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The map label for this gene is aphA [H]

Identifier: 115351186

GI number: 115351186

Start: 1243719

End: 1244741

Strand: Direct

Name: aphA [H]

Synonym: Bamb_1133

Alternate gene names: 115351186

Gene position: 1243719-1244741 (Clockwise)

Preceding gene: 115351185

Following gene: 115351189

Centisome position: 34.97

GC content: 70.09

Gene sequence:

>1023_bases
ATGAAAACCTATTTCCACCCCGAACAGTTGCTGCACCATCCGCGGACCTACCTGTCGCGCGGCAGGATGCGCGAGCCACA
GGAAGTGCCCGAGCGCGCGGCGCGGCTGGTCGCGGCCGTGCGTTCGCTCGACTTCGACGTGCGCGAGCCGGCCGACCGCG
GCACCGCGCCGATCGCGGCCGTGCACGACATGAACTACCTGCGTTTTCTGGAGGAAGCGCACCGCGACTGGAAACGGATG
CCCGACGACTGGGGCGACGAAGTGATGTCGAACGTGTTCGTGCGCGATCCGAATCCGCTGCGCGGCGTGCTCGCGAAAGC
CGCGCGCTATCTCGCAGACGGCAGCTGTCCGGTCGGCGCGAACACGTGGTGCGCCGCGTACTGGTCCGCACAGAGCGCGC
TCGCGGCCGCGGCGGACGTCAACGACGGCGCGCGCGACGCGTACGCGCTGTGCCGCCCGCCCGGCCATCACGCGCGCCGC
GATGCGGCCGGCGGCTTCTGTTACCTGAACAACGCGGCGATCGCCGCGCAGGCGCTGCTCGGCCGCCATTGGCGCGTCGC
GATCCTCGACACCGACATGCATCACGGGCAGGGCGTGCAGGAAATCTTCTACGGCCGCGACGACGTGCTGTACGTGTCGA
TCCACGGCGACCCGACCAATTTCTATCCGGTCGTCGCCGGCTACGAGGAAGAGACGGGCGCGGGGCCCGGCGACGGCTAC
AACCTGAACCTGCCGATGCCGCACGGCGCGCCCGAGTCGACCTTCTTCGAGCGGCTCGACGACGCGCTGCGCGCGCTCGC
GCGGTTCCAGCCGGAGGCGCTCGTGCTCGCGCTCGGCTTCGACATCTACAAGGACGACCCGCAATCGCAGGTGGCCGTCA
CGACCGACGGGTTCGGCCGGCTCGGCGGCGCGATCGGCGCGCTCGGCTTGCCGACGGTGATCGTGCAGGAGGGCGGCTAT
CACCTCGAGAGCCTCGATGCGAATGCGCGTGCATTCTTCGGCGGGTTCGCCGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
CTGCTCAACGCGGTGCTCGCGCGGGCGGGCGTCGCGACGCGCGTGGCTGCAGCGGCAGCCGCGCACGATGCATGACGCGA
CGAATCGACGAGGACCGACG

Downstream 100 bases:

>100_bases
TACGTCGACATGGCGGCCGCGATGCGCGGCCCATCAGCGACAACGCCCGCGTCGGCATCCCGGCGCGGGCGTTGTTCAAT
TGGGCGCCGCGTATCGGCAC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKTYFHPEQLLHHPRTYLSRGRMREPQEVPERAARLVAAVRSLDFDVREPADRGTAPIAAVHDMNYLRFLEEAHRDWKRM
PDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVGANTWCAAYWSAQSALAAAADVNDGARDAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALLGRHWRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGAGPGDGY
NLNLPMPHGAPESTFFERLDDALRALARFQPEALVLALGFDIYKDDPQSQVAVTTDGFGRLGGAIGALGLPTVIVQEGGY
HLESLDANARAFFGGFAAAR

Sequences:

