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The map label for this gene is gabP [H]

Identifier: 115350480

GI number: 115350480

Start: 476147

End: 477538

Strand: Direct

Name: gabP [H]

Synonym: Bamb_0426

Alternate gene names: 115350480

Gene position: 476147-477538 (Clockwise)

Preceding gene: 115350479

Following gene: 115350481

Centisome position: 13.39

GC content: 65.23

Gene sequence:

>1392_bases
ATGAGTGGAAGCAACACAGGCCTCGGCACGGGCCTGAAGCAGCGTCACGTGACGATGATGTCGATTGCCGGCGTCATCGG
CGCGGGCTTGTTCGTCGGCTCCGGCCACGCGATCGCCGAGGCCGGCCCGGCTTCGATCCTCGCGTATGCGATCGCGGGCA
TGCTGGTCGTGCTGGTGATGCGCATGCTCGGCGAGATGGCCGTCGCGCATCCGGACAGCGGTTCGTTCTCGACCTATGCC
GATCGCGCGATCGGCCACTGGGCAGGCTTCACCATCGGCTGGCTGTACTGGTGGTTCTGGGTGCTCGTGATCCCGATCGA
GGCGACGGCCGCCGCGACCATTCTCAATGCGTGGTTCCCCGGCGTCGCGACCTGGATCTTCGCGCTCGGCATCACGCTGC
TGCTGACGATCACCAATCTCTTCTCGGTCAAGAACTACGGCGAATTCGAATTCTGGTTCGCGCTGATCAAGGTCGTCGCG
ATCGTCGTGTTCCTGTGCATCGGCGGTGCGGCGATCGTCGGCATCGTGCCTGCGCCGGCCGTGTCGGGCGTGTCGAACCT
GTTTGCGCATGACGGCTTCATGCCGCATGGCGCCGGCGCGGTGCTCGCGGCGATGCTGACGACGATGTTCTCGTTCCTCG
GCACCGAGATCGTGACGATCGCGGCCGCCGAATCGGATAACCCGCAACGCCAGATCGTGCGTGCGACGAATTCGGTGATC
TGGCGGATCACGCTGTTCTATCTCGGCTCGATCCTCGTCGTCGCGGCGATCGTGCCGTGGAACGATCCGCTGCTGCCGAA
GCACGGCTCGTATCAGCGTGCGATGGAGCTGATCGGCGTGCCGAACGCAAAGGCGATCATCGACGTGATCGTGCTCGTGT
CGGTCGCGAGTTGCCTGAATTCCGCGCTGTACACCGCGTCGCGGATGCTGTTCTCGCTGTCCCGGCGCAAGGACGCGCCC
GCGTTCCTGCACCGCACCGATTCGACCGGCACGCCGCGTGCGGCCGTGCTCGCATCGACGGCGTTCGGTTTCCTGACCGT
GATCGCCAACTACCTGATGCCGGAACAGGTGTTCGGCTTCCTGCTGGCGACGTCGGGCGCGATCGCGCTGCTCGTGTATC
TCGTGATCGCGATCTCGCAGCTGCGGATGCGCAAGACGCTCGAATCGGGCGGCGCCGACCTGCCGCTGCGGATGTGGCTG
TTCCCGTGGCTCACGTGGGCGGTGATCCTGTTCATTTGCGGTACGCTGACCGTGATGTTCGTCAGCGAGGAACACCGGAT
GGAAGTGGGGGCGACGGCCGTGCTGGCGTTGATCGTGCTGTTTGCCGCGTGGCTGAACAAGCGGGGGCGTGATGCGCGGG
TCAGTGAAGGGCGGCGCGTGTCGGCGATGTGA

Upstream 100 bases:

>100_bases
GCGCACGCGCGGCGGGCTGCCGGGTTCAACAACGACAACTCCCCGCGCCGCCTTCACGAGACCCCCGGTCGTACCGGAAT
CGTTTTTTGGAGAGAGACAT

Downstream 100 bases:

>100_bases
TGGAGTGAAGTGATGGCGGGCGGAAAGCCCGCGTCGCGAAACATGGCCCGATCGGTAATTTTCCGGTCGGGCCGTTTTTT
TATCCAATGCGGCGGCTGAA

Product: GABA permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGMLVVLVMRMLGEMAVAHPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWIFALGITLLLTITNLFSVKNYGEFEFWFALIKVVA
IVVFLCIGGAAIVGIVPAPAVSGVSNLFAHDGFMPHGAGAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVI
WRITLFYLGSILVVAAIVPWNDPLLPKHGSYQRAMELIGVPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSRRKDAP
AFLHRTDSTGTPRAAVLASTAFGFLTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKTLESGGADLPLRMWL
FPWLTWAVILFICGTLTVMFVSEEHRMEVGATAVLALIVLFAAWLNKRGRDARVSEGRRVSAM

Sequences:

>Translated_463_residues
MSGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGMLVVLVMRMLGEMAVAHPDSGSFSTYA
DRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWIFALGITLLLTITNLFSVKNYGEFEFWFALIKVVA
IVVFLCIGGAAIVGIVPAPAVSGVSNLFAHDGFMPHGAGAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVI
WRITLFYLGSILVVAAIVPWNDPLLPKHGSYQRAMELIGVPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSRRKDAP
AFLHRTDSTGTPRAAVLASTAFGFLTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKTLESGGADLPLRMWL
FPWLTWAVILFICGTLTVMFVSEEHRMEVGATAVLALIVLFAAWLNKRGRDARVSEGRRVSAM
>Mature_462_residues
SGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGMLVVLVMRMLGEMAVAHPDSGSFSTYAD
RAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFPGVATWIFALGITLLLTITNLFSVKNYGEFEFWFALIKVVAI
VVFLCIGGAAIVGIVPAPAVSGVSNLFAHDGFMPHGAGAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVIW
RITLFYLGSILVVAAIVPWNDPLLPKHGSYQRAMELIGVPNAKAIIDVIVLVSVASCLNSALYTASRMLFSLSRRKDAPA
FLHRTDSTGTPRAAVLASTAFGFLTVIANYLMPEQVFGFLLATSGAIALLVYLVIAISQLRMRKTLESGGADLPLRMWLF
PWLTWAVILFICGTLTVMFVSEEHRMEVGATAVLALIVLFAAWLNKRGRDARVSEGRRVSAM

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=371, Percent_Identity=21.832884097035, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789017, Length=430, Percent_Identity=64.8837209302326, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1786302, Length=424, Percent_Identity=37.9716981132075, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=37.5291375291375, Blast_Score=278, Evalue=4e-76,
Organism=Escherichia coli, GI48994972, Length=463, Percent_Identity=35.85313174946, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1788480, Length=410, Percent_Identity=36.8292682926829, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI87081708, Length=407, Percent_Identity=36.6093366093366, Blast_Score=259, Evalue=4e-70,
Organism=Escherichia coli, GI87081915, Length=460, Percent_Identity=33.4782608695652, Blast_Score=244, Evalue=9e-66,
Organism=Escherichia coli, GI1790653, Length=459, Percent_Identity=31.8082788671024, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1786602, Length=469, Percent_Identity=33.0490405117271, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI87081869, Length=241, Percent_Identity=27.8008298755187, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=368, Percent_Identity=22.2826086956522, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=434, Percent_Identity=34.331797235023, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322892, Length=441, Percent_Identity=34.0136054421769, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6320717, Length=406, Percent_Identity=32.2660098522167, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324061, Length=431, Percent_Identity=31.554524361949, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=422, Percent_Identity=31.7535545023697, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319824, Length=415, Percent_Identity=30.8433734939759, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=402, Percent_Identity=29.6019900497512, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=30.75, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=416, Percent_Identity=30.7692307692308, Blast_Score=173, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6320251, Length=411, Percent_Identity=29.4403892944039, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=29.0243902439024, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6324990, Length=439, Percent_Identity=29.3849658314351, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6324924, Length=476, Percent_Identity=28.5714285714286, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=469, Percent_Identity=28.5714285714286, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322967, Length=396, Percent_Identity=28.7878787878788, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324981, Length=394, Percent_Identity=30.2030456852792, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=418, Percent_Identity=26.0765550239234, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=493, Percent_Identity=24.3407707910751, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24668806, Length=398, Percent_Identity=22.8643216080402, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356285, Length=398, Percent_Identity=22.8643216080402, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668802, Length=398, Percent_Identity=22.8643216080402, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24666159, Length=428, Percent_Identity=20.5607476635514, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221512776, Length=428, Percent_Identity=20.5607476635514, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49687; Mature: 49556

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGSNTGLGTGLKQRHVTMMSIAGVIGAGLFVGSGHAIAEAGPASILAYAIAGMLVVLVM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHH
RMLGEMAVAHPDSGSFSTYADRAIGHWAGFTIGWLYWWFWVLVIPIEATAAATILNAWFP
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVATWIFALGITLLLTITNLFSVKNYGEFEFWFALIKVVAIVVFLCIGGAAIVGIVPAPA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCH
VSGVSNLFAHDGFMPHGAGAVLAAMLTTMFSFLGTEIVTIAAAESDNPQRQIVRATNSVI
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHEEEEECCCCCHHHHHHHHHHHHH
WRITLFYLGSILVVAAIVPWNDPLLPKHGSYQRAMELIGVPNAKAIIDVIVLVSVASCLN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
SALYTASRMLFSLSRRKDAPAFLHRTDSTGTPRAAVLASTAFGFLTVIANYLMPEQVFGF
HHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLATSGAIALLVYLVIAISQLRMRKTLESGGADLPLRMWLFPWLTWAVILFICGTLTVMF
HHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VSEEHRMEVGATAVLALIVLFAAWLNKRGRDARVSEGRRVSAM
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]