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The map label for this gene is bcr [H]

Identifier: 115350878

GI number: 115350878

Start: 908155

End: 909459

Strand: Direct

Name: bcr [H]

Synonym: Bamb_0824

Alternate gene names: 115350878

Gene position: 908155-909459 (Clockwise)

Preceding gene: 115350868

Following gene: 115350882

Centisome position: 25.53

GC content: 71.03

Gene sequence:

>1305_bases
ATGGGCCTGAGCGCCGTCCGCGGCGCGGCCTCCCGTCTTCACCGCCACGCGCGCCCCGATGCGCGCGGGCCTCCATTCCG
GATACCCATGTCCCACGTCGTCCGGCGCCGGCCCGATGCCCGGCTGATCCTGTTGCTCGGCGCGCTCGCCGCCTGCGGGC
CGATTGCCACCGACATGTACCTGCCGAGCCTGCCGTCGATCGCCGACGGCTTCTCCGTGAGCCCCGGCGCCGCGCAGCGC
ACGCTGACGAGCTTCATGGCCGGCTTCTCGATCGGCATGCTGCTGTACGGTCCGCTGTCCGATACGTGGGGCCGCCGCCC
GGTGCTGCTCGGCGGCATCGCACTGTTCACGCTCGCGAGCATCGGCTGCTTCGTGTCGGGCTCGATCGACATGCTGATCA
TCGTGCGCTTCCTGCAGGCGCTCGGCGCGGGCGCCGCGTCGGTGCTCGCCCGCGCGATCGCGCGCGACGCGCACGAGCCG
ACCGACGCGGCGAAGGTGCTGTCGATGGTCGCGATCGTCACCGCGGTCGGGCCGCTGCTCGCGCCGCTGATCGGCGGGCA
GATCCTGCGCTTCGCCGGCTGGCGCGGCGTGTTCGTCGTGCTGGCCGCGTTCGGCGCACTGTGCGCGGCGACCGCGTACC
TGCGCGTGCCCGAAACCTGGCCGAAGGAGCGGCGCAAGAGCGCGGCCGTGCTTGCATCGTTCGCGTCGTACGGGCGCATC
CTGTCCGATCCGGTCGCGTGGGGGCACATGCTGTGCGGCGGGATGGCGTTCGCGGCGATGTTCTCGTACATCACCGCGAC
GCCGTTCGTGTACATCGAGTATTTCCACGTGTCACCGCAGCACTACGGGCTGCTGTTCGGGCTGAACGTCGTCGGGATCA
TGATCGGCAACTTCGCGAACACGCGGCTCGTCGGCCGCATTGGCTCGCTGCGCCTCATTGCCGCCGCGTCGCTGGTGAGC
TGCATCGCGTCGCTCGCGGTCGCGCTCGTCGCGCTGACGGGGTGGGGCGGGCTGTGGTCGATCGTCGTGTGCCTGTTCTT
CGTGGTCGGCGTGGTCGGGATCCTGTCCGCGAACTGCACGACCGACCTGATGCATCGCTACCCGCACAACGCGGGCGCGT
CGGCGGCCGTGTTCGGTGCGATGCAGCTCGCGCTCGGCGCGCTCGCGAGCGTGGCGATCGGCGCACTCGCGGATGGCACG
CCGTTCGCGATGGGCGTGACGATCGGTGTGTCGGGCGTGCTGTGTTTCGCCGGGCGCTACCTTGTGCTGCGCTGGCATGG
CCGGCCGGTGAAAGCGGGGGCGTGA

Upstream 100 bases:

>100_bases
GAATCCACACGCGAACTCGTGCGACACCGATCGTGCGGGCGCTTTCCGGCCATGCGCGTCACACGCGCCGCCGGCACGCA
AAAAAGTTGCGCGTACAATC

Downstream 100 bases:

>100_bases
GCGGAGGCCGCAATGACCGCGGCATGAAAAAACGCCACCGCGCGATGCGTCGGTGGCGTTTTTTTTCGGGCGGTCGGAAA
GTGGCGAGCGCCTGACCGTG

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MGLSAVRGAASRLHRHARPDARGPPFRIPMSHVVRRRPDARLILLLGALAACGPIATDMYLPSLPSIADGFSVSPGAAQR
TLTSFMAGFSIGMLLYGPLSDTWGRRPVLLGGIALFTLASIGCFVSGSIDMLIIVRFLQALGAGAASVLARAIARDAHEP
TDAAKVLSMVAIVTAVGPLLAPLIGGQILRFAGWRGVFVVLAAFGALCAATAYLRVPETWPKERRKSAAVLASFASYGRI
LSDPVAWGHMLCGGMAFAAMFSYITATPFVYIEYFHVSPQHYGLLFGLNVVGIMIGNFANTRLVGRIGSLRLIAAASLVS
CIASLAVALVALTGWGGLWSIVVCLFFVVGVVGILSANCTTDLMHRYPHNAGASAAVFGAMQLALGALASVAIGALADGT
PFAMGVTIGVSGVLCFAGRYLVLRWHGRPVKAGA

