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The map label for this gene is 115350756

Identifier: 115350756

GI number: 115350756

Start: 778888

End: 780192

Strand: Direct

Name: 115350756

Synonym: Bamb_0702

Alternate gene names: NA

Gene position: 778888-780192 (Clockwise)

Preceding gene: 115350755

Following gene: 115350761

Centisome position: 21.9

GC content: 68.81

Gene sequence:

>1305_bases
ATGAGCGAACCCCAAGACTGGCGCGCGACACTCGATCCGGCTCGCAAGAGCTGGGTCGAGACGGCGAACGATCCCGCCTG
CGATTTCCCGATCCAGAACCTGCCGTTCGGGATCTTCAGCGATGCGAAGCAGGCGGCGCGCCGCGCGGGCGTCGCGCTCG
GCGACCAGATCGTCGACCTCGCCGCGCTCGCGCGTACGGGCCTCGTGACGCTTCCGGCCGGCGCCGACGTGTTCGGCGCG
CCGACGCTCAACCCGTTCATCGCGCTCGGCCGCGATGCATGGCGCAGCGTGCGCGTGCAGCTGTCGCAGCTGTTCTCGCG
CGACGACGCGCGGCTGCGCGATGACGCCGCGCTGCGCGCGCAGGTGCTCGTCGCGCAGCGCGACGCGACGCTGCATCTGC
CGGTCGACATTCCCGGCTACACCGATTTCTATTCGTCGAAGGAGCATGCGACCAACGTCGGCTCGATGTTCCGTGATCCG
AAGAATGCGCTGATGCCGAACTGGTCGGAGATGCCGATCGGTTACAACGGCCGCGCGTCGTCGGTGGTCGTGAGCGGCAC
GCCGGTGCGGCGCCCGAGCGGGCAACTGAAGCTGCCCGACGCGGAGCGTCCGGTGTTCGGCGCGTGCCGCAAGCTCGACC
TCGAACTCGAGACGGGCTTCATCGTCGGCCGCGGTAACGCGCTCGGCGAACCGATCGCGTGCGAGGACGCCGAAGCGCAT
ATCTTCGGGATGGTGCTGCTCAACGACTGGAGCGCGCGCGACATCCAGCAGTGGGAATACGTGCCGCTCGGCCCGTTCAA
TTCGAAGGGCTTCGCGACGACGATCTCGCCGTGGATCGTCACGCTCGACGCGCTCGAACCGTTCCGCGTCGCGCAGCCCG
AGCAGTCGCCGCAGCCGCTCGCGTATCTGCGCCACGCGGGCAAGCATGCGTTCGACATCGCGCTCGAAGTGACGCTGCGC
GCGCGAGGGGCGGCCGAAGCGACGTCGATCTGCCGCACCAACTTCAAGTACATGTACTGGACGATGGCGCAGCAGCTCGC
GCATCACACGGTCGCGGGCTGCAACACGCGCGTCGGCGACCTGATGGGCTCGGGGACGATCAGCGGGCCCACCAAGGACT
CGTTCGGCAGCCTGCTCGAACTGACGTGGAACGGCAAGGAGCCGCTCGCGCTGAACGGCGGCGGCAGCCGCACGTTCATC
GAGGACGGCGACGAGCTCACGCTCACGGGCTGGTGCCAGGGCGACGGCTATCGCGTCGGGTTCGGCGTGTGTGCGGGCAA
GATTCTGCCCGCGCGGAGCGCGTGA

Upstream 100 bases:

>100_bases
TGATCCGTCCGACGCGCTACGCGCTCGACACCGCGCAGCTGCAGCCCGACTACTTCGAATGCTGGCAAGGCATCAGGAAA
CATTTCAATCCGGAGCAACC

Downstream 100 bases:

>100_bases
CAGGTCCCGCGGGATTCGGAAGGACAGGGCGGCCCGCATCGCGCGGGCCGTTTTCGTTGGGGGCAGCGAGTGGCGGTGCG
GATGCGCTCGCATGTACCGA

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSEPQDWRATLDPARKSWVETANDPACDFPIQNLPFGIFSDAKQAARRAGVALGDQIVDLAALARTGLVTLPAGADVFGA
PTLNPFIALGRDAWRSVRVQLSQLFSRDDARLRDDAALRAQVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDP
KNALMPNWSEMPIGYNGRASSVVVSGTPVRRPSGQLKLPDAERPVFGACRKLDLELETGFIVGRGNALGEPIACEDAEAH
IFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPEQSPQPLAYLRHAGKHAFDIALEVTLR
ARGAAEATSICRTNFKYMYWTMAQQLAHHTVAGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPLALNGGGSRTFI
EDGDELTLTGWCQGDGYRVGFGVCAGKILPARSA