>Translated_340_residues
MKTYFHPEQLLHHPRTYLSRGRMREPQEVPERAARLVAAVRSLDFDVREPADRGTAPIAAVHDMNYLRFLEEAHRDWKRM
PDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVGANTWCAAYWSAQSALAAAADVNDGARDAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALLGRHWRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGAGPGDGY
NLNLPMPHGAPESTFFERLDDALRALARFQPEALVLALGFDIYKDDPQSQVAVTTDGFGRLGGAIGALGLPTVIVQEGGY
HLESLDANARAFFGGFAAAR
>Mature_340_residues
MKTYFHPEQLLHHPRTYLSRGRMREPQEVPERAARLVAAVRSLDFDVREPADRGTAPIAAVHDMNYLRFLEEAHRDWKRM
PDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVGANTWCAAYWSAQSALAAAADVNDGARDAYALCRPPGHHARR
DAAGGFCYLNNAAIAAQALLGRHWRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGAGPGDGY
NLNLPMPHGAPESTFFERLDDALRALARFQPEALVLALGFDIYKDDPQSQVAVTTDGFGRLGGAIGALGLPTVIVQEGGY
HLESLDANARAFFGGFAAAR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=240, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI20070354, Length=213, Percent_Identity=37.5586854460094, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI8923769, Length=309, Percent_Identity=26.2135922330097, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI17158039, Length=229, Percent_Identity=32.7510917030568, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI13128860, Length=230, Percent_Identity=28.695652173913, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI30795204, Length=215, Percent_Identity=33.4883720930233, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI30795202, Length=215, Percent_Identity=33.4883720930233, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI148539870, Length=230, Percent_Identity=33.4782608695652, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI169234807, Length=230, Percent_Identity=33.4782608695652, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI13128862, Length=232, Percent_Identity=30.1724137931034, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI262073088, Length=178, Percent_Identity=34.2696629213483, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI153085395, Length=263, Percent_Identity=30.7984790874525, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI293336691, Length=205, Percent_Identity=29.7560975609756, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI62750347, Length=193, Percent_Identity=37.3056994818653, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI62750349, Length=193, Percent_Identity=37.3056994818653, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI226529806, Length=216, Percent_Identity=34.2592592592593, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI262073092, Length=259, Percent_Identity=23.9382239382239, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=198, Percent_Identity=38.8888888888889, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI193206283, Length=198, Percent_Identity=38.8888888888889, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17540332, Length=198, Percent_Identity=38.8888888888889, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17508561, Length=311, Percent_Identity=29.5819935691318, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17561978, Length=238, Percent_Identity=30.672268907563, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17534739, Length=212, Percent_Identity=31.1320754716981, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17537347, Length=228, Percent_Identity=32.8947368421053, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI193209491, Length=249, Percent_Identity=30.5220883534137, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25154022, Length=236, Percent_Identity=25.8474576271186, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25154020, Length=236, Percent_Identity=25.8474576271186, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=215, Percent_Identity=33.953488372093, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323999, Length=243, Percent_Identity=28.8065843621399, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6321244, Length=208, Percent_Identity=28.8461538461538, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325325, Length=149, Percent_Identity=26.8456375838926, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644244, Length=274, Percent_Identity=32.1167883211679, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24642142, Length=310, Percent_Identity=29.6774193548387, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI281360899, Length=310, Percent_Identity=29.6774193548387, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24642146, Length=310, Percent_Identity=29.6774193548387, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24642144, Length=310, Percent_Identity=29.6774193548387, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24657891, Length=236, Percent_Identity=31.7796610169492, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI281360801, Length=265, Percent_Identity=33.5849056603774, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24641720, Length=265, Percent_Identity=33.5849056603774, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360799, Length=265, Percent_Identity=33.5849056603774, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37234; Mature: 37234

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYFHPEQLLHHPRTYLSRGRMREPQEVPERAARLVAAVRSLDFDVREPADRGTAPIAA
CCCCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEH
VHDMNYLRFLEEAHRDWKRMPDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVGA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
NTWCAAYWSAQSALAAAADVNDGARDAYALCRPPGHHARRDAAGGFCYLNNAAIAAQALL
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHCCCCCEEEECCHHHHHHHHH
GRHWRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGAGPGDGY
CCCEEEEEEECCCCCCCCHHHHHCCCCCEEEEEEECCCCCCEEEEECCCHHCCCCCCCCE
NLNLPMPHGAPESTFFERLDDALRALARFQPEALVLALGFDIYKDDPQSQVAVTTDGFGR
EEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEEEEECCCHH
LGGAIGALGLPTVIVQEGGYHLESLDANARAFFGGFAAAR
HHHHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKTYFHPEQLLHHPRTYLSRGRMREPQEVPERAARLVAAVRSLDFDVREPADRGTAPIAA
CCCCCCHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEH
VHDMNYLRFLEEAHRDWKRMPDDWGDEVMSNVFVRDPNPLRGVLAKAARYLADGSCPVGA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
NTWCAAYWSAQSALAAAADVNDGARDAYALCRPPGHHARRDAAGGFCYLNNAAIAAQALL
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHCCCCCEEEECCHHHHHHHHH
GRHWRVAILDTDMHHGQGVQEIFYGRDDVLYVSIHGDPTNFYPVVAGYEEETGAGPGDGY
CCCEEEEEEECCCCCCCCHHHHHCCCCCEEEEEEECCCCCCEEEEECCCHHCCCCCCCCE
NLNLPMPHGAPESTFFERLDDALRALARFQPEALVLALGFDIYKDDPQSQVAVTTDGFGR
EEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCCEEEEEECCCHH
LGGAIGALGLPTVIVQEGGYHLESLDANARAFFGGFAAAR
HHHHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]