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The map label for this gene is pyrC' [H]

Identifier: 115350795

GI number: 115350795

Start: 820254

End: 821540

Strand: Direct

Name: pyrC' [H]

Synonym: Bamb_0741

Alternate gene names: 115350795

Gene position: 820254-821540 (Clockwise)

Preceding gene: 115350794

Following gene: 115350796

Centisome position: 23.06

GC content: 71.72

Gene sequence:

>1287_bases
ATGAAGATTCATATCCAAGGCGGCACGCTGATCGATCCGGTCGCCGGCACCGAGCGGCAGGCCGACGTATTCGTCGCGGA
CGGCAAGATCGCCGCGCTCGCGCCGGCCGGTACAGCGCCGGCCGGTTTCAACGCGGAGAAGACGATCGACGCGTCGGGCC
TGATCGTCGCCCCCGGCCTCGTCGACCTGTGCGCGCGGCTGCGCGAGCCCGGCTACGAGCACAAGGCGACGCTCGCGTCC
GAGATGGCCGCGGCCGTCGCGGGCGGCGTCACGACCCTCGTGTGCCCGCCGGACACCGACCCCGTGCTCGACGAGCCGGG
CCTCGTCGAGATGCTCAAGTTCCGCGCGCGCAACCTGCACCAGGCGAACGTCCATCCGCTCGGCGCGCTCACCGTCGGCC
TGAAGGGCGAGGTGATCACCGAGATGGTCGCGCTGACCGAATCGGGCTGCGTCGGCTTCACGCACGCGAACGTGCCGGTG
CGCGACACGCAGGTGCTGCTGCGCGCGCTGCAGTACGCGAGCACCTACGGCTACACGACGTGGCTGCGTCCGCTCGACGC
GTTCATCGGCCGTGGCGGCGTCGCCGCGAGCGGCGCGCTCGCGTCGCGGCTCGGGCTGTCCGGCGTGCCGGTCGCGGCCG
AGACGATCGCACTGCACACGATCTTCGAACTGATGCGCGTGACCGGGGCGCGCGTGCACCTCGCGCGCCTGTCGTCGGCG
GCCGGCCTTGCGCTCGTGCGCGAGGCGAAGGCCGAGGGGCTGCCCGTGACGTGCGACGTCGGCGTGAATCATCTGCACCT
GATCGACATCGACATCGGCTACTTCGATTCGCAGTTCCGGCTCGACCCGCCGCTGCGCGGCGAGCGCGACCGCGAAGCGA
TCCGCGCAGCCCTCGCCGACGGCACGATCGACGCGATCTGCTCCGATCACACGCCGGTCGACGACGACGAGAAGCTGCTG
CCGTTCGCCGAAGCGACGCCCGGTGCGACGGGGCTTGAACTGCTGCTGTCGCTCACGGTGAAGTGGGCCGATGAAACGAA
CACGCCGCTTGCGCAGGCGCTGCGCCGCATCACGGCCGCGCCGGCCGACGTGCTGCAGCTGCCGGCCGGCCGCGTGGCCG
AAGGCGCCGCGGCCGACCTGTGCGTATTCGACCCGCGCGCGCACTGGCGCGTCGAACCGCGTGCGCTGAAGAGCCAGGGG
CACAACTCGCCGTTCCTCGGCTACGAACTGCCGGCCTGCGTACGCGCGACGCTCGTGGCGGGGCAGGTCGCGTTCGAGCG
CCACTGA

Upstream 100 bases:

>100_bases
ATGGCGGTGATGGGCATCGTCGCCGGCAACAGCGACTGAGCCCGCTTTCGCGCATCCTGATCCAGGCATTCAACGCAATC
AACGCATTCACAGACAGCGC

Downstream 100 bases:

>100_bases
ACCACGCCGGATCCTCGCCATGACCGCTCTTCGCAAGCTGCGTCTCGTCTTTCACCTACTGCGCGGCATGACGATCGTCG
CGCTGCGCTTTTCGCATGTC

Product: dihydroorotase

Products: Allantoate; H+ [C]

Alternate protein names: Aspartate carbamoyltransferase 44 kDa Non-catalytic chain [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKIHIQGGTLIDPVAGTERQADVFVADGKIAALAPAGTAPAGFNAEKTIDASGLIVAPGLVDLCARLREPGYEHKATLAS
EMAAAVAGGVTTLVCPPDTDPVLDEPGLVEMLKFRARNLHQANVHPLGALTVGLKGEVITEMVALTESGCVGFTHANVPV
RDTQVLLRALQYASTYGYTTWLRPLDAFIGRGGVAASGALASRLGLSGVPVAAETIALHTIFELMRVTGARVHLARLSSA
AGLALVREAKAEGLPVTCDVGVNHLHLIDIDIGYFDSQFRLDPPLRGERDREAIRAALADGTIDAICSDHTPVDDDEKLL
PFAEATPGATGLELLLSLTVKWADETNTPLAQALRRITAAPADVLQLPAGRVAEGAAADLCVFDPRAHWRVEPRALKSQG
HNSPFLGYELPACVRATLVAGQVAFERH

Sequences:

>Translated_428_residues
MKIHIQGGTLIDPVAGTERQADVFVADGKIAALAPAGTAPAGFNAEKTIDASGLIVAPGLVDLCARLREPGYEHKATLAS
EMAAAVAGGVTTLVCPPDTDPVLDEPGLVEMLKFRARNLHQANVHPLGALTVGLKGEVITEMVALTESGCVGFTHANVPV
RDTQVLLRALQYASTYGYTTWLRPLDAFIGRGGVAASGALASRLGLSGVPVAAETIALHTIFELMRVTGARVHLARLSSA
AGLALVREAKAEGLPVTCDVGVNHLHLIDIDIGYFDSQFRLDPPLRGERDREAIRAALADGTIDAICSDHTPVDDDEKLL
PFAEATPGATGLELLLSLTVKWADETNTPLAQALRRITAAPADVLQLPAGRVAEGAAADLCVFDPRAHWRVEPRALKSQG
HNSPFLGYELPACVRATLVAGQVAFERH
>Mature_428_residues
MKIHIQGGTLIDPVAGTERQADVFVADGKIAALAPAGTAPAGFNAEKTIDASGLIVAPGLVDLCARLREPGYEHKATLAS
EMAAAVAGGVTTLVCPPDTDPVLDEPGLVEMLKFRARNLHQANVHPLGALTVGLKGEVITEMVALTESGCVGFTHANVPV
RDTQVLLRALQYASTYGYTTWLRPLDAFIGRGGVAASGALASRLGLSGVPVAAETIALHTIFELMRVTGARVHLARLSSA
AGLALVREAKAEGLPVTCDVGVNHLHLIDIDIGYFDSQFRLDPPLRGERDREAIRAALADGTIDAICSDHTPVDDDEKLL
PFAEATPGATGLELLLSLTVKWADETNTPLAQALRRITAAPADVLQLPAGRVAEGAAADLCVFDPRAHWRVEPRALKSQG
HNSPFLGYELPACVRATLVAGQVAFERH

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=402, Percent_Identity=26.6169154228856, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1786722, Length=454, Percent_Identity=27.5330396475771, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI87082175, Length=444, Percent_Identity=24.5495495495495, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193204318, Length=404, Percent_Identity=24.7524752475248, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI86575075, Length=429, Percent_Identity=23.7762237762238, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322218, Length=404, Percent_Identity=24.5049504950495, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24642586, Length=376, Percent_Identity=26.3297872340426, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18859883, Length=212, Percent_Identity=31.6037735849057, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.5 [C]

Molecular weight: Translated: 45065; Mature: 45065

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHIQGGTLIDPVAGTERQADVFVADGKIAALAPAGTAPAGFNAEKTIDASGLIVAPGL
CEEEECCCCEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCEECCCCCEECCCH
VDLCARLREPGYEHKATLASEMAAAVAGGVTTLVCPPDTDPVLDEPGLVEMLKFRARNLH
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCC
QANVHPLGALTVGLKGEVITEMVALTESGCVGFTHANVPVRDTQVLLRALQYASTYGYTT
CCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHH
WLRPLDAFIGRGGVAASGALASRLGLSGVPVAAETIALHTIFELMRVTGARVHLARLSSA
HHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHCCC
AGLALVREAKAEGLPVTCDVGVNHLHLIDIDIGYFDSQFRLDPPLRGERDREAIRAALAD
CCHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHC
GTIDAICSDHTPVDDDEKLLPFAEATPGATGLELLLSLTVKWADETNTPLAQALRRITAA
CCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHCC
PADVLQLPAGRVAEGAAADLCVFDPRAHWRVEPRALKSQGHNSPFLGYELPACVRATLVA
CHHHHHCCCCCCCCCCCCCEEEECCCCCEEECHHHHHCCCCCCCCCCCCCHHHHHHHHHH
GQVAFERH
HHHHHCCC
>Mature Secondary Structure
MKIHIQGGTLIDPVAGTERQADVFVADGKIAALAPAGTAPAGFNAEKTIDASGLIVAPGL
CEEEECCCCEECCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCEECCCCCEECCCH
VDLCARLREPGYEHKATLASEMAAAVAGGVTTLVCPPDTDPVLDEPGLVEMLKFRARNLH
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCC
QANVHPLGALTVGLKGEVITEMVALTESGCVGFTHANVPVRDTQVLLRALQYASTYGYTT
CCCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHH
WLRPLDAFIGRGGVAASGALASRLGLSGVPVAAETIALHTIFELMRVTGARVHLARLSSA
HHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHCCC
AGLALVREAKAEGLPVTCDVGVNHLHLIDIDIGYFDSQFRLDPPLRGERDREAIRAALAD
CCHHHHHHHHCCCCCEEEECCCCEEEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHC
GTIDAICSDHTPVDDDEKLLPFAEATPGATGLELLLSLTVKWADETNTPLAQALRRITAA
CCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHCC
PADVLQLPAGRVAEGAAADLCVFDPRAHWRVEPRALKSQGHNSPFLGYELPACVRATLVA
CHHHHHCCCCCCCCCCCCCEEEECCCCCEEECHHHHHCCCCCCCCCCCCCHHHHHHHHHH
GQVAFERH
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Allantoin; H2O [C]

Specific reaction: Allantoin + H2O --> Allantoate + H+ [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: Dithiothreitol; p-Chloromercuribenzene-sulphonic acid [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]