Sequences:

>Translated_434_residues
MSEPQDWRATLDPARKSWVETANDPACDFPIQNLPFGIFSDAKQAARRAGVALGDQIVDLAALARTGLVTLPAGADVFGA
PTLNPFIALGRDAWRSVRVQLSQLFSRDDARLRDDAALRAQVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDP
KNALMPNWSEMPIGYNGRASSVVVSGTPVRRPSGQLKLPDAERPVFGACRKLDLELETGFIVGRGNALGEPIACEDAEAH
IFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPEQSPQPLAYLRHAGKHAFDIALEVTLR
ARGAAEATSICRTNFKYMYWTMAQQLAHHTVAGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPLALNGGGSRTFI
EDGDELTLTGWCQGDGYRVGFGVCAGKILPARSA
>Mature_433_residues
SEPQDWRATLDPARKSWVETANDPACDFPIQNLPFGIFSDAKQAARRAGVALGDQIVDLAALARTGLVTLPAGADVFGAP
TLNPFIALGRDAWRSVRVQLSQLFSRDDARLRDDAALRAQVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDPK
NALMPNWSEMPIGYNGRASSVVVSGTPVRRPSGQLKLPDAERPVFGACRKLDLELETGFIVGRGNALGEPIACEDAEAHI
FGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPEQSPQPLAYLRHAGKHAFDIALEVTLRA
RGAAEATSICRTNFKYMYWTMAQQLAHHTVAGCNTRVGDLMGSGTISGPTKDSFGSLLELTWNGKEPLALNGGGSRTFIE
DGDELTLTGWCQGDGYRVGFGVCAGKILPARSA

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=417, Percent_Identity=59.4724220623501, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17568863, Length=418, Percent_Identity=55.5023923444976, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24657182, Length=407, Percent_Identity=52.3341523341523, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 47089; Mature: 46958

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPQDWRATLDPARKSWVETANDPACDFPIQNLPFGIFSDAKQAARRAGVALGDQIVDL
CCCCCCHHHHCCHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH
AALARTGLVTLPAGADVFGAPTLNPFIALGRDAWRSVRVQLSQLFSRDDARLRDDAALRA
HHHHHCCEEEECCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHE
QVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDPKNALMPNWSEMPIGYNGRAS
EEEEEECCCEEEEEEECCCCCHHCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCC
SVVVSGTPVRRPSGQLKLPDAERPVFGACRKLDLELETGFIVGRGNALGEPIACEDAEAH
EEEEECCCCCCCCCCEECCCCCCCHHHHHHEEEEEEECCEEEECCCCCCCCCCCCCCCCE
IFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPEQSPQPL
EEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCHH
AYLRHAGKHAFDIALEVTLRARGAAEATSICRTNFKYMYWTMAQQLAHHTVAGCNTRVGD
HHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHH
LMGSGTISGPTKDSFGSLLELTWNGKEPLALNGGGSRTFIEDGDELTLTGWCQGDGYRVG
HCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCEEECCCEEEEEEEECCCCEEEE
FGVCAGKILPARSA
HHHHCCCEECCCCC
>Mature Secondary Structure 
SEPQDWRATLDPARKSWVETANDPACDFPIQNLPFGIFSDAKQAARRAGVALGDQIVDL
CCCCCHHHHCCHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH
AALARTGLVTLPAGADVFGAPTLNPFIALGRDAWRSVRVQLSQLFSRDDARLRDDAALRA
HHHHHCCEEEECCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHE
QVLVAQRDATLHLPVDIPGYTDFYSSKEHATNVGSMFRDPKNALMPNWSEMPIGYNGRAS
EEEEEECCCEEEEEEECCCCCHHCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCC
SVVVSGTPVRRPSGQLKLPDAERPVFGACRKLDLELETGFIVGRGNALGEPIACEDAEAH
EEEEECCCCCCCCCCEECCCCCCCHHHHHHEEEEEEECCEEEECCCCCCCCCCCCCCCCE
IFGMVLLNDWSARDIQQWEYVPLGPFNSKGFATTISPWIVTLDALEPFRVAQPEQSPQPL
EEEEEEECCCCCCCCCCCCEEECCCCCCCCCEEECCCEEEEEECCCCCCCCCCCCCCCHH
AYLRHAGKHAFDIALEVTLRARGAAEATSICRTNFKYMYWTMAQQLAHHTVAGCNTRVGD
HHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHH
LMGSGTISGPTKDSFGSLLELTWNGKEPLALNGGGSRTFIEDGDELTLTGWCQGDGYRVG
HCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCEEECCCEEEEEEEECCCCEEEE
FGVCAGKILPARSA
HHHHCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA