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The map label for this gene is gmk

Identifier: 115350913

GI number: 115350913

Start: 943916

End: 944599

Strand: Direct

Name: gmk

Synonym: Bamb_0859

Alternate gene names: 115350913

Gene position: 943916-944599 (Clockwise)

Preceding gene: 115350912

Following gene: 115350914

Centisome position: 26.54

GC content: 64.77

Gene sequence:

>684_bases
ATGACCGAATTCACCCGCGACGGCCACGCGTCGCATGCGCTGCACGGCGGCGTCTATCCCGGCAACCTGTTCATGGTCAT
CGCACCGTCGGGCGCCGGCAAGTCGACGCTCGTGAACGCGCTGCTGTCGAAGGACAGCGACATCTGTCTGTCGATTTCGT
ACACGACCCGCAAGCCGCGCCCGGGCGAGCAGGACGGCCAGCACTACCACTTCACGACCGTCGAGGATTTCCGCGCGCGC
CACGCCGCGCACGAATTCCTCGAGAGCGCGGAAGTGCACGGCAACTACTACGGCACGTCGCGCGTCTGGATCGAAGAGCA
GATGATGAACGGCCACGACGTGCTGCTCGAGATCGACTGGCAGGGCGCGCAGCAGGTGAAGAAGCAGTTCCGCAACGCGG
TCGGCATCTTCATTCTGCCGCCGTCGCTCGATGCGCTCGAGGAGCGCCTGAAGAAGCGCGGGCAGGACGAGCCGAACGTG
ATCACGCGACGCCTGCTCGCCGCGGGCAGCGAGATGGCGCACGCATCCGAGGCGGAATACGTCGTGATCAACGAGAATTT
CGATCGTGCGCTGGCCGAGCTCGAATGCATCGTCACGGCAACGCGCCTGCGCTTTGCTTCGCAGTACGCGCGACACACGG
AGCTGTTCATCGAGCTCGGCATCCATCTGCCCCACGCGGAATGA

Upstream 100 bases:

>100_bases
AGTGCAAAACCTGGAGTAAAGAGATGAAACAACCGTCACTACGTTTGCTGTCCCTCGACGGGGCGGCGAGTGTTATCGGG
GCGGCACGGCGGAGGCTGAC

Downstream 100 bases:

>100_bases
CGCGAGGGTAGAGGGACATAAGGTAGAATAAGGACTATATTCAGAAGGAATTACCAACATGGCTCGCATTACTGTCGAAG
ACTGCCTGAAGCAAATCCCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTEFTRDGHASHALHGGVYPGNLFMVIAPSGAGKSTLVNALLSKDSDICLSISYTTRKPRPGEQDGQHYHFTTVEDFRAR
HAAHEFLESAEVHGNYYGTSRVWIEEQMMNGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNV
ITRRLLAAGSEMAHASEAEYVVINENFDRALAELECIVTATRLRFASQYARHTELFIELGIHLPHAE

Sequences:

>Translated_227_residues
MTEFTRDGHASHALHGGVYPGNLFMVIAPSGAGKSTLVNALLSKDSDICLSISYTTRKPRPGEQDGQHYHFTTVEDFRAR
HAAHEFLESAEVHGNYYGTSRVWIEEQMMNGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNV
ITRRLLAAGSEMAHASEAEYVVINENFDRALAELECIVTATRLRFASQYARHTELFIELGIHLPHAE
>Mature_226_residues
TEFTRDGHASHALHGGVYPGNLFMVIAPSGAGKSTLVNALLSKDSDICLSISYTTRKPRPGEQDGQHYHFTTVEDFRARH
AAHEFLESAEVHGNYYGTSRVWIEEQMMNGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNVI
TRRLLAAGSEMAHASEAEYVVINENFDRALAELECIVTATRLRFASQYARHTELFIELGIHLPHAE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=172, Percent_Identity=40.6976744186046, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4504221, Length=172, Percent_Identity=40.6976744186046, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI226874831, Length=172, Percent_Identity=40.6976744186046, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=28.735632183908, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI262118259, Length=173, Percent_Identity=28.9017341040462, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4505237, Length=173, Percent_Identity=28.9017341040462, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI262118255, Length=173, Percent_Identity=28.9017341040462, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI262118263, Length=173, Percent_Identity=28.9017341040462, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI21361598, Length=198, Percent_Identity=25.2525252525253, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=49.2537313432836, Blast_Score=202, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=35, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=35, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=37.3626373626374, Blast_Score=129, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21356141, Length=158, Percent_Identity=41.7721518987342, Blast_Score=121, Evalue=4e-28,
Organism=Drosophila melanogaster, GI45554481, Length=184, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640542, Length=177, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45554489, Length=177, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI85724806, Length=177, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007136, Length=177, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161077626, Length=177, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25511; Mature: 25380

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFTRDGHASHALHGGVYPGNLFMVIAPSGAGKSTLVNALLSKDSDICLSISYTTRKPR
CCCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCC
PGEQDGQHYHFTTVEDFRARHAAHEFLESAEVHGNYYGTSRVWIEEQMMNGHDVLLEIDW
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCEECCEEEEEEHHHCCCCEEEEEEEC
QGAQQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNVITRRLLAAGSEMAHASEAEY
CCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCE
VVINENFDRALAELECIVTATRLRFASQYARHTELFIELGIHLPHAE
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
>Mature Secondary Structure 
TEFTRDGHASHALHGGVYPGNLFMVIAPSGAGKSTLVNALLSKDSDICLSISYTTRKPR
CCCCCCCCCCHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCC
PGEQDGQHYHFTTVEDFRARHAAHEFLESAEVHGNYYGTSRVWIEEQMMNGHDVLLEIDW
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCEECCEEEEEEHHHCCCCEEEEEEEC
QGAQQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNVITRRLLAAGSEMAHASEAEY
CCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCE
VVINENFDRALAELECIVTATRLRFASQYARHTELFIELGIHLPHAE
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA