following gene: 115351576

Centisome position: 47.04

GC content: 72.02

Gene sequence:

>1458_bases
ATGTTTGCATTGAATGCATGGGCCGCACCGAGGCTTCAGCTCGCGCTGGCCACGGCGCTCGCGCTCGCGGGCTGCTCGCT
CGCGCCGCGTTACGAGCGGCCGGCGGCGCCGGTGCCGGCCAGCTATGCGACGGTCGATGGCGACACGCAGCAGGGCGTCG
GCCCGGCTTCGACGGCCGACGCCGCGCTGCTCGACGACTGGCGCGCGTATTTCACCGATCCGGCGCTGCAGGCATGGATC
GATGCCGCGCTCGCGAACAATCGCGACCTGCGGATCGCGGCCGGCCGGCTCGACGAAGCGCGCGCGCTGTACGGCGTGCA
GCGCGCGGATCTGATGCCGTCGGTCGACGCGAATCTCGGCTACGAACGCACGCGCCAGTACGATCCGGTCGTGCGCGAGA
GCGCGGTGAGCGGGCTGTATCGCGCGGGTGTAGGCGTCAGCGCGTACGAGCTCGACCTGTTCGGCCGCGTGCGCAACCTG
TCCGATGCGGCGCTCGCCGAGTATTTCGCGACGGCCGACGCGCAGCGCACGGTGCGCATCGGCGTGATTGCCGAAGTCGC
GGGGGCGTACGTGTCGGAGCGATCGTTGCACGAACAACTGGTGCTGGCCCAGCGCACGCTCGACGCGCGCGAGCGCATCG
CCGCGCTCACGCAGCGCCGCTACGCGGCCGGCACGAGCGACGCGATCGAACTGCGTTCGGCCGAGATGCTGGTCGCGTCC
GCGCGCGCATCGCAGGCCGCGCTGCAGCGCGAGCATGCGCAATCGGTGCGCGCGCTGCAATTGCTCGCCGGCGATTTCGC
GCGCGGCGTGCCTGCCGACGGCACCGCGCTCGACACGCTCGCGATTGCGCCGGTGGCGCCCGGCGCGCCGAGCGCGCTGC
TCGAGCGGCGGCCGGACATCCGGCAGGCCGAGTCGCGGCTCAAGGCCGCGAACGCGCAGATCGGCGCCGCGCGCGCGGCA
TTCTTCCCGCGCGTCGCGCTGACCACCGACTACGGCTCGGTCAGCGATGCGTTCTCGACCCTGTTCGCGGCCGGCACGAG
CGTGTGGACGTTCGCGCCGCGCATCACGCTGCCGATTTTCGCGGGCGGTCGCAATCGCGCGAATCTCGACGTCGCGAGTG
CGCGCAAGCACATCGCGGTGGCCGAGTACGAGAAGACCGTGCAGACCGCGTTCCGCGAAGTGGCCGACGCATTCGCCGCG
CGCGACTGGATCGATCGCCAGCTCGCTGCGCAGCAGGACGTCTACGCGGCCGACGGCGCGCGGCTGAAACTCGCGGAGCG
CCGCTATGCGGGCGGCGTCGCGACGTATCTCGAACTGCTCGACGCGCAGCGCAGCACGTACGAATCCGGGCATGAGCTGA
TCCGGCTCAAGGCGCTGCGGCTCGCGAATGCGATTGCGCTGTATCGCGCGCTCGGCGGCGGCTGGGCGCCGGCCACCGCT
GGCGAAGCCGCCGCGTGA

Upstream 100 bases:

>100_bases
TCCTCGTCCCGCTGTTTTTCGTGATCGTCGGCCGCCTGTTCGACGTCGGCCCGCGCCGGCGCGGCGGCGCGCAGCCGGCG
GCGATGGAGGGTTCGCAGTG

Downstream 100 bases:

>100_bases
TGGCTTGACCGCGGCATCGGCCAGGTGGCGGCGGCGCATTGTGATGCGTCGCCGCCGCCGCGGTCGGTGTTGCTGCTGTC
GGGTTTCCGGCCGCGATCGA

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MFALNAWAAPRLQLALATALALAGCSLAPRYERPAAPVPASYATVDGDTQQGVGPASTADAALLDDWRAYFTDPALQAWI
DAALANNRDLRIAAGRLDEARALYGVQRADLMPSVDANLGYERTRQYDPVVRESAVSGLYRAGVGVSAYELDLFGRVRNL
SDAALAEYFATADAQRTVRIGVIAEVAGAYVSERSLHEQLVLAQRTLDARERIAALTQRRYAAGTSDAIELRSAEMLVAS
ARASQAALQREHAQSVRALQLLAGDFARGVPADGTALDTLAIAPVAPGAPSALLERRPDIRQAESRLKAANAQIGAARAA
FFPRVALTTDYGSVSDAFSTLFAAGTSVWTFAPRITLPIFAGGRNRANLDVASARKHIAVAEYEKTVQTAFREVADAFAA
RDWIDRQLAAQQDVYAADGARLKLAERRYAGGVATYLELLDAQRSTYESGHELIRLKALRLANAIALYRALGGGWAPATA
GEAAA

