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The map label for this gene is pcaK [H]

Identifier: 115350754

GI number: 115350754

Start: 776180

End: 777541

Strand: Direct

Name: pcaK [H]

Synonym: Bamb_0700

Alternate gene names: 115350754

Gene position: 776180-777541 (Clockwise)

Preceding gene: 115350753

Following gene: 115350755

Centisome position: 21.82

GC content: 71.15

Gene sequence:

>1362_bases
ATGAGCGCGGCGCCGGCCGACGCGCGCGTGCTCGAAGTCGAGCGCGTGATCGACGAGACCCATCGCCCGGGCTTTCACTG
GATGCTGCTCGCGCTGTGCGGGCTGTGCCTCGTGATCGACGGCTTCGATGCGCAGGCGATGGGGTATGTCGCGCCCAGCG
TGATCGCCGAATGGGGCGTGCCGAAGCAGGCGCTCGGTCCGGTGTTCAGCGCGAGCCTGTTCGGGATGCTGCTCGGCGCG
CTCGGGCTGTCGGTGCTCGCCGACCGGATCGGGCGGCGCCCGGTGCTGATCGGCTCGACGCTGTTCTTCGCGGTGACGAT
GCTCGCGACGCCGTTCGCGGGCTCGATCCCGGTGCTGATGGCGCTGCGCTTCGTCACGGGCCTCGGCCTCGGCTGCATCA
TGCCGAACGCGATGGCGCTGGTCGGCGAGTTCAGCCCGGCCGCGCATCGCGTGAAGCGGATGATGATCGTGTCGTGCGGC
TTCACGCTCGGCGCCGCGATCGGCGGCTTCATCAGCGCCGCGCTGATTCCGGCGCTCGGCTGGCGCTCGGTGTTCTTCGT
CGGCGGCGCGGTGCCGCTGGTGCTGACGACCGCGATGCTCGCGCGGCTGCCCGAGTCGCTGCAGTTCCTGGTGCTGAAAG
GGCGCGACGCGCAGGCGCGCGACTGGCTCGCGCGCTTCGCGCCGCAGGCCGGCATCGACGCGAACACGCGTCTGGTCGTG
CGCGAGCGTGCGGCGAGCGGCGCGCCGGTTGCCGAGCTGTTCCGTCATGGCCGCCTGCCGGTCACGCTGCTGCTGTGGGC
CATCAGCTTCATGAACCTGATCGACCTGTACTTCCTGTCGAACTGGCTGCCGACCGTCATGCGCGACGCGGGCTATTCGC
CGGGCACGGCGGTGATCGTCGGCACGGTGCTGCAGACGGGCGGCGTGATCGGCACGCTGTCGCTCGGCTGGTTCATCGAA
CGCCACGGCTTCGTGCGCGTGCTGTTTGCGTGCTTCGCGTGCGCGGCGGTGTCGGTCGGCCTGATCGGCTCGGTCGCGCA
TGCGTTGCCGTGGCTGCTGATCGTCGTGTTCGCGGGCGGCTTCTGCGTGGTCGGCGGGCAGCCGGCCGTCAACGCGCTCG
CGGGCCAGTATTACCCGACGTCGCTGCGCTCGACCGGCATCGGCTGGAGCCTCGGCATCGGCCGGATCGGCTCGGTGCTC
GGGCCGCTCGTCGGCGGACAACTGATTGCGCTCAACTGGACGCACGGCGCGCTGTTCCACGCGGCCGCGGTGCCCGTGCT
GTGCTCGGCGCTGTTCGTGCTCGGGCTGGCCGGCGTAACGCGGCGCGGCGGTGCGCAGGCGCCGAACGCGGCCATGAATT
GA

Upstream 100 bases:

>100_bases
TCGCGAACCACATCGGCGACGCCGACGTGCTGCGCGAAGCGATGGCGCTCGCGCGCCAGGGCGTGACGCCCGCCGTGCAT
CCGGCCGCCGAGGTCGCGCA

Downstream 100 bases:

>100_bases
TGGAGAAAGGAAACGATGACGCTTGACCTGTCGAAACCGGCAACCGCCGGCTACCTGAGCGGATTCGCGAACGAATTCGC
GACCGAGGCGCTGCCCGGCG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSAAPADARVLEVERVIDETHRPGFHWMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVPKQALGPVFSASLFGMLLGA
LGLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPAAHRVKRMMIVSCG
FTLGAAIGGFISAALIPALGWRSVFFVGGAVPLVLTTAMLARLPESLQFLVLKGRDAQARDWLARFAPQAGIDANTRLVV
RERAASGAPVAELFRHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSPGTAVIVGTVLQTGGVIGTLSLGWFIE
RHGFVRVLFACFACAAVSVGLIGSVAHALPWLLIVVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVL
GPLVGGQLIALNWTHGALFHAAAVPVLCSALFVLGLAGVTRRGGAQAPNAAMN

Sequences:

>Translated_453_residues
MSAAPADARVLEVERVIDETHRPGFHWMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVPKQALGPVFSASLFGMLLGA
LGLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPAAHRVKRMMIVSCG
FTLGAAIGGFISAALIPALGWRSVFFVGGAVPLVLTTAMLARLPESLQFLVLKGRDAQARDWLARFAPQAGIDANTRLVV
RERAASGAPVAELFRHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSPGTAVIVGTVLQTGGVIGTLSLGWFIE
RHGFVRVLFACFACAAVSVGLIGSVAHALPWLLIVVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVL
GPLVGGQLIALNWTHGALFHAAAVPVLCSALFVLGLAGVTRRGGAQAPNAAMN
>Mature_452_residues
SAAPADARVLEVERVIDETHRPGFHWMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGVPKQALGPVFSASLFGMLLGAL
GLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLMALRFVTGLGLGCIMPNAMALVGEFSPAAHRVKRMMIVSCGF
TLGAAIGGFISAALIPALGWRSVFFVGGAVPLVLTTAMLARLPESLQFLVLKGRDAQARDWLARFAPQAGIDANTRLVVR
ERAASGAPVAELFRHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSPGTAVIVGTVLQTGGVIGTLSLGWFIER
HGFVRVLFACFACAAVSVGLIGSVAHALPWLLIVVFAGGFCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLG
PLVGGQLIALNWTHGALFHAAAVPVLCSALFVLGLAGVTRRGGAQAPNAAMN

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=427, Percent_Identity=25.7611241217799, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI8923870, Length=369, Percent_Identity=27.10027100271, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI166064021, Length=362, Percent_Identity=26.5193370165746, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI7662270, Length=220, Percent_Identity=25, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI296080721, Length=397, Percent_Identity=25.1889168765743, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI296080719, Length=397, Percent_Identity=25.1889168765743, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI24497499, Length=397, Percent_Identity=25.1889168765743, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87081723, Length=420, Percent_Identity=33.0952380952381, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87082231, Length=427, Percent_Identity=23.6533957845433, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786229, Length=394, Percent_Identity=21.0659898477157, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082404, Length=385, Percent_Identity=22.0779220779221, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788068, Length=454, Percent_Identity=24.6696035242291, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082159, Length=388, Percent_Identity=25.5154639175258, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=422, Percent_Identity=23.4597156398104, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71980582, Length=419, Percent_Identity=22.673031026253, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17565978, Length=277, Percent_Identity=26.3537906137184, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980584, Length=419, Percent_Identity=22.673031026253, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922874, Length=426, Percent_Identity=24.1784037558685, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24640198, Length=226, Percent_Identity=27.8761061946903, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24640196, Length=226, Percent_Identity=27.8761061946903, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24640200, Length=226, Percent_Identity=27.8761061946903, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161077756, Length=463, Percent_Identity=22.8941684665227, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573099, Length=235, Percent_Identity=26.8085106382979, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573101, Length=235, Percent_Identity=26.8085106382979, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47371; Mature: 47240

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAPADARVLEVERVIDETHRPGFHWMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGV
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
PKQALGPVFSASLFGMLLGALGLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCHHHHH
ALRFVTGLGLGCIMPNAMALVGEFSPAAHRVKRMMIVSCGFTLGAAIGGFISAALIPALG
HHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
WRSVFFVGGAVPLVLTTAMLARLPESLQFLVLKGRDAQARDWLARFAPQAGIDANTRLVV
HHHHHHHCCHHHHHHHHHHHHHCCHHHEEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEE
RERAASGAPVAELFRHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSPGTAVIV
EECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
GTVLQTGGVIGTLSLGWFIERHGFVRVLFACFACAAVSVGLIGSVAHALPWLLIVVFAGG
HHHHHCCCCEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLGPLVGGQLIALNWTHGALFH
EEEECCCHHHHHHHCCCCCCHHHCCCCCHHCCHHHHHHHHHHHHCCEEEEEECCCHHHHH
AAAVPVLCSALFVLGLAGVTRRGGAQAPNAAMN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SAAPADARVLEVERVIDETHRPGFHWMLLALCGLCLVIDGFDAQAMGYVAPSVIAEWGV
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
PKQALGPVFSASLFGMLLGALGLSVLADRIGRRPVLIGSTLFFAVTMLATPFAGSIPVLM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCHHHHH
ALRFVTGLGLGCIMPNAMALVGEFSPAAHRVKRMMIVSCGFTLGAAIGGFISAALIPALG
HHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
WRSVFFVGGAVPLVLTTAMLARLPESLQFLVLKGRDAQARDWLARFAPQAGIDANTRLVV
HHHHHHHCCHHHHHHHHHHHHHCCHHHEEEEEECCCCHHHHHHHHHCCCCCCCCCCEEEE
RERAASGAPVAELFRHGRLPVTLLLWAISFMNLIDLYFLSNWLPTVMRDAGYSPGTAVIV
EECCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
GTVLQTGGVIGTLSLGWFIERHGFVRVLFACFACAAVSVGLIGSVAHALPWLLIVVFAGG
HHHHHCCCCEEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FCVVGGQPAVNALAGQYYPTSLRSTGIGWSLGIGRIGSVLGPLVGGQLIALNWTHGALFH
EEEECCCHHHHHHHCCCCCCHHHCCCCCHHCCHHHHHHHHHHHHCCEEEEEECCCHHHHH
AAAVPVLCSALFVLGLAGVTRRGGAQAPNAAMN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]