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The map label for this gene is odhL [H]

Identifier: 115351445

GI number: 115351445

Start: 1534293

End: 1535723

Strand: Direct

Name: odhL [H]

Synonym: Bamb_1392

Alternate gene names: 115351445

Gene position: 1534293-1535723 (Clockwise)

Preceding gene: 115351444

Following gene: 115351446

Centisome position: 43.14

GC content: 64.5

Gene sequence:

>1431_bases
ATGTCCAAGGAATTTGACGTCGTCGTGATCGGCGCCGGCCCCGGTGGCTACATCGCCGCGATTCGCGCCGCGCAGCTCGG
CAAGACCGTTGCCTGTATCGAGAAGTGGAAGAACCCGGCCGGCGCGCTGAAGCTCGGCGGCACCTGCCTGAACGTCGGCT
GCATTCCGTCGAAGGCGCTGCTCGCGTCGTCGGAGGAGTTCGAGAACACGTCGCATCACCTGGCCGACCACGGCATCACG
GTCGACGGCGTGAAGATCGACGTCGCGAAGATGCTCGGCCGCAAGGACGCGATCGTCGAGAAGATGACGAGCGGGATCGA
GTTCCTGTTCAAGAAGAACAAGATCACCTGGCTGAAGGGCCATGGCAAGTTCACCGGCAAGACCGACGCCGGTGTGCAGA
TCGAAGTGAGCGGCGAAGGTGAAACCGAAGTCGTCACCGCGAAGAACGTGATCATCGCGACGGGCTCGAAGGCGCGTCAC
CTGCCGAACGTCCCGGTCGACAACAAGATCGTGTCGGACAACGAAGGTGCGCTGACGTTCGAGTCGGTGCCGAAGAAGCT
CGCCGTGATCGGCGCGGGCGTGATCGGCCTCGAGCTCGGCTCGGTGTGGCGTCGCCTCGGTGCCGAAGTGACGGTGCTCG
AAGCGCTGCCGGCGTTCCTCGGCGCGGCCGACGAAGCGCTCGCGAAGGAAGCGGCCAAGCTGTTCAAGAAGCAGGGCCTC
GACATCCATCTCGGCGTGAAGATCGGTGACGTGAAGACGACCGCAGATGGCGTGTCGATCGCTTACACGGACAAGGACGG
CAACGCGCAGACGCTCGACGCCGACCGCCTGATCGTGTCGGTCGGCCGCGTGCCGAACACCGACAACCTCGGCCTCGAGG
CAATCGGCCTGAAGGCGAACGAGCGCGGCTTCATCGACGTGGACGACCACTGCCGTACGGCCGTGCCGAACGTCTACGCG
ATCGGCGACGTGGTGCGCGGCCCGATGCTCGCGCACAAGGCGGAAGACGAAGGCGTGCTGGTCGCGGAAGTGATCGACGG
CCAGAAGCCGCACATCGACTACAACTGCATTCCGTGGGTGATCTACACGTACCCGGAAATCGCCTGGGTCGGCAAGACGG
AGCAGCAGCTGAAGGCCGAAGGCCGCGAGATCAAGTCGGGCAAGTTCCCGTTCTCGATCAACGGTCGCGCGCTCGGCATG
AACGCGCCGGACGGTTTCGTGAAGATGATCGCGGACGCGAAGACCGACGAACTGCTCGGCGTGCATGTGATCGGGGCGAA
CGCGTCGGACCTGATCGCCGAAGCCGTGGTGGCGATGGAGTTCAAGGCGGCGTCGGAAGACATCGCACGCATCTGCCATC
CGCACCCGTCGATGTCGGAAGTGATGCGCGAAGCGGCGCTCGCCGTCGACAAGCGCTCGCTGAACAGCTGA

Upstream 100 bases:

>100_bases
CCTGCTGCTCGATCTGTAAGCCGAGTCTCACTGCATTGACCCGTTCCGCACGCTCGCGCCACCGCGCGCGCGTGCGGACG
TACAAGTAGAAAGGATTGTC

Downstream 100 bases:

>100_bases
GTGCGGTATAGCGGCGGCCGGCCTTTGGTCGGCGTAGCCGTCTCATGACGAAGGCGGGCGGGAGTTTCCCGCTCGCCTTC
GTTTTTTCCGGTTTGCCCGA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSKEFDVVVIGAGPGGYIAAIRAAQLGKTVACIEKWKNPAGALKLGGTCLNVGCIPSKALLASSEEFENTSHHLADHGIT
VDGVKIDVAKMLGRKDAIVEKMTSGIEFLFKKNKITWLKGHGKFTGKTDAGVQIEVSGEGETEVVTAKNVIIATGSKARH
LPNVPVDNKIVSDNEGALTFESVPKKLAVIGAGVIGLELGSVWRRLGAEVTVLEALPAFLGAADEALAKEAAKLFKKQGL
DIHLGVKIGDVKTTADGVSIAYTDKDGNAQTLDADRLIVSVGRVPNTDNLGLEAIGLKANERGFIDVDDHCRTAVPNVYA
IGDVVRGPMLAHKAEDEGVLVAEVIDGQKPHIDYNCIPWVIYTYPEIAWVGKTEQQLKAEGREIKSGKFPFSINGRALGM
NAPDGFVKMIADAKTDELLGVHVIGANASDLIAEAVVAMEFKAASEDIARICHPHPSMSEVMREAALAVDKRSLNS

Sequences:

>Translated_476_residues
MSKEFDVVVIGAGPGGYIAAIRAAQLGKTVACIEKWKNPAGALKLGGTCLNVGCIPSKALLASSEEFENTSHHLADHGIT
VDGVKIDVAKMLGRKDAIVEKMTSGIEFLFKKNKITWLKGHGKFTGKTDAGVQIEVSGEGETEVVTAKNVIIATGSKARH
LPNVPVDNKIVSDNEGALTFESVPKKLAVIGAGVIGLELGSVWRRLGAEVTVLEALPAFLGAADEALAKEAAKLFKKQGL
DIHLGVKIGDVKTTADGVSIAYTDKDGNAQTLDADRLIVSVGRVPNTDNLGLEAIGLKANERGFIDVDDHCRTAVPNVYA
IGDVVRGPMLAHKAEDEGVLVAEVIDGQKPHIDYNCIPWVIYTYPEIAWVGKTEQQLKAEGREIKSGKFPFSINGRALGM
NAPDGFVKMIADAKTDELLGVHVIGANASDLIAEAVVAMEFKAASEDIARICHPHPSMSEVMREAALAVDKRSLNS
>Mature_475_residues
SKEFDVVVIGAGPGGYIAAIRAAQLGKTVACIEKWKNPAGALKLGGTCLNVGCIPSKALLASSEEFENTSHHLADHGITV
DGVKIDVAKMLGRKDAIVEKMTSGIEFLFKKNKITWLKGHGKFTGKTDAGVQIEVSGEGETEVVTAKNVIIATGSKARHL
PNVPVDNKIVSDNEGALTFESVPKKLAVIGAGVIGLELGSVWRRLGAEVTVLEALPAFLGAADEALAKEAAKLFKKQGLD
IHLGVKIGDVKTTADGVSIAYTDKDGNAQTLDADRLIVSVGRVPNTDNLGLEAIGLKANERGFIDVDDHCRTAVPNVYAI
GDVVRGPMLAHKAEDEGVLVAEVIDGQKPHIDYNCIPWVIYTYPEIAWVGKTEQQLKAEGREIKSGKFPFSINGRALGMN
APDGFVKMIADAKTDELLGVHVIGANASDLIAEAVVAMEFKAASEDIARICHPHPSMSEVMREAALAVDKRSLNS

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=477, Percent_Identity=47.5890985324948, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI50301238, Length=470, Percent_Identity=28.7234042553192, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI22035672, Length=474, Percent_Identity=27.8481012658228, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI33519430, Length=468, Percent_Identity=25.2136752136752, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI33519428, Length=468, Percent_Identity=25.2136752136752, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI33519426, Length=468, Percent_Identity=25.2136752136752, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI148277065, Length=468, Percent_Identity=25.2136752136752, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI148277071, Length=468, Percent_Identity=25.2136752136752, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI291045266, Length=479, Percent_Identity=24.4258872651357, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI291045268, Length=474, Percent_Identity=23.2067510548523, Blast_Score=99, Evalue=9e-21,
Organism=Escherichia coli, GI1786307, Length=468, Percent_Identity=38.8888888888889, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI87082354, Length=475, Percent_Identity=31.5789473684211, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1789915, Length=465, Percent_Identity=30.3225806451613, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI87081717, Length=474, Percent_Identity=28.2700421940928, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32565766, Length=469, Percent_Identity=47.9744136460554, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17557007, Length=494, Percent_Identity=28.5425101214575, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71982272, Length=489, Percent_Identity=26.9938650306748, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=464, Percent_Identity=28.0172413793103, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71983419, Length=464, Percent_Identity=28.0172413793103, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17559934, Length=193, Percent_Identity=30.0518134715026, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=46.0580912863071, Blast_Score=412, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=29.979035639413, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=27.906976744186, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21358499, Length=470, Percent_Identity=50, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24640553, Length=490, Percent_Identity=28.3673469387755, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24640549, Length=490, Percent_Identity=28.3673469387755, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24640551, Length=490, Percent_Identity=28.3673469387755, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17737741, Length=489, Percent_Identity=26.7893660531697, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50495; Mature: 50363

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEFDVVVIGAGPGGYIAAIRAAQLGKTVACIEKWKNPAGALKLGGTCLNVGCIPSKAL
CCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCEEECCEEEEECCCCCHHH
LASSEEFENTSHHLADHGITVDGVKIDVAKMLGRKDAIVEKMTSGIEFLFKKNKITWLKG
HCCCHHHCCCHHHHHHCCEEEECEEEEHHHHCCCHHHHHHHHHHHHHEEEECCCEEEEEC
HGKFTGKTDAGVQIEVSGEGETEVVTAKNVIIATGSKARHLPNVPVDNKIVSDNEGALTF
CCEECCCCCCCEEEEECCCCCEEEEEECEEEEECCCCCCCCCCCCCCCEEECCCCCCEEH
ESVPKKLAVIGAGVIGLELGSVWRRLGAEVTVLEALPAFLGAADEALAKEAAKLFKKQGL
HHHCCEEHHHCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHHCCC
DIHLGVKIGDVKTTADGVSIAYTDKDGNAQTLDADRLIVSVGRVPNTDNLGLEAIGLKAN
EEEEEEEECCEEECCCCEEEEEECCCCCCEEECCCEEEEEECCCCCCCCCCEEEEEEECC
ERGFIDVDDHCRTAVPNVYAIGDVVRGPMLAHKAEDEGVLVAEVIDGQKPHIDYNCIPWV
CCCCEECCCCHHHCCCCEEEEHHHHCCCHHEECCCCCCEEEEEECCCCCCCCCCCCCCEE
IYTYPEIAWVGKTEQQLKAEGREIKSGKFPFSINGRALGMNAPDGFVKMIADAKTDELLG
EEECCCEEEECCCHHHHHHCCCCCCCCCCCEEECCEEEECCCCHHHHHHHHCCCCCCEEE
VHVIGANASDLIAEAVVAMEFKAASEDIARICHPHPSMSEVMREAALAVDKRSLNS
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKEFDVVVIGAGPGGYIAAIRAAQLGKTVACIEKWKNPAGALKLGGTCLNVGCIPSKAL
CCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCEEECCEEEEECCCCCHHH
LASSEEFENTSHHLADHGITVDGVKIDVAKMLGRKDAIVEKMTSGIEFLFKKNKITWLKG
HCCCHHHCCCHHHHHHCCEEEECEEEEHHHHCCCHHHHHHHHHHHHHEEEECCCEEEEEC
HGKFTGKTDAGVQIEVSGEGETEVVTAKNVIIATGSKARHLPNVPVDNKIVSDNEGALTF
CCEECCCCCCCEEEEECCCCCEEEEEECEEEEECCCCCCCCCCCCCCCEEECCCCCCEEH
ESVPKKLAVIGAGVIGLELGSVWRRLGAEVTVLEALPAFLGAADEALAKEAAKLFKKQGL
HHHCCEEHHHCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHHCCC
DIHLGVKIGDVKTTADGVSIAYTDKDGNAQTLDADRLIVSVGRVPNTDNLGLEAIGLKAN
EEEEEEEECCEEECCCCEEEEEECCCCCCEEECCCEEEEEECCCCCCCCCCEEEEEEECC
ERGFIDVDDHCRTAVPNVYAIGDVVRGPMLAHKAEDEGVLVAEVIDGQKPHIDYNCIPWV
CCCCEECCCCHHHCCCCEEEEHHHHCCCHHEECCCCCCEEEEEECCCCCCCCCCCCCCEE
IYTYPEIAWVGKTEQQLKAEGREIKSGKFPFSINGRALGMNAPDGFVKMIADAKTDELLG
EEECCCEEEECCCHHHHHHCCCCCCCCCCCEEECCEEEECCCCHHHHHHHHCCCCCCEEE
VHVIGANASDLIAEAVVAMEFKAASEDIARICHPHPSMSEVMREAALAVDKRSLNS
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8867378 [H]