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The map label for this gene is rfbB [H]

Identifier: 115350805

GI number: 115350805

Start: 833080

End: 834141

Strand: Direct

Name: rfbB [H]

Synonym: Bamb_0751

Alternate gene names: 115350805

Gene position: 833080-834141 (Clockwise)

Preceding gene: 115350804

Following gene: 115350806

Centisome position: 23.42

GC content: 61.86

Gene sequence:

>1062_bases
ATGATCCTGGTGACGGGGGGGGCGGGTTTCATCGGCGCCAACTTTGTTCTCGATTGGCTGCGCCACGACGTCGAGCCCGT
GCTCAATGTCGACAAGCTGACCTATGCGGGCAATCTGCGCACGCTGCAGTCGCTCAGCGGCAATCCGAAGCACGTGTTTG
CGCGTGTCGATATTTGCGATCGGGCCGCGCTCGACGCACTGTTTGCCGAGCACAAGCCGCGCGCCGTCGCGCACTTCGCA
GCCGAGAGTCACGTTGATCGTTCGATTCATGGTCCTGCCGATTTCGTGCAGACCAACGTCGTCGGCACGTTTACGTTGCT
CGAGGCGGCGCGCTCGTACTGGAGCGGGTTGAACGATGCCGACAAGGCCGGATTTCGCTTCCTGCACGTGTCGACCGACG
AGGTATTCGGCTCGCTGTCCCCGACCGATCCGCAATTCTCCGAAACGACGCCGTACGCGCCGAACAGCCCGTACTCGGCA
ACGAAGGCCGGCTCCGATCATCTCGTGCGCGCCTATCACCATACCTACGGCTTGCCGACGCTGACGACGAATTGCTCGAA
CAACTACGGCCCATATCAGTTTCCCGAGAAGCTGATTCCGCTCATGATTGCGAACGCACTTGCGGGCAAGCCTCTGCCGA
TCTACGGCGACGGCCAGAACGTGCGCGACTGGCTGTACGTCGGTGATCATTGCAGTGCGATCCGCGAGGTGCTTGCGCGC
GGCGTGCCCGGCGAGACATACAACGTCGGCGGCTGGAACGAGAAAAAGAATCTCGACGTCGTGCATACGCTATGCGACCT
GCTCGACAGCGCGAGTCCGAAGGCGGCGGGTTCGTACCGCGACCAGATTACCTATGTGACGGATCGTCCCGGTCACGACC
GCCGCTACGCGATCGACGCGCGCAAGCTCGAGCGCGAACTGGGGTGGAAGCCGGCAGAGACGTTCGAGACGGGCCTGGCG
AAGACTGTCCGCTGGTATCTCGATAATCAGGCGTGGGTTGACGACGTCGTGTCGGGCGAATATCGCAACTGGGTCGAGAC
GAATTACGCGCAACGCACTTGA

Upstream 100 bases:

>100_bases
TAAAATCCGGGGCCTGACGTGGCTCGGGCGTTGCCGCCCGTGATATGTCATGCGATGAGCGCCCGCCCGGGCGGGGCCGC
ACATTTCTAAAGGAAGTCTC

Downstream 100 bases:

>100_bases
GGGCATGGTCGATGGCACGTAAAGGCATCATTCTCGCGGGCGGCTCCGGCACGCGGCTGTATCCGATCACGCACGTCGTG
TCGAAACAGCTGCTGCCGGT

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MILVTGGAGFIGANFVLDWLRHDVEPVLNVDKLTYAGNLRTLQSLSGNPKHVFARVDICDRAALDALFAEHKPRAVAHFA
AESHVDRSIHGPADFVQTNVVGTFTLLEAARSYWSGLNDADKAGFRFLHVSTDEVFGSLSPTDPQFSETTPYAPNSPYSA
TKAGSDHLVRAYHHTYGLPTLTTNCSNNYGPYQFPEKLIPLMIANALAGKPLPIYGDGQNVRDWLYVGDHCSAIREVLAR
GVPGETYNVGGWNEKKNLDVVHTLCDLLDSASPKAAGSYRDQITYVTDRPGHDRRYAIDARKLERELGWKPAETFETGLA
KTVRWYLDNQAWVDDVVSGEYRNWVETNYAQRT

Sequences:

>Translated_353_residues
MILVTGGAGFIGANFVLDWLRHDVEPVLNVDKLTYAGNLRTLQSLSGNPKHVFARVDICDRAALDALFAEHKPRAVAHFA
AESHVDRSIHGPADFVQTNVVGTFTLLEAARSYWSGLNDADKAGFRFLHVSTDEVFGSLSPTDPQFSETTPYAPNSPYSA
TKAGSDHLVRAYHHTYGLPTLTTNCSNNYGPYQFPEKLIPLMIANALAGKPLPIYGDGQNVRDWLYVGDHCSAIREVLAR
GVPGETYNVGGWNEKKNLDVVHTLCDLLDSASPKAAGSYRDQITYVTDRPGHDRRYAIDARKLERELGWKPAETFETGLA
KTVRWYLDNQAWVDDVVSGEYRNWVETNYAQRT
>Mature_353_residues
MILVTGGAGFIGANFVLDWLRHDVEPVLNVDKLTYAGNLRTLQSLSGNPKHVFARVDICDRAALDALFAEHKPRAVAHFA
AESHVDRSIHGPADFVQTNVVGTFTLLEAARSYWSGLNDADKAGFRFLHVSTDEVFGSLSPTDPQFSETTPYAPNSPYSA
TKAGSDHLVRAYHHTYGLPTLTTNCSNNYGPYQFPEKLIPLMIANALAGKPLPIYGDGQNVRDWLYVGDHCSAIREVLAR
GVPGETYNVGGWNEKKNLDVVHTLCDLLDSASPKAAGSYRDQITYVTDRPGHDRRYAIDARKLERELGWKPAETFETGLA
KTVRWYLDNQAWVDDVVSGEYRNWVETNYAQRT

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=329, Percent_Identity=34.9544072948328, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI42516563, Length=330, Percent_Identity=24.8484848484848, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI56237023, Length=365, Percent_Identity=27.6712328767123, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI56118217, Length=365, Percent_Identity=27.6712328767123, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI189083684, Length=365, Percent_Identity=27.6712328767123, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI4504031, Length=343, Percent_Identity=24.7813411078717, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788353, Length=359, Percent_Identity=62.6740947075209, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI48994969, Length=344, Percent_Identity=62.2093023255814, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1786974, Length=354, Percent_Identity=27.9661016949153, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788366, Length=301, Percent_Identity=26.578073089701, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17568069, Length=332, Percent_Identity=35.5421686746988, Blast_Score=200, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI115532424, Length=330, Percent_Identity=33.6363636363636, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71982035, Length=372, Percent_Identity=27.1505376344086, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17539532, Length=335, Percent_Identity=23.8805970149254, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI133901786, Length=277, Percent_Identity=25.6317689530686, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539422, Length=277, Percent_Identity=25.6317689530686, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI133901788, Length=277, Percent_Identity=25.6317689530686, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI133901790, Length=277, Percent_Identity=25.6317689530686, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=277, Percent_Identity=25.6317689530686, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17507723, Length=334, Percent_Identity=23.6526946107784, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=363, Percent_Identity=26.7217630853994, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI19923002, Length=364, Percent_Identity=30.2197802197802, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21356223, Length=340, Percent_Identity=25.8823529411765, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24158427, Length=335, Percent_Identity=26.865671641791, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 39219; Mature: 39219

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVTGGAGFIGANFVLDWLRHDVEPVLNVDKLTYAGNLRTLQSLSGNPKHVFARVDICD
CEEEECCCCHHHHHHHHHHHHHCHHHHCCHHHEEECCCHHHHHHCCCCCCEEEEEECHHH
RAALDALFAEHKPRAVAHFAAESHVDRSIHGPADFVQTNVVGTFTLLEAARSYWSGLNDA
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DKAGFRFLHVSTDEVFGSLSPTDPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPT
CCCCEEEEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
LTTNCSNNYGPYQFPEKLIPLMIANALAGKPLPIYGDGQNVRDWLYVGDHCSAIREVLAR
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHEEECHHHHHHHHHHHC
GVPGETYNVGGWNEKKNLDVVHTLCDLLDSASPKAAGSYRDQITYVTDRPGHDRRYAIDA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEHHH
RKLERELGWKPAETFETGLAKTVRWYLDNQAWVDDVVSGEYRNWVETNYAQRT
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MILVTGGAGFIGANFVLDWLRHDVEPVLNVDKLTYAGNLRTLQSLSGNPKHVFARVDICD
CEEEECCCCHHHHHHHHHHHHHCHHHHCCHHHEEECCCHHHHHHCCCCCCEEEEEECHHH
RAALDALFAEHKPRAVAHFAAESHVDRSIHGPADFVQTNVVGTFTLLEAARSYWSGLNDA
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DKAGFRFLHVSTDEVFGSLSPTDPQFSETTPYAPNSPYSATKAGSDHLVRAYHHTYGLPT
CCCCEEEEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
LTTNCSNNYGPYQFPEKLIPLMIANALAGKPLPIYGDGQNVRDWLYVGDHCSAIREVLAR
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCHHEEECHHHHHHHHHHHC
GVPGETYNVGGWNEKKNLDVVHTLCDLLDSASPKAAGSYRDQITYVTDRPGHDRRYAIDA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEHHH
RKLERELGWKPAETFETGLAKTVRWYLDNQAWVDDVVSGEYRNWVETNYAQRT
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1710759; 11677609; 11796113 [H]