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The map label for this gene is glyA

Identifier: 115350737

GI number: 115350737

Start: 762817

End: 764112

Strand: Direct

Name: glyA

Synonym: Bamb_0683

Alternate gene names: 115350737

Gene position: 762817-764112 (Clockwise)

Preceding gene: 115350728

Following gene: 115350738

Centisome position: 21.45

GC content: 63.5

Gene sequence:

>1296_bases
ATGTACTCGGCCGCACCGGTCAACCTGTACACACTTAACGGAAACCGTATGTTTGACAGAGCCCAAAGCACCATCGCGAA
CGTCGATCCCGAACTCTTTGCTGCGATCGAGCAGGAAAACCGCCGCCAGGAAGATCACATCGAGCTGATCGCGTCGGAAA
ACTACACGAGCCCGGCCGTGATGGCCGCCCAGGGCTCGCAGCTCACGAACAAGTACGCGGAAGGTTATCCGGGCAAGCGC
TACTACGGCGGCTGTGAATACGTCGATGTGGTCGAGCAGCTGGCGATCGACCGTGTGAAGCAGCTGTTCGGCGCGGAAGC
CGCGAACGTGCAGCCGAACTCGGGTTCGCAGGCGAACCAGGGCGTGTTCTTCGCGATGCTCAAGCCGGGCGACACGATCA
TGGGCATGAGCCTCGCGCACGGTGGTCACCTGACGCACGGCTCGCCGGTGAACATGTCGGGCAAGTGGTTCAACGTGGTG
AGCTACGGTCTGAACGAGCAGGAAGACATCGACTACGACGCGGCCGAGCAGCTCGCGCAGGAACACAAGCCGAAGCTGAT
CGTCGCGGGTGCATCGGCGTTCGCGCTGAAGATCGACTTCGAGCGTCTGGCGAAGATCGCGAAGTCGGTCGGTGCATACC
TGATGGTCGACATGGCGCACTACGCGGGCCTGATCGCGGCGGGCGTGTATCCGAACCCGGTGCCGCACGCCGACTTCGTG
ACGACGACGACGCACAAGAGCCTGCGCGGCCCGCGCGGTGGCGTGATCCTGATGAAGTCGGAATACGAGAAGCCGATCAA
CTCGGCGATCTTCCCGGGCATCCAGGGTGGCCCGCTGATGCACGTGATCGCGGCGAAGGCCGTGGCGTTCAAGGAAGCGC
TGTCGCCGGAATTCAAGGCGTACCAGGAAAAGGTGGTCGAGAACGCGCGCGTGCTGGCTGAAACGCTGGTCAAGCGCGGC
CTGCGGATCGTGTCGGGCCGCACCGAAAGCCACGTGATGCTGGTGGACCTGCGCGCGAAGAACATCACGGGCAAGGCAGC
GGAAGCAGCGCTCGGTGCCGCGCACATCACGGTGAACAAGAACGCGATCCCGAACGATCCGGAGAAGCCGTTCGTGACGA
GCGGCATCCGTCTGGGTTCGCCGGCGATGACGACGCGCGGCTTTGGCCCGGCGGAAGCGGAACTGGTCGGCAACCTGATC
GCCGACGTGCTCGAGAATCCGGAAGATGCAGCGACGATCGAGCGCGTGCGCACGCAAGTGGCCGAGCTGACCAAGCGTTT
CCCGGTCTATCGCTGA

Upstream 100 bases:

>100_bases
GGGCAGCCGTTGTGCGCCGTTGCGTGCATCGCCGGTGGCTGTCCTGCCTCGCGTCATACGGATTCTTCCGCCACGTCGAG
CTGGTCCCGCCAGCAGCGCA

Downstream 100 bases:

>100_bases
TCCCGCATGCGCTGCCCGTTCTGCCGGCATGAAGACACGCAGGTCGTCGACTCGCGCGTGTCCGAAGATGGCGCCGCCAT
TCGCCGGCGCCGTCGCTGCT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MYSAAPVNLYTLNGNRMFDRAQSTIANVDPELFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKR
YYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVV
SYGLNEQEDIDYDAAEQLAQEHKPKLIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFV
TTTTHKSLRGPRGGVILMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKAYQEKVVENARVLAETLVKRG
LRIVSGRTESHVMLVDLRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGPAEAELVGNLI
ADVLENPEDAATIERVRTQVAELTKRFPVYR

Sequences:

>Translated_431_residues
MYSAAPVNLYTLNGNRMFDRAQSTIANVDPELFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKR
YYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVV
SYGLNEQEDIDYDAAEQLAQEHKPKLIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFV
TTTTHKSLRGPRGGVILMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKAYQEKVVENARVLAETLVKRG
LRIVSGRTESHVMLVDLRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGPAEAELVGNLI
ADVLENPEDAATIERVRTQVAELTKRFPVYR
>Mature_431_residues
MYSAAPVNLYTLNGNRMFDRAQSTIANVDPELFAAIEQENRRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKR
YYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVV
SYGLNEQEDIDYDAAEQLAQEHKPKLIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFV
TTTTHKSLRGPRGGVILMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKAYQEKVVENARVLAETLVKRG
LRIVSGRTESHVMLVDLRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGPAEAELVGNLI
ADVLENPEDAATIERVRTQVAELTKRFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=40.7488986784141, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=40.7488986784141, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=40.7488986784141, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=40.7488986784141, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=40.1766004415011, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=42.9906542056075, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI22547189, Length=413, Percent_Identity=41.4043583535109, Blast_Score=284, Evalue=1e-76,
Organism=Escherichia coli, GI1788902, Length=414, Percent_Identity=63.768115942029, Blast_Score=542, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI25144732, Length=456, Percent_Identity=44.078947368421, Blast_Score=355, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=456, Percent_Identity=44.078947368421, Blast_Score=354, Evalue=6e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=415, Percent_Identity=45.7831325301205, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323087, Length=433, Percent_Identity=43.4180138568129, Blast_Score=337, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24640005, Length=455, Percent_Identity=42.6373626373626, Blast_Score=359, Evalue=2e-99,
Organism=Drosophila melanogaster, GI221329721, Length=455, Percent_Identity=42.6373626373626, Blast_Score=358, Evalue=3e-99,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46643; Mature: 46643

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSAAPVNLYTLNGNRMFDRAQSTIANVDPELFAAIEQENRRQEDHIELIASENYTSPAV
CCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHEEEEECCCCCCCEE
MAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQ
EEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEQEDIDYDAAEQLAQ
CEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCEEEHEECCCCCCCCCCHHHHHHHHH
EHKPKLIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFV
HCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
TTTTHKSLRGPRGGVILMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKA
EECCHHHHCCCCCCEEEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
YQEKVVENARVLAETLVKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGAAHITVNK
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHCEEEEEECC
NAIPNDPEKPFVTSGIRLGSPAMTTRGFGPAEAELVGNLIADVLENPEDAATIERVRTQV
CCCCCCCCCCCEECCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AELTKRFPVYR
HHHHHHCCCCC
>Mature Secondary Structure
MYSAAPVNLYTLNGNRMFDRAQSTIANVDPELFAAIEQENRRQEDHIELIASENYTSPAV
CCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHEEEEECCCCCCCEE
MAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQ
EEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNEQEDIDYDAAEQLAQ
CEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCEEEHEECCCCCCCCCCHHHHHHHHH
EHKPKLIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFV
HCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
TTTTHKSLRGPRGGVILMKSEYEKPINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKA
EECCHHHHCCCCCCEEEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
YQEKVVENARVLAETLVKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGAAHITVNK
HHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHCEEEEEECC
NAIPNDPEKPFVTSGIRLGSPAMTTRGFGPAEAELVGNLIADVLENPEDAATIERVRTQV
CCCCCCCCCCCEECCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AELTKRFPVYR
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA