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The map label for this gene is hisI

Identifier: 115350405

GI number: 115350405

Start: 393473

End: 393889

Strand: Direct

Name: hisI

Synonym: Bamb_0350

Alternate gene names: 115350405

Gene position: 393473-393889 (Clockwise)

Preceding gene: 115350404

Following gene: 115350406

Centisome position: 11.06

GC content: 61.87

Gene sequence:

>417_bases
ATGAATACGGAAACGAAAGCGCTGCCCGCGTGGCTCGACAAGGTCCGCTGGGACGACAACGGCCTCGTGCCGGTGATCGC
GCAGGAAGCATCGACGAACGACGTGCTGATGTTCGCGTGGATGAATCGCGAAGCGCTCGCGAAGACGATCGAAACGCAGC
GCGCGGTTTATTATTCGCGTTCGCGCAAGCGCCTGTGGTTCAAGGGCGAAGAGTCGGGCCACGTGCAGCACGTGCACGAG
GTGCGGCTCGACTGCGACGAGGACGTCGTGCTGCTGAAGGTCGAGCAGGTGTCGGGCATCGCATGCCACACCGGCCGGCA
TTCGTGCTTCTTCCAGAAATTCGAAGGCACGGTGGACGGCGGCGACTGGGTCGCGGTCGATCCGGTGCTGAAAGACCCCG
AACACATCTACAAATGA

Upstream 100 bases:

>100_bases
CTGACGCGGTGCTGGCCGCCAGCATCTTCCACTACGGCGAGCACACGGTCGGCGAGGCGAAGCGCTTCATGTCCGATCAG
GGCATTCCGGTGAGGCTGTG

Downstream 100 bases:

>100_bases
CGCAATCGACCGAAGACACGCTGCTGCGCCTCGCGGCCGTGATCGATAGCCGCAAGGGCGGCGACCCCGATCAATCGTAC
GTATCGCGCCTGTTTCACAA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MNTETKALPAWLDKVRWDDNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWFKGEESGHVQHVHE
VRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDGGDWVAVDPVLKDPEHIYK

Sequences:

>Translated_138_residues
MNTETKALPAWLDKVRWDDNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWFKGEESGHVQHVHE
VRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDGGDWVAVDPVLKDPEHIYK
>Mature_138_residues
MNTETKALPAWLDKVRWDDNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWFKGEESGHVQHVHE
VRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDGGDWVAVDPVLKDPEHIYK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=45.0549450549451, Blast_Score=91, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=83, Percent_Identity=39.7590361445783, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_BURA4 (B1YRW2)

Other databases:

- EMBL:   CP001025
- RefSeq:   YP_001807076.1
- ProteinModelPortal:   B1YRW2
- SMR:   B1YRW2
- GeneID:   6177622
- GenomeReviews:   CP001025_GR
- KEGG:   bac:BamMC406_0359
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- ProtClustDB:   PRK00051
- BioCyc:   BAMB398577:BAMMC406_0359-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15843; Mature: 15843

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTETKALPAWLDKVRWDDNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSR
CCCCCHHHHHHHHHEEECCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
SRKRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDG
CCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCCEEEECCCCCEEEEECCCCCCC
GDWVAVDPVLKDPEHIYK
CCEEEECCCCCCHHHHCC
>Mature Secondary Structure
MNTETKALPAWLDKVRWDDNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSR
CCCCCHHHHHHHHHEEECCCCEEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
SRKRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDG
CCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCCEEEECCCCCEEEEECCCCCCC
GDWVAVDPVLKDPEHIYK
CCEEEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA