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The map label for this gene is edd [H]

Identifier: 115350609

GI number: 115350609

Start: 621643

End: 623499

Strand: Direct

Name: edd [H]

Synonym: Bamb_0555

Alternate gene names: 115350609

Gene position: 621643-623499 (Clockwise)

Preceding gene: 115350607

Following gene: 115350610

Centisome position: 17.48

GC content: 68.93

Gene sequence:

>1857_bases
ATGACGTCGCTGCACCCCACTCTGGCGAAAGTCACCGAACGCGTGATCGCCCGCAGCCAATCGACCCGTTCCGCCTATCT
GCAGCGCATCGACGGCGCGCAAGGCAAGTTCCCGGCGCGCGGCGCGCTGTCGTGCGCGAACCTCGCGCACGGCTTCGCGG
GTCTCGAAGGCAGCGACAAGTTCCAGATCAAGGCAATCCGCGAGCCGAACATCGGCATCGTGTCCTCGTACAACGAGATG
CTGTCCGCGCACGCGCCGTACAAGGATTTCCCCGACATCATCAAGGCCGCCGCGCGCGAGAACGGCGGCGTCGCGCAATT
CGCGGGCGGCGTGCCGGCGATGTGCGACGGCGTCACGCAGGGCAACCCCGGGATGGAGCTGTCGCTGTTCTCACGCGAGG
CGATCGCGATGGGCACGGCGATCGCGCTCACGCACAACATGTTCGACACGGCGCTCTGCCTCGGCATCTGCGACAAGATC
GTGCCGGGCCTGCTGATCGGCGCGCTGCAGTTCGGCCACCTGCCGACCATCTTCGTGCCGGCCGGCCCGATGACGAGCGG
CCTGTCGAACGACGACAAGGCGAAGATCCGCCAGCAGTTCGCGACGGGCCAAGTGGGCCGCGACGCGCTGCTCGAAGCCG
AATCGGCCGCGTATCACGGCCACGGCACCTGCACGTTCTACGGCACCGCGAACAGCAACCAGATGCTGATGGAGCTGATG
GGCCTGCACCTGCCGGGCTCGGCGTTCGTCCATCCGCACACGCCGCTGCGCGACGCGCTGACCGCCGAAGCCGCGCGCCG
CGTGCTCGACCTGACGGTCGAGCGCGGCCAGTACACGCCGATCGGCCATGTGATCGACGAGAAGGCGATCGTCAACGGGA
TCGTCGCGCTGCTCGCGACAGGCGGCTCGACCAACCACACGCTGCACCTCGTCGCGATCGCGCGTGCGGCCGGCGTGCTG
ATCGACTGGAACGATTTCGACGAGCTGTCGGCCGTCGTGCCGCTGCTCGCGAAGATCTACCCGAACGGCAAGGCGGACGT
GAACCATTTCCACGCGGCGGGTGGCGTTGCGTTCCTGGTGCGCAACCTGCTCGAAGGCGGGCTGCTGCACGAAGACGTGA
CGACGGTCGCCGGCCGTGGCCTGTCGCACTACACGAAGGAGCCGAAGCTGATCGACGGCAAGCTGACGTGGGTCGACGGC
ACGGCCGAGAGCCACGATACGAAGGTGCTGCGCGGCATTCGCGAGCCGTTCCAGCCGGACGGCGGCCTGCGCCTGATGCA
GGGCCGGCTCGGCCGCGGCGTGATCAAGATTTCGGCGGTCGCGCCCGAGCACCGCAAGGTGACGGCGCCCGCGATCGTGT
TCGATTCGCAGGAAGCCGTGCAGGCGGCATTCGATCGCGGCGAGCTGAAGCGCGATTTCGTCGCGGTCGTGCGCTTCCAG
GGCGCGCGCGCGAACGGGATGCCCGAGCTGCACCGTTTGACGCCGCTGCTCGGCGTGCTGCAGGATCAGGGCTTCCACGT
CGCGCTCGTCACCGACGGCCGCATGTCCGGCGCATCGGGCAAGGTGCCGGCGGTGATCCACGTGTCGCCGGAAGCGCTGC
TGGCCGGCCCGCTGGGCAAGGTGCAGACGGGCGACACGCTCGTGATCGACGCGGAAGCCGGCATTCTCGACATCGAGGTC
GACGAAGCCGAGTGGCAAGCGCGCGCGGTCGCGCAGCCGCTGCACCAGGCCGACAACGAGACGGGTTTCGGGCGCGAACT
GTTCGGCGTGTTCCGCGCGGCGGCCGCGCCGGCCGAGCAGGGCGCATCGGTTTTCGGAACGCTGGTCGGCGAAACGGCCG
TCGGCGTCGCTGCATGA

Upstream 100 bases:

>100_bases
TATGTAGTTTTTCTACTAGACTTGCTTCGTTCGTTCGACGTACTCGACCGTCCCCACGATTCCAACCGCCGGTGTCGTCC
GGCATACAGGAGCGCCCAGC

Downstream 100 bases:

>100_bases
ATTTCAAGGAGTGTCTTCAATGAAGAGGATTGGCGAAATCGTGAAGCTGGGCCCGGTGATTCCGGTGCTCGCATTCGACT
CGGTCGAGCAGGGTGAACAT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MTSLHPTLAKVTERVIARSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGSDKFQIKAIREPNIGIVSSYNEM
LSAHAPYKDFPDIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSREAIAMGTAIALTHNMFDTALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
GLHLPGSAFVHPHTPLRDALTAEAARRVLDLTVERGQYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGVL
IDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGRGLSHYTKEPKLIDGKLTWVDG
TAESHDTKVLRGIREPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQAAFDRGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPLGKVQTGDTLVIDAEAGILDIEV
DEAEWQARAVAQPLHQADNETGFGRELFGVFRAAAAPAEQGASVFGTLVGETAVGVAA

Sequences:

>Translated_618_residues
MTSLHPTLAKVTERVIARSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGSDKFQIKAIREPNIGIVSSYNEM
LSAHAPYKDFPDIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSREAIAMGTAIALTHNMFDTALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
GLHLPGSAFVHPHTPLRDALTAEAARRVLDLTVERGQYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGVL
IDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGRGLSHYTKEPKLIDGKLTWVDG
TAESHDTKVLRGIREPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQAAFDRGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPLGKVQTGDTLVIDAEAGILDIEV
DEAEWQARAVAQPLHQADNETGFGRELFGVFRAAAAPAEQGASVFGTLVGETAVGVAA
>Mature_617_residues
TSLHPTLAKVTERVIARSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGSDKFQIKAIREPNIGIVSSYNEML
SAHAPYKDFPDIIKAAARENGGVAQFAGGVPAMCDGVTQGNPGMELSLFSREAIAMGTAIALTHNMFDTALCLGICDKIV
PGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELMG
LHLPGSAFVHPHTPLRDALTAEAARRVLDLTVERGQYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGVLI
DWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGRGLSHYTKEPKLIDGKLTWVDGT
AESHDTKVLRGIREPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQAAFDRGELKRDFVAVVRFQG
ARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPLGKVQTGDTLVIDAEAGILDIEVD
EAEWQARAVAQPLHQADNETGFGRELFGVFRAAAAPAEQGASVFGTLVGETAVGVAA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=58.8039867109634, Blast_Score=717, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=546, Percent_Identity=30.952380952381, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI2367371, Length=507, Percent_Identity=30.7692307692308, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786464, Length=495, Percent_Identity=31.7171717171717, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322476, Length=526, Percent_Identity=27.9467680608365, Blast_Score=181, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65236; Mature: 65105

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLHPTLAKVTERVIARSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGSDK
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
FQIKAIREPNIGIVSSYNEMLSAHAPYKDFPDIIKAAARENGGVAQFAGGVPAMCDGVTQ
EEEEEECCCCCCEEECHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCCCHHHCCCCC
GNPGMELSLFSREAIAMGTAIALTHNMFDTALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCEECCCEEEEEEECCCCCHHHHHHH
GLHLPGSAFVHPHTPLRDALTAEAARRVLDLTVERGQYTPIGHVIDEKAIVNGIVALLAT
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGVLIDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLV
CCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHEDVTTVAGRGLSHYTKEPKLIDGKLTWVDGTAESHDTKVLRGIREPFQPD
HHHHCCCCCHHHHHHHHCCCCHHHCCCCCEECCEEEEECCCCCCHHHHHHHHHHHCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQAAFDRGELKRDFVAVVRFQ
CCEEEECCCCCCCEEEEEEECCCCCCEECCEEEECCHHHHHHHHHHHHHHHHHHHHHEEC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPLGK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCHHHHCCCCCC
VQTGDTLVIDAEAGILDIEVDEAEWQARAVAQPLHQADNETGFGRELFGVFRAAAAPAEQ
CCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHC
GASVFGTLVGETAVGVAA
CHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSLHPTLAKVTERVIARSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGSDK
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
FQIKAIREPNIGIVSSYNEMLSAHAPYKDFPDIIKAAARENGGVAQFAGGVPAMCDGVTQ
EEEEEECCCCCCEEECHHHHHHCCCCCCCHHHHHHHHHCCCCCEEECCCCCCHHHCCCCC
GNPGMELSLFSREAIAMGTAIALTHNMFDTALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCEECCCEEEEEEECCCCCHHHHHHH
GLHLPGSAFVHPHTPLRDALTAEAARRVLDLTVERGQYTPIGHVIDEKAIVNGIVALLAT
CCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGVLIDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLV
CCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHEDVTTVAGRGLSHYTKEPKLIDGKLTWVDGTAESHDTKVLRGIREPFQPD
HHHHCCCCCHHHHHHHHCCCCHHHCCCCCEECCEEEEECCCCCCHHHHHHHHHHHCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVTAPAIVFDSQEAVQAAFDRGELKRDFVAVVRFQ
CCEEEECCCCCCCEEEEEEECCCCCCEECCEEEECCHHHHHHHHHHHHHHHHHHHHHEEC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHVSPEALLAGPLGK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCHHHHCCCCCC
VQTGDTLVIDAEAGILDIEVDEAEWQARAVAQPLHQADNETGFGRELFGVFRAAAAPAEQ
CCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHC
GASVFGTLVGETAVGVAA
CHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]