Sequences:

>Translated_485_residues
MFALNAWAAPRLQLALATALALAGCSLAPRYERPAAPVPASYATVDGDTQQGVGPASTADAALLDDWRAYFTDPALQAWI
DAALANNRDLRIAAGRLDEARALYGVQRADLMPSVDANLGYERTRQYDPVVRESAVSGLYRAGVGVSAYELDLFGRVRNL
SDAALAEYFATADAQRTVRIGVIAEVAGAYVSERSLHEQLVLAQRTLDARERIAALTQRRYAAGTSDAIELRSAEMLVAS
ARASQAALQREHAQSVRALQLLAGDFARGVPADGTALDTLAIAPVAPGAPSALLERRPDIRQAESRLKAANAQIGAARAA
FFPRVALTTDYGSVSDAFSTLFAAGTSVWTFAPRITLPIFAGGRNRANLDVASARKHIAVAEYEKTVQTAFREVADAFAA
RDWIDRQLAAQQDVYAADGARLKLAERRYAGGVATYLELLDAQRSTYESGHELIRLKALRLANAIALYRALGGGWAPATA
GEAAA
>Mature_485_residues
MFALNAWAAPRLQLALATALALAGCSLAPRYERPAAPVPASYATVDGDTQQGVGPASTADAALLDDWRAYFTDPALQAWI
DAALANNRDLRIAAGRLDEARALYGVQRADLMPSVDANLGYERTRQYDPVVRESAVSGLYRAGVGVSAYELDLFGRVRNL
SDAALAEYFATADAQRTVRIGVIAEVAGAYVSERSLHEQLVLAQRTLDARERIAALTQRRYAAGTSDAIELRSAEMLVAS
ARASQAALQREHAQSVRALQLLAGDFARGVPADGTALDTLAIAPVAPGAPSALLERRPDIRQAESRLKAANAQIGAARAA
FFPRVALTTDYGSVSDAFSTLFAAGTSVWTFAPRITLPIFAGGRNRANLDVASARKHIAVAEYEKTVQTAFREVADAFAA
RDWIDRQLAAQQDVYAADGARLKLAERRYAGGVATYLELLDAQRSTYESGHELIRLKALRLANAIALYRALGGGWAPATA
GEAAA

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=467, Percent_Identity=39.186295503212, Blast_Score=319, Evalue=3e-88,
Organism=Escherichia coli, GI2367348, Length=433, Percent_Identity=25.4041570438799, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51731; Mature: 51731

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALNAWAAPRLQLALATALALAGCSLAPRYERPAAPVPASYATVDGDTQQGVGPASTAD
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCH
AALLDDWRAYFTDPALQAWIDAALANNRDLRIAAGRLDEARALYGVQRADLMPSVDANLG
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
YERTRQYDPVVRESAVSGLYRAGVGVSAYELDLFGRVRNLSDAALAEYFATADAQRTVRI
HHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEE
GVIAEVAGAYVSERSLHEQLVLAQRTLDARERIAALTQRRYAAGTSDAIELRSAEMLVAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ARASQAALQREHAQSVRALQLLAGDFARGVPADGTALDTLAIAPVAPGAPSALLERRPDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEECCCCCCCCHHHHHCCCCH
RQAESRLKAANAQIGAARAAFFPRVALTTDYGSVSDAFSTLFAAGTSVWTFAPRITLPIF
HHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCEEECCCEEEEEE
AGGRNRANLDVASARKHIAVAEYEKTVQTAFREVADAFAARDWIDRQLAAQQDVYAADGA
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCC
RLKLAERRYAGGVATYLELLDAQRSTYESGHELIRLKALRLANAIALYRALGGGWAPATA
EEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GEAAA
CCCCC
>Mature Secondary Structure
MFALNAWAAPRLQLALATALALAGCSLAPRYERPAAPVPASYATVDGDTQQGVGPASTAD
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCH
AALLDDWRAYFTDPALQAWIDAALANNRDLRIAAGRLDEARALYGVQRADLMPSVDANLG
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
YERTRQYDPVVRESAVSGLYRAGVGVSAYELDLFGRVRNLSDAALAEYFATADAQRTVRI
HHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEE
GVIAEVAGAYVSERSLHEQLVLAQRTLDARERIAALTQRRYAAGTSDAIELRSAEMLVAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ARASQAALQREHAQSVRALQLLAGDFARGVPADGTALDTLAIAPVAPGAPSALLERRPDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEEECCCCCCCCHHHHHCCCCH
RQAESRLKAANAQIGAARAAFFPRVALTTDYGSVSDAFSTLFAAGTSVWTFAPRITLPIF
HHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCEEECCCEEEEEE
AGGRNRANLDVASARKHIAVAEYEKTVQTAFREVADAFAARDWIDRQLAAQQDVYAADGA
ECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCC
RLKLAERRYAGGVATYLELLDAQRSTYESGHELIRLKALRLANAIALYRALGGGWAPATA
EEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GEAAA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]