Sequences:

>Translated_434_residues
MGLSAVRGAASRLHRHARPDARGPPFRIPMSHVVRRRPDARLILLLGALAACGPIATDMYLPSLPSIADGFSVSPGAAQR
TLTSFMAGFSIGMLLYGPLSDTWGRRPVLLGGIALFTLASIGCFVSGSIDMLIIVRFLQALGAGAASVLARAIARDAHEP
TDAAKVLSMVAIVTAVGPLLAPLIGGQILRFAGWRGVFVVLAAFGALCAATAYLRVPETWPKERRKSAAVLASFASYGRI
LSDPVAWGHMLCGGMAFAAMFSYITATPFVYIEYFHVSPQHYGLLFGLNVVGIMIGNFANTRLVGRIGSLRLIAAASLVS
CIASLAVALVALTGWGGLWSIVVCLFFVVGVVGILSANCTTDLMHRYPHNAGASAAVFGAMQLALGALASVAIGALADGT
PFAMGVTIGVSGVLCFAGRYLVLRWHGRPVKAGA
>Mature_433_residues
GLSAVRGAASRLHRHARPDARGPPFRIPMSHVVRRRPDARLILLLGALAACGPIATDMYLPSLPSIADGFSVSPGAAQRT
LTSFMAGFSIGMLLYGPLSDTWGRRPVLLGGIALFTLASIGCFVSGSIDMLIIVRFLQALGAGAASVLARAIARDAHEPT
DAAKVLSMVAIVTAVGPLLAPLIGGQILRFAGWRGVFVVLAAFGALCAATAYLRVPETWPKERRKSAAVLASFASYGRIL
SDPVAWGHMLCGGMAFAAMFSYITATPFVYIEYFHVSPQHYGLLFGLNVVGIMIGNFANTRLVGRIGSLRLIAAASLVSC
IASLAVALVALTGWGGLWSIVVCLFFVVGVVGILSANCTTDLMHRYPHNAGASAAVFGAMQLALGALASVAIGALADGTP
FAMGVTIGVSGVLCFAGRYLVLRWHGRPVKAGA

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=397, Percent_Identity=34.5088161209068, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI48994889, Length=396, Percent_Identity=27.7777777777778, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI87082312, Length=349, Percent_Identity=29.2263610315186, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790146, Length=257, Percent_Identity=28.0155642023346, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787065, Length=257, Percent_Identity=26.8482490272374, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1790794, Length=223, Percent_Identity=25.1121076233184, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790195, Length=163, Percent_Identity=29.4478527607362, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322071, Length=215, Percent_Identity=26.046511627907, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319657, Length=198, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324264, Length=178, Percent_Identity=24.1573033707865, Blast_Score=63, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45234; Mature: 45103

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEEEECCCCCCCCC
>Mature Secondary Structure 
GLSAVRGAASRLHRHARPDARGPPFRIPMSHVVRRRPDARLILLLGALAACGPIATDMY
CCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHH
LPSLPSIADGFSVSPGAAQRTLTSFMAGFSIGMLLYGPLSDTWGRRPVLLGGIALFTLAS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHH
IGCFVSGSIDMLIIVRFLQALGAGAASVLARAIARDAHEPTDAAKVLSMVAIVTAVGPLL
HHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
APLIGGQILRFAGWRGVFVVLAAFGALCAATAYLRVPETWPKERRKSAAVLASFASYGRI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LSDPVAWGHMLCGGMAFAAMFSYITATPFVYIEYFHVSPQHYGLLFGLNVVGIMIGNFAN
HCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCC
TRLVGRIGSLRLIAAASLVSCIASLAVALVALTGWGGLWSIVVCLFFVVGVVGILSANCT
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCH
TDLMHRYPHNAGASAAVFGAMQLALGALASVAIGALADGTPFAMGVTIGVSGVLCFAGRY
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHCCCE
LVLRWHGRPVKAGA
EEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]