Click here to switch to the map view.

The map label for this gene is tyrS [H]

Identifier: 115350631

GI number: 115350631

Start: 649435

End: 650676

Strand: Direct

Name: tyrS [H]

Synonym: Bamb_0577

Alternate gene names: 115350631

Gene position: 649435-650676 (Clockwise)

Preceding gene: 115350629

Following gene: 115350632

Centisome position: 18.26

GC content: 65.38

Gene sequence:

>1242_bases
ATGAGCACCGAACCCAGTTCCAAGCCTGTTTTCCCGATCACCGACGAAGTCCGTCATGCGCTCGCCGTCACGAAGCGCGG
CGTCGACGAACTGCTGATCGAGGAAGAGTTCGCGCAGAAGCTCGCGCGCAGCGCGGCCACCGGCACGCCGCTGCGCATCA
AGCTCGGCCTCGACCCGACCGCGCCCGACATCCACATCGGCCATACGGTCGTGCTGAACAAGATGCGTCAGCTGCAGGAC
CTCGGTCATACCGTGATCTTCCTGATCGGCGATTTCACGTCGCTGATCGGCGATCCGTCGGGCCGCAACGCGACGCGTCC
GCCGCTCACGCGCGAACAGATCGAATCGAACGCGAAGACCTATTTCGAACAGGCCGCGCTCGTGCTCGACCGCGAAAAGA
CCGAGATCCGCTACAACAGCGAATGGTCGATGCCGCTCGGCGCGGACGGGATGATCAAGCTCGCGTCGCGCTACACGGTC
GCGCGGATCCTCGAGCGCGAGGACTTCACGAAGCGTTTCCAGGGCGGCGTGCCGATCTCGATCCACGAATTCCTGTACCC
GCTGATGCAGGGCTACGACTCGGTCGCGCTGAACGCCGATCTCGAGCTCGGCGGCACCGACCAGAAGTTCAACCTGCTGG
TCGGCCGCGAACTGCAGAAGCAGTACGGCCAGGAACAGCAGTGCATCCTGACGATGCCGCTGCTCGAAGGCCTCGACGGC
GTCGAGAAGATGTCGAAGTCGAAGGGCAACTACGTCGGCATCAGCGAGAAGCCGACCGACATGTTCGGCAAGCTGATGAG
CATCTCGGACACGCTGATGTGGCGTTACTTCGAACTGCTGTCGTTCCGCAGCCTCGACGAGATCGCCGGCTTCAAGCGCG
ACGCCGAAGGCGGCCGCAACCCGCGCGACTTCAAGGTGCTGCTCGCGCAGGAAATCGTCGCGCGCTTCCACTCGCAGGCC
GACGCCGAGCGTGCGCTCGACGACTTCAACCACCGCGCGAAGGGCGGCGTGCCGGACGACATCCCGTCGGTCACGCTCGC
GGGCGCGCCGCTCGCGATCGGCCAGTTGCTGAAGCAGGCCGGCCTCGTGCCGTCGACGAGCGAAGCGCTGCGCAACATCG
AGCAGGGCGGCGTGAAGATCGACGGTGCGACCGTGTCCGACAAGGGCCTGAAGGTCGAGGCCGGCGAGTTCGTCGTCCAG
GTCGGCAAGCGCCGCTTCGCGCGCGTCACGCTGAGCGCATGA

Upstream 100 bases:

>100_bases
GCCTTGCGCCCGATTATCCGCGCAACCTGACGCATCGTTAAGCGATGCACGCGCAAGTTATGGGAAAATCCCTGTCTTTG
CGACATTCTTCCCGGCACCG

Downstream 100 bases:

>100_bases
TCGCGCTGATCCAGCGCGTGAAGCGTGCCGACGTGCGCGTCGGCGACCGCACGACGGGCGAGATCGGCGCGGGCCTGCTC
GCGCTCGTCTGCGCGGAGCG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSTEPSSKPVFPITDEVRHALAVTKRGVDELLIEEEFAQKLARSAATGTPLRIKLGLDPTAPDIHIGHTVVLNKMRQLQD
LGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTV
ARILEREDFTKRFQGGVPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
VEKMSKSKGNYVGISEKPTDMFGKLMSISDTLMWRYFELLSFRSLDEIAGFKRDAEGGRNPRDFKVLLAQEIVARFHSQA
DAERALDDFNHRAKGGVPDDIPSVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKGLKVEAGEFVVQ
VGKRRFARVTLSA

Sequences:

>Translated_413_residues
MSTEPSSKPVFPITDEVRHALAVTKRGVDELLIEEEFAQKLARSAATGTPLRIKLGLDPTAPDIHIGHTVVLNKMRQLQD
LGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTV
ARILEREDFTKRFQGGVPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
VEKMSKSKGNYVGISEKPTDMFGKLMSISDTLMWRYFELLSFRSLDEIAGFKRDAEGGRNPRDFKVLLAQEIVARFHSQA
DAERALDDFNHRAKGGVPDDIPSVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKGLKVEAGEFVVQ
VGKRRFARVTLSA
>Mature_412_residues
STEPSSKPVFPITDEVRHALAVTKRGVDELLIEEEFAQKLARSAATGTPLRIKLGLDPTAPDIHIGHTVVLNKMRQLQDL
GHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTVA
RILEREDFTKRFQGGVPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDGV
EKMSKSKGNYVGISEKPTDMFGKLMSISDTLMWRYFELLSFRSLDEIAGFKRDAEGGRNPRDFKVLLAQEIVARFHSQAD
AERALDDFNHRAKGGVPDDIPSVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKGLKVEAGEFVVQV
GKRRFARVTLSA

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=398, Percent_Identity=25.8793969849246, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1787925, Length=424, Percent_Identity=29.0094339622642, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI25145802, Length=210, Percent_Identity=29.5238095238095, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325160, Length=380, Percent_Identity=25.2631578947368, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI20130383, Length=450, Percent_Identity=25.1111111111111, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45588; Mature: 45457

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEPSSKPVFPITDEVRHALAVTKRGVDELLIEEEFAQKLARSAATGTPLRIKLGLDPT
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
APDIHIGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKT
CCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
YFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTVARILEREDFTKRFQGGVPIS
HHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
HHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCHH
VEKMSKSKGNYVGISEKPTDMFGKLMSISDTLMWRYFELLSFRSLDEIAGFKRDAEGGRN
HHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCC
PRDFKVLLAQEIVARFHSQADAERALDDFNHRAKGGVPDDIPSVTLAGAPLAIGQLLKQA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHC
GLVPSTSEALRNIEQGGVKIDGATVSDKGLKVEAGEFVVQVGKRRFARVTLSA
CCCCCHHHHHHHHHHCCEEECCCEECCCCCEEEHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
STEPSSKPVFPITDEVRHALAVTKRGVDELLIEEEFAQKLARSAATGTPLRIKLGLDPT
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
APDIHIGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKT
CCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
YFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTVARILEREDFTKRFQGGVPIS
HHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
HHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCHH
VEKMSKSKGNYVGISEKPTDMFGKLMSISDTLMWRYFELLSFRSLDEIAGFKRDAEGGRN
HHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCC
PRDFKVLLAQEIVARFHSQADAERALDDFNHRAKGGVPDDIPSVTLAGAPLAIGQLLKQA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHC
GLVPSTSEALRNIEQGGVKIDGATVSDKGLKVEAGEFVVQVGKRRFARVTLSA
CCCCCHHHHHHHHHHCCEEECCCEECCCCCEEEHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA